Influence of age, social patterns and nasopharyngeal carriage on antibodies to three conserved pneumococcal surface proteins (PhtD, PcpA and PrtA) ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08-18

AUTHORS

A. Hagerman, K. M. Posfay-Barbe, S. Grillet, M. M. Ochs, R. H. Brookes, D. Greenberg, N. Givon-Lavi, R. Dagan, C.-A. Siegrist

ABSTRACT

The acquisition of specific antibodies is paramount to protect children against pneumococcal diseases, and a better understanding of how age, ethnicity and/or Streptococcus pneumoniae (Spn) nasopharyngeal carriage influence the acquisition of antibodies to pneumococcal surface proteins (PSP) is important for the development of novel serodiagnostic and immunisation strategies. IgG antibody titres against three conserved PSP (PhtD, PcpA and PrtA) in the sera of 451 healthy children aged 1 to 24 months from Israel [Jewish (50.1 %) and Bedouin (49.9 %)] were measured by enzyme-linked immunosorbent assay (ELISA), while nasopharyngeal swabs from these children were assessed for the presence of Spn. Globally, anti-PhtD and anti-PrtA geometric mean concentrations (GMC; EU/ml) were high at <2.5 months of age [PhtD: 35.3, 95 % confidence interval (CI) 30.6–40.6; PrtA: 71.2, 95 % CI 60–84.5], was lower at 5–7 months of age (PhtD: 10, 95 % CI 8–12.4; PrtA: 17.9, 95 % CI 14.4–22.1) and only increased after 11 months of age. In contrast, an increase in anti-PcpA was observed at 5–7 months of age. Anti-PcpA and anti-PrtA, but not anti-PhtD, were significantly higher in Bedouin children (PcpA: 361.6 vs. 226.3, p = 0.02; PrtA: 67.2 vs. 29.5, p < 0.001) in whom Spn nasopharyngeal carriage was identified earlier (60 % vs. 38 % of carriers <6 months of age, p = 0.002). Spn carriage was associated with significantly higher anti-PSP concentrations in carriers than in non-carriers (p < 0.001 for each PSP). Thus, age, ethnicity and, essentially, nasopharyngeal carriage exert distinct cumulative influences on infant responses to PSP. These specific characteristics are worthwhile to include in the evaluation of pneumococcal seroresponses and the development of new PSP-based vaccines. More... »

PAGES

43-49

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-012-1712-9

DOI

http://dx.doi.org/10.1007/s10096-012-1712-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048848235

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22903166


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69 geometric mean concentrations
70 healthy children
71 healthy young children
72 immunisation strategies
73 immunosorbent assay
74 increase
75 infants' responses
76 influence
77 influence of age
78 mean concentration
79 months
80 months of age
81 nasopharyngeal carriage
82 nasopharyngeal carriage exert distinct cumulative influences
83 nasopharyngeal carriage influence
84 nasopharyngeal swabs
85 new PSP
86 novel serodiagnostic
87 patterns
88 pneumococcal disease
89 pneumococcal seroresponses
90 pneumococcal surface proteins
91 pneumoniae (Spn) nasopharyngeal carriage influence
92 presence
93 presence of Spn
94 protein
95 response
96 serodiagnostics
97 seroresponses
98 serum
99 social patterns
100 specific antibodies
101 specific characteristics
102 strategies
103 surface proteins
104 swabs
105 understanding
106 vaccine
107 young children
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