Pneumocystosis: a network survey in the Paris area 2003–2008 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01-13

AUTHORS

D. Magne, A. Angoulvant, F. Botterel, C. Bouges-Michel, M.-E. Bougnoux, P. Bouree, C. Chochillon, M. Cornet, E. Dannaoui, A. Fekkar, G. Galeazzi, H. Yera, C. Sarfati, P. Roux

ABSTRACT

The aims of this network group were to collect epidemiological data of PcP cases in 14 hospitals in the Paris area and to determine the Di-Hydro Pteroate Synthase (DHPS) genotypes, genetic markers for possible sulfamide resistance. From January 1, 2003 to December 31, 2008, 993 (mean 166/year) PcP cases have been reported. Sixty-five percent of patients were HIV-positive. The median count of CD4 lymphocytes was 32/mm3 (30 in HIV-positive patients, 152 in HIV-negative patients). In HIV-positive patients, PcP revealed the HIV infection in 39%. Among 304 PcP occurring in HIV known infected patients, no prophylaxis was prescribed for 64%; cotrimoxazole prophylaxis had been prescribed to 47 patients but only one of them had the right compliance. In HIV-negative patients (264), corticosteroids were prescribed in 59% and cytotoxic chemotherapies in 34%; 78% did not receive prophylaxis. One hundred sixty nine tumoral pathologies and 116 transplantations were notified. The mortality rate was 16% at day 14 (13% in HIV-positive patients, 26% in HIV-negative patients). Mutations in DHPS genes were detected in 18.5% of samples; 12.5% of patients were infected with several strains. The total annual number of cases has been stable for five years but the proportion of HIV-negative patients increased from 25% to 43%. More... »

PAGES

673-675

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-010-1139-0

DOI

http://dx.doi.org/10.1007/s10096-010-1139-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037050532

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21229281


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28 schema:description The aims of this network group were to collect epidemiological data of PcP cases in 14 hospitals in the Paris area and to determine the Di-Hydro Pteroate Synthase (DHPS) genotypes, genetic markers for possible sulfamide resistance. From January 1, 2003 to December 31, 2008, 993 (mean 166/year) PcP cases have been reported. Sixty-five percent of patients were HIV-positive. The median count of CD4 lymphocytes was 32/mm3 (30 in HIV-positive patients, 152 in HIV-negative patients). In HIV-positive patients, PcP revealed the HIV infection in 39%. Among 304 PcP occurring in HIV known infected patients, no prophylaxis was prescribed for 64%; cotrimoxazole prophylaxis had been prescribed to 47 patients but only one of them had the right compliance. In HIV-negative patients (264), corticosteroids were prescribed in 59% and cytotoxic chemotherapies in 34%; 78% did not receive prophylaxis. One hundred sixty nine tumoral pathologies and 116 transplantations were notified. The mortality rate was 16% at day 14 (13% in HIV-positive patients, 26% in HIV-negative patients). Mutations in DHPS genes were detected in 18.5% of samples; 12.5% of patients were infected with several strains. The total annual number of cases has been stable for five years but the proportion of HIV-negative patients increased from 25% to 43%.
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35 schema:keywords CD4 lymphocytes
36 DHPS gene
37 HIV
38 HIV infection
39 HIV-negative patients
40 HIV-positive patients
41 PCP
42 PCP cases
43 Paris area
44 aim
45 annual number
46 area
47 cases
48 chemotherapy
49 compliance
50 corticosteroids
51 cotrimoxazole prophylaxis
52 count
53 cytotoxic chemotherapy
54 data
55 day 14
56 epidemiological data
57 genes
58 genetic markers
59 genotypes
60 group
61 hospital
62 infected patients
63 infection
64 lymphocytes
65 markers
66 median count
67 mm3
68 mortality rate
69 mutations
70 network groups
71 network survey
72 number
73 pathology
74 patients
75 percent
76 percent of patients
77 prophylaxis
78 proportion
79 rate
80 resistance
81 rights compliance
82 samples
83 strains
84 survey
85 synthase genotype
86 total annual number
87 transplantation
88 tumoral pathology
89 years
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