Risk factors for opportunistic infections in infliximab-treated patients: the importance of screening in prevention View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-09-17

AUTHORS

C. Garcia-Vidal, S. Rodríguez-Fernández, S. Teijón, M. Esteve, M. Rodríguez-Carballeira, J. M. Lacasa, G. Salvador, J. Garau

ABSTRACT

We sought to determine factors associated with opportunistic infections (OI) in infliximab-treated patients. A retrospective study cohort (1999–2004) was examined. Nine OI were diagnosed in 94 infliximab-treated patients: tuberculosis (four), visceral leishmaniasis (one), pyogenic muscular abscess (one Salmonella spp. and one Streptococcus pneumoniae), and two viral infections (hepatitis B virus [HBV] and zoster ophthalmicus). The risk for OI was significantly higher in the first year of treatment (odds ratio [OR] 8; 95% confidence interval [CI] 2–50). Previous treatment with more than two immunosuppressive drugs was the only factor related to OI (OR 8.686; 95% CI 1.889–39.943). We identified the subset of patients treated with infliximab who had a higher risk for OI. The screening of latent infections is key to diminishing the incidence of these infections. More... »

PAGES

331-337

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-008-0628-x

DOI

http://dx.doi.org/10.1007/s10096-008-0628-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019904257

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18797940


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