Adverse effects of antifungal therapies in invasive fungal infections: review and meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-02-11

AUTHORS

S. B. Girois, F. Chapuis, E. Decullier, B. G. P. Revol

ABSTRACT

Amphotericin B is the main therapeutic agent for the treatment of invasive fungal infections; however, it is associated with significant toxicities that limit its use. Other systemic antifungal agents have been developed to improve tolerability while maintaining the efficacy profile of conventional amphotericin B. Fifty-four studies involving 9,228 patients were assessed for the frequency of adverse effects of the main systemic antifungal agents. While the results suggest that liposomal amphotericin B is the least nephrotoxic of the lipid formulations (14.6%), that conventional amphotericin B is the most nephrotoxic (33.2%), and that itraconazole is the most hepatotoxic (31.5%), the lack of standard definitions of antifungal-related adverse effects limits the validity of these results. Furthermore, heterogeneous patient pools and differing protocols make it difficult to draw direct comparisons between studies. With the advent of newer classes of systemic antifungal agents, future trials should conform to definitions that are universally applicable and clinically relevant to allow for such comparisons and to enable evidence-based decision-making. More... »

PAGES

138

References to SciGraph publications

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  • 2000-02-01. Side-effects of Amphotericin B lipid complex (Abelcet) in the Scandinavian population in BONE MARROW TRANSPLANTATION
  • 1999-03-23. Treatment of invasive fungal infections with amphotericin B colloidal dispersion in bone marrow transplant recipients in BONE MARROW TRANSPLANTATION
  • 1997-04. Large-scale multicentre study of fluconazole in the treatment of hospitalised patients with fungal infections in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 1997-02-01. Efficacy of amphotericin B lipid complex injection (ABLC) in bone marrow transplant recipients with life-threatening systemic mycoses in BONE MARROW TRANSPLANTATION
  • 1997-05. Multicenter randomized trial of fluconazole versus amphotericin B for treatment of candidemia in non-neutropenic patients in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 1994-01. Tolerance of high doses of amphotericin B by infusion of a liposomal formulation in children with cancer in ANNALS OF HEMATOLOGY
  • 1998-10-01. Severe and common side-effects of amphotericin B lipid complex (Abelcet) in BONE MARROW TRANSPLANTATION
  • 1996-11. A randomized study comparing fluconazole with amphotericin B/5-flucytosine for the treatment of systemicCandida infections in intensive care patients in INFECTION
  • 2000-04-01. Amphotericin B colloidal dispersion (Amphocil) vs fluconazole for the prevention of fungal infections in neutropenic patients: data of a prematurely stopped clinical trial in BONE MARROW TRANSPLANTATION
  • 1997-07-01. Amphotericin B lipid complex (ABLC) for the treatment of confirmed or presumed fungal infections in immunocompromised patients with hematologic malignancies in BONE MARROW TRANSPLANTATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10096-005-0080-0

    DOI

    http://dx.doi.org/10.1007/s10096-005-0080-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032632336

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16622909


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