Prevalence, Determinants, and Molecular Epidemiology of Streptococcus pneumoniae Isolates Colonizing the Nasopharynx of Healthy Children in Rome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

N. Petrosillo, A. Pantosti, E. Bordi, A. Spanó, M. Del Grosso, B. Tallarida, G. Ippolito

ABSTRACT

The aim of this study was to determine the factors favouring Streptococcus pneumoniae nasopharyngeal colonization of healthy children attending daycare centres and to describe the circulation of penicillin-nonsusceptible strains using molecular techniques. A single nasopharyngeal swab was obtained from 610 children attending daycare centres in the southeast area of Rome. Streptococcus pneumoniae isolates were serotyped, and antibiotic susceptibility was assayed by the E test. The genetic determinants of erythromycin resistance were detected by a duplex polymerase chain reaction, and the penicillin-nonsusceptible isolates were typed by pulsed-field gel electrophoresis. The overall carriage rate of Streptococcus pneumoniae was 14.9%. Living with more than three persons in the same household was the only risk factor statistically associated with carriage. Sixteen of 85 (18.8%) strains were nonsusceptible to penicillin, and 44 (52%) were resistant to erythromycin. Of the erythromycin-resistant strains, the vast majority showed a high level of resistance and carried the erm(B) gene. The penicillin-nonsusceptible strains belonged to six different serotypes; molecular typing showed that in only one case (2 strains) was there a circulation of the same clone in the same daycare centre. In view of the high rate of resistant Streptococcus pneumoniae strains, risk factors for carriage of resistant strains were evaluated. Children who received macrolides in the previous month had a higher risk of being colonized by macrolide-resistant strains as well as by strains resistant to both penicillin and erythromycin. Limiting the use of antibiotics in children seems the most appropriate measure to control the spread of antibiotic-resistant strains. More... »

PAGES

181-188

References to SciGraph publications

  • 1999-06. Resistance Patterns of Streptococcus pneumoniae from Children in Central Italy in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 1998-12. Previous Antibiotic Consumption and Other Risk Factors for Carriage of Penicillin-Resistant Streptococcus pneumoniae in Children in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10096-001-0689-6

    DOI

    http://dx.doi.org/10.1007/s10096-001-0689-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003207813

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11957019


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anti-Bacterial Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier State", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child Day Care Centers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child, Preschool", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Resistance, Bacterial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Health", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Macrolides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microbial Sensitivity Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pharynx", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pneumococcal Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prevalence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Serotyping", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Streptococcus pneumoniae", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Istituti di Ricovero e Cura a Carattere Scientifico", 
              "id": "https://www.grid.ac/institutes/grid.414603.4", 
              "name": [
                "II Infectious Diseases Division, Istituto Nazionale per le Malattie Infettive, \"Lazzaro Spallanzani\", IRCCS, Via Portuense 292, 00149 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petrosillo", 
            "givenName": "N.", 
            "id": "sg:person.0620664002.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620664002.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Superiore di Sanit\u00e0", 
              "id": "https://www.grid.ac/institutes/grid.416651.1", 
              "name": [
                "Bacteriology and Medical Mycology Laboratory, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pantosti", 
            "givenName": "A.", 
            "id": "sg:person.01222157475.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222157475.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituti di Ricovero e Cura a Carattere Scientifico", 
              "id": "https://www.grid.ac/institutes/grid.414603.4", 
              "name": [
                "Clinical Pathology Laboratory, Istituto Nazionale per le Malattie Infettive, \"Lazzaro Spallanzani\", IRCCS, Via Portuense 292, 00149 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bordi", 
            "givenName": "E.", 
            "id": "sg:person.01252072740.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252072740.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Microbiology Laboratory, Hospital \"Sandro Pertini\", Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Span\u00f3", 
            "givenName": "A.", 
            "id": "sg:person.01320662637.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320662637.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Superiore di Sanit\u00e0", 
              "id": "https://www.grid.ac/institutes/grid.416651.1", 
              "name": [
                "Bacteriology and Medical Mycology Laboratory, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Del Grosso", 
            "givenName": "M.", 
            "id": "sg:person.01240644744.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240644744.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Sanitaria Locale", 
              "id": "https://www.grid.ac/institutes/grid.432296.8", 
              "name": [
                "Department of Maternal and Child Health, Local Health Unit ASL RMB, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tallarida", 
            "givenName": "B.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituti di Ricovero e Cura a Carattere Scientifico", 
              "id": "https://www.grid.ac/institutes/grid.414603.4", 
              "name": [
                "Scientific Direction, Istituto Nazionale per le Malattie Infettive, \u201cLazzaro Spallanzani\u201d, IRCCS, Via Portuense 292, 00149 Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ippolito", 
            "givenName": "G.", 
            "id": "sg:person.0710457221.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710457221.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.3109/00365549709035893", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001347595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/clinids/23.4.712", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008081266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1994.03510330073037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009937814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s100960050202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010616111", 
              "https://doi.org/10.1007/s100960050202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-3476(95)70108-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010933068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpedi.153.5.495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013375034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00015024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019678584", 
              "https://doi.org/10.1007/pl00015024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-198603000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020396130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-198603000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020396130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-198603000-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020396130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/313981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029094325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/02724936.1997.11747894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044130573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/317502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047878643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1651-2227.1995.tb13545.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049469592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/174.6.1352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049784695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-0691.1998.tb00344.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053525833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/515239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058789629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/142.6.923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059697657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/157.2.256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059700748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/infdis/163.6.1273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059702628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-199707000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060265592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-199707000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060265592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-199707000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060265592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-199907000-00016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060266398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-199907000-00016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060266398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006454-199907000-00016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060266398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.aje.a113452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082171072"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2002-03", 
        "datePublishedReg": "2002-03-01", 
        "description": "The aim of this study was to determine the factors favouring Streptococcus pneumoniae nasopharyngeal colonization of healthy children attending daycare centres and to describe the circulation of penicillin-nonsusceptible strains using molecular techniques. A single nasopharyngeal swab was obtained from 610 children attending daycare centres in the southeast area of Rome. Streptococcus pneumoniae isolates were serotyped, and antibiotic susceptibility was assayed by the E test. The genetic determinants of erythromycin resistance were detected by a duplex polymerase chain reaction, and the penicillin-nonsusceptible isolates were typed by pulsed-field gel electrophoresis. The overall carriage rate of Streptococcus pneumoniae was 14.9%. Living with more than three persons in the same household was the only risk factor statistically associated with carriage. Sixteen of 85 (18.8%) strains were nonsusceptible to penicillin, and 44 (52%) were resistant to erythromycin. Of the erythromycin-resistant strains, the vast majority showed a high level of resistance and carried the erm(B) gene. The penicillin-nonsusceptible strains belonged to six different serotypes; molecular typing showed that in only one case (2 strains) was there a circulation of the same clone in the same daycare centre. In view of the high rate of resistant Streptococcus pneumoniae strains, risk factors for carriage of resistant strains were evaluated. Children who received macrolides in the previous month had a higher risk of being colonized by macrolide-resistant strains as well as by strains resistant to both penicillin and erythromycin. Limiting the use of antibiotics in children seems the most appropriate measure to control the spread of antibiotic-resistant strains.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10096-001-0689-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1093599", 
            "issn": [
              "0934-9723", 
              "1435-4373"
            ], 
            "name": "European Journal of Clinical Microbiology & Infectious Diseases", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "21"
          }
        ], 
        "name": "Prevalence, Determinants, and Molecular Epidemiology of Streptococcus pneumoniae Isolates Colonizing the Nasopharynx of Healthy Children in Rome", 
        "pagination": "181-188", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0f47b3b4ee9d31926b7f668bc80ccdfe40e191e1745a3812f65d61cd7b82320e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11957019"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8804297"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10096-001-0689-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1003207813"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10096-001-0689-6", 
          "https://app.dimensions.ai/details/publication/pub.1003207813"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000485.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s10096-001-0689-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10096-001-0689-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10096-001-0689-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10096-001-0689-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10096-001-0689-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    257 TRIPLES      21 PREDICATES      68 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10096-001-0689-6 schema:about N14c60fdc43c7481a839315de9b348a8a
    2 N16adf8f8c70f41f79fb0684275930f7d
    3 N199610b912dc48f98c17ccd062afedef
    4 N2e356e046e94408885508af83d4db679
    5 N4387062ad3db4d74a900134af1337c4b
    6 N4ec6409916ef44c28cd038cfd7cdb7a1
    7 N527b33e8755c431daf46cb3c8bf642d2
    8 N5769c7b652d74c79ad606b6aec08fae5
    9 N5d3f472e9c8c45149978ac859b4f4e98
    10 N675244cee81640eba8eef52ea7cff29d
    11 N72a01569021a4d7cacadf2b193c231c0
    12 N7d7733da261544198511b17fcbba5802
    13 N7f0fdc2d43864d7f8ad536a500a6fb8c
    14 N97735f61dd81496a95a59b9bd3c54b22
    15 Nb341499a4c424fe1b8de04bdb5bee382
    16 Nb5c911aa252d4725a36e364bdaf4de3e
    17 Nc66799b672944a51b5ed2e1199439523
    18 Nec8bb85d2a0645938cc22287b27d70c6
    19 anzsrc-for:11
    20 anzsrc-for:1108
    21 schema:author Nd8a72bb4ba784c3399a6794cb0e2b056
    22 schema:citation sg:pub.10.1007/pl00015024
    23 sg:pub.10.1007/s100960050202
    24 https://doi.org/10.1001/archpedi.153.5.495
    25 https://doi.org/10.1001/jama.1994.03510330073037
    26 https://doi.org/10.1016/s0022-3476(95)70108-7
    27 https://doi.org/10.1080/02724936.1997.11747894
    28 https://doi.org/10.1086/313981
    29 https://doi.org/10.1086/317502
    30 https://doi.org/10.1086/515239
    31 https://doi.org/10.1093/clinids/23.4.712
    32 https://doi.org/10.1093/infdis/142.6.923
    33 https://doi.org/10.1093/infdis/157.2.256
    34 https://doi.org/10.1093/infdis/163.6.1273
    35 https://doi.org/10.1093/infdis/174.6.1352
    36 https://doi.org/10.1093/oxfordjournals.aje.a113452
    37 https://doi.org/10.1097/00006454-198603000-00009
    38 https://doi.org/10.1097/00006454-199707000-00007
    39 https://doi.org/10.1097/00006454-199907000-00016
    40 https://doi.org/10.1111/j.1469-0691.1998.tb00344.x
    41 https://doi.org/10.1111/j.1651-2227.1995.tb13545.x
    42 https://doi.org/10.3109/00365549709035893
    43 schema:datePublished 2002-03
    44 schema:datePublishedReg 2002-03-01
    45 schema:description The aim of this study was to determine the factors favouring Streptococcus pneumoniae nasopharyngeal colonization of healthy children attending daycare centres and to describe the circulation of penicillin-nonsusceptible strains using molecular techniques. A single nasopharyngeal swab was obtained from 610 children attending daycare centres in the southeast area of Rome. Streptococcus pneumoniae isolates were serotyped, and antibiotic susceptibility was assayed by the E test. The genetic determinants of erythromycin resistance were detected by a duplex polymerase chain reaction, and the penicillin-nonsusceptible isolates were typed by pulsed-field gel electrophoresis. The overall carriage rate of Streptococcus pneumoniae was 14.9%. Living with more than three persons in the same household was the only risk factor statistically associated with carriage. Sixteen of 85 (18.8%) strains were nonsusceptible to penicillin, and 44 (52%) were resistant to erythromycin. Of the erythromycin-resistant strains, the vast majority showed a high level of resistance and carried the erm(B) gene. The penicillin-nonsusceptible strains belonged to six different serotypes; molecular typing showed that in only one case (2 strains) was there a circulation of the same clone in the same daycare centre. In view of the high rate of resistant Streptococcus pneumoniae strains, risk factors for carriage of resistant strains were evaluated. Children who received macrolides in the previous month had a higher risk of being colonized by macrolide-resistant strains as well as by strains resistant to both penicillin and erythromycin. Limiting the use of antibiotics in children seems the most appropriate measure to control the spread of antibiotic-resistant strains.
    46 schema:genre research_article
    47 schema:inLanguage en
    48 schema:isAccessibleForFree false
    49 schema:isPartOf N2f7a85175d6648efae4b286dcb3e7455
    50 N5c6103309b3240e091986a5a24b84dc1
    51 sg:journal.1093599
    52 schema:name Prevalence, Determinants, and Molecular Epidemiology of Streptococcus pneumoniae Isolates Colonizing the Nasopharynx of Healthy Children in Rome
    53 schema:pagination 181-188
    54 schema:productId N4cb370aa0a224b589579d525b20636c9
    55 N5d458b29ba4149cbb69144b2de625c16
    56 Nc8c6f269e30f40199945adba485adc80
    57 Nd4f4cf70e42049c8bc78eb075c1b4792
    58 Ndf39ccecd3944cc08bf19675dfc7d00d
    59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003207813
    60 https://doi.org/10.1007/s10096-001-0689-6
    61 schema:sdDatePublished 2019-04-11T01:01
    62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    63 schema:sdPublisher Nc57f8b46571b4930ad05f32ccef180fa
    64 schema:url http://link.springer.com/10.1007/s10096-001-0689-6
    65 sgo:license sg:explorer/license/
    66 sgo:sdDataset articles
    67 rdf:type schema:ScholarlyArticle
    68 N14c60fdc43c7481a839315de9b348a8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    69 schema:name Carrier State
    70 rdf:type schema:DefinedTerm
    71 N16adf8f8c70f41f79fb0684275930f7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    72 schema:name Pharynx
    73 rdf:type schema:DefinedTerm
    74 N199610b912dc48f98c17ccd062afedef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    75 schema:name Nose
    76 rdf:type schema:DefinedTerm
    77 N2e356e046e94408885508af83d4db679 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    78 schema:name Streptococcus pneumoniae
    79 rdf:type schema:DefinedTerm
    80 N2f7a85175d6648efae4b286dcb3e7455 schema:issueNumber 3
    81 rdf:type schema:PublicationIssue
    82 N316b45b3baa74cefbff2af740585bef9 rdf:first sg:person.01240644744.54
    83 rdf:rest Na62d1d25a8e34e4c99ce1b54fe42ae6b
    84 N34e1ad3969dc4abd95578a1adee95d78 rdf:first sg:person.01320662637.59
    85 rdf:rest N316b45b3baa74cefbff2af740585bef9
    86 N4387062ad3db4d74a900134af1337c4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Rome
    88 rdf:type schema:DefinedTerm
    89 N4cb370aa0a224b589579d525b20636c9 schema:name readcube_id
    90 schema:value 0f47b3b4ee9d31926b7f668bc80ccdfe40e191e1745a3812f65d61cd7b82320e
    91 rdf:type schema:PropertyValue
    92 N4ec6409916ef44c28cd038cfd7cdb7a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Risk Factors
    94 rdf:type schema:DefinedTerm
    95 N521946ed36284bfc95a1d56231257a09 schema:affiliation https://www.grid.ac/institutes/grid.432296.8
    96 schema:familyName Tallarida
    97 schema:givenName B.
    98 rdf:type schema:Person
    99 N527b33e8755c431daf46cb3c8bf642d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Health
    101 rdf:type schema:DefinedTerm
    102 N5769c7b652d74c79ad606b6aec08fae5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Serotyping
    104 rdf:type schema:DefinedTerm
    105 N5c6103309b3240e091986a5a24b84dc1 schema:volumeNumber 21
    106 rdf:type schema:PublicationVolume
    107 N5d3f472e9c8c45149978ac859b4f4e98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Child Day Care Centers
    109 rdf:type schema:DefinedTerm
    110 N5d458b29ba4149cbb69144b2de625c16 schema:name doi
    111 schema:value 10.1007/s10096-001-0689-6
    112 rdf:type schema:PropertyValue
    113 N675244cee81640eba8eef52ea7cff29d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Humans
    115 rdf:type schema:DefinedTerm
    116 N72a01569021a4d7cacadf2b193c231c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Prevalence
    118 rdf:type schema:DefinedTerm
    119 N79d6613cfd4445b1b779dfd68b949da5 rdf:first sg:person.01252072740.80
    120 rdf:rest N34e1ad3969dc4abd95578a1adee95d78
    121 N7d7733da261544198511b17fcbba5802 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Anti-Bacterial Agents
    123 rdf:type schema:DefinedTerm
    124 N7f0fdc2d43864d7f8ad536a500a6fb8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Child, Preschool
    126 rdf:type schema:DefinedTerm
    127 N8927aeafb54b4481a250c8145515b752 schema:name Microbiology Laboratory, Hospital "Sandro Pertini", Rome, Italy
    128 rdf:type schema:Organization
    129 N97735f61dd81496a95a59b9bd3c54b22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Macrolides
    131 rdf:type schema:DefinedTerm
    132 Na62d1d25a8e34e4c99ce1b54fe42ae6b rdf:first N521946ed36284bfc95a1d56231257a09
    133 rdf:rest Nc5719265f67e4a1c84105e4d391eefda
    134 Nb341499a4c424fe1b8de04bdb5bee382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Pneumococcal Infections
    136 rdf:type schema:DefinedTerm
    137 Nb5c911aa252d4725a36e364bdaf4de3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Infant
    139 rdf:type schema:DefinedTerm
    140 Nc5719265f67e4a1c84105e4d391eefda rdf:first sg:person.0710457221.03
    141 rdf:rest rdf:nil
    142 Nc57f8b46571b4930ad05f32ccef180fa schema:name Springer Nature - SN SciGraph project
    143 rdf:type schema:Organization
    144 Nc66799b672944a51b5ed2e1199439523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Drug Resistance, Bacterial
    146 rdf:type schema:DefinedTerm
    147 Nc8c6f269e30f40199945adba485adc80 schema:name pubmed_id
    148 schema:value 11957019
    149 rdf:type schema:PropertyValue
    150 Nd4f4cf70e42049c8bc78eb075c1b4792 schema:name nlm_unique_id
    151 schema:value 8804297
    152 rdf:type schema:PropertyValue
    153 Nd8a72bb4ba784c3399a6794cb0e2b056 rdf:first sg:person.0620664002.71
    154 rdf:rest Nf347e65627bf415ab4042088154d47b0
    155 Ndf39ccecd3944cc08bf19675dfc7d00d schema:name dimensions_id
    156 schema:value pub.1003207813
    157 rdf:type schema:PropertyValue
    158 Nec8bb85d2a0645938cc22287b27d70c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Microbial Sensitivity Tests
    160 rdf:type schema:DefinedTerm
    161 Nf347e65627bf415ab4042088154d47b0 rdf:first sg:person.01222157475.42
    162 rdf:rest N79d6613cfd4445b1b779dfd68b949da5
    163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Medical and Health Sciences
    165 rdf:type schema:DefinedTerm
    166 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Medical Microbiology
    168 rdf:type schema:DefinedTerm
    169 sg:journal.1093599 schema:issn 0934-9723
    170 1435-4373
    171 schema:name European Journal of Clinical Microbiology & Infectious Diseases
    172 rdf:type schema:Periodical
    173 sg:person.01222157475.42 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
    174 schema:familyName Pantosti
    175 schema:givenName A.
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222157475.42
    177 rdf:type schema:Person
    178 sg:person.01240644744.54 schema:affiliation https://www.grid.ac/institutes/grid.416651.1
    179 schema:familyName Del Grosso
    180 schema:givenName M.
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240644744.54
    182 rdf:type schema:Person
    183 sg:person.01252072740.80 schema:affiliation https://www.grid.ac/institutes/grid.414603.4
    184 schema:familyName Bordi
    185 schema:givenName E.
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252072740.80
    187 rdf:type schema:Person
    188 sg:person.01320662637.59 schema:affiliation N8927aeafb54b4481a250c8145515b752
    189 schema:familyName Spanó
    190 schema:givenName A.
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320662637.59
    192 rdf:type schema:Person
    193 sg:person.0620664002.71 schema:affiliation https://www.grid.ac/institutes/grid.414603.4
    194 schema:familyName Petrosillo
    195 schema:givenName N.
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620664002.71
    197 rdf:type schema:Person
    198 sg:person.0710457221.03 schema:affiliation https://www.grid.ac/institutes/grid.414603.4
    199 schema:familyName Ippolito
    200 schema:givenName G.
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710457221.03
    202 rdf:type schema:Person
    203 sg:pub.10.1007/pl00015024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019678584
    204 https://doi.org/10.1007/pl00015024
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/s100960050202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010616111
    207 https://doi.org/10.1007/s100960050202
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1001/archpedi.153.5.495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013375034
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1001/jama.1994.03510330073037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009937814
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/s0022-3476(95)70108-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010933068
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1080/02724936.1997.11747894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044130573
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1086/313981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029094325
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1086/317502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047878643
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1086/515239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058789629
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1093/clinids/23.4.712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081266
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1093/infdis/142.6.923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059697657
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1093/infdis/157.2.256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059700748
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1093/infdis/163.6.1273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059702628
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1093/infdis/174.6.1352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049784695
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1093/oxfordjournals.aje.a113452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082171072
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1097/00006454-198603000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020396130
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1097/00006454-199707000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060265592
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1097/00006454-199907000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060266398
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1111/j.1469-0691.1998.tb00344.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053525833
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1111/j.1651-2227.1995.tb13545.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049469592
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.3109/00365549709035893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001347595
    246 rdf:type schema:CreativeWork
    247 https://www.grid.ac/institutes/grid.414603.4 schema:alternateName Istituti di Ricovero e Cura a Carattere Scientifico
    248 schema:name Clinical Pathology Laboratory, Istituto Nazionale per le Malattie Infettive, "Lazzaro Spallanzani", IRCCS, Via Portuense 292, 00149 Rome, Italy
    249 II Infectious Diseases Division, Istituto Nazionale per le Malattie Infettive, "Lazzaro Spallanzani", IRCCS, Via Portuense 292, 00149 Rome, Italy
    250 Scientific Direction, Istituto Nazionale per le Malattie Infettive, “Lazzaro Spallanzani”, IRCCS, Via Portuense 292, 00149 Rome, Italy
    251 rdf:type schema:Organization
    252 https://www.grid.ac/institutes/grid.416651.1 schema:alternateName Istituto Superiore di Sanità
    253 schema:name Bacteriology and Medical Mycology Laboratory, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
    254 rdf:type schema:Organization
    255 https://www.grid.ac/institutes/grid.432296.8 schema:alternateName Azienda Sanitaria Locale
    256 schema:name Department of Maternal and Child Health, Local Health Unit ASL RMB, Rome, Italy
    257 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...