Possible Mechanism of Toxicity of Zidovudine by Induction of Apoptosis of CD4+ and CD8+ T-Cells in Vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11-28

AUTHORS

O. Benveniste, J. Estaquier, J. Lelièvre, J. Vildé, J. Ameisen, C. Leport

ABSTRACT

. Some HIV-infected patients have a discordant response to highly active antiretroviral therapy with a low virus load and an incomplete restoration of CD4+ T-cell counts. Zidovudine may limit CD4+ restoration by a hematotoxic mechanism. Apoptosis and T-cell counts were assessed in two patients before and after they switched from zidovudine to stavudine. Whereas CD4+ T-cell apoptosis fell from 52% and 66% before the zidovudine switch to 7% and 12%, respectively, after the switch, the patients' CD4+ counts rose gradually to +183 and +150 cells, respectively. It was therefore hypothesized that zidovudine directly induced apoptosis. Zidovudine withdrawal could be tested before immunological interventions such as interleukin-2 therapy are considered. More... »

PAGES

896-897

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10096-001-0635-7

DOI

http://dx.doi.org/10.1007/s10096-001-0635-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006996701

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11837644


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