High-dose versus low-dose inhaled levodopa (CVT-301) in patients with Parkinson disease for the treatment of OFF episodes: a meta-analysis of ... View Full Text


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Article Info

DATE

2022-07-30

AUTHORS

Zeya Yan, Wei Wang, Xinyu Tao, Wei Cheng, Gang Zuo, Zhouqing Chen, Zhong Wang, Gang Chen

ABSTRACT

BackgroundLevodopa is the most commonly used first-line drug for Parkinson’s disease. However, during the period of medication, the generation of motor fluctuations affects the life quality of patients. CVT-301, as an inhaled levodopa for the treatment of OFF episodes, rose in response to this condition.MethodsWe systematically searched Medline, EMBASE, Cochrane Library, and Clinicaltrials.gov for relevant randomized controlled trials, from the earliest available date to February 12, 2022, to evaluate the efficacy of high and low dose of inhaled levodopa in patients with Parkinson’s disease.ResultsA total of six multicenter, randomized controlled trials with 1166 patients were included. Compared with placebo, CVT-301 has a statistically significant effect on the treatment of Parkinson’s patients with OFF episodes of medication interval. The UPDRS Part III score decreased more significantly in the high-dose group 30 minutes after administration than the low-dose group (WMD = − 4.51; 95% CI, − 7.34 to − 1.68; p = 0.002). More patients in the high-dose group achieved and maintained an on state up to 60 min after receiving study medication (RR = 1.17; 95% CI, 1.08 to 1.27; p < 0.001). And more patients were proved with improved PGIC scores in the high-dose group (RR = 1.13; 95% CI, 1.05 to 1.21; p = 0.001).ConclusionsHigh doses CVT-301 can improve the motor function of the patient to some extent. There seems no risk of increasing adverse reactions. More... »

PAGES

6233-6241

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10072-022-06298-z

DOI

http://dx.doi.org/10.1007/s10072-022-06298-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149869678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35907110


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