Compensating for verbal-motor deficits in neuropsychological assessment in movement disorders: sensitivity and specificity of the ECAS in Parkinson’s and Huntington’s ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-03-16

AUTHORS

Laura Carelli, Federica Solca, Simone Migliore, Silvia Torre, Agostino Brugnera, Francesca Mancini, Sofia Tagini, Roberta Ferrucci, Sabrina Maffi, Consuelo Ceccarelli, Jacopo Pasquini, Jenny Sassone, Ferdinando Squitieri, Andrea Ciammola, Vincenzo Silani, Barbara Poletti

ABSTRACT

IntroductionThe study aims at investigating psychometric properties of the Edinburgh cognitive and behavioural ALS screen (ECAS) in Parkinson’s (PD) and Huntington’s (HD) diseases. The sensitivity and specificity of the ECAS in highlighting HD and PD cognitive-behavioural features and in differentiating between these two populations and from healthy controls (HC) were evaluated. Moreover, correlations between the ECAS and traditional cognitive measures, together with core clinical features, were analysed.MethodsSeventy-three PD patients, 38 HD patients, and 49 education-matched healthy participants were enrolled. Participants were administered the ECAS, together with other cognitive screening tools and psychological questionnaires. Patients’ behavioural assessment was also carried out with carers.ResultsThe ECAS distinguished between HD patients and HC and between the two clinical syndromes with high sensitivity and specificity. Even if the diagnostic accuracy of the ECAS in distinguishing between PD and HC was low, the PD cognitive phenotype was very well described by the ECAS performances. Convergent validity of the ECAS against other traditional cognitive screening was observed, as well as correlations with psychological aspects and typical clinical features, especially for the HD group.ConclusionsThe ECAS represents a rapid and feasible tool, useful also in other neurodegenerative disorders affecting verbal-motor abilities than the amyotrophic lateral sclerosis such as PD and HD. Clinical applications in these neurodegenerative conditions require further investigations and, probably, some adaptations of the original test. More... »

PAGES

4997-5006

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10072-021-05169-3

DOI

http://dx.doi.org/10.1007/s10072-021-05169-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1136444861

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33728549


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65 feasible tool
66 features
67 further investigation
68 group
69 healthy controls
70 healthy participants
71 high sensitivity
72 investigation
73 lateral sclerosis
74 measures
75 movement disorders
76 neurodegenerative conditions
77 neurodegenerative disorders
78 neuropsychological assessment
79 original test
80 participants
81 patients
82 performance
83 phenotype
84 population
85 properties
86 psychological aspects
87 psychological questionnaires
88 psychometric properties
89 questionnaire
90 sclerosis
91 screen
92 screening
93 screening tool
94 sensitivity
95 specificity
96 study
97 syndrome
98 test
99 tool
100 traditional cognitive measures
101 traditional cognitive screening
102 typical clinical features
103 validity
104 verbal-motor abilities
105 verbal-motor deficits
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