The potential roles of aquaporin 4 in amyotrophic lateral sclerosis. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-13

AUTHORS

Shuang Zou, Yu-Long Lan, Hongjin Wang, Bo Zhang, Yan-Guo Sun

ABSTRACT

Aquaporin 4 (AQP4) is a primary water channel found on astrocytes in the central nervous system (CNS). Besides its function in water and ion homeostasis, AQP4 has also been documented to be involved in a myriad of acute and chronic cerebral pathologies, including autoimmune neurodegenerative diseases. AQP4 has been postulated to be associated with the incidence of a progressive neurodegenerative disorder known as amyotrophic lateral sclerosis (ALS), a disease that targets the motor neurons, causing muscle weakness and eventually paralysis. Raised AQP4 levels were noted in association with vessels surrounded with swollen astrocytic processes as well as in the brainstem, cortex, and gray matter in patients with terminal ALS. AQP4 depolarization may lead to motor neuron degeneration in ALS via GLT-1. Besides, alterations in AQP4 expression in ALS may result in the loss of blood-brain barrier (BBB) integrity. Changes in AQP4 function may also disrupt K+ homeostasis and cause connexin dysregulation, the latter of which is associated to ALS disease progression. Furthermore, AQP4 suppression augments recovery in motor function in ALS, a phenomenon thought to be associated to NGF. No therapeutic drug targeting AQP4 has been developed to date. Nevertheless, the plethora of suggestive experimental results underscores the significance of further exploration into this area. More... »

References to SciGraph publications

  • 2019-03. Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat in ACTA NEUROPATHOLOGICA
  • 2008-05. Gap Junctions Couple Astrocytes and Oligodendrocytes in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2008-04. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration in NATURE NEUROSCIENCE
  • 2014-06. Aquaporin-4 Mitigates Retrograde Degeneration of Rubrospinal Neurons by Facilitating Edema Clearance and Glial Scar Formation After Spinal Cord Injury in Mice in MOLECULAR NEUROBIOLOGY
  • 2016-10. The Potential Roles of Aquaporin 4 in Alzheimer’s Disease in MOLECULAR NEUROBIOLOGY
  • 2015-02. Myelotomy reduces spinal cord edema and inhibits aquaporin-4 and aquaporin-9 expression in rats with spinal cord injury in SPINAL CORD
  • 2014-12. Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model in JOURNAL OF NEUROINFLAMMATION
  • 2017-09. Essential trace elements in amyotrophic lateral sclerosis (ALS): Results in a population of a risk area of Italy in NEUROLOGICAL SCIENCES
  • 2000-02. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke in NATURE MEDICINE
  • 2017-12. Targeted deletion of Aqp4 promotes the formation of astrocytic gap junctions in BRAIN STRUCTURE AND FUNCTION
  • 2017-12. Changes in routine laboratory tests and survival in amyotrophic lateral sclerosis in NEUROLOGICAL SCIENCES
  • 2010-10. Reactive astrocytes as therapeutic targets for CNS disorders in NEUROTHERAPEUTICS
  • 2019-03-15. A review of electrophysiological studies of lower motor neuron involvement in amyotrophic lateral sclerosis in NEUROLOGICAL SCIENCES
  • 2006-12. Mechanisms of Disease: astrocytes in neurodegenerative disease in NATURE REVIEWS NEUROLOGY
  • 2008-07. Aquaporins and cell migration in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2017. Aquaporins in Nervous System in AQUAPORINS
  • 2007-06. Aquaporin-4 and brain edema in PEDIATRIC NEPHROLOGY
  • 1995-02. Regional changes of ciliary neurotrophic factor and nerve growth factor levels in post mortem spinal cord and cerebral cortex from patients with motor disease in NATURE MEDICINE
  • 2013-07. Developing Therapeutic Antibodies for Neurodegenerative Disease in NEUROTHERAPEUTICS
  • 2007-05. Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model in NATURE NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10072-019-03877-5

    DOI

    http://dx.doi.org/10.1007/s10072-019-03877-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113380518

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30980198


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Dalian Medical University", 
              "id": "https://www.grid.ac/institutes/grid.411971.b", 
              "name": [
                "Computer Center, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China.", 
                "Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China.", 
                "Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.", 
                "Department of Physiology, Dalian Medical University, Dalian, 116044, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zou", 
            "givenName": "Shuang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Dalian Medical University", 
              "id": "https://www.grid.ac/institutes/grid.411971.b", 
              "name": [
                "Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China.", 
                "Department of Physiology, Dalian Medical University, Dalian, 116044, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lan", 
            "givenName": "Yu-Long", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Affiliated Hospital of Dalian Medical University", 
              "id": "https://www.grid.ac/institutes/grid.452828.1", 
              "name": [
                "Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116011, China."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Hongjin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "ShenZhen People\u2019s Hospital", 
              "id": "https://www.grid.ac/institutes/grid.440218.b", 
              "name": [
                "Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China. zhangbodl@126.com.", 
                "Department of Neurosurgery, Shenzhen People's Hospital, Shenzhen, 518020, China. zhangbodl@126.com."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Bo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Affiliated Hospital of Dalian Medical University", 
              "id": "https://www.grid.ac/institutes/grid.452828.1", 
              "name": [
                "Computer Center, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China. sunyanguo888@163.com."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sun", 
            "givenName": "Yan-Guo", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1096/fj.06-6848com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000582685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200402090-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001378959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200402090-00009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001378959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1015217108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001678083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2009.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002783854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.22023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003167213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1110689108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003519562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410380114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003542866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0295-168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004298355", 
              "https://doi.org/10.1038/nm0295-168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.21927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005065366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wnr.0b013e3282f2b4eb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005299463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wnr.0b013e3282f2b4eb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005299463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0001205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006232162"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ar.20838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006421486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/cclm.2011.083", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006914327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20081241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009007135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.04131.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009086193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinph.2006.04.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009740585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2009.03.069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010151960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010857317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awg073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011081235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011431327", 
              "https://doi.org/10.1038/nn1885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011431327", 
              "https://doi.org/10.1038/nn1885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011431327", 
              "https://doi.org/10.1038/nn1885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12031-007-9027-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013263906", 
              "https://doi.org/10.1007/s12031-007-9027-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2004.08.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013471655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013843548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2007.04.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015056581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.04164.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017171392"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.nurt.2010.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017909952", 
              "https://doi.org/10.1016/j.nurt.2010.07.003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13311-013-0187-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018242086", 
              "https://doi.org/10.1007/s13311-013-0187-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2013.08.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020235869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.035758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020324109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2004.05.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022647265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-013-8607-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023354373", 
              "https://doi.org/10.1007/s12035-013-8607-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-007-0357-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023553556", 
              "https://doi.org/10.1007/s00424-007-0357-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-007-0357-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023553556", 
              "https://doi.org/10.1007/s00424-007-0357-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn2073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024401100", 
              "https://doi.org/10.1038/nn2073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-11-42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024787151", 
              "https://doi.org/10.1186/1742-2094-11-42"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22414", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026808709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.032539299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028506890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2008.01.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030662568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.22635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031576407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199205283262204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034278798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200312190-00018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035552033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200312190-00018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035552033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1369/0022155414537495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035871396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1369/0022155414537495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035871396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1987-15.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036153665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2006.08.079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036498225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2003.12.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037285256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.21169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038049191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.10-177279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039639606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/nxi.0000000000000311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039921235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/nxi.0000000000000311", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039921235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2009.12.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040268427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sc.2014.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040884499", 
              "https://doi.org/10.1038/sc.2014.209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainresbull.2013.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041689997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-015-9446-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042364738", 
              "https://doi.org/10.1007/s12035-015-9446-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2336064100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046005375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046288978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20318", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046288978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/02699052.2010.542432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047181677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.410100602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047858829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awn014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048681551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/72256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048691293", 
              "https://doi.org/10.1038/72256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncpneuro0355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049103495", 
              "https://doi.org/10.1038/ncpneuro0355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncpneuro0355", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049103495", 
              "https://doi.org/10.1038/ncpneuro0355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2010.01.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049835021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2016/4626593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050690133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051699609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051699609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.prp.2004.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052012399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.prp.2004.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052012399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-006-0411-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053180891", 
              "https://doi.org/10.1007/s00467-006-0411-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00467-006-0411-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053180891", 
              "https://doi.org/10.1007/s00467-006-0411-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cercor/bhu157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059458458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6474173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062637676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2014.2867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071522215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2014.2867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071522215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/19336950.2014.949188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072288627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.21-06-01983.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074782268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-141068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078959821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainresbull.2017.02.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084062914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-94-024-1057-0_5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084496913", 
              "https://doi.org/10.1007/978-94-024-1057-0_5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2017.05.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085569412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00429-017-1448-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085612784", 
              "https://doi.org/10.1007/s00429-017-1448-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00429-017-1448-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085612784", 
              "https://doi.org/10.1007/s00429-017-1448-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lfs.2017.05.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085709653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10072-017-3018-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085967412", 
              "https://doi.org/10.1007/s10072-017-3018-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10072-017-3018-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085967412", 
              "https://doi.org/10.1007/s10072-017-3018-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2017.6786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086053977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1381612823666170714144844", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090747674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10072-017-3138-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092057184", 
              "https://doi.org/10.1007/s10072-017-3138-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/14728222.2017.1398236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092360914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/nan.12475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100837680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1106343312", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fpsyt.2018.00657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110531747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fpsyt.2018.00657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110531747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fpsyt.2018.00657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110531747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1950-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110751344", 
              "https://doi.org/10.1007/s00401-018-1950-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1950-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110751344", 
              "https://doi.org/10.1007/s00401-018-1950-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1950-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110751344", 
              "https://doi.org/10.1007/s00401-018-1950-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10072-019-03832-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112772912", 
              "https://doi.org/10.1007/s10072-019-03832-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10072-019-03832-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112772912", 
              "https://doi.org/10.1007/s10072-019-03832-4"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-13", 
        "datePublishedReg": "2019-04-13", 
        "description": "Aquaporin 4 (AQP4) is a primary water channel found on astrocytes in the central nervous system (CNS). Besides its function in water and ion homeostasis, AQP4 has also been documented to be involved in a myriad of acute and chronic cerebral pathologies, including autoimmune neurodegenerative diseases. AQP4 has been postulated to be associated with the incidence of a progressive neurodegenerative disorder known as amyotrophic lateral sclerosis (ALS), a disease that targets the motor neurons, causing muscle weakness and eventually paralysis. Raised AQP4 levels were noted in association with vessels surrounded with swollen astrocytic processes as well as in the brainstem, cortex, and gray matter in patients with terminal ALS. AQP4 depolarization may lead to motor neuron degeneration in ALS via GLT-1. Besides, alterations in AQP4 expression in ALS may result in the loss of blood-brain barrier (BBB) integrity. Changes in AQP4 function may also disrupt K+ homeostasis and cause connexin dysregulation, the latter of which is associated to ALS disease progression. Furthermore, AQP4 suppression augments recovery in motor function in ALS, a phenomenon thought to be associated to NGF. No therapeutic drug targeting AQP4 has been developed to date. Nevertheless, the plethora of suggestive experimental results underscores the significance of further exploration into this area.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10072-019-03877-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1294956", 
            "issn": [
              "1590-1874", 
              "1126-5442"
            ], 
            "name": "Neurological Sciences", 
            "type": "Periodical"
          }
        ], 
        "name": "The potential roles of aquaporin 4 in amyotrophic lateral sclerosis.", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10072-019-03877-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113380518"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100959175"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30980198"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10072-019-03877-5", 
          "https://app.dimensions.ai/details/publication/pub.1113380518"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-16T06:26", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106844_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s10072-019-03877-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10072-019-03877-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10072-019-03877-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10072-019-03877-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10072-019-03877-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    363 TRIPLES      20 PREDICATES      108 URIs      16 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10072-019-03877-5 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author N2ab8774a132f4b36b61cfd36e72646d4
    4 schema:citation sg:pub.10.1007/978-94-024-1057-0_5
    5 sg:pub.10.1007/s00401-018-1950-8
    6 sg:pub.10.1007/s00424-007-0357-5
    7 sg:pub.10.1007/s00429-017-1448-5
    8 sg:pub.10.1007/s00467-006-0411-0
    9 sg:pub.10.1007/s10072-017-3018-2
    10 sg:pub.10.1007/s10072-017-3138-8
    11 sg:pub.10.1007/s10072-019-03832-4
    12 sg:pub.10.1007/s12031-007-9027-5
    13 sg:pub.10.1007/s12035-013-8607-3
    14 sg:pub.10.1007/s12035-015-9446-1
    15 sg:pub.10.1007/s13311-013-0187-4
    16 sg:pub.10.1016/j.nurt.2010.07.003
    17 sg:pub.10.1038/72256
    18 sg:pub.10.1038/ncpneuro0355
    19 sg:pub.10.1038/nm0295-168
    20 sg:pub.10.1038/nn1885
    21 sg:pub.10.1038/nn2073
    22 sg:pub.10.1038/sc.2014.209
    23 sg:pub.10.1186/1742-2094-11-42
    24 https://app.dimensions.ai/details/publication/pub.1106343312
    25 https://doi.org/10.1002/ana.22023
    26 https://doi.org/10.1002/ana.410100602
    27 https://doi.org/10.1002/ana.410380114
    28 https://doi.org/10.1002/ar.20838
    29 https://doi.org/10.1002/glia.20318
    30 https://doi.org/10.1002/glia.21169
    31 https://doi.org/10.1002/glia.22277
    32 https://doi.org/10.1002/glia.22319
    33 https://doi.org/10.1002/glia.22414
    34 https://doi.org/10.1002/glia.22635
    35 https://doi.org/10.1002/jnr.20664
    36 https://doi.org/10.1002/jnr.21927
    37 https://doi.org/10.1016/j.brainres.2007.04.044
    38 https://doi.org/10.1016/j.brainres.2017.05.018
    39 https://doi.org/10.1016/j.brainresbull.2013.02.004
    40 https://doi.org/10.1016/j.brainresbull.2017.02.011
    41 https://doi.org/10.1016/j.clinph.2006.04.005
    42 https://doi.org/10.1016/j.lfs.2017.05.028
    43 https://doi.org/10.1016/j.nbd.2003.12.007
    44 https://doi.org/10.1016/j.neuron.2008.01.003
    45 https://doi.org/10.1016/j.neuropharm.2013.08.009
    46 https://doi.org/10.1016/j.neuroscience.2004.05.044
    47 https://doi.org/10.1016/j.neuroscience.2004.08.053
    48 https://doi.org/10.1016/j.neuroscience.2006.08.079
    49 https://doi.org/10.1016/j.neuroscience.2009.03.069
    50 https://doi.org/10.1016/j.neuroscience.2009.09.016
    51 https://doi.org/10.1016/j.neuroscience.2009.12.017
    52 https://doi.org/10.1016/j.neuroscience.2010.01.037
    53 https://doi.org/10.1016/j.prp.2004.01.011
    54 https://doi.org/10.1056/nejm199205283262204
    55 https://doi.org/10.1073/pnas.032539299
    56 https://doi.org/10.1073/pnas.1015217108
    57 https://doi.org/10.1073/pnas.1110689108
    58 https://doi.org/10.1073/pnas.2336064100
    59 https://doi.org/10.1080/14728222.2017.1398236
    60 https://doi.org/10.1084/jem.20081241
    61 https://doi.org/10.1093/brain/awg073
    62 https://doi.org/10.1093/brain/awn014
    63 https://doi.org/10.1093/cercor/bhu157
    64 https://doi.org/10.1096/fj.06-6848com
    65 https://doi.org/10.1096/fj.10-177279
    66 https://doi.org/10.1097/00001756-200312190-00018
    67 https://doi.org/10.1097/00001756-200402090-00009
    68 https://doi.org/10.1097/wnr.0b013e3282f2b4eb
    69 https://doi.org/10.1111/j.1471-4159.2006.04131.x
    70 https://doi.org/10.1111/j.1471-4159.2006.04164.x
    71 https://doi.org/10.1111/nan.12475
    72 https://doi.org/10.1126/science.6474173
    73 https://doi.org/10.1155/2016/4626593
    74 https://doi.org/10.1212/nxi.0000000000000311
    75 https://doi.org/10.1242/jcs.035758
    76 https://doi.org/10.1369/0022155414537495
    77 https://doi.org/10.1371/journal.pone.0001205
    78 https://doi.org/10.1515/cclm.2011.083
    79 https://doi.org/10.1523/jneurosci.1987-15.2015
    80 https://doi.org/10.1523/jneurosci.21-06-01983.2001
    81 https://doi.org/10.2174/1381612823666170714144844
    82 https://doi.org/10.3109/02699052.2010.542432
    83 https://doi.org/10.3233/jad-141068
    84 https://doi.org/10.3389/fpsyt.2018.00657
    85 https://doi.org/10.3892/mmr.2014.2867
    86 https://doi.org/10.3892/mmr.2017.6786
    87 https://doi.org/10.4161/19336950.2014.949188
    88 schema:datePublished 2019-04-13
    89 schema:datePublishedReg 2019-04-13
    90 schema:description Aquaporin 4 (AQP4) is a primary water channel found on astrocytes in the central nervous system (CNS). Besides its function in water and ion homeostasis, AQP4 has also been documented to be involved in a myriad of acute and chronic cerebral pathologies, including autoimmune neurodegenerative diseases. AQP4 has been postulated to be associated with the incidence of a progressive neurodegenerative disorder known as amyotrophic lateral sclerosis (ALS), a disease that targets the motor neurons, causing muscle weakness and eventually paralysis. Raised AQP4 levels were noted in association with vessels surrounded with swollen astrocytic processes as well as in the brainstem, cortex, and gray matter in patients with terminal ALS. AQP4 depolarization may lead to motor neuron degeneration in ALS via GLT-1. Besides, alterations in AQP4 expression in ALS may result in the loss of blood-brain barrier (BBB) integrity. Changes in AQP4 function may also disrupt K<sup>+</sup> homeostasis and cause connexin dysregulation, the latter of which is associated to ALS disease progression. Furthermore, AQP4 suppression augments recovery in motor function in ALS, a phenomenon thought to be associated to NGF. No therapeutic drug targeting AQP4 has been developed to date. Nevertheless, the plethora of suggestive experimental results underscores the significance of further exploration into this area.
    91 schema:genre research_article
    92 schema:inLanguage en
    93 schema:isAccessibleForFree false
    94 schema:isPartOf sg:journal.1294956
    95 schema:name The potential roles of aquaporin 4 in amyotrophic lateral sclerosis.
    96 schema:productId N294f4cc942d24b6d8bc2f8880860b0d1
    97 N5eda5917c0764f649f5090fd799aedfb
    98 N6f99c27109494c15897d9242ade3af45
    99 Na67c60efedd74002a094aeb0f2dedb93
    100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113380518
    101 https://doi.org/10.1007/s10072-019-03877-5
    102 schema:sdDatePublished 2019-04-16T06:26
    103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    104 schema:sdPublisher Nd12815448e3a43129b3982eb82b9f751
    105 schema:url http://link.springer.com/10.1007/s10072-019-03877-5
    106 sgo:license sg:explorer/license/
    107 sgo:sdDataset articles
    108 rdf:type schema:ScholarlyArticle
    109 N1de4af6cee524f8fb316bebfef90895e schema:affiliation https://www.grid.ac/institutes/grid.452828.1
    110 schema:familyName Wang
    111 schema:givenName Hongjin
    112 rdf:type schema:Person
    113 N294f4cc942d24b6d8bc2f8880860b0d1 schema:name dimensions_id
    114 schema:value pub.1113380518
    115 rdf:type schema:PropertyValue
    116 N2ab8774a132f4b36b61cfd36e72646d4 rdf:first Nbb76caf6c1a8419297cbf0a5aa5e6a77
    117 rdf:rest N563f109e9ca1409f9d06866abe1c8522
    118 N33e17eb6c4784f6babf8789e093eef12 rdf:first N5ff6cd2bb238472d966387dc7dd291df
    119 rdf:rest N94acfbb8f6414da7a440c6f70fcdc553
    120 N563f109e9ca1409f9d06866abe1c8522 rdf:first N8ec5930f10fc436a9701d2a3667f5eeb
    121 rdf:rest N8d09d26a202e41b2983316ba25a8ae55
    122 N5eda5917c0764f649f5090fd799aedfb schema:name doi
    123 schema:value 10.1007/s10072-019-03877-5
    124 rdf:type schema:PropertyValue
    125 N5ff6cd2bb238472d966387dc7dd291df schema:affiliation https://www.grid.ac/institutes/grid.440218.b
    126 schema:familyName Zhang
    127 schema:givenName Bo
    128 rdf:type schema:Person
    129 N6f99c27109494c15897d9242ade3af45 schema:name pubmed_id
    130 schema:value 30980198
    131 rdf:type schema:PropertyValue
    132 N8d09d26a202e41b2983316ba25a8ae55 rdf:first N1de4af6cee524f8fb316bebfef90895e
    133 rdf:rest N33e17eb6c4784f6babf8789e093eef12
    134 N8ec5930f10fc436a9701d2a3667f5eeb schema:affiliation https://www.grid.ac/institutes/grid.411971.b
    135 schema:familyName Lan
    136 schema:givenName Yu-Long
    137 rdf:type schema:Person
    138 N94acfbb8f6414da7a440c6f70fcdc553 rdf:first Nc11673aaa4fc47fe9b3e09bdf5588e63
    139 rdf:rest rdf:nil
    140 Na67c60efedd74002a094aeb0f2dedb93 schema:name nlm_unique_id
    141 schema:value 100959175
    142 rdf:type schema:PropertyValue
    143 Nbb76caf6c1a8419297cbf0a5aa5e6a77 schema:affiliation https://www.grid.ac/institutes/grid.411971.b
    144 schema:familyName Zou
    145 schema:givenName Shuang
    146 rdf:type schema:Person
    147 Nc11673aaa4fc47fe9b3e09bdf5588e63 schema:affiliation https://www.grid.ac/institutes/grid.452828.1
    148 schema:familyName Sun
    149 schema:givenName Yan-Guo
    150 rdf:type schema:Person
    151 Nd12815448e3a43129b3982eb82b9f751 schema:name Springer Nature - SN SciGraph project
    152 rdf:type schema:Organization
    153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    154 schema:name Medical and Health Sciences
    155 rdf:type schema:DefinedTerm
    156 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Neurosciences
    158 rdf:type schema:DefinedTerm
    159 sg:journal.1294956 schema:issn 1126-5442
    160 1590-1874
    161 schema:name Neurological Sciences
    162 rdf:type schema:Periodical
    163 sg:pub.10.1007/978-94-024-1057-0_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084496913
    164 https://doi.org/10.1007/978-94-024-1057-0_5
    165 rdf:type schema:CreativeWork
    166 sg:pub.10.1007/s00401-018-1950-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110751344
    167 https://doi.org/10.1007/s00401-018-1950-8
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1007/s00424-007-0357-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023553556
    170 https://doi.org/10.1007/s00424-007-0357-5
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1007/s00429-017-1448-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085612784
    173 https://doi.org/10.1007/s00429-017-1448-5
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1007/s00467-006-0411-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053180891
    176 https://doi.org/10.1007/s00467-006-0411-0
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/s10072-017-3018-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085967412
    179 https://doi.org/10.1007/s10072-017-3018-2
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/s10072-017-3138-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092057184
    182 https://doi.org/10.1007/s10072-017-3138-8
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s10072-019-03832-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112772912
    185 https://doi.org/10.1007/s10072-019-03832-4
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s12031-007-9027-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013263906
    188 https://doi.org/10.1007/s12031-007-9027-5
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/s12035-013-8607-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023354373
    191 https://doi.org/10.1007/s12035-013-8607-3
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s12035-015-9446-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042364738
    194 https://doi.org/10.1007/s12035-015-9446-1
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1007/s13311-013-0187-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018242086
    197 https://doi.org/10.1007/s13311-013-0187-4
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1016/j.nurt.2010.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017909952
    200 https://doi.org/10.1016/j.nurt.2010.07.003
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/72256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048691293
    203 https://doi.org/10.1038/72256
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/ncpneuro0355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049103495
    206 https://doi.org/10.1038/ncpneuro0355
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nm0295-168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004298355
    209 https://doi.org/10.1038/nm0295-168
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nn1885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011431327
    212 https://doi.org/10.1038/nn1885
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nn2073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024401100
    215 https://doi.org/10.1038/nn2073
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/sc.2014.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040884499
    218 https://doi.org/10.1038/sc.2014.209
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1186/1742-2094-11-42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024787151
    221 https://doi.org/10.1186/1742-2094-11-42
    222 rdf:type schema:CreativeWork
    223 https://app.dimensions.ai/details/publication/pub.1106343312 schema:CreativeWork
    224 https://doi.org/10.1002/ana.22023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003167213
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1002/ana.410100602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047858829
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1002/ana.410380114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003542866
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1002/ar.20838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006421486
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1002/glia.20318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046288978
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1002/glia.21169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038049191
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1002/glia.22277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013843548
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1002/glia.22319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010857317
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1002/glia.22414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026808709
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1002/glia.22635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031576407
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1002/jnr.20664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051699609
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1002/jnr.21927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005065366
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.brainres.2007.04.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015056581
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.brainres.2017.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085569412
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.brainresbull.2013.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041689997
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.brainresbull.2017.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084062914
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/j.clinph.2006.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009740585
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/j.lfs.2017.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085709653
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.nbd.2003.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037285256
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.neuron.2008.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030662568
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.neuropharm.2013.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020235869
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.neuroscience.2004.05.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022647265
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.neuroscience.2004.08.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013471655
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.neuroscience.2006.08.079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036498225
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.neuroscience.2009.03.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010151960
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.neuroscience.2009.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002783854
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.neuroscience.2009.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040268427
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.neuroscience.2010.01.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049835021
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.prp.2004.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052012399
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1056/nejm199205283262204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034278798
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1073/pnas.032539299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028506890
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1073/pnas.1015217108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001678083
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1073/pnas.1110689108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003519562
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1073/pnas.2336064100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046005375
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1080/14728222.2017.1398236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092360914
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1084/jem.20081241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009007135
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1093/brain/awg073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011081235
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1093/brain/awn014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048681551
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1093/cercor/bhu157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059458458
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1096/fj.06-6848com schema:sameAs https://app.dimensions.ai/details/publication/pub.1000582685
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1096/fj.10-177279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039639606
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1097/00001756-200312190-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035552033
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1097/00001756-200402090-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001378959
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1097/wnr.0b013e3282f2b4eb schema:sameAs https://app.dimensions.ai/details/publication/pub.1005299463
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1111/j.1471-4159.2006.04131.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009086193
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1111/j.1471-4159.2006.04164.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017171392
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1111/nan.12475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100837680
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1126/science.6474173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062637676
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1155/2016/4626593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050690133
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1212/nxi.0000000000000311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039921235
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1242/jcs.035758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020324109
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1369/0022155414537495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035871396
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1371/journal.pone.0001205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006232162
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1515/cclm.2011.083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006914327
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1523/jneurosci.1987-15.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036153665
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1523/jneurosci.21-06-01983.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074782268
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.2174/1381612823666170714144844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090747674
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.3109/02699052.2010.542432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047181677
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.3233/jad-141068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078959821
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.3389/fpsyt.2018.00657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110531747
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.3892/mmr.2014.2867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071522215
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.3892/mmr.2017.6786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086053977
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.4161/19336950.2014.949188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072288627
    349 rdf:type schema:CreativeWork
    350 https://www.grid.ac/institutes/grid.411971.b schema:alternateName Dalian Medical University
    351 schema:name Computer Center, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China.
    352 Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
    353 Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China.
    354 Department of Physiology, Dalian Medical University, Dalian, 116044, China.
    355 rdf:type schema:Organization
    356 https://www.grid.ac/institutes/grid.440218.b schema:alternateName ShenZhen People’s Hospital
    357 schema:name Department of Neurosurgery, Shenzhen People's Hospital, Shenzhen, 518020, China. zhangbodl@126.com.
    358 Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China. zhangbodl@126.com.
    359 rdf:type schema:Organization
    360 https://www.grid.ac/institutes/grid.452828.1 schema:alternateName Second Affiliated Hospital of Dalian Medical University
    361 schema:name Computer Center, The Second Affiliated Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, China. sunyanguo888@163.com.
    362 Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
    363 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...