Working memory in posterior cortical atrophy. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-08

AUTHORS

Laura Trotta, Delphine Lamoureux, Paolo Bartolomeo, Raffaella Migliaccio

ABSTRACT

We used an ad hoc created neuropsychological battery to evaluate in details both verbal and visuospatial working memory (WM) in patients with posterior cortical atrophy (PCA, n = 5). PCA is a rare, early-onset neurodegenerative dementia, often due to Alzheimer's disease (AD) pathology. Clinically, PCA patients present with visual, visuospatial, and visuomotor deficits, and no memory complaints. PCA patients' patterns of performance were compared with those of 11 typical, amnestic AD patients matched for disease severity, as well as with 17 age-matched healthy controls. Both groups of patients had impaired WM performance compared to controls. However, PCA patients were more impaired than typical AD patients for both verbal and visuospatial WM. Moreover, PCA patients showed a more consistent impairment of visuospatial WM, as compared with verbal WM. Systematic WM evaluation should be part of the standard assessment in PCA. WM deficits affect patients' quality of life and can be detrimental to rehabilitation programs. More... »

References to SciGraph publications

  • 2003-10. Working memory: looking back and looking forward in NATURE REVIEWS NEUROSCIENCE
  • 2013. Visual and Motor Mental Imagery After Brain Damage in MULTISENSORY IMAGERY
  • Journal

    TITLE

    Neurological Sciences

    ISSUE

    N/A

    VOLUME

    N/A

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10072-019-03869-5

    DOI

    http://dx.doi.org/10.1007/s10072-019-03869-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113301070

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30963338


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