KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-05

AUTHORS

Salvatore Mazzeo, Valentina Bessi, Sonia Padiglioni, Silvia Bagnoli, Laura Bracco, Sandro Sorbi, Benedetta Nacmias

ABSTRACT

KIBRA is a signal transducer protein, mainly expressed in the kidney and brain. A single-nucleotide polymorphism (SNP rs17070145, T → C exchange) has been linked to different cognitive function. In 2008, we studied 70 subjects who complained of subjective cognitive decline (SCD) and found that CT/TT carriers performed worse than CC carriers on a long-term memory test. We followed up the 70 SCD subjects and also 31 subjects affected by mild cognitive impairment (MCI) for a mean follow-up time of 7 years, during which 16 SCD subjects progressed to MCI and 14 MCI subjects progressed to Alzheimer's disease (AD). Carrying the T allele was associated with MCI and with a two times-higher risk of developing MCI than CC carriers. In the SCD sample, CT/TT carriers showed a greater worsening on Rivermead Behavioral Memory Test (RBMT) compared to CC carriers. In the MCI sample, CT/TT carriers performed worse than CC carriers on RBMT. There is a lack of consensus on the effect of KIBRA gene variants on cognitive performances in episodic memory and on the risk of AD. Our results confirm a role of T allele on progression of cognitive decline. More... »

References to SciGraph publications

Journal

TITLE

Neurological Sciences

ISSUE

N/A

VOLUME

N/A

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10072-019-03866-8

DOI

http://dx.doi.org/10.1007/s10072-019-03866-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113261852

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30953258


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzeo", 
        "givenName": "Salvatore", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bessi", 
        "givenName": "Valentina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Padiglioni", 
        "givenName": "Sonia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bagnoli", 
        "givenName": "Silvia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bracco", 
        "givenName": "Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.", 
            "IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sorbi", 
        "givenName": "Sandro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Florence", 
          "id": "https://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy. nacmias@unifi.it."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nacmias", 
        "givenName": "Benedetta", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jalz.2014.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000671015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2014.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000671015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2015.203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002020577", 
          "https://doi.org/10.1038/npp.2015.203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.b.30658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007494438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01997792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007658377", 
          "https://doi.org/10.1007/bf01997792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01997792", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007658377", 
          "https://doi.org/10.1007/bf01997792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02699052.2012.700089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010017161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000320482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010547835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1041610292000991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012131748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1041610292000991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012131748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12017-015-8348-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014974985", 
          "https://doi.org/10.1007/s12017-015-8348-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2011.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015460770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2009.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016255132", 
          "https://doi.org/10.1038/npp.2009.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2009.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016255132", 
          "https://doi.org/10.1038/npp.2009.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2008.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017727380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2007.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021832318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2011.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025279802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nrl.2013.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026817507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2007.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026871547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2011.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027106371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(94)90054-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027193703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3940(94)90054-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027193703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2004.01380.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027683931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-013-2830-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033251474", 
          "https://doi.org/10.1007/s11033-013-2830-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11033-013-2830-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033251474", 
          "https://doi.org/10.1007/s11033-013-2830-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(02)02945-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033837627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(02)02945-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033837627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2016.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034714482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-3956(90)90011-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035169871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s100720200003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035449565", 
          "https://doi.org/10.1007/s100720200003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3292-11.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037252834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2008.07.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039285362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psychres.2015.01.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040381435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15622971003797258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040813917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hipo.22148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040935907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropsychologia.2009.09.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040993839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2011.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041548665", 
          "https://doi.org/10.1038/npp.2011.16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.23.1.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042824373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jalz.2011.05.720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043159415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2008.06.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045259155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/a0030829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046473997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2008.00229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048554610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fnagi.2014.00270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049621105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2013.09.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050828018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0894-4105.11.2.187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052678442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/geront/9.3_part_1.179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059635232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1129837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2017.08.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091391771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-20513-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100671627", 
          "https://doi.org/10.1038/s41598-018-20513-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-171180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104108893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-171180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104108893"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04-05", 
    "datePublishedReg": "2019-04-05", 
    "description": "KIBRA is a signal transducer protein, mainly expressed in the kidney and brain. A single-nucleotide polymorphism (SNP rs17070145, T\u2009\u2192\u2009C exchange) has been linked to different cognitive function. In 2008, we studied 70 subjects who complained of subjective cognitive decline (SCD) and found that CT/TT carriers performed worse than CC carriers on a long-term memory test. We followed up the 70 SCD subjects and also 31 subjects affected by mild cognitive impairment (MCI) for a mean follow-up time of 7\u00a0years, during which 16 SCD subjects progressed to MCI and 14 MCI subjects progressed to Alzheimer's disease (AD). Carrying the T allele was associated with MCI and with a two times-higher risk of developing MCI than CC carriers. In the SCD sample, CT/TT carriers showed a greater worsening on Rivermead Behavioral Memory Test (RBMT) compared to CC carriers. In the MCI sample, CT/TT carriers performed worse than CC carriers on RBMT. There is a lack of consensus on the effect of KIBRA gene variants on cognitive performances in episodic memory and on the risk of AD. Our results confirm a role of T allele on progression of cognitive decline.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10072-019-03866-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294956", 
        "issn": [
          "1590-1874", 
          "1126-5442"
        ], 
        "name": "Neurological Sciences", 
        "type": "Periodical"
      }
    ], 
    "name": "KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment.", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30953258"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100959175"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10072-019-03866-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113261852"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10072-019-03866-8", 
      "https://app.dimensions.ai/details/publication/pub.1113261852"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117100_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10072-019-03866-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10072-019-03866-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10072-019-03866-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10072-019-03866-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10072-019-03866-8'


 

This table displays all metadata directly associated to this object as RDF triples.

232 TRIPLES      20 PREDICATES      67 URIs      16 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10072-019-03866-8 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N8342609b030747e285e8c576eb6d32a0
4 schema:citation sg:pub.10.1007/bf01997792
5 sg:pub.10.1007/s100720200003
6 sg:pub.10.1007/s11033-013-2830-x
7 sg:pub.10.1007/s12017-015-8348-8
8 sg:pub.10.1038/npp.2009.80
9 sg:pub.10.1038/npp.2011.16
10 sg:pub.10.1038/npp.2015.203
11 sg:pub.10.1038/s41598-018-20513-y
12 https://doi.org/10.1002/ajmg.b.30658
13 https://doi.org/10.1002/hipo.22148
14 https://doi.org/10.1016/0022-3956(90)90011-e
15 https://doi.org/10.1016/0304-3940(94)90054-x
16 https://doi.org/10.1016/j.biopsych.2013.09.036
17 https://doi.org/10.1016/j.jalz.2011.03.005
18 https://doi.org/10.1016/j.jalz.2011.03.008
19 https://doi.org/10.1016/j.jalz.2011.05.720
20 https://doi.org/10.1016/j.jalz.2011.11.010
21 https://doi.org/10.1016/j.jalz.2014.01.001
22 https://doi.org/10.1016/j.neulet.2008.03.008
23 https://doi.org/10.1016/j.neulet.2017.08.057
24 https://doi.org/10.1016/j.neurobiolaging.2007.02.001
25 https://doi.org/10.1016/j.neurobiolaging.2007.07.003
26 https://doi.org/10.1016/j.neurobiolaging.2008.07.014
27 https://doi.org/10.1016/j.neuron.2016.03.005
28 https://doi.org/10.1016/j.neuropsychologia.2009.09.031
29 https://doi.org/10.1016/j.neuroscience.2008.06.054
30 https://doi.org/10.1016/j.nrl.2013.07.004
31 https://doi.org/10.1016/j.psychres.2015.01.012
32 https://doi.org/10.1016/s0006-291x(02)02945-5
33 https://doi.org/10.1017/s1041610292000991
34 https://doi.org/10.1037/0894-4105.11.2.187
35 https://doi.org/10.1037/a0030829
36 https://doi.org/10.1093/geront/9.3_part_1.179
37 https://doi.org/10.1111/j.1365-2796.2004.01380.x
38 https://doi.org/10.1111/j.1582-4934.2008.00229.x
39 https://doi.org/10.1126/science.1129837
40 https://doi.org/10.1136/jnnp.23.1.56
41 https://doi.org/10.1159/000320482
42 https://doi.org/10.1523/jneurosci.3292-11.2011
43 https://doi.org/10.3109/02699052.2012.700089
44 https://doi.org/10.3109/15622971003797258
45 https://doi.org/10.3233/jad-171180
46 https://doi.org/10.3389/fnagi.2014.00270
47 schema:datePublished 2019-04-05
48 schema:datePublishedReg 2019-04-05
49 schema:description KIBRA is a signal transducer protein, mainly expressed in the kidney and brain. A single-nucleotide polymorphism (SNP rs17070145, T → C exchange) has been linked to different cognitive function. In 2008, we studied 70 subjects who complained of subjective cognitive decline (SCD) and found that CT/TT carriers performed worse than CC carriers on a long-term memory test. We followed up the 70 SCD subjects and also 31 subjects affected by mild cognitive impairment (MCI) for a mean follow-up time of 7 years, during which 16 SCD subjects progressed to MCI and 14 MCI subjects progressed to Alzheimer's disease (AD). Carrying the T allele was associated with MCI and with a two times-higher risk of developing MCI than CC carriers. In the SCD sample, CT/TT carriers showed a greater worsening on Rivermead Behavioral Memory Test (RBMT) compared to CC carriers. In the MCI sample, CT/TT carriers performed worse than CC carriers on RBMT. There is a lack of consensus on the effect of KIBRA gene variants on cognitive performances in episodic memory and on the risk of AD. Our results confirm a role of T allele on progression of cognitive decline.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf sg:journal.1294956
54 schema:name KIBRA T allele influences memory performance and progression of cognitive decline: a 7-year follow-up study in subjective cognitive decline and mild cognitive impairment.
55 schema:productId N7ced41f2248f40d4822aa97e09c647bc
56 Nbcecce49aa4a451fb010ac0047975359
57 Nc5124a68d4064e64b358c099197cf211
58 Nf7110c4050fb4248adb81ccb8627cfaa
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113261852
60 https://doi.org/10.1007/s10072-019-03866-8
61 schema:sdDatePublished 2019-04-11T14:18
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N93681c5ac18a4da582f0d0aaa37e10a5
64 schema:url http://link.springer.com/10.1007/s10072-019-03866-8
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N02250d0452fa42f3837a342305282826 rdf:first Naf77bae5c8824c56b4b4e4272820bbbe
69 rdf:rest N44141ec74fec403980ff620dd495a7dd
70 N06c3cb9008be4c02b4e28cd6a0bf84eb schema:affiliation https://www.grid.ac/institutes/grid.8404.8
71 schema:familyName Bessi
72 schema:givenName Valentina
73 rdf:type schema:Person
74 N0e431b9df4aa4fa29e5228a01dcd3b08 schema:affiliation https://www.grid.ac/institutes/grid.8404.8
75 schema:familyName Padiglioni
76 schema:givenName Sonia
77 rdf:type schema:Person
78 N3c0adfec01ae4a029d8952940b3662b4 schema:affiliation https://www.grid.ac/institutes/grid.8404.8
79 schema:familyName Mazzeo
80 schema:givenName Salvatore
81 rdf:type schema:Person
82 N44141ec74fec403980ff620dd495a7dd rdf:first Na1a6e56abf294e269c799e77be03c18f
83 rdf:rest N9e2528057417467aa262540fb07ff4fe
84 N4d883c9f23af4a19a6223f715fb0e9a6 rdf:first Ndddc6ee08b954ecd83498556cb62850e
85 rdf:rest rdf:nil
86 N738c0e5900b24d539285d0e3e66e6020 schema:affiliation https://www.grid.ac/institutes/grid.8404.8
87 schema:familyName Sorbi
88 schema:givenName Sandro
89 rdf:type schema:Person
90 N7ced41f2248f40d4822aa97e09c647bc schema:name dimensions_id
91 schema:value pub.1113261852
92 rdf:type schema:PropertyValue
93 N8342609b030747e285e8c576eb6d32a0 rdf:first N3c0adfec01ae4a029d8952940b3662b4
94 rdf:rest Ne552bdcb1aaf4814a0a288dd1630cf3d
95 N93681c5ac18a4da582f0d0aaa37e10a5 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N9e2528057417467aa262540fb07ff4fe rdf:first N738c0e5900b24d539285d0e3e66e6020
98 rdf:rest N4d883c9f23af4a19a6223f715fb0e9a6
99 Na1a6e56abf294e269c799e77be03c18f schema:affiliation https://www.grid.ac/institutes/grid.8404.8
100 schema:familyName Bracco
101 schema:givenName Laura
102 rdf:type schema:Person
103 Naf77bae5c8824c56b4b4e4272820bbbe schema:affiliation https://www.grid.ac/institutes/grid.8404.8
104 schema:familyName Bagnoli
105 schema:givenName Silvia
106 rdf:type schema:Person
107 Nbcecce49aa4a451fb010ac0047975359 schema:name nlm_unique_id
108 schema:value 100959175
109 rdf:type schema:PropertyValue
110 Nc5124a68d4064e64b358c099197cf211 schema:name doi
111 schema:value 10.1007/s10072-019-03866-8
112 rdf:type schema:PropertyValue
113 Nc7bad51338874e62811b6517ac428e30 rdf:first N0e431b9df4aa4fa29e5228a01dcd3b08
114 rdf:rest N02250d0452fa42f3837a342305282826
115 Ndddc6ee08b954ecd83498556cb62850e schema:affiliation https://www.grid.ac/institutes/grid.8404.8
116 schema:familyName Nacmias
117 schema:givenName Benedetta
118 rdf:type schema:Person
119 Ne552bdcb1aaf4814a0a288dd1630cf3d rdf:first N06c3cb9008be4c02b4e28cd6a0bf84eb
120 rdf:rest Nc7bad51338874e62811b6517ac428e30
121 Nf7110c4050fb4248adb81ccb8627cfaa schema:name pubmed_id
122 schema:value 30953258
123 rdf:type schema:PropertyValue
124 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
125 schema:name Medical and Health Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
128 schema:name Clinical Sciences
129 rdf:type schema:DefinedTerm
130 sg:journal.1294956 schema:issn 1126-5442
131 1590-1874
132 schema:name Neurological Sciences
133 rdf:type schema:Periodical
134 sg:pub.10.1007/bf01997792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007658377
135 https://doi.org/10.1007/bf01997792
136 rdf:type schema:CreativeWork
137 sg:pub.10.1007/s100720200003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035449565
138 https://doi.org/10.1007/s100720200003
139 rdf:type schema:CreativeWork
140 sg:pub.10.1007/s11033-013-2830-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033251474
141 https://doi.org/10.1007/s11033-013-2830-x
142 rdf:type schema:CreativeWork
143 sg:pub.10.1007/s12017-015-8348-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014974985
144 https://doi.org/10.1007/s12017-015-8348-8
145 rdf:type schema:CreativeWork
146 sg:pub.10.1038/npp.2009.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016255132
147 https://doi.org/10.1038/npp.2009.80
148 rdf:type schema:CreativeWork
149 sg:pub.10.1038/npp.2011.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041548665
150 https://doi.org/10.1038/npp.2011.16
151 rdf:type schema:CreativeWork
152 sg:pub.10.1038/npp.2015.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002020577
153 https://doi.org/10.1038/npp.2015.203
154 rdf:type schema:CreativeWork
155 sg:pub.10.1038/s41598-018-20513-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1100671627
156 https://doi.org/10.1038/s41598-018-20513-y
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1002/ajmg.b.30658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007494438
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1002/hipo.22148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040935907
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/0022-3956(90)90011-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1035169871
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/0304-3940(94)90054-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027193703
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.biopsych.2013.09.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050828018
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.jalz.2011.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015460770
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.jalz.2011.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025279802
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.jalz.2011.05.720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043159415
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.jalz.2011.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027106371
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.jalz.2014.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000671015
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.neulet.2008.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017727380
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.neulet.2017.08.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091391771
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.neurobiolaging.2007.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021832318
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.neurobiolaging.2007.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026871547
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.neurobiolaging.2008.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039285362
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.neuron.2016.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034714482
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.neuropsychologia.2009.09.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040993839
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.neuroscience.2008.06.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045259155
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.nrl.2013.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026817507
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.psychres.2015.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040381435
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0006-291x(02)02945-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033837627
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1017/s1041610292000991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012131748
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1037/0894-4105.11.2.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052678442
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1037/a0030829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046473997
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1093/geront/9.3_part_1.179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059635232
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/j.1365-2796.2004.01380.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027683931
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/j.1582-4934.2008.00229.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048554610
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1126/science.1129837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453969
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1136/jnnp.23.1.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042824373
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1159/000320482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010547835
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1523/jneurosci.3292-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037252834
219 rdf:type schema:CreativeWork
220 https://doi.org/10.3109/02699052.2012.700089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010017161
221 rdf:type schema:CreativeWork
222 https://doi.org/10.3109/15622971003797258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040813917
223 rdf:type schema:CreativeWork
224 https://doi.org/10.3233/jad-171180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104108893
225 rdf:type schema:CreativeWork
226 https://doi.org/10.3389/fnagi.2014.00270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049621105
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.8404.8 schema:alternateName University of Florence
229 schema:name Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
230 Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy. nacmias@unifi.it.
231 IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
232 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...