Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-10

AUTHORS

Piero Barbanti, Fiorella Guadagni, Maria Laura De Marchis, Cristiano Ialongo, Gabriella Egeo, Luisa Fofi, Cinzia Aurilia, Domenica Lovero, David Della-Morte, Patrizia Ferroni, Raffaele Palmirotta

ABSTRACT

Dopamine-beta-hydroxylase (DBH) enzyme activity is modulated at the genetic level by the presence of several polymorphisms. Among these, the 19-bp insertion/deletion (I/D) polymorphism (rs72393728/rs141116007) was investigated in several genetic association studies for its correlation with the susceptibility to develop episodic migraine, but conflicting results were achieved. In the present study we analyzed this genetic variant in a carefully characterized population of migraineurs encompassing both episodic and chronic migraine (with and without medication overuse) with the aim to perform a replication study and verify any possible correlation with migraine endophenotypes. Genotyping of the DBH 19-bp I/D polymorphism was performed on 400 migraine patients and 204 healthy individuals. The associations between genotypic frequencies and the clinical and sociodemographic features of migraineurs were then investigated. The DBH 19-bp I/D polymorphism did not correlate with migraine susceptibility or most clinical variables, with the exception of a statistically significant correlation within the subgroup of patients affected by chronic migraine were the individuals carrying the deleted (D) allele were significantly more prone to abuse in analgesics. As a result of this finding, the DBH 19-bp I/D polymorphism does not influence migraine susceptibility, but it might contribute to the development of medication overuse in patient with chronic migraine. More... »

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10072-019-03865-9

DOI

http://dx.doi.org/10.1007/s10072-019-03865-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113356215

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30972508


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262 Biotechnology Unit, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana "M. Aleandri", Rome, Italy.
263 Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy.
264 Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy.
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268 Department of Systems Medicine University of Rome "Tor Vergata", Rome, Italy.
269 Evelyn F McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA.
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272 schema:name Biobanca InterIstituzionale Multidisciplinare, IRCCS San Raffaele Pisana, Rome, Italy. raffaelepalmirotta@gmail.com.
273 Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
274 Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy. raffaelepalmirotta@gmail.com.
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277 schema:name Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
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