Health-related quality of life in clinically isolated syndrome and risk of conversion to multiple sclerosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09-25

AUTHORS

Elisa Baldin, Trond Riise, Katia Mattarozzi, Alberto Gajofatto, Franco Granella, Maurizio Leone, Alessandra Lugaresi, Susanna Malagù, Luisa Motti, Walter Neri, Ilaria Pesci, Mario Santangelo, Cinzia Scandellari, Maria Rosaria Tola, Luca Vignatelli, Corrado Zenesini, Roberto D’Alessandro, on behalf of G.E.Ro.N.I.Mu.S. study group

ABSTRACT

Background and objectivesA few studies have found that low scores on self-rated health and quality of life measures are associated with following worsening disability in multiple sclerosis (MS). We wanted to estimate the association between self-rated quality of life scores among patients with clinically isolated syndrome (CIS) and the risk of subsequent conversion to definite MS.MethodsOne hundred sixty-two patients from the GERONIMUS cohort with a symptom or sign suggestive of MS and without a definite diagnosis of MS at the time of inclusion were asked to evaluate their health-related quality of life according to MSQoL-54 scale. They were clinically assessed and mood and depression scales were applied. The association between the scores of these scales and the risk of converting to definite MS during a 5-year follow-up was estimated using the Cox- proportional hazard regression model.ResultsQuality of life at examination was significantly lower compared to those of an age- and sex-adjusted general Italian population. During the follow-up, 116 patients (72%) converted to definite MS. No significant predictive effects were found for the summary scales of MSQol-54 or other scales. The estimates did not change after adjusting for age, sex, BMI, education, MRI findings, Expanded Disability Status Scale (EDSS) score, and treatment at time of examination.ConclusionPersons with CIS in this cohort reported reduced self-rated quality of life compared to the general population, but variation in these scores was not associated with subsequent conversion from CIS to clinical definite MS. More... »

PAGES

75-80

Journal

TITLE

Neurological Sciences

ISSUE

1

VOLUME

40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10072-018-3582-0

DOI

http://dx.doi.org/10.1007/s10072-018-3582-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107227416

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30255488


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26 schema:description Background and objectivesA few studies have found that low scores on self-rated health and quality of life measures are associated with following worsening disability in multiple sclerosis (MS). We wanted to estimate the association between self-rated quality of life scores among patients with clinically isolated syndrome (CIS) and the risk of subsequent conversion to definite MS.MethodsOne hundred sixty-two patients from the GERONIMUS cohort with a symptom or sign suggestive of MS and without a definite diagnosis of MS at the time of inclusion were asked to evaluate their health-related quality of life according to MSQoL-54 scale. They were clinically assessed and mood and depression scales were applied. The association between the scores of these scales and the risk of converting to definite MS during a 5-year follow-up was estimated using the Cox- proportional hazard regression model.ResultsQuality of life at examination was significantly lower compared to those of an age- and sex-adjusted general Italian population. During the follow-up, 116 patients (72%) converted to definite MS. No significant predictive effects were found for the summary scales of MSQol-54 or other scales. The estimates did not change after adjusting for age, sex, BMI, education, MRI findings, Expanded Disability Status Scale (EDSS) score, and treatment at time of examination.ConclusionPersons with CIS in this cohort reported reduced self-rated quality of life compared to the general population, but variation in these scores was not associated with subsequent conversion from CIS to clinical definite MS.
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