Antiangiogenic therapy of brain tumors: the role of bevacizumab View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04

AUTHORS

Elisa Trevisan, Luca Bertero, Chiara Bosa, Michela Magistrello, Alessia Pellerino, Roberta Rudà, Riccardo Soffietti

ABSTRACT

Angiogenesis is one of the hallmarks of cancer, including brain tumors. Malignant gliomas have the highest degree of vascular proliferation among solid tumors; thus, angiogenic pathways represent an attractive target to interfere with tumor growth. Up to date VEGF pathway targeting with specific drugs has yielded interesting therapeutics results. In particular bevacizumab, a monoclonal antibody against VEGF-A, has shown clinical activity in malignant gliomas, especially glioblastomas, in terms of a high response rate on MRI and a significant increase in progression-free survival. More... »

PAGES

507-514

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10072-014-1627-6

DOI

http://dx.doi.org/10.1007/s10072-014-1627-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040120599

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24442487


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