Antioxidant activity of topiramate: an antiepileptic agent View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06-04

AUTHORS

N. Cárdenas-Rodríguez, E. Coballase-Urrutia, B. Huerta-Gertrudis, M. E. García-Cruz, J. Pedraza-Chaverri, R. Coria-Jiménez, C. Bandala, M. Ruíz-García

ABSTRACT

A number of experimental and clinical reports suggest the involvement of oxidative stress in pathophysiology of epilepsy. Topiramate, a new antiepileptic drug, induces antioxidant effect in epileptic animals. However, to date, no further studies appear to be carried out in order to demonstrate the ability of topiramate to act as antioxidant. Therefore, the objective of this work was to evaluate the in vitro superoxide (O2·−), hydroxyl radical (OH·), hypochlorous acid (HOCl), hydrogen peroxide (H2O2), singlet oxygen (1O2) and peroxynitrite (ONOO−) scavenging capacity of topiramate in comparison with reference compounds. In addition, we investigated the possible antitumour activity of this compound in some cancer cell lines. Topiramate displays a scavenging capacity compared to the reference compound, with the exception of ONOO−, although it was less efficient than nordihydroguaiaretic acid, dimethylthiourea, ascorbic acid, sodium pyruvate and glutathione for O2·−, OH·, HOCl, H2O2 and 1O2 (P < 0.0001), respectively, and not induced significant growth inhibition in cancer cell lines. The direct antioxidant properties of topiramate could explain the neuroprotective effects attributed to this compound and suggest its use as chemopreventive agent in a future. More... »

PAGES

741-747

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10072-012-1127-5

DOI

http://dx.doi.org/10.1007/s10072-012-1127-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046365231

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22661103


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