Scintigraphic, neuroradiological and clinical comparison in two patients with primary sporadic and two with secondary Fahr’s disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-04

AUTHORS

Giovanni Caranci, Giovanni Grillea, Francesco Barbato, Alexandra Brunetti, Tiziana Tassinari, Mariarita Di Ruzza, Francesco Lena, Barbara Gandolfi, Anna Elisa Castellano, Marcello Bartolo, Claudio Colonnese, Nicola Modugno, Stefano Ruggieri, Mario Manfredi

ABSTRACT

Bilateral striopallidodentate calcification, usually termed Fahr's disease, can give rise to various clinical manifestations including hyperkinetic movement disorders or a hypokinetic Parkinsonian syndrome, behavioural and mood changes, cognitive deficits and even frank dementia. We describe four patients all of whom underwent a detailed scintigraphic, neuroradiological and clinical work-up: two had primary, sporadic Fahr's disease and two had Fahr's disease secondary to hypoparathyroidism. The neuroradiological and clinical studies disclosed similar anatomical and pathological changes in the four patients but variable and sometimes unexpected clinical manifestations. Both patients with primary forms had hypokinetic Parkinsonian syndrome, both patients with secondary forms had hyperkinetic movements. Dopamine autotransporter scan brain scintigraphy disclosed an unexpected unilateral putamen involvement despite substantially symmetric calcifications. More... »

PAGES

337-341

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10072-010-0444-9

DOI

http://dx.doi.org/10.1007/s10072-010-0444-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046228103

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21057841


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