SMYD3-associated pathway is involved in the anti-tumor effects of sulforaphane on gastric carcinoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-08

AUTHORS

Qing-Qing Dong, Qiu-Tong Wang, Lei Wang, Ya-Xin Jiang, Mei-Ling Liu, Hai-Jie Hu, Yong Liu, Hao Zhou, Hong-Peng He, Tong-Cun Zhang, Xue-Gang Luo

ABSTRACT

Sulforaphane (SFN), a natural compound derived from cruciferous vegetables, has been proved to possess potent anti-cancer activity. SMYD3 is a histone methyltransferase which is closely related to the proliferation and migration of cancer cells. This study showed that SFN could dose-dependently induce cell cycle arrest, stimulate apoptosis, and inhibit proliferation and migration of gastric carcinoma cells. Accompanied with these anti-cancer effects, SMYD3 and its downstream genes, myosin regulatory light chain 9, and cysteine-rich angiogenic inducer 61, was downregulated by SFN. Furthermore, overexpression of SMYD3 via transfection could abolish the effects of SFN, suggesting that SMYD3 might be an important mediator of SFN. To the best of our knowledge, this is the first report describing the role of SMYD3 in the anti-cancer of SFN. These findings might throw light on the development of novel anti-cancer drugs and functional food using SFN-rich cruciferous vegetables. More... »

PAGES

1165-1173

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10068-018-0337-x

DOI

http://dx.doi.org/10.1007/s10068-018-0337-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101698611

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30263847


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10068-018-0337-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10068-018-0337-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10068-018-0337-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10068-018-0337-x'


 

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