Change in PsAID-12 scores in patients continuing or discontinuing anti-TNF treatments in psoriatic arthritis: results from the HUR-BIO biologic registry View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-21

AUTHORS

Umut Kalyoncu, Sedat Kiraz, Sule Apras Bilgen, Omer Karadag, Ali Akdogan, Levent Kilic, Abdulsamet Erden, Berkan Armagan, Alper Sari, Ihsan Ertenli

ABSTRACT

ObjectivePsoriatic Arthritis Impact of Disease 12-item questionnaire (PsAID-12) has been developed to be used in psoriatic arthritis in daily practice. The aim of the present study was to assess the change values of PsAID-12 in PsA patients continuing or discontinuing anti-TNF treatment.MethodsWe recruited patients from the Hacettepe University biological database (HUR-BIO). Overall, 70 PsA patients had PsAID-12 score before the initiation of the first anti-TNF treatment. Stopping or switching the anti-TNF treatment due to inefficacy was definitely considered a negative response. Changes were evaluated by the comparison with the baseline PsAID-12 score in compliance with the favorable and unfavorable responses to anti-TNF treatments. The standardized response mean (SRM) was used for determining the response.ResultsSeventy (78.6% female) patients were analyzed and their mean age was 45.5 years (12.0 years). The mean follow-up duration was 18.3 months (12.6 months). At baseline, the mean PsAID-12 score was 6.6 (1.5). Physicians stopped or switched the treatment in 28 patients (40.0%) due to the inefficacy of anti-TNF treatment. The ΔPsAID-12 score was 0.25 (1.71) in the patients discontinuing anti-TNF treatment and 3.52 (2.31) in the patients continuing their anti-TNF treatment (p < 0.001). The SRM scores higher for PsAID-12, particularly in the well response to anti-TNF treatments.ConclusionA decrease of 3.5 units in PsAID-12 score shows a favorable response to anti-TNF treatment. Changes in PsAID-12 score had well discrimination capacity for anti-TNF treatments. More... »

PAGES

1187-1192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-019-04426-3

DOI

http://dx.doi.org/10.1007/s10067-019-04426-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111573628

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30663017


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