Anti-RNP/Sm antibodies in patients with systemic lupus erythematosus and its role in thrombosis: a case-control study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

María del Carmen Zamora-Medina, Andrea Hinojosa-Azaola, Carlos A. Nuñez-Alvarez, Angel Gabriel Vargas-Ruiz, Juanita Romero-Diaz

ABSTRACT

OBJECTIVE: To validate the association of thrombotic events with positive lupus anticoagulant (LA) and co-presence of anti-RNP/Sm, as well as the diagnostic accuracy of this combination of antibodies for thrombosis. METHODS: Case-control study of patients with systemic lupus erythematosus (SLE) who presented thrombosis after SLE diagnosis and controls with SLE without thrombosis. Comorbidities, traditional risk factors, clinical variables, and treatment were evaluated. Antiphospholipid (aPL) and anti-RNP/Sm antibodies were determined. RESULTS: Sixty-three cases and 63 controls were studied, 88% women, median age of 40 years, and disease duration of 135 months at study inclusion. No differences were found between groups regarding age, comorbidities, or clinical characteristics at SLE diagnosis. Patients with thrombosis were more frequently positive for anti-RNP/Sm (p = 0.001), IgG aCL (p = 0.02), IgG anti-B2GPI (p = 0.02), IgM anti-B2GPI (p = 0.02), LA (p < 0.001), the combination of anti-RNP/Sm + LA (p < 0.001), and aPL triple marker (p = 0.002), compared to controls. The combination of anti-RNP/Sm + LA, SLEDAI-2 K, and prednisone dose was associated with thrombosis (p < 0.05). The combination of anti-RNP/Sm + LA showed 56% sensitivity, 79% specificity, 73% positive predictive value, 64% negative predictive value, positive likelihood ratio (LR) 2.69, and negative LR 0.56 for predicting thrombosis. No difference was found in the comparison of area under the curve between LA alone and the combination of anti-RNP/Sm + LA (p = 0.73). CONCLUSION: Thrombosis was associated with disease activity, dose of prednisone, and the combination of anti-RNP/Sm antibodies and LA. This combination of antibodies could be useful in the identification of SLE patients at risk of thrombosis. More... »

PAGES

885-893

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-018-4381-y

DOI

http://dx.doi.org/10.1007/s10067-018-4381-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110377792

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30515663


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n", 
          "id": "https://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga No. 15, Col. Secci\u00f3n XVI, Tlalpan, 14000, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zamora-Medina", 
        "givenName": "Mar\u00eda del Carmen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n", 
          "id": "https://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga No. 15, Col. Secci\u00f3n XVI, Tlalpan, 14000, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hinojosa-Azaola", 
        "givenName": "Andrea", 
        "id": "sg:person.0651413346.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651413346.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n", 
          "id": "https://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga No. 15, Col. Secci\u00f3n XVI, Tlalpan, 14000, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nu\u00f1ez-Alvarez", 
        "givenName": "Carlos A.", 
        "id": "sg:person.0673727432.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673727432.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n", 
          "id": "https://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Hematology and Oncology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vargas-Ruiz", 
        "givenName": "Angel Gabriel", 
        "id": "sg:person.01165320037.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165320037.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n", 
          "id": "https://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga No. 15, Col. Secci\u00f3n XVI, Tlalpan, 14000, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romero-Diaz", 
        "givenName": "Juanita", 
        "id": "sg:person.0624010037.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624010037.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood-2011-03-340232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000581478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03009749609069986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003240006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2008.093013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003701512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.1999.00864.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004643036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/kel050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005308237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005737047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005737047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006232244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006232244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.39247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007747543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.24232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010137553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2006.08.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010523891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012574626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012574626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203315575586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014970710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203315575586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014970710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203315575586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014970710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2010.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014976736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fimmu.2012.00428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016750784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3001201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017433124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.2001.01669.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017632673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.md.0000091181.93122.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020884601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.md.0000091181.93122.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020884601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.md.0000091181.93122.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020884601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2005.05753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022280498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2005.05753.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022280498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.39938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023503209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.39938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023503209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203316645204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024978307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203316645204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024978307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203316645204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024978307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-04-457671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028960000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2009.03555.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031025120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2009.03555.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031025120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780400928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032541017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1364-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033248013", 
          "https://doi.org/10.1007/s10067-009-1364-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1364-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033248013", 
          "https://doi.org/10.1007/s10067-009-1364-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2009.03674.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033699930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2009.03674.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033699930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203314545410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035470549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203314545410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035470549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203314545410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035470549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038796819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203306074767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041690301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203306074767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041690301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203306074767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041690301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.1996.20707.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043662618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780400506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044536285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203314538332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046510959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203314538332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046510959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203314538332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046510959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780251101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051582030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2005.035295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053567022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0032-1311991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057262015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.071244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071541424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.150506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071543906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4330/wjc.v7.i12.829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072525397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5114/reum.2015.51509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072592276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075346364", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077294247", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/kex466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099818234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1705454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104159728"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03", 
    "datePublishedReg": "2019-03-01", 
    "description": "OBJECTIVE: To validate the association of thrombotic events with positive lupus anticoagulant (LA) and co-presence of anti-RNP/Sm, as well as the diagnostic accuracy of this combination of antibodies for thrombosis.\nMETHODS: Case-control study of patients with systemic lupus erythematosus (SLE) who presented thrombosis after SLE diagnosis and controls with SLE without thrombosis. Comorbidities, traditional risk factors, clinical variables, and treatment were evaluated. Antiphospholipid (aPL) and anti-RNP/Sm antibodies were determined.\nRESULTS: Sixty-three cases and 63 controls were studied, 88% women, median age of 40\u00a0years, and disease duration of 135\u00a0months at study inclusion. No differences were found between groups regarding age, comorbidities, or clinical characteristics at SLE diagnosis. Patients with thrombosis were more frequently positive for anti-RNP/Sm (p\u2009=\u20090.001), IgG aCL (p\u2009=\u20090.02), IgG anti-B2GPI (p\u2009=\u20090.02), IgM anti-B2GPI (p\u2009=\u20090.02), LA (p\u2009<\u20090.001), the combination of anti-RNP/Sm\u2009+\u2009LA (p\u2009<\u20090.001), and aPL triple marker (p\u2009=\u20090.002), compared to controls. The combination of anti-RNP/Sm\u2009+\u2009LA, SLEDAI-2\u00a0K, and prednisone dose was associated with thrombosis (p\u2009<\u20090.05). The combination of anti-RNP/Sm\u2009+\u2009LA showed 56% sensitivity, 79% specificity, 73% positive predictive value, 64% negative predictive value, positive likelihood ratio (LR) 2.69, and negative LR 0.56 for predicting thrombosis. No difference was found in the comparison of area under the curve between LA alone and the combination of anti-RNP/Sm\u2009+\u2009LA (p\u2009=\u20090.73).\nCONCLUSION: Thrombosis was associated with disease activity, dose of prednisone, and the combination of anti-RNP/Sm antibodies and LA. This combination of antibodies could be useful in the identification of SLE patients at risk of thrombosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10067-018-4381-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1093299", 
        "issn": [
          "0770-3198", 
          "1434-9949"
        ], 
        "name": "Clinical Rheumatology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Anti-RNP/Sm antibodies in patients with systemic lupus erythematosus and its role in thrombosis: a case-control study", 
    "pagination": "885-893", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c7c7d26d635bdd2ba0a09007cea30ff4621887b858b6b7d0792b641207dd0dfa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30515663"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8211469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10067-018-4381-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110377792"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10067-018-4381-y", 
      "https://app.dimensions.ai/details/publication/pub.1110377792"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77579_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10067-018-4381-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10067-018-4381-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10067-018-4381-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10067-018-4381-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10067-018-4381-y'


 

This table displays all metadata directly associated to this object as RDF triples.

222 TRIPLES      21 PREDICATES      71 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10067-018-4381-y schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N504bd7dc7c5c4a2c954a4e3965286db1
4 schema:citation sg:pub.10.1007/s10067-009-1364-z
5 https://app.dimensions.ai/details/publication/pub.1075346364
6 https://app.dimensions.ai/details/publication/pub.1077294247
7 https://doi.org/10.1002/art.1780251101
8 https://doi.org/10.1002/art.1780400506
9 https://doi.org/10.1002/art.1780400928
10 https://doi.org/10.1002/art.21149
11 https://doi.org/10.1002/art.21224
12 https://doi.org/10.1002/art.21314
13 https://doi.org/10.1002/art.21414
14 https://doi.org/10.1002/art.24232
15 https://doi.org/10.1002/art.39247
16 https://doi.org/10.1002/art.39938
17 https://doi.org/10.1016/j.autrev.2006.08.007
18 https://doi.org/10.1016/j.jaut.2010.06.015
19 https://doi.org/10.1046/j.1365-2249.1996.20707.x
20 https://doi.org/10.1046/j.1365-2249.1999.00864.x
21 https://doi.org/10.1046/j.1365-2249.2001.01669.x
22 https://doi.org/10.1055/s-0032-1311991
23 https://doi.org/10.1056/nejmra1705454
24 https://doi.org/10.1093/rheumatology/kel050
25 https://doi.org/10.1093/rheumatology/kex466
26 https://doi.org/10.1097/01.md.0000091181.93122.55
27 https://doi.org/10.1111/j.1365-2141.2005.05753.x
28 https://doi.org/10.1111/j.1538-7836.2009.03555.x
29 https://doi.org/10.1111/j.1538-7836.2009.03674.x
30 https://doi.org/10.1126/scitranslmed.3001201
31 https://doi.org/10.1136/ard.2005.035295
32 https://doi.org/10.1136/ard.2008.093013
33 https://doi.org/10.1177/0961203306074767
34 https://doi.org/10.1177/0961203314538332
35 https://doi.org/10.1177/0961203314545410
36 https://doi.org/10.1177/0961203315575586
37 https://doi.org/10.1177/0961203316645204
38 https://doi.org/10.1182/blood-2011-03-340232
39 https://doi.org/10.1182/blood-2013-04-457671
40 https://doi.org/10.3109/03009749609069986
41 https://doi.org/10.3389/fimmu.2012.00428
42 https://doi.org/10.3899/jrheum.071244
43 https://doi.org/10.3899/jrheum.150506
44 https://doi.org/10.4330/wjc.v7.i12.829
45 https://doi.org/10.5114/reum.2015.51509
46 schema:datePublished 2019-03
47 schema:datePublishedReg 2019-03-01
48 schema:description OBJECTIVE: To validate the association of thrombotic events with positive lupus anticoagulant (LA) and co-presence of anti-RNP/Sm, as well as the diagnostic accuracy of this combination of antibodies for thrombosis. METHODS: Case-control study of patients with systemic lupus erythematosus (SLE) who presented thrombosis after SLE diagnosis and controls with SLE without thrombosis. Comorbidities, traditional risk factors, clinical variables, and treatment were evaluated. Antiphospholipid (aPL) and anti-RNP/Sm antibodies were determined. RESULTS: Sixty-three cases and 63 controls were studied, 88% women, median age of 40 years, and disease duration of 135 months at study inclusion. No differences were found between groups regarding age, comorbidities, or clinical characteristics at SLE diagnosis. Patients with thrombosis were more frequently positive for anti-RNP/Sm (p = 0.001), IgG aCL (p = 0.02), IgG anti-B2GPI (p = 0.02), IgM anti-B2GPI (p = 0.02), LA (p < 0.001), the combination of anti-RNP/Sm + LA (p < 0.001), and aPL triple marker (p = 0.002), compared to controls. The combination of anti-RNP/Sm + LA, SLEDAI-2 K, and prednisone dose was associated with thrombosis (p < 0.05). The combination of anti-RNP/Sm + LA showed 56% sensitivity, 79% specificity, 73% positive predictive value, 64% negative predictive value, positive likelihood ratio (LR) 2.69, and negative LR 0.56 for predicting thrombosis. No difference was found in the comparison of area under the curve between LA alone and the combination of anti-RNP/Sm + LA (p = 0.73). CONCLUSION: Thrombosis was associated with disease activity, dose of prednisone, and the combination of anti-RNP/Sm antibodies and LA. This combination of antibodies could be useful in the identification of SLE patients at risk of thrombosis.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N770908ebe1944c4392878e25a9232cc1
53 Nfee37901a8314bfd8a49d2e6e3916499
54 sg:journal.1093299
55 schema:name Anti-RNP/Sm antibodies in patients with systemic lupus erythematosus and its role in thrombosis: a case-control study
56 schema:pagination 885-893
57 schema:productId N4736a7c41fb0435196de14fda707a3d6
58 N5dfc2121dfce483cae996fdcfe14b50f
59 N620b0f48456c41c7b26db948c403113b
60 Ncce9f608cb26425fb7490c9903a05c5a
61 Nea582710c435475891fb5ea093b1ddc4
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110377792
63 https://doi.org/10.1007/s10067-018-4381-y
64 schema:sdDatePublished 2019-04-11T10:50
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N3b0d5d45e17046c3a73388b8e8c70ba8
67 schema:url https://link.springer.com/10.1007%2Fs10067-018-4381-y
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N1d4fe39b3a8c41e6903ec4309619899b schema:affiliation https://www.grid.ac/institutes/grid.416850.e
72 schema:familyName Zamora-Medina
73 schema:givenName María del Carmen
74 rdf:type schema:Person
75 N3b0d5d45e17046c3a73388b8e8c70ba8 schema:name Springer Nature - SN SciGraph project
76 rdf:type schema:Organization
77 N4736a7c41fb0435196de14fda707a3d6 schema:name nlm_unique_id
78 schema:value 8211469
79 rdf:type schema:PropertyValue
80 N504bd7dc7c5c4a2c954a4e3965286db1 rdf:first N1d4fe39b3a8c41e6903ec4309619899b
81 rdf:rest Nf4466c27a20249bc8ccd4dfff4c555a8
82 N5dfc2121dfce483cae996fdcfe14b50f schema:name doi
83 schema:value 10.1007/s10067-018-4381-y
84 rdf:type schema:PropertyValue
85 N620b0f48456c41c7b26db948c403113b schema:name pubmed_id
86 schema:value 30515663
87 rdf:type schema:PropertyValue
88 N770908ebe1944c4392878e25a9232cc1 schema:volumeNumber 38
89 rdf:type schema:PublicationVolume
90 N8d32223977d849b19178e245cba2fed9 rdf:first sg:person.01165320037.50
91 rdf:rest N9a24a0f8d7594ab0b4dd68bea72eb71d
92 N9a24a0f8d7594ab0b4dd68bea72eb71d rdf:first sg:person.0624010037.06
93 rdf:rest rdf:nil
94 Nb3c67d6e925641f08f5e4cdee568e7df rdf:first sg:person.0673727432.14
95 rdf:rest N8d32223977d849b19178e245cba2fed9
96 Ncce9f608cb26425fb7490c9903a05c5a schema:name readcube_id
97 schema:value c7c7d26d635bdd2ba0a09007cea30ff4621887b858b6b7d0792b641207dd0dfa
98 rdf:type schema:PropertyValue
99 Nea582710c435475891fb5ea093b1ddc4 schema:name dimensions_id
100 schema:value pub.1110377792
101 rdf:type schema:PropertyValue
102 Nf4466c27a20249bc8ccd4dfff4c555a8 rdf:first sg:person.0651413346.14
103 rdf:rest Nb3c67d6e925641f08f5e4cdee568e7df
104 Nfee37901a8314bfd8a49d2e6e3916499 schema:issueNumber 3
105 rdf:type schema:PublicationIssue
106 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
107 schema:name Medical and Health Sciences
108 rdf:type schema:DefinedTerm
109 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
110 schema:name Immunology
111 rdf:type schema:DefinedTerm
112 sg:journal.1093299 schema:issn 0770-3198
113 1434-9949
114 schema:name Clinical Rheumatology
115 rdf:type schema:Periodical
116 sg:person.01165320037.50 schema:affiliation https://www.grid.ac/institutes/grid.416850.e
117 schema:familyName Vargas-Ruiz
118 schema:givenName Angel Gabriel
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165320037.50
120 rdf:type schema:Person
121 sg:person.0624010037.06 schema:affiliation https://www.grid.ac/institutes/grid.416850.e
122 schema:familyName Romero-Diaz
123 schema:givenName Juanita
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624010037.06
125 rdf:type schema:Person
126 sg:person.0651413346.14 schema:affiliation https://www.grid.ac/institutes/grid.416850.e
127 schema:familyName Hinojosa-Azaola
128 schema:givenName Andrea
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651413346.14
130 rdf:type schema:Person
131 sg:person.0673727432.14 schema:affiliation https://www.grid.ac/institutes/grid.416850.e
132 schema:familyName Nuñez-Alvarez
133 schema:givenName Carlos A.
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673727432.14
135 rdf:type schema:Person
136 sg:pub.10.1007/s10067-009-1364-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033248013
137 https://doi.org/10.1007/s10067-009-1364-z
138 rdf:type schema:CreativeWork
139 https://app.dimensions.ai/details/publication/pub.1075346364 schema:CreativeWork
140 https://app.dimensions.ai/details/publication/pub.1077294247 schema:CreativeWork
141 https://doi.org/10.1002/art.1780251101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051582030
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1002/art.1780400506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044536285
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1002/art.1780400928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032541017
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1002/art.21149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038796819
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1002/art.21224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012574626
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1002/art.21314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006232244
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1002/art.21414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005737047
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1002/art.24232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010137553
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1002/art.39247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007747543
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1002/art.39938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023503209
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/j.autrev.2006.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010523891
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/j.jaut.2010.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014976736
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1046/j.1365-2249.1996.20707.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043662618
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1046/j.1365-2249.1999.00864.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004643036
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1046/j.1365-2249.2001.01669.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017632673
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1055/s-0032-1311991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057262015
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1056/nejmra1705454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104159728
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1093/rheumatology/kel050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005308237
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1093/rheumatology/kex466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099818234
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1097/01.md.0000091181.93122.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020884601
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1111/j.1365-2141.2005.05753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022280498
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1111/j.1538-7836.2009.03555.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031025120
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1111/j.1538-7836.2009.03674.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033699930
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1126/scitranslmed.3001201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017433124
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1136/ard.2005.035295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053567022
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1136/ard.2008.093013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003701512
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1177/0961203306074767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041690301
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1177/0961203314538332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046510959
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1177/0961203314545410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035470549
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1177/0961203315575586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014970710
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1177/0961203316645204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024978307
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1182/blood-2011-03-340232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000581478
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1182/blood-2013-04-457671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028960000
206 rdf:type schema:CreativeWork
207 https://doi.org/10.3109/03009749609069986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003240006
208 rdf:type schema:CreativeWork
209 https://doi.org/10.3389/fimmu.2012.00428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016750784
210 rdf:type schema:CreativeWork
211 https://doi.org/10.3899/jrheum.071244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071541424
212 rdf:type schema:CreativeWork
213 https://doi.org/10.3899/jrheum.150506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071543906
214 rdf:type schema:CreativeWork
215 https://doi.org/10.4330/wjc.v7.i12.829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072525397
216 rdf:type schema:CreativeWork
217 https://doi.org/10.5114/reum.2015.51509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072592276
218 rdf:type schema:CreativeWork
219 https://www.grid.ac/institutes/grid.416850.e schema:alternateName Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
220 schema:name Department of Hematology and Oncology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
221 Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col. Sección XVI, Tlalpan, 14000, Mexico City, Mexico
222 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...