C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03-20

AUTHORS

Yemil Atisha-Fregoso, Guadalupe Lima, Eduardo Carrillo-Maravilla, Rosalinda Posadas-Sánchez, Nonanzit Pérez-Hernández, Miguel Baños-Peláez, Alejandra Iturralde-Chávez, Nora Hernández-Díaz, Juan Jakez-Ocampo, José Manuel Rodríguez-Pérez, Gilberto Vargas-Alarcón, Luis Llorente, Juanita Romero-Díaz

ABSTRACT

To evaluate the association of C-reactive protein (CRP) polymorphisms with risk of development SLE in a group of Mexican individuals. Five CRP polymorphisms (rs3093059, rs3093062, rs1800947, rs1130864, and rs1205) were determined by PCR-restriction fragment length polymorphism and SNP rs3093061 by refractory mutation system PCR assay in 126 SLE patients and 131 controls. Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108–0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143–0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270–0.942, P = 0.032). The rs3091244 polymorphism was associated with decreased risk of SLE mostly under additive (OR = 0.605, 95% CI 0.393–0.931. P = 0.022) model. Our study establishes that rs3093061, rs1130864, rs1205, and rs3091244 polymorphisms are associated with decreased risk of developing SLE. More... »

PAGES

1817-1824

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-018-4059-5

DOI

http://dx.doi.org/10.1007/s10067-018-4059-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101631091

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29556849


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lupus Erythematosus, Systemic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mexico", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Restriction Fragment Length", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Instituto Tecnol\u00f3gico de Estudios Superiores de Monterrey, Campus Ciudad de M\u00e9xico, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.419886.a", 
          "name": [
            "Division of Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico", 
            "Instituto Tecnol\u00f3gico de Estudios Superiores de Monterrey, Campus Ciudad de M\u00e9xico, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atisha-Fregoso", 
        "givenName": "Yemil", 
        "id": "sg:person.0710131741.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710131741.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lima", 
        "givenName": "Guadalupe", 
        "id": "sg:person.01200242024.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200242024.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Division of Medicine, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carrillo-Maravilla", 
        "givenName": "Eduardo", 
        "id": "sg:person.01317307441.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317307441.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology, Instituto Nacional de Cardfiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Endocrinology, Instituto Nacional de Cardfiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Posadas-S\u00e1nchez", 
        "givenName": "Rosalinda", 
        "id": "sg:person.01272032453.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272032453.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.419172.8", 
          "name": [
            "Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e9rez-Hern\u00e1ndez", 
        "givenName": "Nonanzit", 
        "id": "sg:person.01325435147.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325435147.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ba\u00f1os-Pel\u00e1ez", 
        "givenName": "Miguel", 
        "id": "sg:person.0603720375.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603720375.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iturralde-Ch\u00e1vez", 
        "givenName": "Alejandra", 
        "id": "sg:person.014104165725.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104165725.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hern\u00e1ndez-D\u00edaz", 
        "givenName": "Nora", 
        "id": "sg:person.07430753623.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07430753623.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jakez-Ocampo", 
        "givenName": "Juan", 
        "id": "sg:person.01251174241.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251174241.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.419172.8", 
          "name": [
            "Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodr\u00edguez-P\u00e9rez", 
        "givenName": "Jos\u00e9 Manuel", 
        "id": "sg:person.01030314542.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030314542.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.419172.8", 
          "name": [
            "Department of Molecular Biology, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Mexico City, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vargas-Alarc\u00f3n", 
        "givenName": "Gilberto", 
        "id": "sg:person.01321134100.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321134100.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Llorente", 
        "givenName": "Luis", 
        "id": "sg:person.0756245141.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756245141.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico", 
          "id": "http://www.grid.ac/institutes/grid.416850.e", 
          "name": [
            "Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Romero-D\u00edaz", 
        "givenName": "Juanita", 
        "id": "sg:person.0624010037.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624010037.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrrheum.2011.37", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027504697", 
          "https://doi.org/10.1038/nrrheum.2011.37"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60327-411-1_26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040662782", 
          "https://doi.org/10.1007/978-1-60327-411-1_26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043158572", 
          "https://doi.org/10.1038/ng.200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-008-0517-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041583778", 
          "https://doi.org/10.1007/s00439-008-0517-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040037212", 
          "https://doi.org/10.1038/sj.gene.6363820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015810411", 
          "https://doi.org/10.1038/ng.81"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6364459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022210157", 
          "https://doi.org/10.1038/sj.gene.6364459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.472", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024785230", 
          "https://doi.org/10.1038/ng.472"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-03-20", 
    "datePublishedReg": "2018-03-20", 
    "description": "To evaluate the association of C-reactive protein (CRP) polymorphisms with risk of development SLE in a group of Mexican individuals. Five CRP polymorphisms (rs3093059, rs3093062, rs1800947, rs1130864, and rs1205) were determined by PCR-restriction fragment length polymorphism and SNP rs3093061 by refractory mutation system PCR assay in 126 SLE patients and 131 controls. Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR\u2009=\u20090.219, 95% CI 0.108\u20130.785, P\u00a0=\u20090.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR\u2009=\u20090.288, 95% CI 0.143\u20130.581, P\u00a0=\u20090.001) model. rs1205 was associated under the over-dominant model (OR\u2009=\u20090.504, 95% CI 0.270\u20130.942, P\u00a0=\u20090.032). The rs3091244 polymorphism was associated with decreased risk of SLE mostly under additive (OR\u2009=\u20090.605, 95% CI 0.393\u20130.931. P\u00a0=\u20090.022) model. Our study establishes that rs3093061, rs1130864, rs1205, and rs3091244 polymorphisms are associated with decreased risk of developing SLE.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10067-018-4059-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1093299", 
        "issn": [
          "0770-3198", 
          "1434-9949"
        ], 
        "name": "Clinical Rheumatology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "keywords": [
      "reactive protein polymorphisms", 
      "serum CRP levels", 
      "risk of SLE", 
      "over-dominant model", 
      "PCR-restriction fragment length polymorphism", 
      "SLE patients", 
      "refractory mutation system PCR", 
      "CRP levels", 
      "CRP polymorphisms", 
      "lower risk", 
      "SLE susceptibility", 
      "SLE", 
      "Mexican individuals", 
      "Mexican population", 
      "patients", 
      "rs1130864", 
      "risk", 
      "rs1205", 
      "fragment length polymorphism", 
      "polymorphism", 
      "length polymorphism", 
      "lupus", 
      "control", 
      "association", 
      "PCR", 
      "protein polymorphisms", 
      "group", 
      "population", 
      "susceptibility", 
      "individuals", 
      "levels", 
      "differences", 
      "activity", 
      "haplotypes", 
      "study", 
      "model", 
      "development SLE", 
      "SNP rs3093061", 
      "rs3093061", 
      "mutation system PCR", 
      "system PCR", 
      "rs3093061 polymorphism", 
      "rs3091244 polymorphism"
    ], 
    "name": "C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population", 
    "pagination": "1817-1824", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101631091"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10067-018-4059-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29556849"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10067-018-4059-5", 
      "https://app.dimensions.ai/details/publication/pub.1101631091"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_770.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10067-018-4059-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10067-018-4059-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10067-018-4059-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10067-018-4059-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10067-018-4059-5'


 

This table displays all metadata directly associated to this object as RDF triples.

285 TRIPLES      22 PREDICATES      90 URIs      74 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10067-018-4059-5 schema:about N1e68ad026c7f4e1b99749c21c5b488b6
2 N2821ca8b167a4f0c9cb9ec3fdb63ee66
3 N30b28c1175b24ff78bf04fd7a9dc62da
4 N469de56f670d458690d663d12f02fdb4
5 N6839f3ad3798451a8206b05418a0ffff
6 N701506afa17647e88349c299c2edbb7d
7 Nb5367f825cbd422e83ee08d148e85171
8 Nbf4cb414ff1e4e5da7746c89f7a11b87
9 Nc84c8f05b3824a239bb5ef59a66c387f
10 Nd2f0d110c03c4da1ba7513bc41dbbcbe
11 Nda1d2f2c35804c8b911e4806cb2db7fb
12 Ne05f7e9741c347e689d9df11813c3a2e
13 Ne67654fbc214443a9d18e9327d569fb4
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author Nb7c34e997dab4db6a7d266bbe2107abd
17 schema:citation sg:pub.10.1007/978-1-60327-411-1_26
18 sg:pub.10.1007/s00439-008-0517-5
19 sg:pub.10.1038/ng.200
20 sg:pub.10.1038/ng.472
21 sg:pub.10.1038/ng.81
22 sg:pub.10.1038/nrrheum.2011.37
23 sg:pub.10.1038/sj.gene.6363820
24 sg:pub.10.1038/sj.gene.6364459
25 schema:datePublished 2018-03-20
26 schema:datePublishedReg 2018-03-20
27 schema:description To evaluate the association of C-reactive protein (CRP) polymorphisms with risk of development SLE in a group of Mexican individuals. Five CRP polymorphisms (rs3093059, rs3093062, rs1800947, rs1130864, and rs1205) were determined by PCR-restriction fragment length polymorphism and SNP rs3093061 by refractory mutation system PCR assay in 126 SLE patients and 131 controls. Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108–0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143–0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270–0.942, P = 0.032). The rs3091244 polymorphism was associated with decreased risk of SLE mostly under additive (OR = 0.605, 95% CI 0.393–0.931. P = 0.022) model. Our study establishes that rs3093061, rs1130864, rs1205, and rs3091244 polymorphisms are associated with decreased risk of developing SLE.
28 schema:genre article
29 schema:inLanguage en
30 schema:isAccessibleForFree false
31 schema:isPartOf N530945a718ab43b2b915d89047047857
32 Nef489e9c9a6a4d16a8e0088441368396
33 sg:journal.1093299
34 schema:keywords CRP levels
35 CRP polymorphisms
36 Mexican individuals
37 Mexican population
38 PCR
39 PCR-restriction fragment length polymorphism
40 SLE
41 SLE patients
42 SLE susceptibility
43 SNP rs3093061
44 activity
45 association
46 control
47 development SLE
48 differences
49 fragment length polymorphism
50 group
51 haplotypes
52 individuals
53 length polymorphism
54 levels
55 lower risk
56 lupus
57 model
58 mutation system PCR
59 over-dominant model
60 patients
61 polymorphism
62 population
63 protein polymorphisms
64 reactive protein polymorphisms
65 refractory mutation system PCR
66 risk
67 risk of SLE
68 rs1130864
69 rs1205
70 rs3091244 polymorphism
71 rs3093061
72 rs3093061 polymorphism
73 serum CRP levels
74 study
75 susceptibility
76 system PCR
77 schema:name C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population
78 schema:pagination 1817-1824
79 schema:productId N90bbbf4e2e604b8596561d17385e66d2
80 Nc5baa103354b486db8ba5d0c6519e9f4
81 Nf8d6c9c920b44e0eb9987e95921e63d1
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101631091
83 https://doi.org/10.1007/s10067-018-4059-5
84 schema:sdDatePublished 2022-01-01T18:47
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N2f58e347e6d04d9d8cff3278ce3cbef8
87 schema:url https://doi.org/10.1007/s10067-018-4059-5
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N1e68ad026c7f4e1b99749c21c5b488b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name C-Reactive Protein
93 rdf:type schema:DefinedTerm
94 N262eb754d4ef48af86864c63fbc55443 rdf:first sg:person.0756245141.50
95 rdf:rest N3f0b5225f84947c2b51c7ff5e42b815e
96 N278886e065db47bea409cd61e21a67ed rdf:first sg:person.01325435147.86
97 rdf:rest Nac0a7fc29c314cc791bf2b8f9f52cace
98 N2821ca8b167a4f0c9cb9ec3fdb63ee66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Mexico
100 rdf:type schema:DefinedTerm
101 N2f58e347e6d04d9d8cff3278ce3cbef8 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N30b28c1175b24ff78bf04fd7a9dc62da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N31c7c22755e14a5dad0ecea1a873f6b9 rdf:first sg:person.01200242024.12
107 rdf:rest N4242de416a9347d99eedb6715dee3620
108 N3f0b5225f84947c2b51c7ff5e42b815e rdf:first sg:person.0624010037.06
109 rdf:rest rdf:nil
110 N4242de416a9347d99eedb6715dee3620 rdf:first sg:person.01317307441.22
111 rdf:rest Nb42ef16b168041d3b9127d62fb34968c
112 N469de56f670d458690d663d12f02fdb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Gene Frequency
114 rdf:type schema:DefinedTerm
115 N51593bc34d914eb7b5a1b7d9e7ec62d0 rdf:first sg:person.01251174241.57
116 rdf:rest Nffb89682c24147c0983b2304dd377b7c
117 N530945a718ab43b2b915d89047047857 schema:issueNumber 7
118 rdf:type schema:PublicationIssue
119 N6839f3ad3798451a8206b05418a0ffff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Haplotypes
121 rdf:type schema:DefinedTerm
122 N701506afa17647e88349c299c2edbb7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Genetic Predisposition to Disease
124 rdf:type schema:DefinedTerm
125 N8adc0eeef4354a469725b70df0ef8b12 rdf:first sg:person.07430753623.29
126 rdf:rest N51593bc34d914eb7b5a1b7d9e7ec62d0
127 N90bbbf4e2e604b8596561d17385e66d2 schema:name dimensions_id
128 schema:value pub.1101631091
129 rdf:type schema:PropertyValue
130 Nac0a7fc29c314cc791bf2b8f9f52cace rdf:first sg:person.0603720375.72
131 rdf:rest Nebee37b1b53f4031963c76585abe3a1c
132 Nb42ef16b168041d3b9127d62fb34968c rdf:first sg:person.01272032453.98
133 rdf:rest N278886e065db47bea409cd61e21a67ed
134 Nb5367f825cbd422e83ee08d148e85171 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Case-Control Studies
136 rdf:type schema:DefinedTerm
137 Nb7c34e997dab4db6a7d266bbe2107abd rdf:first sg:person.0710131741.79
138 rdf:rest N31c7c22755e14a5dad0ecea1a873f6b9
139 Nbf4cb414ff1e4e5da7746c89f7a11b87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Genotype
141 rdf:type schema:DefinedTerm
142 Nc5baa103354b486db8ba5d0c6519e9f4 schema:name pubmed_id
143 schema:value 29556849
144 rdf:type schema:PropertyValue
145 Nc84c8f05b3824a239bb5ef59a66c387f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Polymorphism, Single Nucleotide
147 rdf:type schema:DefinedTerm
148 Nd2f0d110c03c4da1ba7513bc41dbbcbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Lupus Erythematosus, Systemic
150 rdf:type schema:DefinedTerm
151 Nda1d2f2c35804c8b911e4806cb2db7fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Female
153 rdf:type schema:DefinedTerm
154 Ne05f7e9741c347e689d9df11813c3a2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Polymorphism, Restriction Fragment Length
156 rdf:type schema:DefinedTerm
157 Ne67654fbc214443a9d18e9327d569fb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Male
159 rdf:type schema:DefinedTerm
160 Nebee37b1b53f4031963c76585abe3a1c rdf:first sg:person.014104165725.09
161 rdf:rest N8adc0eeef4354a469725b70df0ef8b12
162 Ned538be59ea54f228c5cf281657817ab rdf:first sg:person.01321134100.91
163 rdf:rest N262eb754d4ef48af86864c63fbc55443
164 Nef489e9c9a6a4d16a8e0088441368396 schema:volumeNumber 37
165 rdf:type schema:PublicationVolume
166 Nf8d6c9c920b44e0eb9987e95921e63d1 schema:name doi
167 schema:value 10.1007/s10067-018-4059-5
168 rdf:type schema:PropertyValue
169 Nffb89682c24147c0983b2304dd377b7c rdf:first sg:person.01030314542.48
170 rdf:rest Ned538be59ea54f228c5cf281657817ab
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
175 schema:name Clinical Sciences
176 rdf:type schema:DefinedTerm
177 sg:journal.1093299 schema:issn 0770-3198
178 1434-9949
179 schema:name Clinical Rheumatology
180 schema:publisher Springer Nature
181 rdf:type schema:Periodical
182 sg:person.01030314542.48 schema:affiliation grid-institutes:grid.419172.8
183 schema:familyName Rodríguez-Pérez
184 schema:givenName José Manuel
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030314542.48
186 rdf:type schema:Person
187 sg:person.01200242024.12 schema:affiliation grid-institutes:grid.416850.e
188 schema:familyName Lima
189 schema:givenName Guadalupe
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200242024.12
191 rdf:type schema:Person
192 sg:person.01251174241.57 schema:affiliation grid-institutes:grid.416850.e
193 schema:familyName Jakez-Ocampo
194 schema:givenName Juan
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251174241.57
196 rdf:type schema:Person
197 sg:person.01272032453.98 schema:affiliation grid-institutes:None
198 schema:familyName Posadas-Sánchez
199 schema:givenName Rosalinda
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272032453.98
201 rdf:type schema:Person
202 sg:person.01317307441.22 schema:affiliation grid-institutes:grid.416850.e
203 schema:familyName Carrillo-Maravilla
204 schema:givenName Eduardo
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317307441.22
206 rdf:type schema:Person
207 sg:person.01321134100.91 schema:affiliation grid-institutes:grid.419172.8
208 schema:familyName Vargas-Alarcón
209 schema:givenName Gilberto
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321134100.91
211 rdf:type schema:Person
212 sg:person.01325435147.86 schema:affiliation grid-institutes:grid.419172.8
213 schema:familyName Pérez-Hernández
214 schema:givenName Nonanzit
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325435147.86
216 rdf:type schema:Person
217 sg:person.014104165725.09 schema:affiliation grid-institutes:grid.416850.e
218 schema:familyName Iturralde-Chávez
219 schema:givenName Alejandra
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014104165725.09
221 rdf:type schema:Person
222 sg:person.0603720375.72 schema:affiliation grid-institutes:grid.416850.e
223 schema:familyName Baños-Peláez
224 schema:givenName Miguel
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603720375.72
226 rdf:type schema:Person
227 sg:person.0624010037.06 schema:affiliation grid-institutes:grid.416850.e
228 schema:familyName Romero-Díaz
229 schema:givenName Juanita
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624010037.06
231 rdf:type schema:Person
232 sg:person.0710131741.79 schema:affiliation grid-institutes:grid.419886.a
233 schema:familyName Atisha-Fregoso
234 schema:givenName Yemil
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710131741.79
236 rdf:type schema:Person
237 sg:person.07430753623.29 schema:affiliation grid-institutes:grid.416850.e
238 schema:familyName Hernández-Díaz
239 schema:givenName Nora
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07430753623.29
241 rdf:type schema:Person
242 sg:person.0756245141.50 schema:affiliation grid-institutes:grid.416850.e
243 schema:familyName Llorente
244 schema:givenName Luis
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756245141.50
246 rdf:type schema:Person
247 sg:pub.10.1007/978-1-60327-411-1_26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040662782
248 https://doi.org/10.1007/978-1-60327-411-1_26
249 rdf:type schema:CreativeWork
250 sg:pub.10.1007/s00439-008-0517-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041583778
251 https://doi.org/10.1007/s00439-008-0517-5
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/ng.200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043158572
254 https://doi.org/10.1038/ng.200
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/ng.472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024785230
257 https://doi.org/10.1038/ng.472
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/ng.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015810411
260 https://doi.org/10.1038/ng.81
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/nrrheum.2011.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027504697
263 https://doi.org/10.1038/nrrheum.2011.37
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/sj.gene.6363820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040037212
266 https://doi.org/10.1038/sj.gene.6363820
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/sj.gene.6364459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022210157
269 https://doi.org/10.1038/sj.gene.6364459
270 rdf:type schema:CreativeWork
271 grid-institutes:None schema:alternateName Department of Endocrinology, Instituto Nacional de Cardfiología Ignacio Chávez, Mexico City, Mexico
272 schema:name Department of Endocrinology, Instituto Nacional de Cardfiología Ignacio Chávez, Mexico City, Mexico
273 rdf:type schema:Organization
274 grid-institutes:grid.416850.e schema:alternateName Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México
275 Division of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
276 schema:name Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México
277 Division of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
278 rdf:type schema:Organization
279 grid-institutes:grid.419172.8 schema:alternateName Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
280 schema:name Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
281 rdf:type schema:Organization
282 grid-institutes:grid.419886.a schema:alternateName Instituto Tecnológico de Estudios Superiores de Monterrey, Campus Ciudad de México, Mexico City, Mexico
283 schema:name Division of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
284 Instituto Tecnológico de Estudios Superiores de Monterrey, Campus Ciudad de México, Mexico City, Mexico
285 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...