Clinical characteristics associated with subcutaneous tophi formation in Chinese gout patients: a retrospective study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01-22

AUTHORS

Lidan Ma, Ruixia Sun, Zhaotong Jia, Yaowu Zou, Ying Xin, Xiaoyu Cheng, Tian Liu, Lingling Cui, Zhen Liu, Xinjiang Wu, Changgui Li

ABSTRACT

The objective of this study is to analyze clinical characteristics associated with the formation of subcutaneous tophi among Chinese gout patients. It was a retrospective outpatient cohort study. Five thousand six hundred ninety-three gout patients treated at the Affiliated Hospital of Qingdao University from March 2011 to February 2016 were included and divided into the tophus group and non-tophus group according to the presence of megascopic tophus. Relevant clinical information and biochemical parameters were analyzed to identify potential risk factors for the incidence of subcutaneous tophi. There are significant difference (P < 0.05) between the tophus and non-tophus groups in gender, family history, exercise, incidence of obesity, hypertension, renal dysfunction, kidney stone, coronary heart disease, and upper limb joint involvement. Between the two groups, significant difference (P < 0.01) was detected in the onset age (43.80 ± 13.82 years vs. 45.40 ± 13.77 years), duration of disease (10.28 ± 7.54 years vs. 5.11 ± 6.06 years), number of joint involved (3.11 ± 2.15 vs. 1.81 ± 1.35), systolic pressure (138.53 ± 19.46 mmHg vs. 133.87 ± 17.93 mmHg), diastolic pressure (89.55 ± 12.73 mmHg vs. 87.48 ± 11.77 mmHg), serum uric acid (487.15 ± 120.13 μmol/L vs. 458.89 ± 119.04 μmol/L), creatinine (93.87 ± 54.19 μmol/L vs. 85.51 ± 37.71 μmol/L), and creatinine clearance rate (Ccr) (93.05 ± 48.7 mL/min vs. 106.61 ± 51.76 mL/min). Logistic regression analysis suggests that duration of disease, number of joints involved, involvement of upper limb joints, kidney stones, diastolic pressure, and serum uric acid are associated with the subcutaneous tophi formation, while exercise and obesity are protective factors. The present study has identified several clinical parameters (such as duration of disease, involvement of upper limb joints, involved joints, kidney stone, hypertension) as risk factors for the incidence of subcutaneous tophi, which provides insights into the treatment and prevention of tophus. More... »

PAGES

1359-1365

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-017-3969-y

DOI

http://dx.doi.org/10.1007/s10067-017-3969-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100553929

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29354873


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24 schema:description The objective of this study is to analyze clinical characteristics associated with the formation of subcutaneous tophi among Chinese gout patients. It was a retrospective outpatient cohort study. Five thousand six hundred ninety-three gout patients treated at the Affiliated Hospital of Qingdao University from March 2011 to February 2016 were included and divided into the tophus group and non-tophus group according to the presence of megascopic tophus. Relevant clinical information and biochemical parameters were analyzed to identify potential risk factors for the incidence of subcutaneous tophi. There are significant difference (P < 0.05) between the tophus and non-tophus groups in gender, family history, exercise, incidence of obesity, hypertension, renal dysfunction, kidney stone, coronary heart disease, and upper limb joint involvement. Between the two groups, significant difference (P < 0.01) was detected in the onset age (43.80 ± 13.82 years vs. 45.40 ± 13.77 years), duration of disease (10.28 ± 7.54 years vs. 5.11 ± 6.06 years), number of joint involved (3.11 ± 2.15 vs. 1.81 ± 1.35), systolic pressure (138.53 ± 19.46 mmHg vs. 133.87 ± 17.93 mmHg), diastolic pressure (89.55 ± 12.73 mmHg vs. 87.48 ± 11.77 mmHg), serum uric acid (487.15 ± 120.13 μmol/L vs. 458.89 ± 119.04 μmol/L), creatinine (93.87 ± 54.19 μmol/L vs. 85.51 ± 37.71 μmol/L), and creatinine clearance rate (Ccr) (93.05 ± 48.7 mL/min vs. 106.61 ± 51.76 mL/min). Logistic regression analysis suggests that duration of disease, number of joints involved, involvement of upper limb joints, kidney stones, diastolic pressure, and serum uric acid are associated with the subcutaneous tophi formation, while exercise and obesity are protective factors. The present study has identified several clinical parameters (such as duration of disease, involvement of upper limb joints, involved joints, kidney stone, hypertension) as risk factors for the incidence of subcutaneous tophi, which provides insights into the treatment and prevention of tophus.
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31 Chinese gout patients
32 Qingdao University
33 University
34 acid
35 age
36 analysis
37 biochemical parameters
38 characteristics
39 clearance rate
40 clinical characteristics
41 clinical information
42 clinical parameters
43 cohort study
44 coronary heart disease
45 creatinine
46 creatinine clearance rate
47 diastolic pressure
48 differences
49 disease
50 duration
51 duration of disease
52 dysfunction
53 exercise
54 factors
55 family history
56 formation
57 gender
58 gout patients
59 group
60 heart disease
61 history
62 hospital
63 hypertension
64 incidence
65 incidence of obesity
66 information
67 insights
68 involvement
69 joint involvement
70 joints
71 kidney stones
72 limb joints
73 logistic regression analysis
74 number
75 number of joints
76 obesity
77 objective
78 onset age
79 outpatient cohort study
80 parameters
81 patients
82 potential risk factors
83 presence
84 present study
85 pressure
86 prevention
87 protective factors
88 rate
89 regression analysis
90 relevant clinical information
91 renal dysfunction
92 retrospective study
93 risk factors
94 serum uric acid
95 significant differences
96 stones
97 study
98 subcutaneous tophi
99 systolic pressure
100 tophi
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103 treatment
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