Diverse patterns of anti-TNF-α-induced lupus: case series and review of the literature View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-02

AUTHORS

Ora Shovman, Shalev Tamar, Howard Amital, Abdulla Watad, Yehuda Shoenfeld

ABSTRACT

The induction of autoantibodies is common following therapy with anti-TNF-α agents. However, anti-TNF-α-induced lupus (ATIL) is rare. We assessed the clinical characteristics of three patients with inflammatory bowel disease (IBD) who were treated with infliximab and developed distinct subsets of ATIL. Also, we searched for similar cases in the published literature. We describe three patients with ATIL. The first patient had a classical drug-induced lupus (DIL) presented by thrombocytopenia that resolved after infliximab discontinuation. The second case experienced symmetric polyarthritis of 14 joints in rheumatoid arthritis (RA)-like distribution accompanied by lymphopenia. The third one had a severe serositis including ascites and pleural and pericardial effusions along with pancytopenia. In this patient, ATIL coexisted with anti-TNF-α-induced hepatitis. The second and third patients met the American College of Rheumatology classification criteria for SLE. Nevertheless, all three cases exhibited ANA and anti-dsDNA positivity, and only the second patient had anticardiolipin (aCL IgG) and anti-histone antibodies. The coexistence of both lupus-like syndrome and hepatitis following anti-TNF-α therapy in the same patient is very rare, and to the best of our knowledge, only four such case reports are mentioned in literature. Patients with mild ATIL may tolerate another anti-TNF-α agent without recurrence of the disease. Rheumatologists should be aware of the distinct clinical presentations of ATIL and its coexistence with other rare anti-TNF-alpha complications such as hepatitis. More... »

PAGES

563-568

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-017-3884-2

DOI

http://dx.doi.org/10.1007/s10067-017-3884-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092329077

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29063464


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adalimumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antirheumatic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthritis, Rheumatoid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Etanercept", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infliximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lupus Erythematosus, Systemic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sheba Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.413795.d", 
          "name": [
            "Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel", 
            "Department of Medicine \u2018B\u2019, Sheba Medical Center, Tel-Hashomer, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shovman", 
        "givenName": "Ora", 
        "id": "sg:person.01031725703.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031725703.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wolfson Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.414317.4", 
          "name": [
            "Department of Gastroenterology, The E. Wolfson Medical Center, Holon, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tamar", 
        "givenName": "Shalev", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tel Aviv University", 
          "id": "https://www.grid.ac/institutes/grid.12136.37", 
          "name": [
            "Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel", 
            "Department of Medicine \u2018B\u2019, Sheba Medical Center, Tel-Hashomer, Israel", 
            "Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amital", 
        "givenName": "Howard", 
        "id": "sg:person.01253531157.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253531157.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tel Aviv University", 
          "id": "https://www.grid.ac/institutes/grid.12136.37", 
          "name": [
            "Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel", 
            "Department of Medicine \u2018B\u2019, Sheba Medical Center, Tel-Hashomer, Israel", 
            "Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watad", 
        "givenName": "Abdulla", 
        "id": "sg:person.01215547370.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215547370.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tel Aviv University", 
          "id": "https://www.grid.ac/institutes/grid.12136.37", 
          "name": [
            "Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel", 
            "Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel", 
            "Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shoenfeld", 
        "givenName": "Yehuda", 
        "id": "sg:person.01010756664.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010756664.44"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.semarthrit.2007.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001590972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2009.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001867433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005622068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005622068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.crohns.2012.01.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005824974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12865/chsj.40.04.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007853708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.12865/chsj.40.04.11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007853708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.crohns.2012.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008196191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rhu.0b013e318188b1df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011585940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/rhu.0b013e318188b1df", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011585940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar1715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012596633", 
          "https://doi.org/10.1186/ar1715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012826510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.21370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012826510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2005.043166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015096737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015152836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015152836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4065/84.11.979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019060652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1422.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019128658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-012-2617-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020837647", 
          "https://doi.org/10.1007/s00296-012-2617-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3899/jrheum.100830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022534936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-4632.2011.04871.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024813444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0b013e3181441a68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026881022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0b013e3181441a68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026881022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)00701-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027018787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)00701-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027018787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ajd.12054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031379774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1179-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032755523", 
          "https://doi.org/10.1007/s10067-009-1179-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1179-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032755523", 
          "https://doi.org/10.1007/s10067-009-1179-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-009-1179-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032755523", 
          "https://doi.org/10.1007/s10067-009-1179-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000354593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033665733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000354593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033665733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-005-0169-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035242442", 
          "https://doi.org/10.1007/s10067-005-0169-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10067-005-0169-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035242442", 
          "https://doi.org/10.1007/s10067-005-0169-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2010.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035506910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035952979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ibd.20293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035952979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2003.10.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037404020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11739-009-0342-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039892020", 
          "https://doi.org/10.1007/s11739-009-0342-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11739-009-0342-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039892020", 
          "https://doi.org/10.1007/s11739-009-0342-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/annrheumdis-2013-203660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045425153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e3181a745e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046588002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e3181a745e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046588002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e3181a745e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046588002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2012.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046592142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11586210-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050492309", 
          "https://doi.org/10.2165/11586210-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11586210-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050492309", 
          "https://doi.org/10.2165/11586210-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.berh.2008.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051337443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780251101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051582030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000186408.07769.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052955813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000186408.07769.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052955813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mib.0000186408.07769.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052955813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0025-6196(11)60668-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054591520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203316662724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063903658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203316662724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063903658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0961203316662724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063903658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2310/7750.2009.09007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070717864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2310/7750.2009.09007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070717864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v21.i24.7584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071372677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5606/tjr.2011.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073050564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077511474", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5694/j.1326-5377.2007.tb01396.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077511474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077618568", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-02", 
    "datePublishedReg": "2018-02-01", 
    "description": "The induction of autoantibodies is common following therapy with anti-TNF-\u03b1 agents. However, anti-TNF-\u03b1-induced lupus (ATIL) is rare. We assessed the clinical characteristics of three patients with inflammatory bowel disease (IBD) who were treated with infliximab and developed distinct subsets of ATIL. Also, we searched for similar cases in the published literature. We describe three patients with ATIL. The first patient had a classical drug-induced lupus (DIL) presented by thrombocytopenia that resolved after infliximab discontinuation. The second case experienced symmetric polyarthritis of 14 joints in rheumatoid arthritis (RA)-like distribution accompanied by lymphopenia. The third one had a severe serositis including ascites and pleural and pericardial effusions along with pancytopenia. In this patient, ATIL coexisted with anti-TNF-\u03b1-induced hepatitis. The second and third patients met the American College of Rheumatology classification criteria for SLE. Nevertheless, all three cases exhibited ANA and anti-dsDNA positivity, and only the second patient had anticardiolipin (aCL IgG) and anti-histone antibodies. The coexistence of both lupus-like syndrome and hepatitis following anti-TNF-\u03b1 therapy in the same patient is very rare, and to the best of our knowledge, only four such case reports are mentioned in literature. Patients with mild ATIL may tolerate another anti-TNF-\u03b1 agent without recurrence of the disease. Rheumatologists should be aware of the distinct clinical presentations of ATIL and its coexistence with other rare anti-TNF-alpha complications such as hepatitis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10067-017-3884-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1093299", 
        "issn": [
          "0770-3198", 
          "1434-9949"
        ], 
        "name": "Clinical Rheumatology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "Diverse patterns of anti-TNF-\u03b1-induced lupus: case series and review of the literature", 
    "pagination": "563-568", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1bd569e7e4edabdc79859dbc60d8ffceaa9bb90b09711450dbee4dfccde9ac1b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29063464"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8211469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10067-017-3884-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092329077"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10067-017-3884-2", 
      "https://app.dimensions.ai/details/publication/pub.1092329077"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000568.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10067-017-3884-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10067-017-3884-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10067-017-3884-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10067-017-3884-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10067-017-3884-2'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      21 PREDICATES      82 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10067-017-3884-2 schema:about N2a8660f12f13436986de3e01ec689649
2 N43e0d19515354535b0e3a5b057407f18
3 N52a59576eb504ad1ad4d9669e6c46d88
4 N59531f6298f34e40b48a92c5f5378b65
5 N633f594b875f4b0fa56ac42260bc91e7
6 N66c2b92a88f5410f8a1b10eef8d898d4
7 N86ab07f56d9140a8bd69c3e40ac3ad1f
8 N8903c4292a064c80933389a7e0d43fe3
9 Na633d3ef4bd945c99496e12d0d0a7aee
10 Ncc9bd3db36144cd1952dd94591bf6b39
11 Nd7655ddb7f81403eb341ae4f05a29a99
12 Neb5ae05f451946a397703306a100e989
13 anzsrc-for:11
14 anzsrc-for:1107
15 schema:author Nf569ea7d21fe4bad82c7a176a32c15e7
16 schema:citation sg:pub.10.1007/s00296-012-2617-8
17 sg:pub.10.1007/s10067-005-0169-y
18 sg:pub.10.1007/s10067-009-1179-y
19 sg:pub.10.1007/s11739-009-0342-4
20 sg:pub.10.1186/ar1715
21 sg:pub.10.2165/11586210-000000000-00000
22 https://app.dimensions.ai/details/publication/pub.1077511474
23 https://app.dimensions.ai/details/publication/pub.1077618568
24 https://doi.org/10.1002/art.1780251101
25 https://doi.org/10.1002/ibd.20230
26 https://doi.org/10.1002/ibd.20293
27 https://doi.org/10.1002/ibd.20956
28 https://doi.org/10.1002/ibd.21370
29 https://doi.org/10.1016/j.autrev.2009.10.003
30 https://doi.org/10.1016/j.autrev.2010.07.005
31 https://doi.org/10.1016/j.autrev.2012.03.010
32 https://doi.org/10.1016/j.berh.2008.09.008
33 https://doi.org/10.1016/j.crohns.2012.01.017
34 https://doi.org/10.1016/j.crohns.2012.03.005
35 https://doi.org/10.1016/j.semarthrit.2007.08.003
36 https://doi.org/10.1016/s0016-5085(03)00701-7
37 https://doi.org/10.1016/s0025-6196(11)60668-x
38 https://doi.org/10.1053/j.gastro.2003.10.047
39 https://doi.org/10.1097/01.mib.0000186408.07769.78
40 https://doi.org/10.1097/mcg.0b013e3181a745e7
41 https://doi.org/10.1097/md.0b013e3181441a68
42 https://doi.org/10.1097/rhu.0b013e318188b1df
43 https://doi.org/10.1111/ajd.12054
44 https://doi.org/10.1111/j.1365-4632.2011.04871.x
45 https://doi.org/10.1136/annrheumdis-2013-203660
46 https://doi.org/10.1136/ard.2005.043166
47 https://doi.org/10.1159/000354593
48 https://doi.org/10.1177/0961203316662724
49 https://doi.org/10.1196/annals.1422.019
50 https://doi.org/10.12865/chsj.40.04.11
51 https://doi.org/10.2310/7750.2009.09007
52 https://doi.org/10.3748/wjg.v21.i24.7584
53 https://doi.org/10.3899/jrheum.100830
54 https://doi.org/10.4065/84.11.979
55 https://doi.org/10.5606/tjr.2011.053
56 https://doi.org/10.5694/j.1326-5377.2007.tb01396.x
57 schema:datePublished 2018-02
58 schema:datePublishedReg 2018-02-01
59 schema:description The induction of autoantibodies is common following therapy with anti-TNF-α agents. However, anti-TNF-α-induced lupus (ATIL) is rare. We assessed the clinical characteristics of three patients with inflammatory bowel disease (IBD) who were treated with infliximab and developed distinct subsets of ATIL. Also, we searched for similar cases in the published literature. We describe three patients with ATIL. The first patient had a classical drug-induced lupus (DIL) presented by thrombocytopenia that resolved after infliximab discontinuation. The second case experienced symmetric polyarthritis of 14 joints in rheumatoid arthritis (RA)-like distribution accompanied by lymphopenia. The third one had a severe serositis including ascites and pleural and pericardial effusions along with pancytopenia. In this patient, ATIL coexisted with anti-TNF-α-induced hepatitis. The second and third patients met the American College of Rheumatology classification criteria for SLE. Nevertheless, all three cases exhibited ANA and anti-dsDNA positivity, and only the second patient had anticardiolipin (aCL IgG) and anti-histone antibodies. The coexistence of both lupus-like syndrome and hepatitis following anti-TNF-α therapy in the same patient is very rare, and to the best of our knowledge, only four such case reports are mentioned in literature. Patients with mild ATIL may tolerate another anti-TNF-α agent without recurrence of the disease. Rheumatologists should be aware of the distinct clinical presentations of ATIL and its coexistence with other rare anti-TNF-alpha complications such as hepatitis.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N9ac449cc833543f4a18b510724700f84
64 Nbeb349346cec4629829f726aac311262
65 sg:journal.1093299
66 schema:name Diverse patterns of anti-TNF-α-induced lupus: case series and review of the literature
67 schema:pagination 563-568
68 schema:productId N48788a89d85643d8a3e3047fb4cb6df5
69 N5549cf97e1a348ae96fd54e0a8ae4558
70 N63df012a6751434f8b3220bd297cd110
71 Na125decb1a954046b951c939d63db256
72 Na73b07142d394e5f8325f119dbb40c06
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092329077
74 https://doi.org/10.1007/s10067-017-3884-2
75 schema:sdDatePublished 2019-04-10T18:28
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N10f80cc4a57340c99a1b4195d032ffbd
78 schema:url https://link.springer.com/10.1007%2Fs10067-017-3884-2
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N10f80cc4a57340c99a1b4195d032ffbd schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N2a8660f12f13436986de3e01ec689649 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Arthritis, Rheumatoid
86 rdf:type schema:DefinedTerm
87 N43e0d19515354535b0e3a5b057407f18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Lupus Erythematosus, Systemic
89 rdf:type schema:DefinedTerm
90 N48788a89d85643d8a3e3047fb4cb6df5 schema:name pubmed_id
91 schema:value 29063464
92 rdf:type schema:PropertyValue
93 N50b02a848e3b40b585fdb8b3aea9a48d schema:affiliation https://www.grid.ac/institutes/grid.414317.4
94 schema:familyName Tamar
95 schema:givenName Shalev
96 rdf:type schema:Person
97 N52a59576eb504ad1ad4d9669e6c46d88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Adalimumab
99 rdf:type schema:DefinedTerm
100 N5549cf97e1a348ae96fd54e0a8ae4558 schema:name readcube_id
101 schema:value 1bd569e7e4edabdc79859dbc60d8ffceaa9bb90b09711450dbee4dfccde9ac1b
102 rdf:type schema:PropertyValue
103 N59531f6298f34e40b48a92c5f5378b65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Female
105 rdf:type schema:DefinedTerm
106 N633f594b875f4b0fa56ac42260bc91e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Middle Aged
108 rdf:type schema:DefinedTerm
109 N63df012a6751434f8b3220bd297cd110 schema:name doi
110 schema:value 10.1007/s10067-017-3884-2
111 rdf:type schema:PropertyValue
112 N66c2b92a88f5410f8a1b10eef8d898d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Etanercept
114 rdf:type schema:DefinedTerm
115 N66d97d887b7e4029a1c5fc6baa79edbf rdf:first sg:person.01215547370.94
116 rdf:rest Nd062ea1ad336463ba95a37af882f97a7
117 N86ab07f56d9140a8bd69c3e40ac3ad1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adolescent
119 rdf:type schema:DefinedTerm
120 N8903c4292a064c80933389a7e0d43fe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Infliximab
122 rdf:type schema:DefinedTerm
123 N95a36220577a4320ae21dae2df84180b rdf:first sg:person.01253531157.98
124 rdf:rest N66d97d887b7e4029a1c5fc6baa79edbf
125 N9ac449cc833543f4a18b510724700f84 schema:volumeNumber 37
126 rdf:type schema:PublicationVolume
127 Na125decb1a954046b951c939d63db256 schema:name nlm_unique_id
128 schema:value 8211469
129 rdf:type schema:PropertyValue
130 Na633d3ef4bd945c99496e12d0d0a7aee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Aged
132 rdf:type schema:DefinedTerm
133 Na6533f4e141b43abb817b8161286f507 rdf:first N50b02a848e3b40b585fdb8b3aea9a48d
134 rdf:rest N95a36220577a4320ae21dae2df84180b
135 Na73b07142d394e5f8325f119dbb40c06 schema:name dimensions_id
136 schema:value pub.1092329077
137 rdf:type schema:PropertyValue
138 Nbeb349346cec4629829f726aac311262 schema:issueNumber 2
139 rdf:type schema:PublicationIssue
140 Ncc9bd3db36144cd1952dd94591bf6b39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Antirheumatic Agents
142 rdf:type schema:DefinedTerm
143 Nd062ea1ad336463ba95a37af882f97a7 rdf:first sg:person.01010756664.44
144 rdf:rest rdf:nil
145 Nd7655ddb7f81403eb341ae4f05a29a99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Tumor Necrosis Factor-alpha
147 rdf:type schema:DefinedTerm
148 Neb5ae05f451946a397703306a100e989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Humans
150 rdf:type schema:DefinedTerm
151 Nf569ea7d21fe4bad82c7a176a32c15e7 rdf:first sg:person.01031725703.33
152 rdf:rest Na6533f4e141b43abb817b8161286f507
153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical and Health Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
157 schema:name Immunology
158 rdf:type schema:DefinedTerm
159 sg:journal.1093299 schema:issn 0770-3198
160 1434-9949
161 schema:name Clinical Rheumatology
162 rdf:type schema:Periodical
163 sg:person.01010756664.44 schema:affiliation https://www.grid.ac/institutes/grid.12136.37
164 schema:familyName Shoenfeld
165 schema:givenName Yehuda
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010756664.44
167 rdf:type schema:Person
168 sg:person.01031725703.33 schema:affiliation https://www.grid.ac/institutes/grid.413795.d
169 schema:familyName Shovman
170 schema:givenName Ora
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031725703.33
172 rdf:type schema:Person
173 sg:person.01215547370.94 schema:affiliation https://www.grid.ac/institutes/grid.12136.37
174 schema:familyName Watad
175 schema:givenName Abdulla
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215547370.94
177 rdf:type schema:Person
178 sg:person.01253531157.98 schema:affiliation https://www.grid.ac/institutes/grid.12136.37
179 schema:familyName Amital
180 schema:givenName Howard
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253531157.98
182 rdf:type schema:Person
183 sg:pub.10.1007/s00296-012-2617-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020837647
184 https://doi.org/10.1007/s00296-012-2617-8
185 rdf:type schema:CreativeWork
186 sg:pub.10.1007/s10067-005-0169-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1035242442
187 https://doi.org/10.1007/s10067-005-0169-y
188 rdf:type schema:CreativeWork
189 sg:pub.10.1007/s10067-009-1179-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1032755523
190 https://doi.org/10.1007/s10067-009-1179-y
191 rdf:type schema:CreativeWork
192 sg:pub.10.1007/s11739-009-0342-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039892020
193 https://doi.org/10.1007/s11739-009-0342-4
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/ar1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012596633
196 https://doi.org/10.1186/ar1715
197 rdf:type schema:CreativeWork
198 sg:pub.10.2165/11586210-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050492309
199 https://doi.org/10.2165/11586210-000000000-00000
200 rdf:type schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1077511474 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1077618568 schema:CreativeWork
203 https://doi.org/10.1002/art.1780251101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051582030
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/ibd.20230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015152836
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/ibd.20293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035952979
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1002/ibd.20956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005622068
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1002/ibd.21370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012826510
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.autrev.2009.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001867433
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.autrev.2010.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035506910
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.autrev.2012.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046592142
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.berh.2008.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051337443
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.crohns.2012.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005824974
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.crohns.2012.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008196191
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.semarthrit.2007.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001590972
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0016-5085(03)00701-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027018787
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0025-6196(11)60668-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1054591520
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1053/j.gastro.2003.10.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037404020
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1097/01.mib.0000186408.07769.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052955813
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1097/mcg.0b013e3181a745e7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046588002
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/md.0b013e3181441a68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026881022
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1097/rhu.0b013e318188b1df schema:sameAs https://app.dimensions.ai/details/publication/pub.1011585940
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1111/ajd.12054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031379774
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1111/j.1365-4632.2011.04871.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024813444
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1136/annrheumdis-2013-203660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045425153
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1136/ard.2005.043166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015096737
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1159/000354593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033665733
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1177/0961203316662724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063903658
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1196/annals.1422.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019128658
254 rdf:type schema:CreativeWork
255 https://doi.org/10.12865/chsj.40.04.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007853708
256 rdf:type schema:CreativeWork
257 https://doi.org/10.2310/7750.2009.09007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070717864
258 rdf:type schema:CreativeWork
259 https://doi.org/10.3748/wjg.v21.i24.7584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071372677
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3899/jrheum.100830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022534936
262 rdf:type schema:CreativeWork
263 https://doi.org/10.4065/84.11.979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019060652
264 rdf:type schema:CreativeWork
265 https://doi.org/10.5606/tjr.2011.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073050564
266 rdf:type schema:CreativeWork
267 https://doi.org/10.5694/j.1326-5377.2007.tb01396.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077511474
268 rdf:type schema:CreativeWork
269 https://www.grid.ac/institutes/grid.12136.37 schema:alternateName Tel Aviv University
270 schema:name Department of Medicine ‘B’, Sheba Medical Center, Tel-Hashomer, Israel
271 Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
272 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
273 Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel
274 rdf:type schema:Organization
275 https://www.grid.ac/institutes/grid.413795.d schema:alternateName Sheba Medical Center
276 schema:name Department of Medicine ‘B’, Sheba Medical Center, Tel-Hashomer, Israel
277 Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.414317.4 schema:alternateName Wolfson Medical Center
280 schema:name Department of Gastroenterology, The E. Wolfson Medical Center, Holon, Israel
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...