Association of variably expressed KIR3dl1 alleles with psoriatic disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-10

AUTHORS

Jeffrey Berinstein, Remy Pollock, Fawnda Pellett, Arane Thavaneswaran, Vinod Chandran, Dafna D. Gladman

ABSTRACT

The purpose of this study is to examine the genetic interaction of variably expressed killer cell immunoglobulin-like receptor (KIR) 3DL1 alleles with their cognate ligand, human leukocyte antigen (HLA)-Bw4, in susceptibility to psoriatic disease (PsD). A novel allelic typing system was developed to differentiate KIR3DL1 alleles (*High, *Low, *Null expression, and 3DS1), in PsD patients, including those with psoriatic arthritis (PsA) and cutaneous psoriasis without arthritis (PsC) and healthy controls. Frequencies of each KIR3DL1 allele, Bw4-80I and Bw4-80T, as well as the genetic interaction between the KIR3DL1 alleles and the Bw4 epitope were analyzed. KIR3DL1 alleles were successfully genotyped in 392 PsA, 260 PsC, and 371 control subjects. Only the KIR3DL1*Null allele was associated with PsD (OR = 0.69, p = 0.008), both in the PsA (OR = 0.69, p = 0.02) and PsC patients (OR = 0.70, p = 0.04) compared to control subjects. No difference in the frequency of KIR3DL1*Null was found between the PsA and PsC patients. The presence of the HLA-Bw4 epitope was significantly associated with PsD, particularly in the PsA patients compared to controls. Bw4-80I was increased in PsD and PsA subjects, but not in PsC patients compared to controls. Bw4-80T was increased in PsA compared to both PsC patients or to controls. No interaction was detected between any of the KIR3DL1 alleles and HLA-Bw4, Bw4-80I, or Bw4-80T. The novel qPCR technique successfully identified the four variably expressed KIR3DL1 alleles. The HLA-Bw4 epitope was associated with psoriatic disease, particularly with PsA, but no genetic interactions with KIR3DL1 alleles were detected. More... »

PAGES

2261-2266

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-017-3784-5

DOI

http://dx.doi.org/10.1007/s10067-017-3784-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091159788

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28801811


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Arthritis, Psoriatic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epitopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HLA-B Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, KIR3DL1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada", 
            "Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada", 
            "Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berinstein", 
        "givenName": "Jeffrey", 
        "id": "sg:person.014734561661.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014734561661.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada", 
            "Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada", 
            "Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pollock", 
        "givenName": "Remy", 
        "id": "sg:person.01335213772.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335213772.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toronto Western Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417188.3", 
          "name": [
            "University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada", 
            "Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pellett", 
        "givenName": "Fawnda", 
        "id": "sg:person.010364661067.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010364661067.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toronto Western Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417188.3", 
          "name": [
            "University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada", 
            "Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thavaneswaran", 
        "givenName": "Arane", 
        "id": "sg:person.01155030106.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155030106.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada", 
            "Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada", 
            "Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada", 
            "Institute of Medical Science, University of Toronto, Toronto, ON, Canada", 
            "Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chandran", 
        "givenName": "Vinod", 
        "id": "sg:person.01234257431.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234257431.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada", 
            "Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada", 
            "Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada", 
            "Institute of Medical Science, University of Toronto, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gladman", 
        "givenName": "Dafna D.", 
        "id": "sg:person.01136132356.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136132356.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.humimm.2008.04.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001424687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2006.00459.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001512212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2004.032482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002609767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1744-313x.2011.01024.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006685798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjd.14081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007582187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.smim.2008.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010480197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3282ffde7e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021134040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3282ffde7e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021134040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3282ffde7e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021134040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0903657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028977480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.2009.01392.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030161224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.2009.01392.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030161224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0039.2011.01764.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031362198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/ket296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031529145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033619264", 
          "https://doi.org/10.1186/ar1988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2011.155044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038517970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041757826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041757826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0039991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045230706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2009.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045668233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.180.4.1235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047788823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1002514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050093766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1103478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062451059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.5.2992", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074767810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.6.2818", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075119293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076876358", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079923467", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-10", 
    "datePublishedReg": "2017-10-01", 
    "description": "The purpose of this study is to examine the genetic interaction of variably expressed killer cell immunoglobulin-like receptor (KIR) 3DL1 alleles with their cognate ligand, human leukocyte antigen (HLA)-Bw4, in susceptibility to psoriatic disease (PsD). A novel allelic typing system was developed to differentiate KIR3DL1 alleles (*High, *Low, *Null expression, and 3DS1), in PsD patients, including those with psoriatic arthritis (PsA) and cutaneous psoriasis without arthritis (PsC) and healthy controls. Frequencies of each KIR3DL1 allele, Bw4-80I and Bw4-80T, as well as the genetic interaction between the KIR3DL1 alleles and the Bw4 epitope were analyzed. KIR3DL1 alleles were successfully genotyped in 392 PsA, 260 PsC, and 371 control subjects. Only the KIR3DL1*Null allele was associated with PsD (OR\u00a0=\u00a00.69, p\u00a0=\u00a00.008), both in the PsA (OR\u00a0=\u00a00.69, p\u00a0=\u00a00.02) and PsC patients (OR\u00a0=\u00a00.70, p\u00a0=\u00a00.04) compared to control subjects. No difference in the frequency of KIR3DL1*Null was found between the PsA and PsC patients. The presence of the HLA-Bw4 epitope was significantly associated with PsD, particularly in the PsA patients compared to controls. Bw4-80I was increased in PsD and PsA subjects, but not in PsC patients compared to controls. Bw4-80T was increased in PsA compared to both PsC patients or to controls. No interaction was detected between any of the KIR3DL1 alleles and HLA-Bw4, Bw4-80I, or Bw4-80T. The novel qPCR technique successfully identified the four variably expressed KIR3DL1 alleles. The HLA-Bw4 epitope was associated with psoriatic disease, particularly with PsA, but no genetic interactions with KIR3DL1 alleles were detected.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10067-017-3784-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1093299", 
        "issn": [
          "0770-3198", 
          "1434-9949"
        ], 
        "name": "Clinical Rheumatology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Association of variably expressed KIR3dl1 alleles with psoriatic disease", 
    "pagination": "2261-2266", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f541f30c0738238057bc74d438ad67ef672376350bad5fc47b08528775a451d5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28801811"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8211469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10067-017-3784-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091159788"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10067-017-3784-5", 
      "https://app.dimensions.ai/details/publication/pub.1091159788"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54325_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10067-017-3784-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10067-017-3784-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10067-017-3784-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10067-017-3784-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10067-017-3784-5'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      68 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10067-017-3784-5 schema:about N0415b8bd506f42a0ba6237ed9a5a18b6
2 N0506c155ef134dd0a220e38ac939a720
3 N15b14fb0235c480fa7664d886d302501
4 N1abeb54b12df4906b35948f4f0075662
5 N1c79ecdf8abd482689d44b97b6cd9968
6 N2d5a0f35e8a444d98cf9f25f83c498ea
7 N7965995da5b146a1bdffedd0e538e6ba
8 N83b1ebf9e1784383bc00ff097f760d04
9 N89946266b07b42548bde94c6726c2260
10 N922919cf500144debd5ea376383221ed
11 N95e16602845a44ffad1b4ade9e1927c4
12 Nac704cee4100441b850cfdec71c9c424
13 Nbf7c478152df40dd979b0211e5fe4a82
14 Ncd6f2716f61249dda6db510b9b227908
15 Nd383beabce914bccbb3546aefd95ee1f
16 Ne7ac1e78efa74c758db6f0e21961d9f0
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N00f5f8c71ddd4ec79da4ed95dc4c4e70
20 schema:citation sg:pub.10.1186/ar1988
21 https://app.dimensions.ai/details/publication/pub.1076876358
22 https://app.dimensions.ai/details/publication/pub.1079923467
23 https://doi.org/10.1002/art.27332
24 https://doi.org/10.1016/j.humimm.2008.04.012
25 https://doi.org/10.1016/j.jaut.2009.12.001
26 https://doi.org/10.1016/j.smim.2008.06.003
27 https://doi.org/10.1084/jem.180.4.1235
28 https://doi.org/10.1093/rheumatology/ket296
29 https://doi.org/10.1097/qad.0b013e3282ffde7e
30 https://doi.org/10.1111/bjd.14081
31 https://doi.org/10.1111/j.1399-0039.2009.01392.x
32 https://doi.org/10.1111/j.1399-0039.2011.01764.x
33 https://doi.org/10.1111/j.1600-065x.2006.00459.x
34 https://doi.org/10.1111/j.1744-313x.2011.01024.x
35 https://doi.org/10.1126/science.1103478
36 https://doi.org/10.1136/ard.2004.032482
37 https://doi.org/10.1136/ard.2011.155044
38 https://doi.org/10.1371/journal.pgen.1002514
39 https://doi.org/10.1371/journal.pone.0039991
40 https://doi.org/10.4049/jimmunol.0903657
41 https://doi.org/10.4049/jimmunol.166.5.2992
42 https://doi.org/10.4049/jimmunol.169.6.2818
43 schema:datePublished 2017-10
44 schema:datePublishedReg 2017-10-01
45 schema:description The purpose of this study is to examine the genetic interaction of variably expressed killer cell immunoglobulin-like receptor (KIR) 3DL1 alleles with their cognate ligand, human leukocyte antigen (HLA)-Bw4, in susceptibility to psoriatic disease (PsD). A novel allelic typing system was developed to differentiate KIR3DL1 alleles (*High, *Low, *Null expression, and 3DS1), in PsD patients, including those with psoriatic arthritis (PsA) and cutaneous psoriasis without arthritis (PsC) and healthy controls. Frequencies of each KIR3DL1 allele, Bw4-80I and Bw4-80T, as well as the genetic interaction between the KIR3DL1 alleles and the Bw4 epitope were analyzed. KIR3DL1 alleles were successfully genotyped in 392 PsA, 260 PsC, and 371 control subjects. Only the KIR3DL1*Null allele was associated with PsD (OR = 0.69, p = 0.008), both in the PsA (OR = 0.69, p = 0.02) and PsC patients (OR = 0.70, p = 0.04) compared to control subjects. No difference in the frequency of KIR3DL1*Null was found between the PsA and PsC patients. The presence of the HLA-Bw4 epitope was significantly associated with PsD, particularly in the PsA patients compared to controls. Bw4-80I was increased in PsD and PsA subjects, but not in PsC patients compared to controls. Bw4-80T was increased in PsA compared to both PsC patients or to controls. No interaction was detected between any of the KIR3DL1 alleles and HLA-Bw4, Bw4-80I, or Bw4-80T. The novel qPCR technique successfully identified the four variably expressed KIR3DL1 alleles. The HLA-Bw4 epitope was associated with psoriatic disease, particularly with PsA, but no genetic interactions with KIR3DL1 alleles were detected.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N5d4cddc4555b4703b389d4db354603e2
50 Nad6e1e02396943cc81b76d4f2ce9f23e
51 sg:journal.1093299
52 schema:name Association of variably expressed KIR3dl1 alleles with psoriatic disease
53 schema:pagination 2261-2266
54 schema:productId N073181c0101c4dcf9f12e27cf8a4de4c
55 N4a69d8eb54764eca962eec53333edef4
56 N4e932efd7229449b9432abb6db0ea149
57 Nabc5712e551441f0aa1fb57e8319397e
58 Nf2cf68176a554d3390a01f95978e0ba7
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091159788
60 https://doi.org/10.1007/s10067-017-3784-5
61 schema:sdDatePublished 2019-04-11T10:19
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N6c23e19b08284fd4ab4669f01cce97ac
64 schema:url https://link.springer.com/10.1007%2Fs10067-017-3784-5
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N00f5f8c71ddd4ec79da4ed95dc4c4e70 rdf:first sg:person.014734561661.12
69 rdf:rest Nc5bab3798d9a48128da4a754aa1b7799
70 N0415b8bd506f42a0ba6237ed9a5a18b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Case-Control Studies
72 rdf:type schema:DefinedTerm
73 N0506c155ef134dd0a220e38ac939a720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Female
75 rdf:type schema:DefinedTerm
76 N073181c0101c4dcf9f12e27cf8a4de4c schema:name readcube_id
77 schema:value f541f30c0738238057bc74d438ad67ef672376350bad5fc47b08528775a451d5
78 rdf:type schema:PropertyValue
79 N15b14fb0235c480fa7664d886d302501 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Genetic Predisposition to Disease
81 rdf:type schema:DefinedTerm
82 N1abeb54b12df4906b35948f4f0075662 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Arthritis, Psoriatic
84 rdf:type schema:DefinedTerm
85 N1c79ecdf8abd482689d44b97b6cd9968 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Polymerase Chain Reaction
87 rdf:type schema:DefinedTerm
88 N2d5a0f35e8a444d98cf9f25f83c498ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Receptors, KIR3DL1
90 rdf:type schema:DefinedTerm
91 N4a69d8eb54764eca962eec53333edef4 schema:name doi
92 schema:value 10.1007/s10067-017-3784-5
93 rdf:type schema:PropertyValue
94 N4e932efd7229449b9432abb6db0ea149 schema:name dimensions_id
95 schema:value pub.1091159788
96 rdf:type schema:PropertyValue
97 N5d4cddc4555b4703b389d4db354603e2 schema:volumeNumber 36
98 rdf:type schema:PublicationVolume
99 N6c23e19b08284fd4ab4669f01cce97ac schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N7965995da5b146a1bdffedd0e538e6ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N79c0b96af60245fbb6ddf7fd95becfdb rdf:first sg:person.01136132356.43
105 rdf:rest rdf:nil
106 N83b1ebf9e1784383bc00ff097f760d04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name HLA-B Antigens
108 rdf:type schema:DefinedTerm
109 N89946266b07b42548bde94c6726c2260 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Male
111 rdf:type schema:DefinedTerm
112 N922919cf500144debd5ea376383221ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name HLA Antigens
114 rdf:type schema:DefinedTerm
115 N95e16602845a44ffad1b4ade9e1927c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Alleles
117 rdf:type schema:DefinedTerm
118 Nab92bb2ef5164922a6d94b9d2f59e25e rdf:first sg:person.01155030106.27
119 rdf:rest Nfa846e15f7184855aa7a7df8981e9c83
120 Nabc5712e551441f0aa1fb57e8319397e schema:name nlm_unique_id
121 schema:value 8211469
122 rdf:type schema:PropertyValue
123 Nac704cee4100441b850cfdec71c9c424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Epitopes
125 rdf:type schema:DefinedTerm
126 Nad6e1e02396943cc81b76d4f2ce9f23e schema:issueNumber 10
127 rdf:type schema:PublicationIssue
128 Nbf7c478152df40dd979b0211e5fe4a82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Adult
130 rdf:type schema:DefinedTerm
131 Nc5bab3798d9a48128da4a754aa1b7799 rdf:first sg:person.01335213772.87
132 rdf:rest Nde238ff7623c485aaddf2bced1061219
133 Ncd6f2716f61249dda6db510b9b227908 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Inflammation
135 rdf:type schema:DefinedTerm
136 Nd383beabce914bccbb3546aefd95ee1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Genotype
138 rdf:type schema:DefinedTerm
139 Nde238ff7623c485aaddf2bced1061219 rdf:first sg:person.010364661067.14
140 rdf:rest Nab92bb2ef5164922a6d94b9d2f59e25e
141 Ne7ac1e78efa74c758db6f0e21961d9f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Middle Aged
143 rdf:type schema:DefinedTerm
144 Nf2cf68176a554d3390a01f95978e0ba7 schema:name pubmed_id
145 schema:value 28801811
146 rdf:type schema:PropertyValue
147 Nfa846e15f7184855aa7a7df8981e9c83 rdf:first sg:person.01234257431.51
148 rdf:rest N79c0b96af60245fbb6ddf7fd95becfdb
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
153 schema:name Clinical Sciences
154 rdf:type schema:DefinedTerm
155 sg:journal.1093299 schema:issn 0770-3198
156 1434-9949
157 schema:name Clinical Rheumatology
158 rdf:type schema:Periodical
159 sg:person.010364661067.14 schema:affiliation https://www.grid.ac/institutes/grid.417188.3
160 schema:familyName Pellett
161 schema:givenName Fawnda
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010364661067.14
163 rdf:type schema:Person
164 sg:person.01136132356.43 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
165 schema:familyName Gladman
166 schema:givenName Dafna D.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136132356.43
168 rdf:type schema:Person
169 sg:person.01155030106.27 schema:affiliation https://www.grid.ac/institutes/grid.417188.3
170 schema:familyName Thavaneswaran
171 schema:givenName Arane
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155030106.27
173 rdf:type schema:Person
174 sg:person.01234257431.51 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
175 schema:familyName Chandran
176 schema:givenName Vinod
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234257431.51
178 rdf:type schema:Person
179 sg:person.01335213772.87 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
180 schema:familyName Pollock
181 schema:givenName Remy
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335213772.87
183 rdf:type schema:Person
184 sg:person.014734561661.12 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
185 schema:familyName Berinstein
186 schema:givenName Jeffrey
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014734561661.12
188 rdf:type schema:Person
189 sg:pub.10.1186/ar1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033619264
190 https://doi.org/10.1186/ar1988
191 rdf:type schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1076876358 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1079923467 schema:CreativeWork
194 https://doi.org/10.1002/art.27332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041757826
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.humimm.2008.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001424687
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.jaut.2009.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045668233
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.smim.2008.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010480197
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1084/jem.180.4.1235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047788823
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1093/rheumatology/ket296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031529145
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/qad.0b013e3282ffde7e schema:sameAs https://app.dimensions.ai/details/publication/pub.1021134040
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1111/bjd.14081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007582187
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1111/j.1399-0039.2009.01392.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030161224
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1111/j.1399-0039.2011.01764.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031362198
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/j.1600-065x.2006.00459.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001512212
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/j.1744-313x.2011.01024.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006685798
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1126/science.1103478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062451059
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1136/ard.2004.032482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002609767
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1136/ard.2011.155044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038517970
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1371/journal.pgen.1002514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050093766
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1371/journal.pone.0039991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045230706
227 rdf:type schema:CreativeWork
228 https://doi.org/10.4049/jimmunol.0903657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028977480
229 rdf:type schema:CreativeWork
230 https://doi.org/10.4049/jimmunol.166.5.2992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074767810
231 rdf:type schema:CreativeWork
232 https://doi.org/10.4049/jimmunol.169.6.2818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075119293
233 rdf:type schema:CreativeWork
234 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
235 schema:name Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
236 Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
237 Institute of Medical Science, University of Toronto, Toronto, ON, Canada
238 Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
239 University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada
240 rdf:type schema:Organization
241 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
242 schema:name Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
243 Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
244 University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada
245 rdf:type schema:Organization
246 https://www.grid.ac/institutes/grid.417188.3 schema:alternateName Toronto Western Hospital
247 schema:name Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
248 University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, M5T 2S8, Toronto, ON, Canada
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...