Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-02

AUTHORS

Guan-Ying Wang, Sa-Li Zhang, Xiu-Ru Wang, Min Feng, Chun Li, Yuan An, Xiao- Feng Li, Li-Zhi Wang, Cai-Hong Wang, Yong-Fu Wang, Rong Yang, Hui-Ming Yan, Guo-Chun Wang, Xin Lu, Xia Liu, Ping Zhu, Li-Na Chen, Hong-Tao Jin, Jin-Ting Liu, Hui-Fang Guo, Hai-Ying Chen, Jian-Li Xie, Ping Wei, Jun-Xiang Wang, Xiang-Yuan Liu, Lin Sun, Liu-Fu Cui, Rong Shu, Bai-Lu Liu, Ping Yu, Zhuo-Li Zhang, Guang-Tao Li, Zhen-Bin Li, Jing Yang, Jun-Fang Li, Bin Jia, Feng-Xiao Zhang, Jie-Mei Tao, Jin-Ying Lin, Mei-Qiu Wei, Xiao-Min Liu, Dan Ke, Shao-Xian Hu, Cong Ye, Shu-Ling Han, Xiu-Yan Yang, Hao Li, Ci-Bo Huang, Ming Gao, Bei Lai, Yong-Jing Cheng, Xing-Fu Li, Li-Jun Song, Xiao-Xia Yu, Ai-Xue Wang, Li-Jun Wu, Yan-Hua Wang, Lan He, Wen-Wen Sun, Lu Gong, Xiao-Yuan Wang, Yi Wang, Yi Zhao, Xiao-Xia Li, Yan Wang, Yan Zhang, Yin Su, Chun-Fang Zhang, Rong Mu, Zhan-Guo Li

ABSTRACT

The aim of this study is to investigate the remission rate of rheumatoid arthritis (RA) in China and identify its potential determinants. A multi-center cross-sectional study was conducted from July 2009 to January 2012. Data were collected by face-to-face interviews of the rheumatology outpatients in 28 tertiary hospitals in China. The remission rates were calculated in 486 RA patients according to different definitions of remission: the Disease Activity Score in 28 joints (DAS28), the Simplified Disease Activity Index (SDAI), the Clinical Disease Activity Index (CDAI), and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean definition. Potential determinants of RA remission were assessed by univariate and multivariate analyses. The remission rates of RA from this multi-center cohort were 8.6% (DAS28), 8.4% (SDAI), 8.2% (CDAI), and 6.8% (Boolean), respectively. Favorable factors associated with remission were: low Health Assessment Questionnaire (HAQ) score, absence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP), and treatment of methotrexate (MTX) and hydroxychloroquine (HCQ). Younger age was also predictive for the DAS28 and the Boolean remission. Multivariate analyses revealed a low HAQ score, the absence of anti-CCP, and the treatment with HCQ as independent determinants of remission. The clinical remission rate of RA patients was low in China. A low HAQ score, the absence of anti-CCP, and HCQ were significant independent determinants for RA remission. More... »

PAGES

221-230

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-014-2828-3

DOI

http://dx.doi.org/10.1007/s10067-014-2828-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030780129

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25413735


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