Anti-TNF therapy in patients with HBV infection—analysis of 87 patients with inflammatory arthritis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01

AUTHORS

Hua Ye, Xue-wu Zhang, Rong Mu, Lin-kai Fang, Jie-ruo Gu, Jin Lin, Jin-feng Du, Jin-wei Chen, Yi-jia Chen, Li-jun Wu, Xue-feng Pang, Zhan-guo Li

ABSTRACT

This study aims to investigate the incidence of hepatitis B virus (HBV) reactivation in inflammatory arthritis (IA) patients with HBV infection using anti-tumor necrosis factor (TNF) agents and evaluate the efficacy of antiviral therapy in reducing the risk of viral reactivation in chronic HBV infection. IA patients using anti-TNF agents from six centers were enrolled. Their HBV infection conditions and ALT and HBV-DNA levels were monitored periodically. Among the six chronic hepatitis B patients, HBV reactivation was found in two patients without antivirus prophylaxis and no viral replication was detected in the other four patients with antivirus prophylaxis. In the 31 inactive carriers, the increase of viral load was detected in 6 of 22 (27.3 %) patients without antiviral prophylaxis, and there was no viral reactivation in the other 9 patients with antiviral prophylaxis. HBV reactivation was not found in the 50 patients with resolved HBV infection. It is suggested that anti-TNF therapy might increase the risk of HBV reactivation in patients with chronic HBV infection, and antiviral prophylaxis could effectively decrease the risk. Anti-TNF agents seem to be safe in patients with resolved HBV infection. More... »

PAGES

119-123

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-013-2385-1

DOI

http://dx.doi.org/10.1007/s10067-013-2385-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049982859

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24077913


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