Limitations of a single-point evaluation of anti-MDA5 antibody, ferritin, and IL-18 in predicting the prognosis of interstitial lung disease with ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-12-19

AUTHORS

Yoshinao Muro, Kazumitsu Sugiura, Masashi Akiyama

ABSTRACT

Autoantibodies against melanoma differentiation-associated gene 5 (MDA5) are important serological markers in dermatomyositis (DM) with rapidly progressive interstitial lung disease (ILD). Recent studies noted that anti-MDA5 antibody (anti-MDA5ab), ferritin, and IL-18 are useful biomarkers for evaluating the responses to treatment and the status of ILD in anti-MDA5ab-positive DM. In this study, we further studied the importance of anti-MDA5ab levels and of ferritin and IL-18 concentrations in our patients. These biomarkers could be sometimes useful for evaluating ILD status and/or predicting the prognosis in patients with anti-MDA5ab-positive DM with several exceptional cases. A single-point evaluation of anti-MDA5ab levels and of ferritin and IL-18 concentrations has limitations in predicting the prognosis of ILD with DM. We consider that the timing of initial therapy and the anti-MDA5ab isotype, in addition to the patient’s age, are also crucial factors for predicting the prognosis. More... »

PAGES

395-398

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-012-2142-x

DOI

http://dx.doi.org/10.1007/s10067-012-2142-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013267610

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23250474


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