Hybrid 18F-FDG PET–MRI of the hand in rheumatoid arthritis: initial results View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-05-18

AUTHORS

Falk Miese, Axel Scherer, Benedikt Ostendorf, Alexander Heinzel, Rotem S. Lanzman, Patric Kröpil, Dirk Blondin, Hubertus Hautzel, Hans-Jörg Wittsack, Matthias Schneider, Gerald Antoch, Hans Herzog, N. Jon Shah

ABSTRACT

18F-fluorodeoxyglucose PET (18F-FDG PET) is highly sensitive to inflammatory changes within the synovial tissue in rheumatoid arthritis (RA). However, the highest spatial resolution for soft tissue can be achieved with MRI. Here, we report on the first true hybrid PET–MRI examination of the hand in early RA exploiting the advantages of both modalities. PET–MRI was performed with a prototype of an APD-based magneto-insensitive BrainPET detector (Siemens Healthcare, Erlangen, Germany) operated within a standard 3T MR scanner (MAGNETOM Trio, Siemens). PET images were normalized, random, attenuation and scatter-corrected, iteratively reconstructed and calibrated to yield standardized uptake values (SUV) of 18F-FDG uptake. T1-weighted TSE in coronal as well as sagittal orientation prior to and following Gadolinium administration were acquired. Increased 18F-FDG uptake was present in synovitis and tenovaginitis as identified on contrast-enhanced MRI. The tracer distribution was surrounding the metacarpophalangeal joints II and III. Maximum SUV of 3.1 was noted. In RA, true hybrid 18F-FDG PET–MRI of the hand is technically feasible and bears the potential to directly visualize inflammation. More... »

PAGES

1247-1250

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-011-1777-3

DOI

http://dx.doi.org/10.1007/s10067-011-1777-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034925836

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21590292


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