Rituximab in cryoglobulinaemic vasculitis, evidence for its effectivity: a case report and review of literature View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-02

AUTHORS

Freke Wink, Pieternella M. Houtman, Tim L. Th. A. Jansen

ABSTRACT

Cryoglobulinaemia associated with systemic vasculitis mediated by immune complexes is a rare combination. These immune complexes are composed of immunoglobulins and precipitate when exposed to cold temperature. Cryoglobulinaemic vasculitis, treated or untreated, may lead to substantial morbidity and even mortality. Novel targeted therapies may well provide new therapeutic options following or perhaps even prior to the classical cytotoxic therapies. Systemic B cell depletion with rituximab, a chimeric monoclonal antibody against CD20 antigen, is commonly applied in patients with non-Hodgkin's lymphoma or in refractory rheumatoid factor-positive rheumatoid arthritis. Since B cell clones are the source of cryoglobulins, therapeutic effectiveness of rituximab in cryoglobulinaemic vasculitis may be expected. We describe a 72-year-old woman with mixed cryoglobulinaemia type 2, who has successfully been treated with rituximab infusions after failing on prednisone and azathioprine. We reviewed the literature and found 142 cases of cryoglobulinaemic vasculitis, 138 mixed (type 2 or 3) and four, type 1. Rituximab was applied mostly after failure on other treatments. Significant reduction in levels of rheumatoid factor, cryoglobulins and IgM were reported after rituximab therapy. Of the total 142, cases 119 could be evaluated for the response on rituximab therapy, the other 23 cases only regarding side effects. Of the 119 evaluated patients, 71 (60%) had complete response; 28 (23%), partial response and 20 patients (17%), no response. Data were not blinded or placebo-controlled. Side effects were seen in 27 of the 142 patients. Occurrence of the side effects was associated with high baseline levels of cryoglobulins, with a high dose of rituximab infusion of 1,000 mg and with a high level of complement activation. Death was reported four times and was related with the disease. More... »

PAGES

293-300

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-010-1612-2

DOI

http://dx.doi.org/10.1007/s10067-010-1612-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000979528

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21053035


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Murine-Derived", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cryoglobulinemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunologic Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Remission Induction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rituximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vasculitis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Medisch Centrum Leeuwarden", 
          "id": "https://www.grid.ac/institutes/grid.414846.b", 
          "name": [
            "Department of Rheumatology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wink", 
        "givenName": "Freke", 
        "id": "sg:person.0712731176.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712731176.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medisch Centrum Leeuwarden", 
          "id": "https://www.grid.ac/institutes/grid.414846.b", 
          "name": [
            "Department of Rheumatology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houtman", 
        "givenName": "Pieternella M.", 
        "id": "sg:person.010521542564.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010521542564.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Rheumatology, University Medical Centre Nijmegen St. Radboud, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jansen", 
        "givenName": "Tim L. Th. A.", 
        "id": "sg:person.011422102432.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011422102432.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s1590-8658(07)80026-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000234994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.25000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000308649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.25000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000308649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2006.065565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004306770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2003.12.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005644771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200363080-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006375276", 
          "https://doi.org/10.2165/00003495-200363080-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-200363080-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006375276", 
          "https://doi.org/10.2165/00003495-200363080-00005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.61.10.883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008923560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200605000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010802068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200605000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010802068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004836-200605000-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010802068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-007-0462-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013769830", 
          "https://doi.org/10.1007/s00296-007-0462-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-007-0462-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013769830", 
          "https://doi.org/10.1007/s00296-007-0462-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00296-007-0462-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013769830", 
          "https://doi.org/10.1007/s00296-007-0462-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/kel004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015631619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/keh470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016677294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2007.081653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017356741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12016-007-8019-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018039956", 
          "https://doi.org/10.1007/s12016-007-8019-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/clm.2006.n.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019991571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1529-0131(199912)42:12<2507::aid-anr2>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020299883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcv.2009.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021268281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-10-3162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022614023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/gfh564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024121959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.61.10.922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024442724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1413-86702007000100038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024671904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e3180f60b7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026903134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e3180f60b7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026903134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e3180f60b7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026903134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2002.004929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028933801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/keh503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028949135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-09-2856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030831945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(66)90200-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032688185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpneph0823", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035133114", 
          "https://doi.org/10.1038/ncpneph0823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11239-008-0195-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035244896", 
          "https://doi.org/10.1007/s11239-008-0195-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/kel387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038644937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(74)90852-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038950970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.10345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039075290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v99.3.754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039652345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2007.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040567522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.10947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044684559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000183749.79424.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048595739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000183749.79424.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048595739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000183749.79424.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048595739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.21330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049298594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-009-5072-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053162827", 
          "https://doi.org/10.1007/s00415-009-5072-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00415-009-5072-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053162827", 
          "https://doi.org/10.1007/s00415-009-5072-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074558579", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077135703", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077250943", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077596150", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-02", 
    "datePublishedReg": "2011-02-01", 
    "description": "Cryoglobulinaemia associated with systemic vasculitis mediated by immune complexes is a rare combination. These immune complexes are composed of immunoglobulins and precipitate when exposed to cold temperature. Cryoglobulinaemic vasculitis, treated or untreated, may lead to substantial morbidity and even mortality. Novel targeted therapies may well provide new therapeutic options following or perhaps even prior to the classical cytotoxic therapies. Systemic B cell depletion with rituximab, a chimeric monoclonal antibody against CD20 antigen, is commonly applied in patients with non-Hodgkin's lymphoma or in refractory rheumatoid factor-positive rheumatoid arthritis. Since B cell clones are the source of cryoglobulins, therapeutic effectiveness of rituximab in cryoglobulinaemic vasculitis may be expected. We describe a 72-year-old woman with mixed cryoglobulinaemia type 2, who has successfully been treated with rituximab infusions after failing on prednisone and azathioprine. We reviewed the literature and found 142 cases of cryoglobulinaemic vasculitis, 138 mixed (type 2 or 3) and four, type 1. Rituximab was applied mostly after failure on other treatments. Significant reduction in levels of rheumatoid factor, cryoglobulins and IgM were reported after rituximab therapy. Of the total 142, cases 119 could be evaluated for the response on rituximab therapy, the other 23 cases only regarding side effects. Of the 119 evaluated patients, 71 (60%) had complete response; 28 (23%), partial response and 20 patients (17%), no response. Data were not blinded or placebo-controlled. Side effects were seen in 27 of the 142 patients. Occurrence of the side effects was associated with high baseline levels of cryoglobulins, with a high dose of rituximab infusion of 1,000\u00a0mg and with a high level of complement activation. Death was reported four times and was related with the disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10067-010-1612-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1093299", 
        "issn": [
          "0770-3198", 
          "1434-9949"
        ], 
        "name": "Clinical Rheumatology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "name": "Rituximab in cryoglobulinaemic vasculitis, evidence for its effectivity: a case report and review of literature", 
    "pagination": "293-300", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "04aab6773a2cf59ce450bfd18427d57fc7656cc00ffb9da748b4030b5491a233"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21053035"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8211469"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10067-010-1612-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000979528"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10067-010-1612-2", 
      "https://app.dimensions.ai/details/publication/pub.1000979528"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10067-010-1612-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10067-010-1612-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10067-010-1612-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10067-010-1612-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10067-010-1612-2'


 

This table displays all metadata directly associated to this object as RDF triples.

248 TRIPLES      21 PREDICATES      79 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10067-010-1612-2 schema:about N0590df011152464f8752e4eab0fcdc32
2 N3393208ca8234437b05eab76568ddb21
3 N41a71e83a4944deaa7687899a9eb1830
4 N4a5ddbe65a984e4abc2bb44332da0bfc
5 N645ebc71132a4eb8ae19d14ec8521c59
6 N81a50805e2a54b8882ab8e3a9ee7e0d6
7 N82f179f59cb2484cad87985ad6b283cc
8 Nc4a59e759a314fe496ce09a0ab332439
9 Nd8b6f6609d0e461aac5a7ceafd83fd38
10 Ndda78f4ea38849b3868035ff8a814152
11 Ne806c65f8af04175b4dd603f3e6ec764
12 anzsrc-for:11
13 anzsrc-for:1107
14 schema:author N09b1cc56b8b347f180e7121eafce4602
15 schema:citation sg:pub.10.1007/s00296-007-0462-y
16 sg:pub.10.1007/s00415-009-5072-z
17 sg:pub.10.1007/s11239-008-0195-0
18 sg:pub.10.1007/s12016-007-8019-0
19 sg:pub.10.1038/ncpneph0823
20 sg:pub.10.2165/00003495-200363080-00005
21 https://app.dimensions.ai/details/publication/pub.1074558579
22 https://app.dimensions.ai/details/publication/pub.1077135703
23 https://app.dimensions.ai/details/publication/pub.1077250943
24 https://app.dimensions.ai/details/publication/pub.1077596150
25 https://doi.org/10.1002/1529-0131(199912)42:12<2507::aid-anr2>3.0.co;2-#
26 https://doi.org/10.1002/ajh.21330
27 https://doi.org/10.1002/art.10345
28 https://doi.org/10.1002/art.10947
29 https://doi.org/10.1002/art.25000
30 https://doi.org/10.1016/0002-9343(66)90200-2
31 https://doi.org/10.1016/0002-9343(74)90852-3
32 https://doi.org/10.1016/j.clim.2007.06.008
33 https://doi.org/10.1016/j.jcv.2009.10.006
34 https://doi.org/10.1016/s1590-8658(07)80026-0
35 https://doi.org/10.1053/j.ajkd.2003.12.057
36 https://doi.org/10.1093/ndt/gfh564
37 https://doi.org/10.1093/rheumatology/keh470
38 https://doi.org/10.1093/rheumatology/keh503
39 https://doi.org/10.1093/rheumatology/kel004
40 https://doi.org/10.1093/rheumatology/kel387
41 https://doi.org/10.1097/00004836-200605000-00018
42 https://doi.org/10.1097/01.tp.0000183749.79424.b4
43 https://doi.org/10.1097/mcg.0b013e3180f60b7a
44 https://doi.org/10.1136/ard.2002.004929
45 https://doi.org/10.1136/ard.2006.065565
46 https://doi.org/10.1136/ard.2007.081653
47 https://doi.org/10.1136/ard.61.10.883
48 https://doi.org/10.1136/ard.61.10.922
49 https://doi.org/10.1182/blood-2002-09-2856
50 https://doi.org/10.1182/blood-2002-10-3162
51 https://doi.org/10.1182/blood.v99.3.754
52 https://doi.org/10.1590/s1413-86702007000100038
53 https://doi.org/10.3816/clm.2006.n.052
54 schema:datePublished 2011-02
55 schema:datePublishedReg 2011-02-01
56 schema:description Cryoglobulinaemia associated with systemic vasculitis mediated by immune complexes is a rare combination. These immune complexes are composed of immunoglobulins and precipitate when exposed to cold temperature. Cryoglobulinaemic vasculitis, treated or untreated, may lead to substantial morbidity and even mortality. Novel targeted therapies may well provide new therapeutic options following or perhaps even prior to the classical cytotoxic therapies. Systemic B cell depletion with rituximab, a chimeric monoclonal antibody against CD20 antigen, is commonly applied in patients with non-Hodgkin's lymphoma or in refractory rheumatoid factor-positive rheumatoid arthritis. Since B cell clones are the source of cryoglobulins, therapeutic effectiveness of rituximab in cryoglobulinaemic vasculitis may be expected. We describe a 72-year-old woman with mixed cryoglobulinaemia type 2, who has successfully been treated with rituximab infusions after failing on prednisone and azathioprine. We reviewed the literature and found 142 cases of cryoglobulinaemic vasculitis, 138 mixed (type 2 or 3) and four, type 1. Rituximab was applied mostly after failure on other treatments. Significant reduction in levels of rheumatoid factor, cryoglobulins and IgM were reported after rituximab therapy. Of the total 142, cases 119 could be evaluated for the response on rituximab therapy, the other 23 cases only regarding side effects. Of the 119 evaluated patients, 71 (60%) had complete response; 28 (23%), partial response and 20 patients (17%), no response. Data were not blinded or placebo-controlled. Side effects were seen in 27 of the 142 patients. Occurrence of the side effects was associated with high baseline levels of cryoglobulins, with a high dose of rituximab infusion of 1,000 mg and with a high level of complement activation. Death was reported four times and was related with the disease.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf Nc1eb6b993dc84ae2b9252230205b534c
61 Nd71b9195598949a4b88506a24d112b1e
62 sg:journal.1093299
63 schema:name Rituximab in cryoglobulinaemic vasculitis, evidence for its effectivity: a case report and review of literature
64 schema:pagination 293-300
65 schema:productId N016d2e3364d045fea5800f042b4ffdfd
66 N2f55c5955869491abe95275bbc63dcb8
67 N49bf2ca70c844c01b170e69e13544a87
68 Na13ea15de8004ed091e31367816f0d12
69 Nb219ac61de514550bc84f0c061af463d
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000979528
71 https://doi.org/10.1007/s10067-010-1612-2
72 schema:sdDatePublished 2019-04-10T15:00
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N3ce9d176e34240cf8fe5d69b66da9f4b
75 schema:url http://link.springer.com/10.1007%2Fs10067-010-1612-2
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N016d2e3364d045fea5800f042b4ffdfd schema:name pubmed_id
80 schema:value 21053035
81 rdf:type schema:PropertyValue
82 N0590df011152464f8752e4eab0fcdc32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Aged
84 rdf:type schema:DefinedTerm
85 N09b1cc56b8b347f180e7121eafce4602 rdf:first sg:person.0712731176.02
86 rdf:rest N957ea4640d5d48a7a461908ac8b91a79
87 N2f55c5955869491abe95275bbc63dcb8 schema:name doi
88 schema:value 10.1007/s10067-010-1612-2
89 rdf:type schema:PropertyValue
90 N3393208ca8234437b05eab76568ddb21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Antibodies, Monoclonal
92 rdf:type schema:DefinedTerm
93 N3ce9d176e34240cf8fe5d69b66da9f4b schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N3d26ceabeaa948488774dae58a8f85ae rdf:first sg:person.011422102432.46
96 rdf:rest rdf:nil
97 N41a71e83a4944deaa7687899a9eb1830 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Vasculitis
99 rdf:type schema:DefinedTerm
100 N49bf2ca70c844c01b170e69e13544a87 schema:name dimensions_id
101 schema:value pub.1000979528
102 rdf:type schema:PropertyValue
103 N4a5ddbe65a984e4abc2bb44332da0bfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Cryoglobulinemia
105 rdf:type schema:DefinedTerm
106 N645ebc71132a4eb8ae19d14ec8521c59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Immunologic Factors
108 rdf:type schema:DefinedTerm
109 N81a50805e2a54b8882ab8e3a9ee7e0d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Antibodies, Monoclonal, Murine-Derived
111 rdf:type schema:DefinedTerm
112 N82f179f59cb2484cad87985ad6b283cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Rituximab
114 rdf:type schema:DefinedTerm
115 N957ea4640d5d48a7a461908ac8b91a79 rdf:first sg:person.010521542564.75
116 rdf:rest N3d26ceabeaa948488774dae58a8f85ae
117 Na13ea15de8004ed091e31367816f0d12 schema:name readcube_id
118 schema:value 04aab6773a2cf59ce450bfd18427d57fc7656cc00ffb9da748b4030b5491a233
119 rdf:type schema:PropertyValue
120 Nb219ac61de514550bc84f0c061af463d schema:name nlm_unique_id
121 schema:value 8211469
122 rdf:type schema:PropertyValue
123 Nc1eb6b993dc84ae2b9252230205b534c schema:issueNumber 2
124 rdf:type schema:PublicationIssue
125 Nc4a59e759a314fe496ce09a0ab332439 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Treatment Outcome
127 rdf:type schema:DefinedTerm
128 Nceb83c200bb042e2bb3396adb6646650 schema:name Department of Rheumatology, University Medical Centre Nijmegen St. Radboud, Nijmegen, The Netherlands
129 rdf:type schema:Organization
130 Nd71b9195598949a4b88506a24d112b1e schema:volumeNumber 30
131 rdf:type schema:PublicationVolume
132 Nd8b6f6609d0e461aac5a7ceafd83fd38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Female
134 rdf:type schema:DefinedTerm
135 Ndda78f4ea38849b3868035ff8a814152 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Remission Induction
137 rdf:type schema:DefinedTerm
138 Ne806c65f8af04175b4dd603f3e6ec764 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Humans
140 rdf:type schema:DefinedTerm
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
145 schema:name Immunology
146 rdf:type schema:DefinedTerm
147 sg:journal.1093299 schema:issn 0770-3198
148 1434-9949
149 schema:name Clinical Rheumatology
150 rdf:type schema:Periodical
151 sg:person.010521542564.75 schema:affiliation https://www.grid.ac/institutes/grid.414846.b
152 schema:familyName Houtman
153 schema:givenName Pieternella M.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010521542564.75
155 rdf:type schema:Person
156 sg:person.011422102432.46 schema:affiliation Nceb83c200bb042e2bb3396adb6646650
157 schema:familyName Jansen
158 schema:givenName Tim L. Th. A.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011422102432.46
160 rdf:type schema:Person
161 sg:person.0712731176.02 schema:affiliation https://www.grid.ac/institutes/grid.414846.b
162 schema:familyName Wink
163 schema:givenName Freke
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712731176.02
165 rdf:type schema:Person
166 sg:pub.10.1007/s00296-007-0462-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1013769830
167 https://doi.org/10.1007/s00296-007-0462-y
168 rdf:type schema:CreativeWork
169 sg:pub.10.1007/s00415-009-5072-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1053162827
170 https://doi.org/10.1007/s00415-009-5072-z
171 rdf:type schema:CreativeWork
172 sg:pub.10.1007/s11239-008-0195-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035244896
173 https://doi.org/10.1007/s11239-008-0195-0
174 rdf:type schema:CreativeWork
175 sg:pub.10.1007/s12016-007-8019-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018039956
176 https://doi.org/10.1007/s12016-007-8019-0
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/ncpneph0823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035133114
179 https://doi.org/10.1038/ncpneph0823
180 rdf:type schema:CreativeWork
181 sg:pub.10.2165/00003495-200363080-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006375276
182 https://doi.org/10.2165/00003495-200363080-00005
183 rdf:type schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1074558579 schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1077135703 schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1077250943 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1077596150 schema:CreativeWork
188 https://doi.org/10.1002/1529-0131(199912)42:12<2507::aid-anr2>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1020299883
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1002/ajh.21330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049298594
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1002/art.10345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039075290
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1002/art.10947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044684559
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/art.25000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000308649
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/0002-9343(66)90200-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032688185
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0002-9343(74)90852-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038950970
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.clim.2007.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040567522
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.jcv.2009.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021268281
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s1590-8658(07)80026-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000234994
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1053/j.ajkd.2003.12.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005644771
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/ndt/gfh564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024121959
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1093/rheumatology/keh470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016677294
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1093/rheumatology/keh503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028949135
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/rheumatology/kel004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015631619
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1093/rheumatology/kel387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038644937
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1097/00004836-200605000-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010802068
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1097/01.tp.0000183749.79424.b4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048595739
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1097/mcg.0b013e3180f60b7a schema:sameAs https://app.dimensions.ai/details/publication/pub.1026903134
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1136/ard.2002.004929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028933801
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1136/ard.2006.065565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004306770
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1136/ard.2007.081653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017356741
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1136/ard.61.10.883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008923560
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1136/ard.61.10.922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024442724
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1182/blood-2002-09-2856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030831945
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1182/blood-2002-10-3162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022614023
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1182/blood.v99.3.754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039652345
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1590/s1413-86702007000100038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024671904
243 rdf:type schema:CreativeWork
244 https://doi.org/10.3816/clm.2006.n.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019991571
245 rdf:type schema:CreativeWork
246 https://www.grid.ac/institutes/grid.414846.b schema:alternateName Medisch Centrum Leeuwarden
247 schema:name Department of Rheumatology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands
248 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...