Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein–Barr virus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10-19

AUTHORS

Atsushi Komatsuda, Yohsuke Okamoto, Takashi Hatakeyama, Hideki Wakui, Ken-ichi Sawada

ABSTRACT

A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine. A skin biopsy showed hydropic degeneration of keratinocytes and lymphocytic infiltrate. A bone marrow aspiration demonstrated an increased number of macrophages with hemophagocytosis. Although serologic tests for Epstein–Barr virus (EBV) indicated a previous infection, EBV deoxyribonucleic acid was detected in her serum by polymerase chain reaction. Cessation of sulfasalazine and administration of steroids led to dramatic improvement. This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine. More... »

PAGES

395-397

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-007-0753-4

DOI

http://dx.doi.org/10.1007/s10067-007-0753-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047634936

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17952482


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