Wegener's granulomatosis: clinical and laboratory results of a university hospital study of 20 patients from Turkey View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-12-15

AUTHORS

Zeynep Ozbalkan, Sedat Kiraz, M. Akif Ozturk, A. Ihsan Ertenli, Sule Apras, Meral Calguneri

ABSTRACT

The aim of this study was to evaluate the clinical and laboratory features, the treatment approaches, and the long-term outcome of patients with Wegener's granulomatosis (WG) who were followed up in our hospital. The hospital files of the patients with the diagnosis of WG who were followed up between the years 1985 and 2003 in Hacettepe University Hospital were retrospectively evaluated. Male/female ratio was 12:8. The mean age was 39 years (range 20–65 years). Constitutional symptoms and upper and lower airway involvement were seen in 95% of all patients. Renal and musculoskeletal symptoms were seen in 90 and 80% of the patients, respectively. Five patients were treated with oral monotherapy (three with methylprednisolone and two with cyclophosphamide). Three patients were given a combination of orally administered cyclophosphamide and methylprednisolone. Ten patients were treated with pulse cyclophosphamide and methylprednisolone combination together with oral alternate-day methylprednisolone therapy. The remaining two resistant patients were treated with pulse cyclophosphamide, methylprednisolone, and intravenous immunoglobulin combination together with oral alternate-day methylprednisolone. Four patients died because of the disease activity. Intravenous pulse therapies with oral, alternate-day methylprednisolone were well tolerated. Sixteen patients experienced long-term remission after immunosuppressive treatment. Eleven patients have been asymptomatic for more than 12 months. In five patients, residual symptoms persisted: constitutional symptoms and renal and respiratory tract symptoms in varying combinations. The demographic and laboratory findings in this trial were similar with those of the previous results. Alternate-day glucocorticoids plus cyctotoxic drugs may be beneficial in patients with WG. More... »

PAGES

358-363

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10067-005-0057-5

DOI

http://dx.doi.org/10.1007/s10067-005-0057-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029143523

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16362442


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