Regulation of SIRT1 by MicroRNAs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11

AUTHORS

Sung-E Choi, Jongsook Kim Kemper

ABSTRACT

Sirtuin 1 (SIRT1) is an NAD(+)-dependent deacetylase that connects cellular energy levels to homeostatic responses by deacetylating and modulating the activities of many transcriptional regulators. Discovered as a longevity protein in yeast, the mammalian SIRT1 has been intensively studied because of its great potential as a therapeutic target to benefit human health by preventing and improving many age-related diseases. There has been, therefore, substantial interest in developing agents that upregulate SIRT1 expression and activity. SIRT1 is regulated at multiple levels, including post-transcriptionally by microRNAs (miRs), powerful regulators of diverse biological pathways. Here we discuss how expression and activity of SIRT1 and other sirtuins are inhibited by miRs and further discuss the therapeutic potential of targeting miRs for age-related diseases that involve SIRT1 dysfunction, focusing on obesityrelated diseases. More... »

PAGES

385-392

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10059-013-0297-1

DOI

http://dx.doi.org/10.1007/s10059-013-0297-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025321870

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24213676


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