Administration of mesenchymal stem cells and ziprasidone enhanced amelioration of ischemic brain damage in rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Phatcharida Kaengkan, Seung Eun Baek, Ji Yeong Kim, Kyung-Yoon Kam, Byung-Rok Do, Eun Shin Lee, Sung Goo Kang

ABSTRACT

Ziprasidone is a benzisothiazolyl piperazine derivative that was developed from the chemically related antipsychotic drug tiospirone, and it improves neurological functions of the ischemic brain and is effective in treatment of schizophrenia. Mesenchymal stem cells (MSCs) are considered as a leading candidate for neurological regenerative therapy because of their neural differentiation properties in damaged brain. We investigated whether the transplantation of neural progenitor cells (NPCs) derived from adipose mesenchymal stem cells combined with ziprasidone enhances neuroprotective effects in an animal model of focal cerebral ischemia. In combination therapy groups, significant reduction of infarct volume and improvement of neurological functions were observed at 3 days after middle cerebral artery occlusion (MCAO) compared with monotherapy. Co-administration of ziprasidone and NPCs enhanced the anti-apoptotic effect and reduced the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive apoptotic cells compared with the NPCs alone group at 7 days after MCAO. Ziprasidone or the combination of ziprasidone and NPCs induced the expression of endogenous neurotrophic factor gene brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell-derived neurotrophic factor (GDNF). The immunohistochemical investigation revealed that the ziprasidone and NPCs attenuated the increased intensity of microglial marker (Iba-1) in the infarcted cortical area. Moreover, the number of transplanted NPCs on day 7 with combination therapy was significantly higher than with NPCs alone. These effects might be responsible for improved functional behavior and increased survival of NPCs. Our finding indicates that combination therapy of ziprasidone and NPCs enhances neuroprotection against ischemic brain injury. More... »

PAGES

534-541

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10059-013-0235-2

DOI

http://dx.doi.org/10.1007/s10059-013-0235-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043807423

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24292945


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain-Derived Neurotrophic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glial Cell Line-Derived Neurotrophic Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenchymal Stem Cell Transplantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenchymal Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microglia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroprotective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "Department of Biological Sciences, Institute of Basic Science, Inje University, 621-749, Gimhae, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaengkan", 
        "givenName": "Phatcharida", 
        "id": "sg:person.01247047035.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247047035.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "Department of Biological Sciences, Institute of Basic Science, Inje University, 621-749, Gimhae, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baek", 
        "givenName": "Seung Eun", 
        "id": "sg:person.0627311130.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627311130.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "Department of Biological Sciences, Institute of Basic Science, Inje University, 621-749, Gimhae, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Ji Yeong", 
        "id": "sg:person.0675424330.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675424330.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "Department of Occupational Therapy and UHRC, Inje University, 621-749, Gimhae, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kam", 
        "givenName": "Kyung-Yoon", 
        "id": "sg:person.07704040624.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07704040624.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bioengineering Institute, Hurim Biocell Inc., 153-803, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Do", 
        "givenName": "Byung-Rok", 
        "id": "sg:person.01223515157.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223515157.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gyeongsang National University", 
          "id": "https://www.grid.ac/institutes/grid.256681.e", 
          "name": [
            "Department of Rehabilitation Medicine Gyeongsang National University, 660-751, Jinju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Eun Shin", 
        "id": "sg:person.0603251331.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603251331.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "Department of Biological Sciences, Institute of Basic Science, Inje University, 621-749, Gimhae, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Sung Goo", 
        "id": "sg:person.0637671335.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637671335.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1080/19768354.2013.805164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000947593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2011.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002515986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules16021021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005747142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules16021021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005747142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(99)01401-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007069159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1a053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009607712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1a053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009607712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000247888.25985.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009770478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000247888.25985.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009770478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.102.035048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010678165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2005.02.072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012321362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1092852900019842", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013202678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2012.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014560151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hs1101.098367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014769905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2012.02.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016117537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.10440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018612668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2010.06.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021234332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcn.2012.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023388724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-510x(02)00075-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023447721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.105.099218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024108694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.531632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024585515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.531632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024585515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-4547(20000815)61:4<364::aid-jnr2>3.0.co;2-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025904783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-5949.2008.00056.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026177047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.60000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036104395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.20.1.84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041538936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.9.4.819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048680055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2008.07.086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050824552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0166-2236(99)01463-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050900568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/187152411796011321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069220366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.neuropsych.22.2.130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078158387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082413881", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "Ziprasidone is a benzisothiazolyl piperazine derivative that was developed from the chemically related antipsychotic drug tiospirone, and it improves neurological functions of the ischemic brain and is effective in treatment of schizophrenia. Mesenchymal stem cells (MSCs) are considered as a leading candidate for neurological regenerative therapy because of their neural differentiation properties in damaged brain. We investigated whether the transplantation of neural progenitor cells (NPCs) derived from adipose mesenchymal stem cells combined with ziprasidone enhances neuroprotective effects in an animal model of focal cerebral ischemia. In combination therapy groups, significant reduction of infarct volume and improvement of neurological functions were observed at 3 days after middle cerebral artery occlusion (MCAO) compared with monotherapy. Co-administration of ziprasidone and NPCs enhanced the anti-apoptotic effect and reduced the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive apoptotic cells compared with the NPCs alone group at 7 days after MCAO. Ziprasidone or the combination of ziprasidone and NPCs induced the expression of endogenous neurotrophic factor gene brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell-derived neurotrophic factor (GDNF). The immunohistochemical investigation revealed that the ziprasidone and NPCs attenuated the increased intensity of microglial marker (Iba-1) in the infarcted cortical area. Moreover, the number of transplanted NPCs on day 7 with combination therapy was significantly higher than with NPCs alone. These effects might be responsible for improved functional behavior and increased survival of NPCs. Our finding indicates that combination therapy of ziprasidone and NPCs enhances neuroprotection against ischemic brain injury. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10059-013-0235-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1115754", 
        "issn": [
          "1016-8478", 
          "0219-1032"
        ], 
        "name": "Molecules and Cells", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Administration of mesenchymal stem cells and ziprasidone enhanced amelioration of ischemic brain damage in rats", 
    "pagination": "534-541", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d0abe2758648ee1950fe55864412efb0485941764bca64bf2764c34ebfda527c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24292945"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9610936"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10059-013-0235-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043807423"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10059-013-0235-2", 
      "https://app.dimensions.ai/details/publication/pub.1043807423"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000490.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10059-013-0235-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10059-013-0235-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10059-013-0235-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10059-013-0235-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10059-013-0235-2'


 

This table displays all metadata directly associated to this object as RDF triples.

280 TRIPLES      21 PREDICATES      77 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10059-013-0235-2 schema:about N058ec726c4914dd7a9e2ff597603ce06
2 N0739aa01468c4e9c8dad30a63552b24f
3 N13b069eb900440afb2a822ce0c627eda
4 N1d176609dd5c4ea2bb00305ff500b76d
5 N256cb677884b451cac681371b95a9a3e
6 N2bd9f925c7be4a7985627ab5c6d331d8
7 N3375513e62ef4af98ed67f18a7f95fc1
8 N4404971cf2814aaca09110021ddcf9f4
9 N450fc3f52f1c44949fdb571844570320
10 N4da6e070a4884e88b4ba350c9df13b34
11 N54699b5c98bd49f897931fd63d3bcf9d
12 N5921be0afae7432f833f5d7550ef41e7
13 N5fa9dd399d1042679ad8db71c85b9588
14 N6723c54176154c6b888db5ba6e81bad9
15 N7f41001729804af0b1cb769d329293d2
16 N8cafeb403e8546d78e44d5cf9b34b2b6
17 Na4b9a43247fd4154995218e5d39e44d4
18 Nab5202c813b4497ab86ccddafeb816b7
19 Nadd41253f0664bf4b0aa933a553198c5
20 Nbebb1e4c36ee48ef9c3233f3cd3fd0b4
21 anzsrc-for:11
22 anzsrc-for:1109
23 schema:author N19f45daebc26487090c3e909de2c63ca
24 schema:citation https://app.dimensions.ai/details/publication/pub.1082413881
25 https://doi.org/10.1002/1097-4547(20000815)61:4<364::aid-jnr2>3.0.co;2-c
26 https://doi.org/10.1002/ana.60000
27 https://doi.org/10.1002/jnr.10440
28 https://doi.org/10.1016/j.brainres.2005.02.072
29 https://doi.org/10.1016/j.brainres.2008.07.086
30 https://doi.org/10.1016/j.brainres.2012.02.053
31 https://doi.org/10.1016/j.intimp.2010.06.019
32 https://doi.org/10.1016/j.lfs.2011.05.001
33 https://doi.org/10.1016/j.mcn.2012.02.004
34 https://doi.org/10.1016/j.pnpbp.2012.05.010
35 https://doi.org/10.1016/s0022-510x(02)00075-8
36 https://doi.org/10.1016/s0166-2236(99)01401-0
37 https://doi.org/10.1016/s0166-2236(99)01463-0
38 https://doi.org/10.1017/s1092852900019842
39 https://doi.org/10.1080/19768354.2013.805164
40 https://doi.org/10.1111/j.1755-5949.2008.00056.x
41 https://doi.org/10.1124/jpet.102.035048
42 https://doi.org/10.1124/jpet.105.099218
43 https://doi.org/10.1161/01.str.0000247888.25985.62
44 https://doi.org/10.1161/01.str.20.1.84
45 https://doi.org/10.1161/hs1101.098367
46 https://doi.org/10.1161/strokeaha.108.531632
47 https://doi.org/10.1176/appi.neuropsych.22.2.130
48 https://doi.org/10.1345/aph.1a053
49 https://doi.org/10.1517/13543784.9.4.819
50 https://doi.org/10.2174/187152411796011321
51 https://doi.org/10.3390/molecules16021021
52 schema:datePublished 2013-12
53 schema:datePublishedReg 2013-12-01
54 schema:description Ziprasidone is a benzisothiazolyl piperazine derivative that was developed from the chemically related antipsychotic drug tiospirone, and it improves neurological functions of the ischemic brain and is effective in treatment of schizophrenia. Mesenchymal stem cells (MSCs) are considered as a leading candidate for neurological regenerative therapy because of their neural differentiation properties in damaged brain. We investigated whether the transplantation of neural progenitor cells (NPCs) derived from adipose mesenchymal stem cells combined with ziprasidone enhances neuroprotective effects in an animal model of focal cerebral ischemia. In combination therapy groups, significant reduction of infarct volume and improvement of neurological functions were observed at 3 days after middle cerebral artery occlusion (MCAO) compared with monotherapy. Co-administration of ziprasidone and NPCs enhanced the anti-apoptotic effect and reduced the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive apoptotic cells compared with the NPCs alone group at 7 days after MCAO. Ziprasidone or the combination of ziprasidone and NPCs induced the expression of endogenous neurotrophic factor gene brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell-derived neurotrophic factor (GDNF). The immunohistochemical investigation revealed that the ziprasidone and NPCs attenuated the increased intensity of microglial marker (Iba-1) in the infarcted cortical area. Moreover, the number of transplanted NPCs on day 7 with combination therapy was significantly higher than with NPCs alone. These effects might be responsible for improved functional behavior and increased survival of NPCs. Our finding indicates that combination therapy of ziprasidone and NPCs enhances neuroprotection against ischemic brain injury.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N94d775d00d76488285f5fd388a97cb58
59 Ncf47e4c5acd74f69aeb02e72c97717af
60 sg:journal.1115754
61 schema:name Administration of mesenchymal stem cells and ziprasidone enhanced amelioration of ischemic brain damage in rats
62 schema:pagination 534-541
63 schema:productId N198b86bf21c84936a35b84b79f192633
64 N5685a6d002a54a87b181e3cb9251bfc4
65 N77375495972b4809823fdf06f3109cc8
66 N8fbf4b8071ac41568c81a8c60df8c0ed
67 Ndc1bceb4ca4d4758a4b112be49722e31
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043807423
69 https://doi.org/10.1007/s10059-013-0235-2
70 schema:sdDatePublished 2019-04-10T16:37
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N7081de99b135407491e0c21877516088
73 schema:url http://link.springer.com/10.1007/s10059-013-0235-2
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N04e6b040074c4bf191374236a184040a rdf:first sg:person.0627311130.26
78 rdf:rest Nc4811608e5904627a9cc230e31767232
79 N058ec726c4914dd7a9e2ff597603ce06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Humans
81 rdf:type schema:DefinedTerm
82 N0739aa01468c4e9c8dad30a63552b24f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Male
84 rdf:type schema:DefinedTerm
85 N13b069eb900440afb2a822ce0c627eda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Piperazines
87 rdf:type schema:DefinedTerm
88 N198b86bf21c84936a35b84b79f192633 schema:name readcube_id
89 schema:value d0abe2758648ee1950fe55864412efb0485941764bca64bf2764c34ebfda527c
90 rdf:type schema:PropertyValue
91 N19f45daebc26487090c3e909de2c63ca rdf:first sg:person.01247047035.73
92 rdf:rest N04e6b040074c4bf191374236a184040a
93 N1d176609dd5c4ea2bb00305ff500b76d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Cell Survival
95 rdf:type schema:DefinedTerm
96 N23320b0e714d41b580cccdb79cc1b977 rdf:first sg:person.0603251331.15
97 rdf:rest N32d75f1e315846b0ad2ac39c2715f913
98 N256cb677884b451cac681371b95a9a3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Microglia
100 rdf:type schema:DefinedTerm
101 N25feed243cea4c4a9bf35846bca5e99b rdf:first sg:person.01223515157.00
102 rdf:rest N23320b0e714d41b580cccdb79cc1b977
103 N2bd9f925c7be4a7985627ab5c6d331d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Combined Modality Therapy
105 rdf:type schema:DefinedTerm
106 N32d75f1e315846b0ad2ac39c2715f913 rdf:first sg:person.0637671335.99
107 rdf:rest rdf:nil
108 N3375513e62ef4af98ed67f18a7f95fc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Glial Cell Line-Derived Neurotrophic Factor
110 rdf:type schema:DefinedTerm
111 N4404971cf2814aaca09110021ddcf9f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Animals
113 rdf:type schema:DefinedTerm
114 N450fc3f52f1c44949fdb571844570320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Rats
116 rdf:type schema:DefinedTerm
117 N4da6e070a4884e88b4ba350c9df13b34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Neural Stem Cells
119 rdf:type schema:DefinedTerm
120 N54699b5c98bd49f897931fd63d3bcf9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Neuroprotective Agents
122 rdf:type schema:DefinedTerm
123 N5685a6d002a54a87b181e3cb9251bfc4 schema:name nlm_unique_id
124 schema:value 9610936
125 rdf:type schema:PropertyValue
126 N5921be0afae7432f833f5d7550ef41e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Gene Expression Regulation
128 rdf:type schema:DefinedTerm
129 N5fa9dd399d1042679ad8db71c85b9588 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Brain Ischemia
131 rdf:type schema:DefinedTerm
132 N6723c54176154c6b888db5ba6e81bad9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Mesenchymal Stem Cell Transplantation
134 rdf:type schema:DefinedTerm
135 N7081de99b135407491e0c21877516088 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 N77375495972b4809823fdf06f3109cc8 schema:name dimensions_id
138 schema:value pub.1043807423
139 rdf:type schema:PropertyValue
140 N7f41001729804af0b1cb769d329293d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Disease Models, Animal
142 rdf:type schema:DefinedTerm
143 N8cafeb403e8546d78e44d5cf9b34b2b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Thiazoles
145 rdf:type schema:DefinedTerm
146 N8fbf4b8071ac41568c81a8c60df8c0ed schema:name doi
147 schema:value 10.1007/s10059-013-0235-2
148 rdf:type schema:PropertyValue
149 N91ad9abcf6a74c7097e3a815b641e6ae schema:name Bioengineering Institute, Hurim Biocell Inc., 153-803, Seoul, Korea
150 rdf:type schema:Organization
151 N94d775d00d76488285f5fd388a97cb58 schema:volumeNumber 36
152 rdf:type schema:PublicationVolume
153 Na4b9a43247fd4154995218e5d39e44d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Nerve Growth Factor
155 rdf:type schema:DefinedTerm
156 Nab5202c813b4497ab86ccddafeb816b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Mesenchymal Stromal Cells
158 rdf:type schema:DefinedTerm
159 Nadd41253f0664bf4b0aa933a553198c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Rats, Sprague-Dawley
161 rdf:type schema:DefinedTerm
162 Nbebb1e4c36ee48ef9c3233f3cd3fd0b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Brain-Derived Neurotrophic Factor
164 rdf:type schema:DefinedTerm
165 Nc4811608e5904627a9cc230e31767232 rdf:first sg:person.0675424330.55
166 rdf:rest Nf8de41ff72c84991bf2d297814a6b4ca
167 Ncf47e4c5acd74f69aeb02e72c97717af schema:issueNumber 6
168 rdf:type schema:PublicationIssue
169 Ndc1bceb4ca4d4758a4b112be49722e31 schema:name pubmed_id
170 schema:value 24292945
171 rdf:type schema:PropertyValue
172 Nf8de41ff72c84991bf2d297814a6b4ca rdf:first sg:person.07704040624.33
173 rdf:rest N25feed243cea4c4a9bf35846bca5e99b
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
178 schema:name Neurosciences
179 rdf:type schema:DefinedTerm
180 sg:journal.1115754 schema:issn 0219-1032
181 1016-8478
182 schema:name Molecules and Cells
183 rdf:type schema:Periodical
184 sg:person.01223515157.00 schema:affiliation N91ad9abcf6a74c7097e3a815b641e6ae
185 schema:familyName Do
186 schema:givenName Byung-Rok
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223515157.00
188 rdf:type schema:Person
189 sg:person.01247047035.73 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
190 schema:familyName Kaengkan
191 schema:givenName Phatcharida
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247047035.73
193 rdf:type schema:Person
194 sg:person.0603251331.15 schema:affiliation https://www.grid.ac/institutes/grid.256681.e
195 schema:familyName Lee
196 schema:givenName Eun Shin
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603251331.15
198 rdf:type schema:Person
199 sg:person.0627311130.26 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
200 schema:familyName Baek
201 schema:givenName Seung Eun
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627311130.26
203 rdf:type schema:Person
204 sg:person.0637671335.99 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
205 schema:familyName Kang
206 schema:givenName Sung Goo
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637671335.99
208 rdf:type schema:Person
209 sg:person.0675424330.55 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
210 schema:familyName Kim
211 schema:givenName Ji Yeong
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675424330.55
213 rdf:type schema:Person
214 sg:person.07704040624.33 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
215 schema:familyName Kam
216 schema:givenName Kyung-Yoon
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07704040624.33
218 rdf:type schema:Person
219 https://app.dimensions.ai/details/publication/pub.1082413881 schema:CreativeWork
220 https://doi.org/10.1002/1097-4547(20000815)61:4<364::aid-jnr2>3.0.co;2-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1025904783
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/ana.60000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036104395
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/jnr.10440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018612668
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.brainres.2005.02.072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012321362
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.brainres.2008.07.086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050824552
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.brainres.2012.02.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016117537
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.intimp.2010.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021234332
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.lfs.2011.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002515986
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.mcn.2012.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023388724
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.pnpbp.2012.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014560151
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0022-510x(02)00075-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023447721
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0166-2236(99)01401-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007069159
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0166-2236(99)01463-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050900568
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1017/s1092852900019842 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013202678
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1080/19768354.2013.805164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000947593
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1755-5949.2008.00056.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026177047
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1124/jpet.102.035048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010678165
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1124/jpet.105.099218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024108694
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1161/01.str.0000247888.25985.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009770478
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1161/01.str.20.1.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041538936
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1161/hs1101.098367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014769905
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1161/strokeaha.108.531632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024585515
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1176/appi.neuropsych.22.2.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078158387
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1345/aph.1a053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009607712
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1517/13543784.9.4.819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048680055
269 rdf:type schema:CreativeWork
270 https://doi.org/10.2174/187152411796011321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069220366
271 rdf:type schema:CreativeWork
272 https://doi.org/10.3390/molecules16021021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005747142
273 rdf:type schema:CreativeWork
274 https://www.grid.ac/institutes/grid.256681.e schema:alternateName Gyeongsang National University
275 schema:name Department of Rehabilitation Medicine Gyeongsang National University, 660-751, Jinju, Korea
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.411612.1 schema:alternateName Inje University
278 schema:name Department of Biological Sciences, Institute of Basic Science, Inje University, 621-749, Gimhae, Korea
279 Department of Occupational Therapy and UHRC, Inje University, 621-749, Gimhae, Korea
280 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...