Interaction between pericytes and endothelial cells leads to formation of tight junction in hyaloid vessels View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11

AUTHORS

Dong Hyun Jo, Jin Hyoung Kim, Jong-Ik Heo, Jeong Hun Kim, Chung-Hyun Cho

ABSTRACT

The hyaloid vessel is a transient vascular network that nourishes the lens and the primary vitreous in the early developmental periods. In hyaloid vessels devoid of the support of astrocytes, we demonstrate that tight junction proteins, zonula occludens-1 and occludin, are regularly expressed at the junction of endothelial cells. To figure out the factor influencing the formation of tight junctions in hyaloid vessels, we further progress to investigate the interactions between endothelial cells and pericytes, two representative constituent cells in hyaloid vessels. Interestingly, endothelial cells interact with pericytes in the early postnatal periods and the interaction between two cell types provokes the up-regulation of transforming growth factor β1. Further in vitro experiments demonstrate that transforming growth factor β1 induces the activation of Smad2 and Smad3 and the formation of tight junction proteins. Taken together, in hyaloid vessels, pericytes seem to regulate the formation of tight junctions by the interaction with endothelial cells even without the support of astrocytes. Additionally, we suggest that the hyaloid vessel is a valuable system that can be utilized for the investigation of cell-cell interaction in the formation of tight junctions in developing vasculatures. More... »

PAGES

465-471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10059-013-0228-1

DOI

http://dx.doi.org/10.1007/s10059-013-0228-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007979855

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24213675


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Astrocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Occludin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pericytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinal Vessels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tight Junctions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zonula Occludens-1 Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, 110-744, Seoul, Korea", 
            "Department of Biomedical Sciences, Seoul National University, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jo", 
        "givenName": "Dong Hyun", 
        "id": "sg:person.01317661462.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317661462.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jin Hyoung", 
        "id": "sg:person.01344167465.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344167465.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Ischemic/Hypoxic Disease Institute, Seoul National University, 110-744, Seoul, Korea", 
            "Department of Pharmacology, Seoul National University, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heo", 
        "givenName": "Jong-Ik", 
        "id": "sg:person.0727205604.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727205604.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, 110-744, Seoul, Korea", 
            "Department of Biomedical Sciences, Seoul National University, 110-744, Seoul, Korea", 
            "Ischemic/Hypoxic Disease Institute, Seoul National University, 110-744, Seoul, Korea", 
            "Department of Ophthalmology, College of Medicine, Seoul National University, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jeong Hun", 
        "id": "sg:person.0710503762.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710503762.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Biomedical Sciences, Seoul National University, 110-744, Seoul, Korea", 
            "Ischemic/Hypoxic Disease Institute, Seoul National University, 110-744, Seoul, Korea", 
            "Department of Pharmacology, Seoul National University, 110-744, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Chung-Hyun", 
        "id": "sg:person.01303320061.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303320061.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1126/science.277.5323.242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001237539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0000052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002364154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5483/bmbrep.2006.39.4.339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007308645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.33.23463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009418090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.21884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010727544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2009.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011361036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.04-0848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015019363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0005149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018558616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020535258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2007.060693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021658652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022405267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.09-3615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023311724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024041325", 
          "https://doi.org/10.1038/nature09513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024041325", 
          "https://doi.org/10.1038/nature09513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2009.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024344298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2009.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024344298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(88)90119-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027846377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-3806(88)90119-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027846377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029430762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devbrainres.2004.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030659906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2005.01.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032645811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034192474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archopht.123.6.797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037286506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:cemn.0000022776.47302.ce", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038427200", 
          "https://doi.org/10.1023/b:cemn.0000022776.47302.ce"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exer.1998.0632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039027303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)80047-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041281114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045685661", 
          "https://doi.org/10.1038/nature09522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045685661", 
          "https://doi.org/10.1038/nature09522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004290050289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047123632", 
          "https://doi.org/10.1007/s004290050289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1167/iovs.12-10140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053222071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02713680701487871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058314096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1387/ijdb.041895ms", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067190461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.6.7.13306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072290778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076854619", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3928/0191-3913-20040501-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076854619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.6.8.13306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078215623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080097123", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-11", 
    "datePublishedReg": "2013-11-01", 
    "description": "The hyaloid vessel is a transient vascular network that nourishes the lens and the primary vitreous in the early developmental periods. In hyaloid vessels devoid of the support of astrocytes, we demonstrate that tight junction proteins, zonula occludens-1 and occludin, are regularly expressed at the junction of endothelial cells. To figure out the factor influencing the formation of tight junctions in hyaloid vessels, we further progress to investigate the interactions between endothelial cells and pericytes, two representative constituent cells in hyaloid vessels. Interestingly, endothelial cells interact with pericytes in the early postnatal periods and the interaction between two cell types provokes the up-regulation of transforming growth factor \u03b21. Further in vitro experiments demonstrate that transforming growth factor \u03b21 induces the activation of Smad2 and Smad3 and the formation of tight junction proteins. Taken together, in hyaloid vessels, pericytes seem to regulate the formation of tight junctions by the interaction with endothelial cells even without the support of astrocytes. Additionally, we suggest that the hyaloid vessel is a valuable system that can be utilized for the investigation of cell-cell interaction in the formation of tight junctions in developing vasculatures. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10059-013-0228-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1115754", 
        "issn": [
          "1016-8478", 
          "0219-1032"
        ], 
        "name": "Molecules and Cells", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Interaction between pericytes and endothelial cells leads to formation of tight junction in hyaloid vessels", 
    "pagination": "465-471", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "26040aff9c153c05811b26ea87c048ac3bd9f047c6119cccc5fe27594972add6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24213675"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9610936"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10059-013-0228-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007979855"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10059-013-0228-1", 
      "https://app.dimensions.ai/details/publication/pub.1007979855"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000486.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10059-013-0228-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10059-013-0228-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10059-013-0228-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10059-013-0228-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10059-013-0228-1'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      79 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10059-013-0228-1 schema:about N0efede0bab0344c0a161a0efc89ef5a3
2 N289cef21b284422f81d97cc363b8a1e0
3 N32d8490b22b046fc95e9261c9ebce447
4 N42926174b08a49cf9da4a44a35c10ba6
5 N5c127dd66bbb427483b055f5aa3272ad
6 N60fde2875b2e4c0186a2c28ea519586b
7 N6778003ba1f34a21a4c37ab042081829
8 N764ff260f65343508a97e081e1c45b54
9 N9a31f91f999e442fbae6abfb81278c37
10 N9f5b3a18dd20401286469e6d33eb82e7
11 Na02a9df50d374cc08eb73df1b5e61147
12 Nba6d5311f743447fba16c643d39efd79
13 Nbcda959b6f734036b144eb5919f91294
14 Nd4d3b849e13f4269a94afb41dfb8a87f
15 Nd887561e19d649cfbedfae6941da5632
16 Ndf86f4b89d374ebaab921ff2e66c9645
17 Ne12d6cc42fd74d81b12643b318aa2dc8
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N6198792b1c454681898fcac5f323d372
21 schema:citation sg:pub.10.1007/s004290050289
22 sg:pub.10.1023/b:cemn.0000022776.47302.ce
23 sg:pub.10.1038/nature09513
24 sg:pub.10.1038/nature09522
25 https://app.dimensions.ai/details/publication/pub.1076854619
26 https://app.dimensions.ai/details/publication/pub.1080097123
27 https://doi.org/10.1001/archopht.123.6.797
28 https://doi.org/10.1002/dvdy.1200
29 https://doi.org/10.1002/jnr.21884
30 https://doi.org/10.1002/jnr.22607
31 https://doi.org/10.1002/jnr.22700
32 https://doi.org/10.1006/exer.1998.0632
33 https://doi.org/10.1016/0092-8674(93)80047-i
34 https://doi.org/10.1016/0165-3806(88)90119-8
35 https://doi.org/10.1016/j.brainres.2005.01.027
36 https://doi.org/10.1016/j.devbrainres.2004.05.008
37 https://doi.org/10.1016/j.nbd.2009.07.030
38 https://doi.org/10.1038/jcbfm.2009.78
39 https://doi.org/10.1074/jbc.274.33.23463
40 https://doi.org/10.1080/02713680701487871
41 https://doi.org/10.1126/science.277.5323.242
42 https://doi.org/10.1167/iovs.04-0848
43 https://doi.org/10.1167/iovs.09-3615
44 https://doi.org/10.1167/iovs.12-10140
45 https://doi.org/10.1242/dev.01080
46 https://doi.org/10.1371/journal.pbio.0000052
47 https://doi.org/10.1371/journal.pone.0005149
48 https://doi.org/10.1387/ijdb.041895ms
49 https://doi.org/10.2353/ajpath.2007.060693
50 https://doi.org/10.3928/0191-3913-20040501-09
51 https://doi.org/10.4161/auto.6.7.13306
52 https://doi.org/10.4161/auto.6.8.13306
53 https://doi.org/10.5483/bmbrep.2006.39.4.339
54 schema:datePublished 2013-11
55 schema:datePublishedReg 2013-11-01
56 schema:description The hyaloid vessel is a transient vascular network that nourishes the lens and the primary vitreous in the early developmental periods. In hyaloid vessels devoid of the support of astrocytes, we demonstrate that tight junction proteins, zonula occludens-1 and occludin, are regularly expressed at the junction of endothelial cells. To figure out the factor influencing the formation of tight junctions in hyaloid vessels, we further progress to investigate the interactions between endothelial cells and pericytes, two representative constituent cells in hyaloid vessels. Interestingly, endothelial cells interact with pericytes in the early postnatal periods and the interaction between two cell types provokes the up-regulation of transforming growth factor β1. Further in vitro experiments demonstrate that transforming growth factor β1 induces the activation of Smad2 and Smad3 and the formation of tight junction proteins. Taken together, in hyaloid vessels, pericytes seem to regulate the formation of tight junctions by the interaction with endothelial cells even without the support of astrocytes. Additionally, we suggest that the hyaloid vessel is a valuable system that can be utilized for the investigation of cell-cell interaction in the formation of tight junctions in developing vasculatures.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf Nf3feafd024a44c67b81f2c7f5d86808d
61 Nf584b6103ace426c86d0adae81e5f331
62 sg:journal.1115754
63 schema:name Interaction between pericytes and endothelial cells leads to formation of tight junction in hyaloid vessels
64 schema:pagination 465-471
65 schema:productId N29aec6c5c02a4d9c90dd3253e2292cf1
66 N46aeb8b6cf8a418ba02da7b2dbcf32e1
67 N9059686d04314e05b5f058aa4fbf706b
68 Nad92d5edccea44ce83bf1fd6e66d4ed0
69 Nddd985c5b27f48e7a18962ac2f314b32
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007979855
71 https://doi.org/10.1007/s10059-013-0228-1
72 schema:sdDatePublished 2019-04-10T17:25
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N70459c5957c74e9984744e8229e8954a
75 schema:url http://link.springer.com/10.1007/s10059-013-0228-1
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0efede0bab0344c0a161a0efc89ef5a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Mice
81 rdf:type schema:DefinedTerm
82 N1f985e39979f4dd9a35efc1460bc0066 rdf:first sg:person.0710503762.84
83 rdf:rest Naaedc34a25484a45b35f73e1e52e892e
84 N289cef21b284422f81d97cc363b8a1e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Transforming Growth Factor beta
86 rdf:type schema:DefinedTerm
87 N29aec6c5c02a4d9c90dd3253e2292cf1 schema:name doi
88 schema:value 10.1007/s10059-013-0228-1
89 rdf:type schema:PropertyValue
90 N32d8490b22b046fc95e9261c9ebce447 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Signal Transduction
92 rdf:type schema:DefinedTerm
93 N42926174b08a49cf9da4a44a35c10ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Animals
95 rdf:type schema:DefinedTerm
96 N46aeb8b6cf8a418ba02da7b2dbcf32e1 schema:name readcube_id
97 schema:value 26040aff9c153c05811b26ea87c048ac3bd9f047c6119cccc5fe27594972add6
98 rdf:type schema:PropertyValue
99 N5c127dd66bbb427483b055f5aa3272ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Gene Expression Regulation
101 rdf:type schema:DefinedTerm
102 N60fde2875b2e4c0186a2c28ea519586b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Humans
104 rdf:type schema:DefinedTerm
105 N6198792b1c454681898fcac5f323d372 rdf:first sg:person.01317661462.10
106 rdf:rest Nc135e46b9b0847aaa25fad72380abcdf
107 N6778003ba1f34a21a4c37ab042081829 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Female
109 rdf:type schema:DefinedTerm
110 N70459c5957c74e9984744e8229e8954a schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 N764ff260f65343508a97e081e1c45b54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Endothelium, Vascular
114 rdf:type schema:DefinedTerm
115 N9059686d04314e05b5f058aa4fbf706b schema:name pubmed_id
116 schema:value 24213675
117 rdf:type schema:PropertyValue
118 N9a31f91f999e442fbae6abfb81278c37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Pericytes
120 rdf:type schema:DefinedTerm
121 N9f5b3a18dd20401286469e6d33eb82e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cell Line
123 rdf:type schema:DefinedTerm
124 Na02a9df50d374cc08eb73df1b5e61147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Zonula Occludens-1 Protein
126 rdf:type schema:DefinedTerm
127 Naaedc34a25484a45b35f73e1e52e892e rdf:first sg:person.01303320061.15
128 rdf:rest rdf:nil
129 Nad92d5edccea44ce83bf1fd6e66d4ed0 schema:name dimensions_id
130 schema:value pub.1007979855
131 rdf:type schema:PropertyValue
132 Nba6d5311f743447fba16c643d39efd79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Mice, Inbred C57BL
134 rdf:type schema:DefinedTerm
135 Nbcda959b6f734036b144eb5919f91294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Tight Junctions
137 rdf:type schema:DefinedTerm
138 Nc135e46b9b0847aaa25fad72380abcdf rdf:first sg:person.01344167465.12
139 rdf:rest Ne746f87d4f6d4b59a764610792b101ae
140 Nd4d3b849e13f4269a94afb41dfb8a87f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Occludin
142 rdf:type schema:DefinedTerm
143 Nd887561e19d649cfbedfae6941da5632 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Endothelial Cells
145 rdf:type schema:DefinedTerm
146 Nddd985c5b27f48e7a18962ac2f314b32 schema:name nlm_unique_id
147 schema:value 9610936
148 rdf:type schema:PropertyValue
149 Ndf86f4b89d374ebaab921ff2e66c9645 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Astrocytes
151 rdf:type schema:DefinedTerm
152 Ne12d6cc42fd74d81b12643b318aa2dc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Retinal Vessels
154 rdf:type schema:DefinedTerm
155 Ne746f87d4f6d4b59a764610792b101ae rdf:first sg:person.0727205604.00
156 rdf:rest N1f985e39979f4dd9a35efc1460bc0066
157 Nf3feafd024a44c67b81f2c7f5d86808d schema:issueNumber 5
158 rdf:type schema:PublicationIssue
159 Nf584b6103ace426c86d0adae81e5f331 schema:volumeNumber 36
160 rdf:type schema:PublicationVolume
161 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
162 schema:name Biological Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
165 schema:name Biochemistry and Cell Biology
166 rdf:type schema:DefinedTerm
167 sg:journal.1115754 schema:issn 0219-1032
168 1016-8478
169 schema:name Molecules and Cells
170 rdf:type schema:Periodical
171 sg:person.01303320061.15 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
172 schema:familyName Cho
173 schema:givenName Chung-Hyun
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303320061.15
175 rdf:type schema:Person
176 sg:person.01317661462.10 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
177 schema:familyName Jo
178 schema:givenName Dong Hyun
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317661462.10
180 rdf:type schema:Person
181 sg:person.01344167465.12 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
182 schema:familyName Kim
183 schema:givenName Jin Hyoung
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344167465.12
185 rdf:type schema:Person
186 sg:person.0710503762.84 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
187 schema:familyName Kim
188 schema:givenName Jeong Hun
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710503762.84
190 rdf:type schema:Person
191 sg:person.0727205604.00 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
192 schema:familyName Heo
193 schema:givenName Jong-Ik
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727205604.00
195 rdf:type schema:Person
196 sg:pub.10.1007/s004290050289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047123632
197 https://doi.org/10.1007/s004290050289
198 rdf:type schema:CreativeWork
199 sg:pub.10.1023/b:cemn.0000022776.47302.ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1038427200
200 https://doi.org/10.1023/b:cemn.0000022776.47302.ce
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/nature09513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024041325
203 https://doi.org/10.1038/nature09513
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/nature09522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045685661
206 https://doi.org/10.1038/nature09522
207 rdf:type schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1076854619 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1080097123 schema:CreativeWork
210 https://doi.org/10.1001/archopht.123.6.797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037286506
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/dvdy.1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022405267
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/jnr.21884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010727544
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/jnr.22607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020535258
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/jnr.22700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034192474
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1006/exer.1998.0632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039027303
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0092-8674(93)80047-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1041281114
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/0165-3806(88)90119-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027846377
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.brainres.2005.01.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032645811
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.devbrainres.2004.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030659906
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.nbd.2009.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011361036
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1038/jcbfm.2009.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024344298
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1074/jbc.274.33.23463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009418090
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1080/02713680701487871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058314096
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1126/science.277.5323.242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001237539
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1167/iovs.04-0848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015019363
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1167/iovs.09-3615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023311724
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1167/iovs.12-10140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053222071
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1242/dev.01080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029430762
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1371/journal.pbio.0000052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002364154
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1371/journal.pone.0005149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018558616
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1387/ijdb.041895ms schema:sameAs https://app.dimensions.ai/details/publication/pub.1067190461
253 rdf:type schema:CreativeWork
254 https://doi.org/10.2353/ajpath.2007.060693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021658652
255 rdf:type schema:CreativeWork
256 https://doi.org/10.3928/0191-3913-20040501-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076854619
257 rdf:type schema:CreativeWork
258 https://doi.org/10.4161/auto.6.7.13306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290778
259 rdf:type schema:CreativeWork
260 https://doi.org/10.4161/auto.6.8.13306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078215623
261 rdf:type schema:CreativeWork
262 https://doi.org/10.5483/bmbrep.2006.39.4.339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007308645
263 rdf:type schema:CreativeWork
264 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
265 schema:name Department of Biomedical Sciences, Seoul National University, 110-744, Seoul, Korea
266 Department of Ophthalmology, College of Medicine, Seoul National University, 110-744, Seoul, Korea
267 Department of Pharmacology, Seoul National University, 110-744, Seoul, Korea
268 Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, 110-744, Seoul, Korea
269 Ischemic/Hypoxic Disease Institute, Seoul National University, 110-744, Seoul, Korea
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.412484.f schema:alternateName Seoul National University Hospital
272 schema:name Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, 110-744, Seoul, Korea
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...