An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10

AUTHORS

Seung Hun Jeong, In Sung Song, Hyoung Kyu Kim, Sung Ryul Lee, Suhee Song, Hongsuk Suh, Young Geol Yoon, Young Hyun Yoo, Nari Kim, Byoung Doo Rhee, Kyung Soo Ko, Jin Han

ABSTRACT

Resveratrol is a phytoalexin and polyphenol derived from grapes, berries, and peanuts. It has been shown to mediate death of a wide variety of cancer cells. Although resveratrol is considered an important potential chemotherapeutic agent, it is required at high doses to achieve a biologically or physiologically significant effect, which may be impractical for treating cancer. Thus, a more stable and potent derivative of resveratrol, with more effective tumoricidal activity, must be developed. A novel resveratrol analog, HS-1793, has recently been synthesized and was determined to exhibit a greater decrease in cancer cell viability than resveratrol. However, the underlying mechanism of HS-1793-induced cancer cell death remains unknown. We thus investigated the mechanism by which HS-1793 induces cell death and assessed whether this occurs through a mitochondrial-mediated mechanism. Using the MCF-7 breast cancer cell line, we determined that HS-1793 treatment significantly increased cell death at a relatively low dose compared with resveratrol. HS-1793 treatment more significantly decreased mitochondrial membrane potential, cellular ATP concentration, and cellular oxygen consumption rate than resveratrol treatment. At the molecular level, HS-1793 treatment down-regulated the expression of major mitochondrial biogenesis-regulating proteins, including mitochondrial transcriptional factor A (TFAM), Tu translation elongation factor (TUFM), and single-stranded DNA-binding protein. We conclude that HS- 1793 acts by regulating the expression of TFAM and TUFM, leading to a block in normal mitochondrial function, which sensitizes cancer cells to cell death. We therefore propose that HS-1793 can be a useful chemosensitization agent, which together with other such agents can efficiently target cancer cells. More... »

PAGES

357-365

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10059-012-0081-7

DOI

http://dx.doi.org/10.1007/s10059-012-0081-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039842413

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23104437


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Screening Assays, Antitumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MCF-7 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potential, Mitochondrial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Turnover", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naphthols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Resorcinols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stilbenes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeong", 
        "givenName": "Seung Hun", 
        "id": "sg:person.01331061643.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331061643.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "In Sung", 
        "id": "sg:person.01001342362.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001342362.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyoung Kyu", 
        "id": "sg:person.0672430733.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672430733.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sung Ryul", 
        "id": "sg:person.01072417444.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072417444.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pusan National University", 
          "id": "https://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, 609-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Suhee", 
        "id": "sg:person.01115203545.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115203545.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pusan National University", 
          "id": "https://www.grid.ac/institutes/grid.262229.f", 
          "name": [
            "Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, 609-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suh", 
        "givenName": "Hongsuk", 
        "id": "sg:person.0730657674.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730657674.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jungwon University", 
          "id": "https://www.grid.ac/institutes/grid.440940.d", 
          "name": [
            "Department of Biomedical Science, Institute for Biomedical and Health Sciences, Jungwon University, 367-700, Goesan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoon", 
        "givenName": "Young Geol", 
        "id": "sg:person.01000126637.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000126637.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dong-A University", 
          "id": "https://www.grid.ac/institutes/grid.255166.3", 
          "name": [
            "Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, College of Medicine, Dong-A University, 602-714, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Young Hyun", 
        "id": "sg:person.0662621067.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662621067.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Nari", 
        "id": "sg:person.0577670435.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577670435.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rhee", 
        "givenName": "Byoung Doo", 
        "id": "sg:person.0704631126.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704631126.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ko", 
        "givenName": "Kyung Soo", 
        "id": "sg:person.01231462570.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231462570.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inje University", 
          "id": "https://www.grid.ac/institutes/grid.411612.1", 
          "name": [
            "National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Jin", 
        "id": "sg:person.01030345435.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030345435.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/hmg/ddh109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000179443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1673-8527(08)60099-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002401710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.expneurol.2010.05.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006786546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2010.05864.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010632909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00527-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010708516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2007.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014416698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2007.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014416698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(97)01572-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014549953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(00)00511-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014792551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2003.055095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015073072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1003428107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015828504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016341645", 
          "https://doi.org/10.1038/ng909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016341645", 
          "https://doi.org/10.1038/ng909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.66.1.409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017386774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mrgentox.2011.01.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017454939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2008.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020398107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0605208103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021964374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-2-27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536321", 
          "https://doi.org/10.1186/1471-2407-2-27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00524-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024010065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00126-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025002057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mito.2006.11.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027208552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2008.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027319354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10059-011-0276-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030204153", 
          "https://doi.org/10.1007/s10059-011-0276-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-7843.2011.00697.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030287643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m500655200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030612521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031431852", 
          "https://doi.org/10.1038/ncb1575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031431852", 
          "https://doi.org/10.1038/ncb1575"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(99)00410-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031893065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2010.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032183641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymeth.2010.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032183641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2002.6554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036007591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/22.8.1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037088684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0398-231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037709004", 
          "https://doi.org/10.1038/ng0398-231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.6.1353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039121570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-4644(20000901)78:3<429::aid-jcb8>3.0.co;2-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039166703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.10.7087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040107210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041523948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2003.09.076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041737203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2003.09.076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041737203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/23.12.2031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042205319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2007.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048706172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2009.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049954279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050952027", 
          "https://doi.org/10.1038/nature03317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050952027", 
          "https://doi.org/10.1038/nature03317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051556699", 
          "https://doi.org/10.1038/sj.onc.1209600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051556699", 
          "https://doi.org/10.1038/sj.onc.1209600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052657146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200639r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200639r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np970488q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056239061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np970488q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056239061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5297.218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062555467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/3509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070915708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.15.2.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071511083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo_00000453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071518434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.11.2.441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071529104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/131.8.2197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074857602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074896151", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075014954", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/132.11.3482s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075187606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083296933", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-10", 
    "datePublishedReg": "2012-10-01", 
    "description": "Resveratrol is a phytoalexin and polyphenol derived from grapes, berries, and peanuts. It has been shown to mediate death of a wide variety of cancer cells. Although resveratrol is considered an important potential chemotherapeutic agent, it is required at high doses to achieve a biologically or physiologically significant effect, which may be impractical for treating cancer. Thus, a more stable and potent derivative of resveratrol, with more effective tumoricidal activity, must be developed. A novel resveratrol analog, HS-1793, has recently been synthesized and was determined to exhibit a greater decrease in cancer cell viability than resveratrol. However, the underlying mechanism of HS-1793-induced cancer cell death remains unknown. We thus investigated the mechanism by which HS-1793 induces cell death and assessed whether this occurs through a mitochondrial-mediated mechanism. Using the MCF-7 breast cancer cell line, we determined that HS-1793 treatment significantly increased cell death at a relatively low dose compared with resveratrol. HS-1793 treatment more significantly decreased mitochondrial membrane potential, cellular ATP concentration, and cellular oxygen consumption rate than resveratrol treatment. At the molecular level, HS-1793 treatment down-regulated the expression of major mitochondrial biogenesis-regulating proteins, including mitochondrial transcriptional factor A (TFAM), Tu translation elongation factor (TUFM), and single-stranded DNA-binding protein. We conclude that HS- 1793 acts by regulating the expression of TFAM and TUFM, leading to a block in normal mitochondrial function, which sensitizes cancer cells to cell death. We therefore propose that HS-1793 can be a useful chemosensitization agent, which together with other such agents can efficiently target cancer cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10059-012-0081-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1115754", 
        "issn": [
          "1016-8478", 
          "0219-1032"
        ], 
        "name": "Molecules and Cells", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression", 
    "pagination": "357-365", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "bdca7b0ed05f7ade2c1787606743c3e91b2c48951e4b57cbec9e88267fabbded"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23104437"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9610936"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10059-012-0081-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039842413"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10059-012-0081-7", 
      "https://app.dimensions.ai/details/publication/pub.1039842413"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000490.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10059-012-0081-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10059-012-0081-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10059-012-0081-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10059-012-0081-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10059-012-0081-7'


 

This table displays all metadata directly associated to this object as RDF triples.

375 TRIPLES      21 PREDICATES      96 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10059-012-0081-7 schema:about N0c1e1d3603a549b897b0bbcd11a2a837
2 N0ccfb2914c8e4846be02c18e376e12a7
3 N182b167396ee4a69b91ee9f23d26f666
4 N436e7a7946e842cd930a96a7bbb1cb81
5 N4523f2b5563a4a1088ef3ef825786b66
6 N72421a433df04563a15ad6f952f7f7df
7 N7bac15835b0346b2a3f4a8166973c14a
8 N9422e90f2fc54a729f9a290a02fb6a31
9 Na47ae27efce04b57a830f6f9d5f25357
10 Nb519a3a6afa548d799897d63d0190832
11 Nb9026af2262f40b181c48364493da8a3
12 Nbc228e240b1147078ce0f39a59b13000
13 Ncbcf024957b5449ba6007f3c02874ba7
14 Nd532a7b18e6e4a38a52a8b26bd4def98
15 Nf865d78c22994d6e9a526b1d7df99f42
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N8ba51dce256a45ca9bb883f9818ae0f9
19 schema:citation sg:pub.10.1007/s10059-011-0276-3
20 sg:pub.10.1038/nature03317
21 sg:pub.10.1038/ncb1575
22 sg:pub.10.1038/ng0398-231
23 sg:pub.10.1038/ng909
24 sg:pub.10.1038/sj.onc.1209600
25 sg:pub.10.1186/1471-2407-2-27
26 https://app.dimensions.ai/details/publication/pub.1074896151
27 https://app.dimensions.ai/details/publication/pub.1075014954
28 https://app.dimensions.ai/details/publication/pub.1083296933
29 https://doi.org/10.1002/1097-4644(20000901)78:3<429::aid-jcb8>3.0.co;2-m
30 https://doi.org/10.1002/ijc.10932
31 https://doi.org/10.1006/bbrc.2002.6554
32 https://doi.org/10.1016/j.bbrc.2003.09.076
33 https://doi.org/10.1016/j.bcp.2007.08.001
34 https://doi.org/10.1016/j.bcp.2009.01.002
35 https://doi.org/10.1016/j.ccr.2008.05.005
36 https://doi.org/10.1016/j.expneurol.2010.05.006
37 https://doi.org/10.1016/j.mito.2006.11.017
38 https://doi.org/10.1016/j.mrgentox.2011.01.012
39 https://doi.org/10.1016/j.tcb.2008.01.006
40 https://doi.org/10.1016/j.ymeth.2007.11.007
41 https://doi.org/10.1016/j.ymeth.2010.03.006
42 https://doi.org/10.1016/s0014-5793(97)01572-x
43 https://doi.org/10.1016/s0024-3205(99)00410-5
44 https://doi.org/10.1016/s0092-8674(01)00524-4
45 https://doi.org/10.1016/s0092-8674(01)00527-x
46 https://doi.org/10.1016/s0092-8674(04)00126-6
47 https://doi.org/10.1016/s0304-3835(00)00511-5
48 https://doi.org/10.1016/s1673-8527(08)60099-5
49 https://doi.org/10.1021/jm200639r
50 https://doi.org/10.1021/np970488q
51 https://doi.org/10.1038/sj.emboj.7600244
52 https://doi.org/10.1073/pnas.0605208103
53 https://doi.org/10.1073/pnas.1003428107
54 https://doi.org/10.1074/jbc.275.10.7087
55 https://doi.org/10.1074/jbc.m500655200
56 https://doi.org/10.1093/carcin/22.8.1111
57 https://doi.org/10.1093/carcin/23.12.2031
58 https://doi.org/10.1093/emboj/20.6.1353
59 https://doi.org/10.1093/hmg/ddh109
60 https://doi.org/10.1093/jn/131.8.2197
61 https://doi.org/10.1093/jn/132.11.3482s
62 https://doi.org/10.1111/j.1742-7843.2011.00697.x
63 https://doi.org/10.1111/j.1749-6632.2010.05864.x
64 https://doi.org/10.1113/jphysiol.2003.055095
65 https://doi.org/10.1126/science.275.5297.218
66 https://doi.org/10.1146/annurev.biochem.66.1.409
67 https://doi.org/10.2741/3509
68 https://doi.org/10.3892/ijo.15.2.245
69 https://doi.org/10.3892/ijo_00000453
70 https://doi.org/10.3892/or.11.2.441
71 schema:datePublished 2012-10
72 schema:datePublishedReg 2012-10-01
73 schema:description Resveratrol is a phytoalexin and polyphenol derived from grapes, berries, and peanuts. It has been shown to mediate death of a wide variety of cancer cells. Although resveratrol is considered an important potential chemotherapeutic agent, it is required at high doses to achieve a biologically or physiologically significant effect, which may be impractical for treating cancer. Thus, a more stable and potent derivative of resveratrol, with more effective tumoricidal activity, must be developed. A novel resveratrol analog, HS-1793, has recently been synthesized and was determined to exhibit a greater decrease in cancer cell viability than resveratrol. However, the underlying mechanism of HS-1793-induced cancer cell death remains unknown. We thus investigated the mechanism by which HS-1793 induces cell death and assessed whether this occurs through a mitochondrial-mediated mechanism. Using the MCF-7 breast cancer cell line, we determined that HS-1793 treatment significantly increased cell death at a relatively low dose compared with resveratrol. HS-1793 treatment more significantly decreased mitochondrial membrane potential, cellular ATP concentration, and cellular oxygen consumption rate than resveratrol treatment. At the molecular level, HS-1793 treatment down-regulated the expression of major mitochondrial biogenesis-regulating proteins, including mitochondrial transcriptional factor A (TFAM), Tu translation elongation factor (TUFM), and single-stranded DNA-binding protein. We conclude that HS- 1793 acts by regulating the expression of TFAM and TUFM, leading to a block in normal mitochondrial function, which sensitizes cancer cells to cell death. We therefore propose that HS-1793 can be a useful chemosensitization agent, which together with other such agents can efficiently target cancer cells.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree true
77 schema:isPartOf N0ada6288a492401fa235e7bdf61dcec0
78 Nfdcb1d83b76f42919f5f661e6fa420ff
79 sg:journal.1115754
80 schema:name An analogue of resveratrol HS-1793 exhibits anticancer activity against MCF-7 cells via inhibition of mitochondrial biogenesis gene expression
81 schema:pagination 357-365
82 schema:productId N146f53de83134ed699cfb9074aad8656
83 N37537fa7b6df453d91e83f2f6b56759d
84 N7bc9b80d1eff405a9cb320372ab7477d
85 Nc321a3b7bf74426ba47bc1d569f260a4
86 Ndbd079bbbdf04b8db468c9d574aa5a51
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039842413
88 https://doi.org/10.1007/s10059-012-0081-7
89 schema:sdDatePublished 2019-04-11T01:54
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N8c0847f3c1c14cb4814af0ae1ef1b137
92 schema:url http://link.springer.com/10.1007/s10059-012-0081-7
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N048ae233632b42f4a4570aaea46dc6ab rdf:first sg:person.0672430733.56
97 rdf:rest Na0b578bd84b94e3695f484cb8d0e5384
98 N04feda2e16b74b7989c577583fb974ee rdf:first sg:person.0704631126.36
99 rdf:rest N7b28430bd4734017aa1f2c47f91f3cb3
100 N0666df6e5c694900b7293a3c40fb2e86 rdf:first sg:person.01001342362.12
101 rdf:rest N048ae233632b42f4a4570aaea46dc6ab
102 N0ada6288a492401fa235e7bdf61dcec0 schema:volumeNumber 34
103 rdf:type schema:PublicationVolume
104 N0c1e1d3603a549b897b0bbcd11a2a837 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Antineoplastic Agents
106 rdf:type schema:DefinedTerm
107 N0ccfb2914c8e4846be02c18e376e12a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name MCF-7 Cells
109 rdf:type schema:DefinedTerm
110 N146f53de83134ed699cfb9074aad8656 schema:name dimensions_id
111 schema:value pub.1039842413
112 rdf:type schema:PropertyValue
113 N182b167396ee4a69b91ee9f23d26f666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cell Survival
115 rdf:type schema:DefinedTerm
116 N37537fa7b6df453d91e83f2f6b56759d schema:name pubmed_id
117 schema:value 23104437
118 rdf:type schema:PropertyValue
119 N436e7a7946e842cd930a96a7bbb1cb81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Caspases
121 rdf:type schema:DefinedTerm
122 N4523f2b5563a4a1088ef3ef825786b66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Mitochondrial Turnover
124 rdf:type schema:DefinedTerm
125 N53ad0e9d163b4f7ab1aac54736a1c0ab rdf:first sg:person.01000126637.63
126 rdf:rest Nf7d8ff81a7d64928835e9becdc7d0384
127 N5991af4773d64cdbaf998d903d268cf6 rdf:first sg:person.01030345435.02
128 rdf:rest rdf:nil
129 N72421a433df04563a15ad6f952f7f7df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Membrane Potential, Mitochondrial
131 rdf:type schema:DefinedTerm
132 N7b28430bd4734017aa1f2c47f91f3cb3 rdf:first sg:person.01231462570.63
133 rdf:rest N5991af4773d64cdbaf998d903d268cf6
134 N7bac15835b0346b2a3f4a8166973c14a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Down-Regulation
136 rdf:type schema:DefinedTerm
137 N7bc9b80d1eff405a9cb320372ab7477d schema:name readcube_id
138 schema:value bdca7b0ed05f7ade2c1787606743c3e91b2c48951e4b57cbec9e88267fabbded
139 rdf:type schema:PropertyValue
140 N8ba51dce256a45ca9bb883f9818ae0f9 rdf:first sg:person.01331061643.11
141 rdf:rest N0666df6e5c694900b7293a3c40fb2e86
142 N8c0847f3c1c14cb4814af0ae1ef1b137 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 N9422e90f2fc54a729f9a290a02fb6a31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Naphthols
146 rdf:type schema:DefinedTerm
147 Na0b578bd84b94e3695f484cb8d0e5384 rdf:first sg:person.01072417444.47
148 rdf:rest Ne5b921352e1741ca8d96e9e260aff4d9
149 Na47ae27efce04b57a830f6f9d5f25357 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Mitochondrial Proteins
151 rdf:type schema:DefinedTerm
152 Nb519a3a6afa548d799897d63d0190832 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Drug Screening Assays, Antitumor
154 rdf:type schema:DefinedTerm
155 Nb9026af2262f40b181c48364493da8a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Resorcinols
157 rdf:type schema:DefinedTerm
158 Nbc228e240b1147078ce0f39a59b13000 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Oxidative Phosphorylation
160 rdf:type schema:DefinedTerm
161 Nc321a3b7bf74426ba47bc1d569f260a4 schema:name doi
162 schema:value 10.1007/s10059-012-0081-7
163 rdf:type schema:PropertyValue
164 Ncbcf024957b5449ba6007f3c02874ba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Humans
166 rdf:type schema:DefinedTerm
167 Nd532a7b18e6e4a38a52a8b26bd4def98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Gene Expression Regulation, Neoplastic
169 rdf:type schema:DefinedTerm
170 Nd71a733739fd416f8ef990e6a45dfdb1 rdf:first sg:person.0730657674.79
171 rdf:rest N53ad0e9d163b4f7ab1aac54736a1c0ab
172 Ndbd079bbbdf04b8db468c9d574aa5a51 schema:name nlm_unique_id
173 schema:value 9610936
174 rdf:type schema:PropertyValue
175 Ne5b921352e1741ca8d96e9e260aff4d9 rdf:first sg:person.01115203545.17
176 rdf:rest Nd71a733739fd416f8ef990e6a45dfdb1
177 Nf7d8ff81a7d64928835e9becdc7d0384 rdf:first sg:person.0662621067.79
178 rdf:rest Nfdd64966301440d3b41a90afe39ffd78
179 Nf865d78c22994d6e9a526b1d7df99f42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Stilbenes
181 rdf:type schema:DefinedTerm
182 Nfdcb1d83b76f42919f5f661e6fa420ff schema:issueNumber 4
183 rdf:type schema:PublicationIssue
184 Nfdd64966301440d3b41a90afe39ffd78 rdf:first sg:person.0577670435.47
185 rdf:rest N04feda2e16b74b7989c577583fb974ee
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
190 schema:name Oncology and Carcinogenesis
191 rdf:type schema:DefinedTerm
192 sg:journal.1115754 schema:issn 0219-1032
193 1016-8478
194 schema:name Molecules and Cells
195 rdf:type schema:Periodical
196 sg:person.01000126637.63 schema:affiliation https://www.grid.ac/institutes/grid.440940.d
197 schema:familyName Yoon
198 schema:givenName Young Geol
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000126637.63
200 rdf:type schema:Person
201 sg:person.01001342362.12 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
202 schema:familyName Song
203 schema:givenName In Sung
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001342362.12
205 rdf:type schema:Person
206 sg:person.01030345435.02 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
207 schema:familyName Han
208 schema:givenName Jin
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030345435.02
210 rdf:type schema:Person
211 sg:person.01072417444.47 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
212 schema:familyName Lee
213 schema:givenName Sung Ryul
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072417444.47
215 rdf:type schema:Person
216 sg:person.01115203545.17 schema:affiliation https://www.grid.ac/institutes/grid.262229.f
217 schema:familyName Song
218 schema:givenName Suhee
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115203545.17
220 rdf:type schema:Person
221 sg:person.01231462570.63 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
222 schema:familyName Ko
223 schema:givenName Kyung Soo
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231462570.63
225 rdf:type schema:Person
226 sg:person.01331061643.11 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
227 schema:familyName Jeong
228 schema:givenName Seung Hun
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331061643.11
230 rdf:type schema:Person
231 sg:person.0577670435.47 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
232 schema:familyName Kim
233 schema:givenName Nari
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577670435.47
235 rdf:type schema:Person
236 sg:person.0662621067.79 schema:affiliation https://www.grid.ac/institutes/grid.255166.3
237 schema:familyName Yoo
238 schema:givenName Young Hyun
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662621067.79
240 rdf:type schema:Person
241 sg:person.0672430733.56 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
242 schema:familyName Kim
243 schema:givenName Hyoung Kyu
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672430733.56
245 rdf:type schema:Person
246 sg:person.0704631126.36 schema:affiliation https://www.grid.ac/institutes/grid.411612.1
247 schema:familyName Rhee
248 schema:givenName Byoung Doo
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704631126.36
250 rdf:type schema:Person
251 sg:person.0730657674.79 schema:affiliation https://www.grid.ac/institutes/grid.262229.f
252 schema:familyName Suh
253 schema:givenName Hongsuk
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730657674.79
255 rdf:type schema:Person
256 sg:pub.10.1007/s10059-011-0276-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030204153
257 https://doi.org/10.1007/s10059-011-0276-3
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/nature03317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050952027
260 https://doi.org/10.1038/nature03317
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/ncb1575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031431852
263 https://doi.org/10.1038/ncb1575
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/ng0398-231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037709004
266 https://doi.org/10.1038/ng0398-231
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/ng909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016341645
269 https://doi.org/10.1038/ng909
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/sj.onc.1209600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051556699
272 https://doi.org/10.1038/sj.onc.1209600
273 rdf:type schema:CreativeWork
274 sg:pub.10.1186/1471-2407-2-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536321
275 https://doi.org/10.1186/1471-2407-2-27
276 rdf:type schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1074896151 schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1075014954 schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1083296933 schema:CreativeWork
280 https://doi.org/10.1002/1097-4644(20000901)78:3<429::aid-jcb8>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1039166703
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/ijc.10932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052657146
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1006/bbrc.2002.6554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036007591
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.bbrc.2003.09.076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041737203
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.bcp.2007.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048706172
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.bcp.2009.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049954279
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.ccr.2008.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027319354
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.expneurol.2010.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006786546
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.mito.2006.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027208552
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.mrgentox.2011.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017454939
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.tcb.2008.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020398107
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.ymeth.2007.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014416698
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.ymeth.2010.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032183641
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/s0014-5793(97)01572-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014549953
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/s0024-3205(99)00410-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031893065
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0092-8674(01)00524-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024010065
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0092-8674(01)00527-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010708516
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s0092-8674(04)00126-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025002057
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0304-3835(00)00511-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014792551
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s1673-8527(08)60099-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002401710
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1021/jm200639r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055952409
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1021/np970488q schema:sameAs https://app.dimensions.ai/details/publication/pub.1056239061
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1038/sj.emboj.7600244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041523948
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1073/pnas.0605208103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021964374
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.1003428107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015828504
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1074/jbc.275.10.7087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040107210
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1074/jbc.m500655200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030612521
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/carcin/22.8.1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037088684
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/carcin/23.12.2031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042205319
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/emboj/20.6.1353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039121570
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/hmg/ddh109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000179443
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/jn/131.8.2197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074857602
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1093/jn/132.11.3482s schema:sameAs https://app.dimensions.ai/details/publication/pub.1075187606
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1111/j.1742-7843.2011.00697.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030287643
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1111/j.1749-6632.2010.05864.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010632909
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1113/jphysiol.2003.055095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015073072
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1126/science.275.5297.218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555467
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1146/annurev.biochem.66.1.409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017386774
355 rdf:type schema:CreativeWork
356 https://doi.org/10.2741/3509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070915708
357 rdf:type schema:CreativeWork
358 https://doi.org/10.3892/ijo.15.2.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071511083
359 rdf:type schema:CreativeWork
360 https://doi.org/10.3892/ijo_00000453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071518434
361 rdf:type schema:CreativeWork
362 https://doi.org/10.3892/or.11.2.441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071529104
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.255166.3 schema:alternateName Dong-A University
365 schema:name Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, College of Medicine, Dong-A University, 602-714, Busan, Korea
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.262229.f schema:alternateName Pusan National University
368 schema:name Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, 609-735, Busan, Korea
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.411612.1 schema:alternateName Inje University
371 schema:name National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, 614-735, Busan, Korea
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.440940.d schema:alternateName Jungwon University
374 schema:name Department of Biomedical Science, Institute for Biomedical and Health Sciences, Jungwon University, 367-700, Goesan, Korea
375 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...