Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06

AUTHORS

Do Hee Lee, Youra Lee, Joohyun Ryu, Sung Goo Park, Sayeon Cho, Je-Jung Lee, Chan Choi, Byoung Chul Park

ABSTRACT

In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells. More... »

PAGES

563-571

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10059-011-1053-z

DOI

http://dx.doi.org/10.1007/s10059-011-1053-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017428121

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21533548


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