Ontology type: schema:ScholarlyArticle Open Access: True
2011-06
AUTHORSDo Hee Lee, Youra Lee, Joohyun Ryu, Sung Goo Park, Sayeon Cho, Je-Jung Lee, Chan Choi, Byoung Chul Park
ABSTRACTIn a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells. More... »
PAGES563-571
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DOIhttp://dx.doi.org/10.1007/s10059-011-1053-z
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