ATG5 expression induced by MDMA (ecstasy), interferes with neuronal differentiation of neuroblastoma cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-05-15

AUTHORS

Myounghee Chae, Gyu-Seek Rhee, Ik-Soon Jang, Kwangsoo Kim, Ji-Hae Lee, Seung-Yeul Lee, Minjung Kim, Junyoung Yang, Junsoo Park, Seung-Hoon Lee

ABSTRACT

The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression. More... »

PAGES

571-575

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10059-009-0075-2

DOI

http://dx.doi.org/10.1007/s10059-009-0075-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004910488

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19466606


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