Bilirubin in the early course of venovenous extracorporeal membrane oxygenation support for refractory ARDS View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-03

AUTHORS

Chiara Lazzeri, Manuela Bonizzoli, Giovanni Cianchi, Stefano Batacchi, Marco Chiostri, Giorgio Enzo Fulceri, Laura Tadini Buoninsegni, Adriano Peris

ABSTRACT

Bilirubin is known as a marker of hepatic dysfunction and is incorporated in scoring algorithms to assess prognosis in critically ill patients. No data are so far available on the prognostic role of hepatic dysfunction in patients with severe ARDS on venovenous extracorporeal membrane oxygenation (VV-ECMO) support. In 112 consecutive patients with severe ARDS treated with VV-ECMO, we aimed at assessing whether increased bilirubin during the first 72 h could affect early death. Increased serum bilirubin (≥1.2 mg/dl) was detectable in 29 patients (25.9%) who were older (p = 0.031), exhibited a higher SOFA score (p = 0.006), were more frequently given pre-ECMO muscular blockers (p = 0.001) and supported with ECMO for a longer period (p = 0.024), when compared to patients with normal bilirubin. No difference in in-ICU mortality rate was observed between the two subgroups. In survivors, bilirubin showed a progressive and significant decrease (p = 0.032) during the first 72 h of ECMO support, while it increased in dead patients (p = 0.007).The mortality rate was higher in patients with increased bilirubin at 24, 48 and 72 h after ECMO start in respect to that of patients with normal values. Pre-ECMO increased bilirubin values (≥1.2 mg/dl), being detectable in about one-fourth of the entire population, is not associated with increased in-ICU mortality, while the persistence of increased bilirubin values after 24 h of ECMO start and within the first 3 days identified a subgroup of patients at higher risk of death. More... »

PAGES

61-67

References to SciGraph publications

  • 2013-10. Prevalence and prognosis of cor pulmonale during protective ventilation for acute respiratory distress syndrome in INTENSIVE CARE MEDICINE
  • 2016-02. Impact of acute liver failure on mortality during adult ECLS in INTENSIVE CARE MEDICINE
  • 2017-03. Body mass index and echocardiography in refractory ARDS treated with veno-venous extracorporeal membrane oxygenation in JOURNAL OF ARTIFICIAL ORGANS
  • 2011-12. Feasibility of inter-hospital transportation using extra-corporeal membrane oxygenation (ECMO) support of patients affected by severe swine-flu(H1N1)-related ARDS in SCANDINAVIAN JOURNAL OF TRAUMA, RESUSCITATION AND EMERGENCY MEDICINE
  • 2015-06. Clinical significance of echocardiography in patients supported by venous–venous extracorporeal membrane oxygenation in JOURNAL OF ARTIFICIAL ORGANS
  • 1996-07. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure in INTENSIVE CARE MEDICINE
  • 2009-08. ‘Liver function tests’ on the intensive care unit: a prospective, observational study in INTENSIVE CARE MEDICINE
  • 2015-12. Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review in CRITICAL CARE
  • 2016-12. Liver function predicts survival in patients undergoing extracorporeal membrane oxygenation following cardiovascular surgery in CRITICAL CARE
  • 2011-12. Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center in BMC PULMONARY MEDICINE
  • 2013-02. Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score in INTENSIVE CARE MEDICINE
  • 2014-04. Prediction of mortality in adult patients with severe acute lung failure receiving veno-venous extracorporeal membrane oxygenation: a prospective observational study in CRITICAL CARE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10047-017-0979-0

    DOI

    http://dx.doi.org/10.1007/s10047-017-0979-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091241494

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28821973


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bilirubin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Extracorporeal Membrane Oxygenation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiratory Distress Syndrome, Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retrospective Studies", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
              "id": "https://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lazzeri", 
            "givenName": "Chiara", 
            "id": "sg:person.01132610634.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132610634.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
              "id": "https://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bonizzoli", 
            "givenName": "Manuela", 
            "id": "sg:person.0655055354.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655055354.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
              "id": "https://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cianchi", 
            "givenName": "Giovanni", 
            "id": "sg:person.0620213030.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620213030.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
              "id": "https://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Batacchi", 
            "givenName": "Stefano", 
            "id": "sg:person.01204402217.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204402217.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
              "id": "https://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chiostri", 
            "givenName": "Marco", 
            "id": "sg:person.01167346300.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167346300.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
              "id": "https://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fulceri", 
            "givenName": "Giorgio Enzo", 
            "id": "sg:person.010256536657.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010256536657.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
              "id": "https://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buoninsegni", 
            "givenName": "Laura Tadini", 
            "id": "sg:person.01117257155.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117257155.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Azienda Ospedaliero-Universitaria Careggi", 
              "id": "https://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peris", 
            "givenName": "Adriano", 
            "id": "sg:person.01104102004.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104102004.74"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1478-3231.2011.02655.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000083588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-015-4123-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003706620", 
              "https://doi.org/10.1007/s00134-015-4123-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc13824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008958558", 
              "https://doi.org/10.1186/cc13824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/aas.12643", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010037929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.athoracsur.2016.06.087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011789417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1757-7241-19-32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012549744", 
              "https://doi.org/10.1186/1757-7241-19-32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201404-0630cp", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014212061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1511-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014222873", 
              "https://doi.org/10.1007/s00134-009-1511-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1511-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014222873", 
              "https://doi.org/10.1007/s00134-009-1511-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1511-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014222873", 
              "https://doi.org/10.1007/s00134-009-1511-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-013-2941-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016834941", 
              "https://doi.org/10.1007/s00134-013-2941-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-012-2747-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017318566", 
              "https://doi.org/10.1007/s00134-012-2747-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ejcts/ezr249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028738696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2466-11-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029419852", 
              "https://doi.org/10.1186/1471-2466-11-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-016-1242-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034016313", 
              "https://doi.org/10.1186/s13054-016-1242-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.echo.2014.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035112289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13054-015-0806-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035930261", 
              "https://doi.org/10.1186/s13054-015-0806-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0144278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037052172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1993.03510240069035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037698576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000206103.35460.1f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039785799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000206103.35460.1f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039785799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10047-015-0824-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044637178", 
              "https://doi.org/10.1007/s10047-015-0824-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10047-016-0931-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048574135", 
              "https://doi.org/10.1007/s10047-016-0931-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10047-016-0931-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048574135", 
              "https://doi.org/10.1007/s10047-016-0931-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-1241.2005.00609.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051138411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-1241.2005.00609.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051138411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01709751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052044737", 
              "https://doi.org/10.1007/bf01709751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01709751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052044737", 
              "https://doi.org/10.1007/bf01709751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.14.1389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071360111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079239049", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.23736/s0375-9393.16.11442-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079356513"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-03", 
        "datePublishedReg": "2018-03-01", 
        "description": "Bilirubin is known as a marker of hepatic dysfunction and is incorporated in scoring algorithms to assess prognosis in critically ill patients. No data are so far available on the prognostic role of hepatic dysfunction in patients with severe ARDS on venovenous extracorporeal membrane oxygenation (VV-ECMO) support. In 112 consecutive patients with severe ARDS treated with VV-ECMO, we aimed at assessing whether increased bilirubin during the first 72\u00a0h could affect early death. Increased serum bilirubin (\u22651.2\u00a0mg/dl) was detectable in 29 patients (25.9%) who were older (p\u00a0=\u00a00.031), exhibited a higher SOFA score (p\u00a0=\u00a00.006), were more frequently given pre-ECMO muscular blockers (p\u00a0=\u00a00.001) and supported with ECMO for a longer period (p\u00a0=\u00a00.024), when compared to patients with normal bilirubin. No difference in in-ICU mortality rate was observed between the two subgroups. In survivors, bilirubin showed a progressive and significant decrease (p\u00a0=\u00a00.032) during the first 72\u00a0h of ECMO support, while it increased in dead patients (p\u00a0=\u00a00.007).The mortality rate was higher in patients with increased bilirubin at 24, 48 and 72\u00a0h after ECMO start in respect to that of patients with normal values. Pre-ECMO increased bilirubin values (\u22651.2\u00a0mg/dl), being detectable in about one-fourth of the entire population, is not associated with increased in-ICU mortality, while the persistence of increased bilirubin values after 24\u00a0h of ECMO start and within the first 3\u00a0days identified a subgroup of patients at higher risk of death.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10047-017-0979-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1101514", 
            "issn": [
              "1434-7229", 
              "1619-0904"
            ], 
            "name": "Journal of Artificial Organs", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "21"
          }
        ], 
        "name": "Bilirubin in the early course of venovenous extracorporeal membrane oxygenation support for refractory ARDS", 
        "pagination": "61-67", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e862b625141cf7dee1a403ee6edb51446d91031ce9d82dd1a301e4d93281a2a8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28821973"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9815648"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10047-017-0979-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1091241494"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10047-017-0979-0", 
          "https://app.dimensions.ai/details/publication/pub.1091241494"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113677_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs10047-017-0979-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10047-017-0979-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10047-017-0979-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10047-017-0979-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10047-017-0979-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    240 TRIPLES      21 PREDICATES      63 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10047-017-0979-0 schema:about N3a0b336fcf83423fa8d3813b8c435600
    2 N489cd28fc66d43a8ab358777360ebba9
    3 N61524bfed1254bfa8712b36e448fa1c4
    4 N6468795302a24e5daf65ec84c255e81f
    5 N98bc4c84b6654049a77bdf58aa65963b
    6 Nbe2061e28bd540d98f61b17e142d178d
    7 Nd1324df60583407c901e178ea7c37346
    8 Ne250167b370f40ce8ab80d770254cb79
    9 Nf89b0d26220340369b0c0a48a20a6e0e
    10 anzsrc-for:11
    11 anzsrc-for:1103
    12 schema:author N79404d7382dc4e4ab6376dea2b79fdca
    13 schema:citation sg:pub.10.1007/bf01709751
    14 sg:pub.10.1007/s00134-009-1511-7
    15 sg:pub.10.1007/s00134-012-2747-1
    16 sg:pub.10.1007/s00134-013-2941-9
    17 sg:pub.10.1007/s00134-015-4123-4
    18 sg:pub.10.1007/s10047-015-0824-2
    19 sg:pub.10.1007/s10047-016-0931-8
    20 sg:pub.10.1186/1471-2466-11-2
    21 sg:pub.10.1186/1757-7241-19-32
    22 sg:pub.10.1186/cc13824
    23 sg:pub.10.1186/s13054-015-0806-z
    24 sg:pub.10.1186/s13054-016-1242-4
    25 https://app.dimensions.ai/details/publication/pub.1079239049
    26 https://doi.org/10.1001/jama.1993.03510240069035
    27 https://doi.org/10.1016/j.athoracsur.2016.06.087
    28 https://doi.org/10.1016/j.echo.2014.10.003
    29 https://doi.org/10.1093/ejcts/ezr249
    30 https://doi.org/10.1097/01.ccm.0000206103.35460.1f
    31 https://doi.org/10.1111/aas.12643
    32 https://doi.org/10.1111/j.1478-3231.2011.02655.x
    33 https://doi.org/10.1111/j.1742-1241.2005.00609.x
    34 https://doi.org/10.1164/rccm.201404-0630cp
    35 https://doi.org/10.1371/journal.pone.0144278
    36 https://doi.org/10.23736/s0375-9393.16.11442-7
    37 https://doi.org/10.3748/wjg.14.1389
    38 schema:datePublished 2018-03
    39 schema:datePublishedReg 2018-03-01
    40 schema:description Bilirubin is known as a marker of hepatic dysfunction and is incorporated in scoring algorithms to assess prognosis in critically ill patients. No data are so far available on the prognostic role of hepatic dysfunction in patients with severe ARDS on venovenous extracorporeal membrane oxygenation (VV-ECMO) support. In 112 consecutive patients with severe ARDS treated with VV-ECMO, we aimed at assessing whether increased bilirubin during the first 72 h could affect early death. Increased serum bilirubin (≥1.2 mg/dl) was detectable in 29 patients (25.9%) who were older (p = 0.031), exhibited a higher SOFA score (p = 0.006), were more frequently given pre-ECMO muscular blockers (p = 0.001) and supported with ECMO for a longer period (p = 0.024), when compared to patients with normal bilirubin. No difference in in-ICU mortality rate was observed between the two subgroups. In survivors, bilirubin showed a progressive and significant decrease (p = 0.032) during the first 72 h of ECMO support, while it increased in dead patients (p = 0.007).The mortality rate was higher in patients with increased bilirubin at 24, 48 and 72 h after ECMO start in respect to that of patients with normal values. Pre-ECMO increased bilirubin values (≥1.2 mg/dl), being detectable in about one-fourth of the entire population, is not associated with increased in-ICU mortality, while the persistence of increased bilirubin values after 24 h of ECMO start and within the first 3 days identified a subgroup of patients at higher risk of death.
    41 schema:genre research_article
    42 schema:inLanguage en
    43 schema:isAccessibleForFree false
    44 schema:isPartOf N5ae70afa731e41deac8baf90c0a52f56
    45 N5f0b119788cd46f287bb4353992ae288
    46 sg:journal.1101514
    47 schema:name Bilirubin in the early course of venovenous extracorporeal membrane oxygenation support for refractory ARDS
    48 schema:pagination 61-67
    49 schema:productId N0146e416799b41ec9aa01842efd82970
    50 N409c04a9ea5e43cab4bafc52de2dd8a6
    51 Na9aca7e190864c758db95240423407ae
    52 Nbb42e9dd85534eaba07740be38a2e6c1
    53 Nd73d610a8df840ecb70377d5ca22e7c9
    54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091241494
    55 https://doi.org/10.1007/s10047-017-0979-0
    56 schema:sdDatePublished 2019-04-11T10:38
    57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    58 schema:sdPublisher N059eff50c8dc4132bc21968a4a05315f
    59 schema:url https://link.springer.com/10.1007%2Fs10047-017-0979-0
    60 sgo:license sg:explorer/license/
    61 sgo:sdDataset articles
    62 rdf:type schema:ScholarlyArticle
    63 N0146e416799b41ec9aa01842efd82970 schema:name pubmed_id
    64 schema:value 28821973
    65 rdf:type schema:PropertyValue
    66 N059eff50c8dc4132bc21968a4a05315f schema:name Springer Nature - SN SciGraph project
    67 rdf:type schema:Organization
    68 N10abdc992437408ebf52b9a18061e55a rdf:first sg:person.0620213030.03
    69 rdf:rest Nea458468b1f2431fb9c7df13bae943f9
    70 N3a0b336fcf83423fa8d3813b8c435600 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    71 schema:name Prognosis
    72 rdf:type schema:DefinedTerm
    73 N409c04a9ea5e43cab4bafc52de2dd8a6 schema:name readcube_id
    74 schema:value e862b625141cf7dee1a403ee6edb51446d91031ce9d82dd1a301e4d93281a2a8
    75 rdf:type schema:PropertyValue
    76 N489cd28fc66d43a8ab358777360ebba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Humans
    78 rdf:type schema:DefinedTerm
    79 N5ae70afa731e41deac8baf90c0a52f56 schema:volumeNumber 21
    80 rdf:type schema:PublicationVolume
    81 N5f0b119788cd46f287bb4353992ae288 schema:issueNumber 1
    82 rdf:type schema:PublicationIssue
    83 N61524bfed1254bfa8712b36e448fa1c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    84 schema:name Male
    85 rdf:type schema:DefinedTerm
    86 N6468795302a24e5daf65ec84c255e81f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Bilirubin
    88 rdf:type schema:DefinedTerm
    89 N7349efc1272f48c0aa4d39f74e36bc51 rdf:first sg:person.01117257155.23
    90 rdf:rest Nd67edd0c80fe455c806fd9e0051d0ab6
    91 N79404d7382dc4e4ab6376dea2b79fdca rdf:first sg:person.01132610634.46
    92 rdf:rest Nf6feb2f1f8d04105acd52054ddd12b9b
    93 N98bc4c84b6654049a77bdf58aa65963b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Retrospective Studies
    95 rdf:type schema:DefinedTerm
    96 Na2413e6ccab94a0bad776a0aa430f58f rdf:first sg:person.010256536657.15
    97 rdf:rest N7349efc1272f48c0aa4d39f74e36bc51
    98 Na9aca7e190864c758db95240423407ae schema:name doi
    99 schema:value 10.1007/s10047-017-0979-0
    100 rdf:type schema:PropertyValue
    101 Nbb42e9dd85534eaba07740be38a2e6c1 schema:name nlm_unique_id
    102 schema:value 9815648
    103 rdf:type schema:PropertyValue
    104 Nbe2061e28bd540d98f61b17e142d178d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Middle Aged
    106 rdf:type schema:DefinedTerm
    107 Nd1324df60583407c901e178ea7c37346 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Extracorporeal Membrane Oxygenation
    109 rdf:type schema:DefinedTerm
    110 Nd67edd0c80fe455c806fd9e0051d0ab6 rdf:first sg:person.01104102004.74
    111 rdf:rest rdf:nil
    112 Nd73d610a8df840ecb70377d5ca22e7c9 schema:name dimensions_id
    113 schema:value pub.1091241494
    114 rdf:type schema:PropertyValue
    115 Nde598cdea9aa40d1aba98b89426c5b25 rdf:first sg:person.01167346300.70
    116 rdf:rest Na2413e6ccab94a0bad776a0aa430f58f
    117 Ne250167b370f40ce8ab80d770254cb79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Female
    119 rdf:type schema:DefinedTerm
    120 Nea458468b1f2431fb9c7df13bae943f9 rdf:first sg:person.01204402217.15
    121 rdf:rest Nde598cdea9aa40d1aba98b89426c5b25
    122 Nf6feb2f1f8d04105acd52054ddd12b9b rdf:first sg:person.0655055354.25
    123 rdf:rest N10abdc992437408ebf52b9a18061e55a
    124 Nf89b0d26220340369b0c0a48a20a6e0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Respiratory Distress Syndrome, Adult
    126 rdf:type schema:DefinedTerm
    127 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    128 schema:name Medical and Health Sciences
    129 rdf:type schema:DefinedTerm
    130 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    131 schema:name Clinical Sciences
    132 rdf:type schema:DefinedTerm
    133 sg:journal.1101514 schema:issn 1434-7229
    134 1619-0904
    135 schema:name Journal of Artificial Organs
    136 rdf:type schema:Periodical
    137 sg:person.010256536657.15 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
    138 schema:familyName Fulceri
    139 schema:givenName Giorgio Enzo
    140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010256536657.15
    141 rdf:type schema:Person
    142 sg:person.01104102004.74 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
    143 schema:familyName Peris
    144 schema:givenName Adriano
    145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104102004.74
    146 rdf:type schema:Person
    147 sg:person.01117257155.23 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
    148 schema:familyName Buoninsegni
    149 schema:givenName Laura Tadini
    150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117257155.23
    151 rdf:type schema:Person
    152 sg:person.01132610634.46 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
    153 schema:familyName Lazzeri
    154 schema:givenName Chiara
    155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132610634.46
    156 rdf:type schema:Person
    157 sg:person.01167346300.70 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
    158 schema:familyName Chiostri
    159 schema:givenName Marco
    160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167346300.70
    161 rdf:type schema:Person
    162 sg:person.01204402217.15 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
    163 schema:familyName Batacchi
    164 schema:givenName Stefano
    165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204402217.15
    166 rdf:type schema:Person
    167 sg:person.0620213030.03 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
    168 schema:familyName Cianchi
    169 schema:givenName Giovanni
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620213030.03
    171 rdf:type schema:Person
    172 sg:person.0655055354.25 schema:affiliation https://www.grid.ac/institutes/grid.24704.35
    173 schema:familyName Bonizzoli
    174 schema:givenName Manuela
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655055354.25
    176 rdf:type schema:Person
    177 sg:pub.10.1007/bf01709751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052044737
    178 https://doi.org/10.1007/bf01709751
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1007/s00134-009-1511-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014222873
    181 https://doi.org/10.1007/s00134-009-1511-7
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/s00134-012-2747-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017318566
    184 https://doi.org/10.1007/s00134-012-2747-1
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/s00134-013-2941-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016834941
    187 https://doi.org/10.1007/s00134-013-2941-9
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s00134-015-4123-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003706620
    190 https://doi.org/10.1007/s00134-015-4123-4
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1007/s10047-015-0824-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044637178
    193 https://doi.org/10.1007/s10047-015-0824-2
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1007/s10047-016-0931-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048574135
    196 https://doi.org/10.1007/s10047-016-0931-8
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1186/1471-2466-11-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029419852
    199 https://doi.org/10.1186/1471-2466-11-2
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1186/1757-7241-19-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012549744
    202 https://doi.org/10.1186/1757-7241-19-32
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1186/cc13824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008958558
    205 https://doi.org/10.1186/cc13824
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1186/s13054-015-0806-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035930261
    208 https://doi.org/10.1186/s13054-015-0806-z
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1186/s13054-016-1242-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034016313
    211 https://doi.org/10.1186/s13054-016-1242-4
    212 rdf:type schema:CreativeWork
    213 https://app.dimensions.ai/details/publication/pub.1079239049 schema:CreativeWork
    214 https://doi.org/10.1001/jama.1993.03510240069035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037698576
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/j.athoracsur.2016.06.087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011789417
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/j.echo.2014.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035112289
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1093/ejcts/ezr249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028738696
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1097/01.ccm.0000206103.35460.1f schema:sameAs https://app.dimensions.ai/details/publication/pub.1039785799
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1111/aas.12643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010037929
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1111/j.1478-3231.2011.02655.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000083588
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1111/j.1742-1241.2005.00609.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051138411
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1164/rccm.201404-0630cp schema:sameAs https://app.dimensions.ai/details/publication/pub.1014212061
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1371/journal.pone.0144278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037052172
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.23736/s0375-9393.16.11442-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079356513
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.3748/wjg.14.1389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071360111
    237 rdf:type schema:CreativeWork
    238 https://www.grid.ac/institutes/grid.24704.35 schema:alternateName Azienda Ospedaliero-Universitaria Careggi
    239 schema:name Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy
    240 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...