Preparation and in vitro/in vivo evaluations of dimpled poly(l-lactic acid) fibers mixed/coated with hydroxyapatite nanocrystals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Hiroshi Yanagida, Masahiro Okada, Miwa Masuda, Isao Narama, Shigeyuki Nakano, Satoshi Kitao, Kazuo Takakuda, Tsutomu Furuzono

ABSTRACT

A novel hydroxyapatite (HAp)/poly(L-lactic acid) (PLLA) nanocomposite nonwoven fabric, which was coated and mixed with calcined HAp nanocrystals, and has submicron-sized dimples on its surface, was fabricated. First, HAp-mixed PLLA fabric was prepared by electrospinning a HAp nanocrystal dispersion in dichloromethane (DCM)-dissolved PLLA. It was found that most of the HAp nanocrystals were not exposed on the HAp-mixed PLLA fiber surface but covered with the PLLA matrix. A HAp-nanocrystal coating was applied onto the surface of the HAp-mixed PLLA fabric after corona discharge treatment followed by ethanol washing. The submicron-sized dimples were enlarged after the ethanol washing. After the HAp-nanocrystal coating, the HAp-mixed PLLA fabric surface was uniformly coated with the HAp nanocrystals. In vitro cell spread tests showed that the rat osteoblasts spread more on HAp-nanocrystal-coated fabrics than on non-HAp-coated fabrics. Upon covering calvarial defects, the in vivo hard tissue responses suggested earlier restoration of the defects with HAp-nanocrystal-coated fabrics than those with non-HAp-coated fabrics. More... »

PAGES

331-341

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10047-011-0594-4

    DOI

    http://dx.doi.org/10.1007/s10047-011-0594-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004593110

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21833703


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