Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-11-01

AUTHORS

Y. Ichigotani, S. Matsuda, K. Machida, K. Oshima, T. Iwamoto, K. Yamaki, T. Hayakawa, M. Hamaguchi

ABSTRACT

A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1735 base pairs and has a predicted open reading frame (ORF) encoding 354 amino acids. It possesses a putative signal sequence, a long extracellular domain, a transmembrane region, a short intracellular domain, and no catalytic domain, which is highly homologous to signal-regulatory protein (SIRP)-β, suggesting that it seems to be a new member of the SIRP family. Polymerase chain reaction (PCR)-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 20p13 near the marker D20S906. More... »

PAGES

378-382

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s100380070013

DOI

http://dx.doi.org/10.1007/s100380070013

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014888671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11185750


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