Molecular cloning, mapping, and characterization of a novel human gene, MTA1-L1, showing homology to a metastasis-associated gene, MTA1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-01-15

AUTHORS

Manabu Futamura, Hiroyuki Nishimori, Takayuki Shiratsuchi, Shigetoyo Saji, Yusuke Nakamura, Takashi Tokino

ABSTRACT

Through large-scale sequencing of clones randomly selected from libraries of human cDNAs, we have isolated a novel human gene encoding a product with 59.6% identity in amino acid sequence to human MTA1, a protein associated with tumor invasion and metastasis. This cDNA, named MTA1-L1 (MTA1 like 1), consists of 2736 nucleotides with an open reading frame encoding 668 amino acids. A single 3.0-kb transcript of MTA1-L1 was expressed ubiquitously on Northern blots. Structural analysis of the MTA1-L1 gene revealed 18 exons spanning 8.1 kb of genomic DNA. We assigned the MTA1-L1 locus to chromosomal band 11q12-13.1 by fluorescence in situ hybridization. More... »

PAGES

52

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s100380050107

DOI

http://dx.doi.org/10.1007/s100380050107

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005914752

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9929979


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