Ontology type: schema:ScholarlyArticle Open Access: True
2008-01-31
AUTHORSNuripa Jenishbekovna Aidaralieva, Kouzin Kamino, Ryo Kimura, Mitsuko Yamamoto, Takeshi Morihara, Hiroaki Kazui, Ryota Hashimoto, Toshihisa Tanaka, Takashi Kudo, Tomoyuki Kida, Jun-Ichiro Okuda, Takeshi Uema, Hidehisa Yamagata, Tetsuro Miki, Hiroyasu Akatsu, Kenji Kosaka, Masatoshi Takeda
ABSTRACTAlzheimer disease (AD) is characterized by progressive cognitive decline caused by synaptic dysfunction and neurodegeneration in the brain, and late-onset AD (LOAD), genetically classified as a polygenetic disease, is the major form of dementia in the elderly. It has been shown that β amyloid, deposited in the AD brain, interacts with dynamin 1 and that the dynamin 2 (DNM2) gene homologous to the dynamin 1 gene is encoded at chromosome 19p13.2 where a susceptibility locus has been detected by linkage analysis. To test the genetic association of LOAD with the DNM2 gene, we performed a case–control study of 429 patients with LOAD and 438 sex- and age-matched control subjects in a Japanese population. We found a significant association of LOAD with single nucleotide polymorphism markers of the DNM2 gene, especially in non-carriers of the apolipoprotein E-ε4 allele. Even though subjects with the genotype homozygous for the risk allele at rs892086 showed no mutation in exons of the DNM2 gene, expression of DNM2 mRNA in the hippocampus was decreased in the patients compared to non-demented controls. We propose that the DNM2 gene is a novel susceptibility gene for LOAD. More... »
PAGES296-302
http://scigraph.springernature.com/pub.10.1007/s10038-008-0251-9
DOIhttp://dx.doi.org/10.1007/s10038-008-0251-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1002336140
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/18236001
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alzheimer Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dynamin II",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Predisposition to Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Linkage Disequilibrium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymorphism, Single Nucleotide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sequence Analysis, DNA",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Aidaralieva",
"givenName": "Nuripa Jenishbekovna",
"id": "sg:person.0674717025.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674717025.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shoraiso National Hospital, Yamatokoriyama, Nara, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"Shoraiso National Hospital, Yamatokoriyama, Nara, Japan"
],
"type": "Organization"
},
"familyName": "Kamino",
"givenName": "Kouzin",
"id": "sg:person.01011145425.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011145425.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Kimura",
"givenName": "Ryo",
"id": "sg:person.01165530454.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165530454.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Yamamoto",
"givenName": "Mitsuko",
"id": "sg:person.01241622425.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241622425.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Morihara",
"givenName": "Takeshi",
"id": "sg:person.01356051025.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356051025.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Kazui",
"givenName": "Hiroaki",
"id": "sg:person.01207327153.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207327153.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Hashimoto",
"givenName": "Ryota",
"id": "sg:person.01172504713.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172504713.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Toshihisa",
"id": "sg:person.0710536753.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710536753.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Kudo",
"givenName": "Takashi",
"id": "sg:person.01242622146.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242622146.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shoraiso National Hospital, Yamatokoriyama, Nara, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Shoraiso National Hospital, Yamatokoriyama, Nara, Japan"
],
"type": "Organization"
},
"familyName": "Kida",
"givenName": "Tomoyuki",
"id": "sg:person.01361712125.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361712125.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shoraiso National Hospital, Yamatokoriyama, Nara, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Shoraiso National Hospital, Yamatokoriyama, Nara, Japan"
],
"type": "Organization"
},
"familyName": "Okuda",
"givenName": "Jun-Ichiro",
"id": "sg:person.01234350505.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234350505.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka General Medical Center, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.416985.7",
"name": [
"Department of Psychiatry, Osaka General Medical Center, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Uema",
"givenName": "Takeshi",
"id": "sg:person.01236760206.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236760206.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan",
"id": "http://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Yamagata",
"givenName": "Hidehisa",
"id": "sg:person.01135076225.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135076225.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan",
"id": "http://www.grid.ac/institutes/grid.255464.4",
"name": [
"Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan"
],
"type": "Organization"
},
"familyName": "Miki",
"givenName": "Tetsuro",
"id": "sg:person.011202245512.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011202245512.26"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi, Japan"
],
"type": "Organization"
},
"familyName": "Akatsu",
"givenName": "Hiroyasu",
"id": "sg:person.01365553225.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365553225.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi, Japan"
],
"type": "Organization"
},
"familyName": "Kosaka",
"givenName": "Kenji",
"id": "sg:person.01206306412.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206306412.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Takeda",
"givenName": "Masatoshi",
"id": "sg:person.01275321421.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275321421.76"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/ng1514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024145043",
"https://doi.org/10.1038/ng1514"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.mp.4001109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003902194",
"https://doi.org/10.1038/sj.mp.4001109"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/347256a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028569139",
"https://doi.org/10.1038/347256a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrm1313",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023258012",
"https://doi.org/10.1038/nrm1313"
],
"type": "CreativeWork"
}
],
"datePublished": "2008-01-31",
"datePublishedReg": "2008-01-31",
"description": "Alzheimer disease (AD) is characterized by progressive cognitive decline caused by synaptic dysfunction and neurodegeneration in the brain, and late-onset AD (LOAD), genetically classified as a polygenetic disease, is the major form of dementia in the elderly. It has been shown that \u03b2 amyloid, deposited in the AD brain, interacts with dynamin 1 and that the dynamin 2 (DNM2) gene homologous to the dynamin 1 gene is encoded at chromosome 19p13.2 where a susceptibility locus has been detected by linkage analysis. To test the genetic association of LOAD with the DNM2 gene, we performed a case\u2013control study of 429 patients with LOAD and 438 sex- and age-matched control subjects in a Japanese population. We found a significant association of LOAD with single nucleotide polymorphism markers of the DNM2 gene, especially in non-carriers of the apolipoprotein E-\u03b54 allele. Even though subjects with the genotype homozygous for the risk allele at rs892086 showed no mutation in exons of the DNM2 gene, expression of DNM2 mRNA in the hippocampus was decreased in the patients compared to non-demented controls. We propose that the DNM2 gene is a novel susceptibility gene for LOAD.",
"genre": "article",
"id": "sg:pub.10.1007/s10038-008-0251-9",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1294984",
"issn": [
"1434-5161",
"1435-232X"
],
"name": "Journal of Human Genetics",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "53"
}
],
"keywords": [
"late-onset AD",
"novel susceptibility genes",
"late-onset Alzheimer's disease",
"Alzheimer's disease",
"dynamin 2 gene",
"single nucleotide polymorphism (SNP) markers",
"susceptibility genes",
"dynamin 1 gene",
"age-matched control subjects",
"DNM2 gene",
"apolipoprotein E (APOE) \u03b54 allele",
"progressive cognitive decline",
"case-control study",
"non-demented controls",
"polymorphism markers",
"dynamin 1",
"chromosome 19p13.2",
"synaptic dysfunction",
"AD brain",
"control subjects",
"\u03b54 carriers",
"linkage analysis",
"susceptibility loci",
"genes",
"polygenetic disease",
"DNM2 mRNA",
"\u03b2-amyloid",
"cognitive decline",
"significant association",
"risk alleles",
"genetic association",
"Japanese population",
"disease",
"patients",
"brain",
"alleles",
"major form",
"association",
"subjects",
"exons",
"loci",
"dysfunction",
"hippocampus",
"dementia",
"neurodegeneration",
"mutations",
"mRNA",
"amyloid",
"sex",
"expression",
"markers",
"genotypes",
"population",
"decline",
"control",
"study",
"carriers",
"analysis",
"form"
],
"name": "Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-\u03b54 carriers",
"pagination": "296-302",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1002336140"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10038-008-0251-9"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"18236001"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10038-008-0251-9",
"https://app.dimensions.ai/details/publication/pub.1002336140"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_454.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s10038-008-0251-9"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10038-008-0251-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10038-008-0251-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10038-008-0251-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10038-008-0251-9'
This table displays all metadata directly associated to this object as RDF triples.
302 TRIPLES
21 PREDICATES
98 URIs
84 LITERALS
15 BLANK NODES