SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-10-02

AUTHORS

Hiroshi Inoue, Hiroshi Shiota, Katsuyuki Miyawaki, Kiyoshi Kunika, Maki Moritani, Mitsuo Itakura, Naoto Nakamura, Natsuo Yasui, Parvaneh Keshavarz, Toshihito Tanahashi, Toshikazu Yoshikawa, Yuka Yamaguchi, Yukiko Sakamoto

ABSTRACT

Many genetic association studies support a contribution of genetic variants in the KCNJ11-ABCC8 gene locus to type 2 diabetes (T2D) susceptibility in Caucasians. In non-Caucasian populations, however, there have been only a few association studies, and discordant results were obtained. Herein, we selected a total of 31 SNPs covering a 211.3-kb region of the KCNJ11-ABCC8 locus, characterized the patterns of linkage disequilibrium (LD) and haplotype structure, and performed a case-control association study in a Japanese population consisting of 909 T2D patients and 893 control subjects. We found significant associations between eight SNPs, including the KCNJ11 E23K and ABCC8 S1369A variants, and T2D. These disease-associated SNPs were genetically indistinguishable because of the presence of strong LD, as found previously in Caucasians. For the KCNJ11 E23K variant, the most significant association was obtained under a dominant genetic model (OR 1.32, 95% CI 1.09-1.60, P = 0.004). A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility. Furthermore, we found evidence suggesting that the KCNJ11 E23K genotype is independently associated with higher blood-pressure levels. More... »

PAGES

781

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10038-007-0190-x

DOI

http://dx.doi.org/10.1007/s10038-007-0190-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019727857

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17823772


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