SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-09-06

AUTHORS

Yukiko Sakamoto, Hiroshi Inoue, Parvaneh Keshavarz, Katsuyuki Miyawaki, Yuka Yamaguchi, Maki Moritani, Kiyoshi Kunika, Naoto Nakamura, Toshikazu Yoshikawa, Natsuo Yasui, Hiroshi Shiota, Toshihito Tanahashi, Mitsuo Itakura

ABSTRACT

Many genetic association studies support a contribution of genetic variants in the KCNJ11-ABCC8 gene locus to type 2 diabetes (T2D) susceptibility in Caucasians. In non-Caucasian populations, however, there have been only a few association studies, and discordant results were obtained. Herein, we selected a total of 31 SNPs covering a 211.3-kb region of the KCNJ11-ABCC8 locus, characterized the patterns of linkage disequilibrium (LD) and haplotype structure, and performed a case-control association study in a Japanese population consisting of 909 T2D patients and 893 control subjects. We found significant associations between eight SNPs, including the KCNJ11 E23K and ABCC8 S1369A variants, and T2D. These disease-associated SNPs were genetically indistinguishable because of the presence of strong LD, as found previously in Caucasians. For the KCNJ11 E23K variant, the most significant association was obtained under a dominant genetic model (OR 1.32, 95% CI 1.09–1.60, P = 0.004). A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility. Furthermore, we found evidence suggesting that the KCNJ11 E23K genotype is independently associated with higher blood-pressure levels. More... »

PAGES

781-793

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10038-007-0190-x

DOI

http://dx.doi.org/10.1007/s10038-007-0190-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019727857

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17823772


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28 schema:description Many genetic association studies support a contribution of genetic variants in the KCNJ11-ABCC8 gene locus to type 2 diabetes (T2D) susceptibility in Caucasians. In non-Caucasian populations, however, there have been only a few association studies, and discordant results were obtained. Herein, we selected a total of 31 SNPs covering a 211.3-kb region of the KCNJ11-ABCC8 locus, characterized the patterns of linkage disequilibrium (LD) and haplotype structure, and performed a case-control association study in a Japanese population consisting of 909 T2D patients and 893 control subjects. We found significant associations between eight SNPs, including the KCNJ11 E23K and ABCC8 S1369A variants, and T2D. These disease-associated SNPs were genetically indistinguishable because of the presence of strong LD, as found previously in Caucasians. For the KCNJ11 E23K variant, the most significant association was obtained under a dominant genetic model (OR 1.32, 95% CI 1.09–1.60, P = 0.004). A meta-analysis of East Asian studies, comprising a total of 3,357 T2D patients (77.4% Japanese) and 2,836 control subjects (77.8% Japanese), confirmed the significant role of the KCNJ11 E23K variant in T2D susceptibility. Furthermore, we found evidence suggesting that the KCNJ11 E23K genotype is independently associated with higher blood-pressure levels.
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36 Caucasians
37 E23K
38 E23K variant
39 East Asian studies
40 Herein
41 Japanese population
42 KCNJ11 E23K
43 KCNJ11 E23K variant
44 SNPs
45 T2D patients
46 T2D susceptibility
47 T2D.
48 association
49 association studies
50 blood pressure levels
51 case-control association study
52 contribution
53 control subjects
54 diabetes
55 diabetes susceptibility
56 discordant results
57 disease-associated SNPs
58 disequilibrium
59 dominant genetic model
60 evidence
61 gene locus
62 genes
63 genetic association studies
64 genetic model
65 genetic variants
66 genotypes
67 haplotype structure
68 higher blood pressure levels
69 levels
70 linkage disequilibrium
71 loci
72 model
73 non-Caucasian populations
74 patients
75 patterns
76 population
77 presence
78 pressure levels
79 region
80 results
81 role
82 significant association
83 significant role
84 strong linkage disequilibrium
85 structure
86 study
87 subjects
88 susceptibility
89 total
90 type 2 diabetes
91 variants
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