Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-02

AUTHORS

Jung-Min Koh, Bermseok Oh, Jong Yong Lee, Jong-Keuk Lee, Kuchan Kimm, Ghi Su Kim, Byung Lae Park, Hyun Sub Cheong, Hyoung Doo Shin, Jung Min Hong, Tae-Ho Kim, Eui Kyun Park, Shin-Yoon Kim

ABSTRACT

Bone mineral density (BMD), the major factor determining bone strength, is closely related to osteoporotic fracture risk and is determined largely by multiple genetic factors. Semaphorin 7a (SEMA7A), a recently described member of the semaphorin family, has been shown to play a critical role in the activation of monocyte/macrophages that share progenitors with bone-resorbing osteoclasts and thus might contribute to osteoclast development. In the present study, we directly sequenced the SEMA7A gene in 24 Korean individuals, and identified 15 sequence variants. Five polymorphisms (+15667G > A, +15775C > G, +16285C > T, +19317C > T, +22331A > G) were selected and genotyped in postmenopausal Korean women (n = 560) together with measurement of the areal BMD (g/cm2) of the anterior-posterior lumbar spine and the non-dominant proximal femur using dual-energy X-ray absorptiometry. We found that polymorphisms of the SEMA7A gene were associated with the BMD of the lumbar spine and femoral neck. SEMA7A + 15775C > G and SEMA7A+22331A > G were associated with low BMD of the femoral neck (P = 0.02) and lumbar spine (P = 0.04) in a recessive model. SEMA7A-ht4 also showed an association with risk of vertebral fracture (OR = 1.87-1.93, P = 0.02-0.03). Our results suggest that variations in SEMA7A may play a role in decreased BMD and risk of vertebral fracture. More... »

PAGES

112

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10038-005-0331-z

DOI

http://dx.doi.org/10.1007/s10038-005-0331-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025862933

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16372136


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10038-005-0331-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10038-005-0331-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10038-005-0331-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10038-005-0331-z'


 

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308 schema:name Division of Endocrinology and Metabolism, University of Ulsan College of Medicine, Asan Medical Center, 138-736 Seoul, Republic of Korea
309 Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, 44-2, Samduk 2-ga, Jung-gu, 700-412 Daegu, Republic of Korea
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311 https://www.grid.ac/institutes/grid.415482.e schema:alternateName Korea National Institute of Health
312 schema:name National Genome Research Institute, National Institute of Health, 5 Nokbun-Dong, Eunpyung-Ku, 122-701 Seoul, South Korea
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315 schema:name Department of Genetic Epidemiology, SNP Genetics, 11th Floor, Maehun B/D, 13 Chongro 4 Ga, Chongro Gu, 110-834 Seoul, Republic of Korea
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