Characterization of liver-cirrhosis nodules by analysis of gene-expression profiles and patterns of allelic loss View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-04-21

AUTHORS

Hisaki Nagai, Yoshie Terada, Takashi Tajiri, Aya Yabe, Masamitsu Onda, Takemitsu Nagahata, Yoichi Ezura, Masaharu Minegishi, Maya Horiguchi, Masaru Baba, Noboru Konishi, Mitsuru Emi

ABSTRACT

To disclose genetic mechanisms involved in development or progression of hepatocellular carcinoma (HCC), we used a genome-wide cDNA microarray consisting of 8,448 genes to compare gene-expression profiles among 12 liver-cirrhosis nodules (LCNs) and five specimens of HCC excised from a single patient and carefully prepared by laser-capture microdissection (LCM). The expression patterns enabled us to identify 72 genes that were frequently upregulated and 57 that were downregulated specifically in the LCN specimens as compared to the HCCs. We also documented upregulation of 31 genes and downregulation of seven others in both HCC and LCN tissues. Several types of intracellular kinase, including receptor-type kinase, were upregulated in LCNs. Expression patterns of HCCs and LCNs generally represented two genetically distinct groups when subjected to a hierarchical clustering analysis, although expression profiles of two of the LCNs resembled the HCC pattern. Analysis of allelic losses at microsatellite loci revealed that LCNs showed frequent loss of heterozygosity (LOH) (33%) in chromosomal regions 6q and 22q; over half of the LCNs had lost an allele for at least one of the 28 loci examined. The presence of early genetic changes among LCNs, with additional genetic changes occurring during formation of HCCs, suggests that hepatocellular carcinogenesis follows the multistep model established for colon cancers and that some LCNs may be precancerous lesions. More... »

PAGES

246-255

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10038-004-0141-8

DOI

http://dx.doi.org/10.1007/s10038-004-0141-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030619840

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15362568


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Cirrhosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microdissection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microsatellite Repeats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagai", 
        "givenName": "Hisaki", 
        "id": "sg:person.010462130212.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010462130212.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery I, Nippon Medical School, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
            "Department of Surgery I, Nippon Medical School, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terada", 
        "givenName": "Yoshie", 
        "id": "sg:person.0750300512.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750300512.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery I, Nippon Medical School, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Surgery I, Nippon Medical School, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tajiri", 
        "givenName": "Takashi", 
        "id": "sg:person.01357202667.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357202667.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yabe", 
        "givenName": "Aya", 
        "id": "sg:person.01016413712.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016413712.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onda", 
        "givenName": "Masamitsu", 
        "id": "sg:person.015465413642.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015465413642.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagahata", 
        "givenName": "Takemitsu", 
        "id": "sg:person.0666416066.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666416066.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ezura", 
        "givenName": "Yoichi", 
        "id": "sg:person.01155067465.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155067465.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minegishi", 
        "givenName": "Masaharu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horiguchi", 
        "givenName": "Maya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine III, Mie University School of Medicine, Tsu, Japan", 
          "id": "http://www.grid.ac/institutes/grid.260026.0", 
          "name": [
            "Department of Internal Medicine III, Mie University School of Medicine, Tsu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baba", 
        "givenName": "Masaru", 
        "id": "sg:person.01035725256.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035725256.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Nara Medical University, Kashihara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410814.8", 
          "name": [
            "Department of Pathology, Nara Medical University, Kashihara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konishi", 
        "givenName": "Noboru", 
        "id": "sg:person.01005567302.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005567302.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Emi", 
        "givenName": "Mitsuru", 
        "id": "sg:person.01220643002.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220643002.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/2496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016917923", 
          "https://doi.org/10.1038/2496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034135571", 
          "https://doi.org/10.1038/bjc.1997.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043363395", 
          "https://doi.org/10.1038/sj.onc.1201136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/380152a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046083652", 
          "https://doi.org/10.1038/380152a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051720680", 
          "https://doi.org/10.1038/sj.onc.1202279"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-04-21", 
    "datePublishedReg": "2004-04-21", 
    "description": "To disclose genetic mechanisms involved in development or progression of hepatocellular carcinoma (HCC), we used a genome-wide cDNA microarray consisting of 8,448 genes to compare gene-expression profiles among 12 liver-cirrhosis nodules (LCNs) and five specimens of HCC excised from a single patient and carefully prepared by laser-capture microdissection (LCM). The expression patterns enabled us to identify 72 genes that were frequently upregulated and 57 that were downregulated specifically in the LCN specimens as compared to the HCCs. We also documented upregulation of 31 genes and downregulation of seven others in both HCC and LCN tissues. Several types of intracellular kinase, including receptor-type kinase, were upregulated in LCNs. Expression patterns of HCCs and LCNs generally represented two genetically distinct groups when subjected to a hierarchical clustering analysis, although expression profiles of two of the LCNs resembled the HCC pattern. Analysis of allelic losses at microsatellite loci revealed that LCNs showed frequent loss of heterozygosity (LOH) (33%) in chromosomal regions 6q and 22q; over half of the LCNs had lost an allele for at least one of the 28 loci examined. The presence of early genetic changes among LCNs, with additional genetic changes occurring during formation of HCCs, suggests that hepatocellular carcinogenesis follows the multistep model established for colon cancers and that some LCNs may be precancerous lesions.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10038-004-0141-8", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1294984", 
        "issn": [
          "1434-5161", 
          "1435-232X"
        ], 
        "name": "Journal of Human Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "49"
      }
    ], 
    "keywords": [
      "gene expression profiles", 
      "laser capture microdissection", 
      "expression patterns", 
      "genetic changes", 
      "genome-wide cDNA microarray", 
      "receptor-type kinase", 
      "microsatellite loci", 
      "cDNA microarray", 
      "additional genetic changes", 
      "allelic loss", 
      "genetic mechanisms", 
      "intracellular kinases", 
      "expression profiles", 
      "early genetic changes", 
      "genes", 
      "kinase", 
      "frequent loss", 
      "loci", 
      "distinct groups", 
      "hierarchical clustering analysis", 
      "multistep model", 
      "hepatocellular carcinogenesis", 
      "formation of HCC", 
      "clustering analysis", 
      "colon cancer", 
      "heterozygosity", 
      "microarray", 
      "alleles", 
      "downregulation", 
      "patterns", 
      "microdissection", 
      "upregulation", 
      "hepatocellular carcinoma", 
      "carcinogenesis", 
      "loss", 
      "tissue", 
      "profile", 
      "mechanism", 
      "progression", 
      "analysis", 
      "nodules", 
      "characterization", 
      "changes", 
      "formation", 
      "cancer", 
      "development", 
      "presence", 
      "specimens of HCC", 
      "specimens", 
      "types", 
      "precancerous lesions", 
      "single patient", 
      "half", 
      "HCC pattern", 
      "carcinoma", 
      "group", 
      "patients", 
      "lesions", 
      "model"
    ], 
    "name": "Characterization of liver-cirrhosis nodules by analysis of gene-expression profiles and patterns of allelic loss", 
    "pagination": "246-255", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030619840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10038-004-0141-8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15362568"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10038-004-0141-8", 
      "https://app.dimensions.ai/details/publication/pub.1030619840"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_385.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10038-004-0141-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10038-004-0141-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10038-004-0141-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10038-004-0141-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10038-004-0141-8'


 

This table displays all metadata directly associated to this object as RDF triples.

267 TRIPLES      21 PREDICATES      100 URIs      87 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10038-004-0141-8 schema:about N0590cfa79a2a4efcbf839bf837c642ca
2 N202edb4c16d9465894f5dd24936216c2
3 N257783bfbb6d45f28478a409c60366d8
4 N375061e7cf2c41bc89e0cee1833b2247
5 N401e97b39f7449c7909d94314ad2e1a4
6 N6aedb7fd97d340188aee32c211a21375
7 N775db69319bc499d907e9a0a78f38e16
8 N974cd3ea605f4564970498ae4546d84c
9 N9b3f198550ba48cca6910e4ae8946aae
10 Na0a113bcae464256bf239db7e69fff1e
11 Nb6d7acca63674ce28e0d90fc1fa1e7b5
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author Nb640a62f18e943898782b7b32bcbd6e3
15 schema:citation sg:pub.10.1038/2496
16 sg:pub.10.1038/380152a0
17 sg:pub.10.1038/bjc.1997.43
18 sg:pub.10.1038/sj.onc.1201136
19 sg:pub.10.1038/sj.onc.1202279
20 schema:datePublished 2004-04-21
21 schema:datePublishedReg 2004-04-21
22 schema:description To disclose genetic mechanisms involved in development or progression of hepatocellular carcinoma (HCC), we used a genome-wide cDNA microarray consisting of 8,448 genes to compare gene-expression profiles among 12 liver-cirrhosis nodules (LCNs) and five specimens of HCC excised from a single patient and carefully prepared by laser-capture microdissection (LCM). The expression patterns enabled us to identify 72 genes that were frequently upregulated and 57 that were downregulated specifically in the LCN specimens as compared to the HCCs. We also documented upregulation of 31 genes and downregulation of seven others in both HCC and LCN tissues. Several types of intracellular kinase, including receptor-type kinase, were upregulated in LCNs. Expression patterns of HCCs and LCNs generally represented two genetically distinct groups when subjected to a hierarchical clustering analysis, although expression profiles of two of the LCNs resembled the HCC pattern. Analysis of allelic losses at microsatellite loci revealed that LCNs showed frequent loss of heterozygosity (LOH) (33%) in chromosomal regions 6q and 22q; over half of the LCNs had lost an allele for at least one of the 28 loci examined. The presence of early genetic changes among LCNs, with additional genetic changes occurring during formation of HCCs, suggests that hepatocellular carcinogenesis follows the multistep model established for colon cancers and that some LCNs may be precancerous lesions.
23 schema:genre article
24 schema:isAccessibleForFree true
25 schema:isPartOf N7517fa97b7f9451ca01cb40693684378
26 Ncadedb0e7e5145a594593d4538830a69
27 sg:journal.1294984
28 schema:keywords HCC pattern
29 additional genetic changes
30 alleles
31 allelic loss
32 analysis
33 cDNA microarray
34 cancer
35 carcinogenesis
36 carcinoma
37 changes
38 characterization
39 clustering analysis
40 colon cancer
41 development
42 distinct groups
43 downregulation
44 early genetic changes
45 expression patterns
46 expression profiles
47 formation
48 formation of HCC
49 frequent loss
50 gene expression profiles
51 genes
52 genetic changes
53 genetic mechanisms
54 genome-wide cDNA microarray
55 group
56 half
57 hepatocellular carcinogenesis
58 hepatocellular carcinoma
59 heterozygosity
60 hierarchical clustering analysis
61 intracellular kinases
62 kinase
63 laser capture microdissection
64 lesions
65 loci
66 loss
67 mechanism
68 microarray
69 microdissection
70 microsatellite loci
71 model
72 multistep model
73 nodules
74 patients
75 patterns
76 precancerous lesions
77 presence
78 profile
79 progression
80 receptor-type kinase
81 single patient
82 specimens
83 specimens of HCC
84 tissue
85 types
86 upregulation
87 schema:name Characterization of liver-cirrhosis nodules by analysis of gene-expression profiles and patterns of allelic loss
88 schema:pagination 246-255
89 schema:productId N59adfb1d75434e67b02bd4dd1cf624b1
90 N6548c84fae0e403391dee291be69f351
91 N7e4e5ac69f8648c99234d5dcf9874e70
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030619840
93 https://doi.org/10.1007/s10038-004-0141-8
94 schema:sdDatePublished 2022-12-01T06:24
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N4eec446a2abe430196c3a24c8e5d2bb6
97 schema:url https://doi.org/10.1007/s10038-004-0141-8
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N0590cfa79a2a4efcbf839bf837c642ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Male
103 rdf:type schema:DefinedTerm
104 N10c8bf8810c34395826696c522be1113 rdf:first sg:person.015465413642.39
105 rdf:rest Nb2c23bdc0fef40fab2a2d687376eaeab
106 N202edb4c16d9465894f5dd24936216c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Oligonucleotide Array Sequence Analysis
108 rdf:type schema:DefinedTerm
109 N2338c802d70f487f85fe08bbc0a51adc rdf:first sg:person.01016413712.17
110 rdf:rest N10c8bf8810c34395826696c522be1113
111 N24fe0d40f5c94997b96d6365f49d0ae7 schema:affiliation grid-institutes:grid.410821.e
112 schema:familyName Horiguchi
113 schema:givenName Maya
114 rdf:type schema:Person
115 N257783bfbb6d45f28478a409c60366d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Microdissection
117 rdf:type schema:DefinedTerm
118 N2f99d41d506e47b89969a9c208d09fc8 rdf:first sg:person.01155067465.94
119 rdf:rest N68f7da5d99cb489eb886147c3d519a71
120 N375061e7cf2c41bc89e0cee1833b2247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Loss of Heterozygosity
122 rdf:type schema:DefinedTerm
123 N401e97b39f7449c7909d94314ad2e1a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Liver Cirrhosis
125 rdf:type schema:DefinedTerm
126 N4029fbf6c0ee4b2688e9a665b640d98f schema:affiliation grid-institutes:grid.410821.e
127 schema:familyName Minegishi
128 schema:givenName Masaharu
129 rdf:type schema:Person
130 N4c3a9c3c48164f65a46bac857f9a196a rdf:first sg:person.01005567302.78
131 rdf:rest Nf94ff8f57af4412abb42ae84fe829af7
132 N4eec446a2abe430196c3a24c8e5d2bb6 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N59adfb1d75434e67b02bd4dd1cf624b1 schema:name pubmed_id
135 schema:value 15362568
136 rdf:type schema:PropertyValue
137 N6548c84fae0e403391dee291be69f351 schema:name doi
138 schema:value 10.1007/s10038-004-0141-8
139 rdf:type schema:PropertyValue
140 N68f7da5d99cb489eb886147c3d519a71 rdf:first N4029fbf6c0ee4b2688e9a665b640d98f
141 rdf:rest Ncf1082f254ae431ab3e0c8ef2379b6ad
142 N6946cc69257c4630bbb2ad026a20b26f rdf:first sg:person.0750300512.91
143 rdf:rest N7d89bfa6588d469f9b68113eaeff1d0c
144 N6aedb7fd97d340188aee32c211a21375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Liver Neoplasms
146 rdf:type schema:DefinedTerm
147 N7517fa97b7f9451ca01cb40693684378 schema:issueNumber 5
148 rdf:type schema:PublicationIssue
149 N775db69319bc499d907e9a0a78f38e16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Middle Aged
151 rdf:type schema:DefinedTerm
152 N7d89bfa6588d469f9b68113eaeff1d0c rdf:first sg:person.01357202667.08
153 rdf:rest N2338c802d70f487f85fe08bbc0a51adc
154 N7e4e5ac69f8648c99234d5dcf9874e70 schema:name dimensions_id
155 schema:value pub.1030619840
156 rdf:type schema:PropertyValue
157 N974cd3ea605f4564970498ae4546d84c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Gene Expression Profiling
159 rdf:type schema:DefinedTerm
160 N9b3f198550ba48cca6910e4ae8946aae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Carcinoma, Hepatocellular
162 rdf:type schema:DefinedTerm
163 N9dd28d5033e948fd82e8571456902190 rdf:first sg:person.01035725256.12
164 rdf:rest N4c3a9c3c48164f65a46bac857f9a196a
165 Na0a113bcae464256bf239db7e69fff1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 Nb2c23bdc0fef40fab2a2d687376eaeab rdf:first sg:person.0666416066.97
169 rdf:rest N2f99d41d506e47b89969a9c208d09fc8
170 Nb640a62f18e943898782b7b32bcbd6e3 rdf:first sg:person.010462130212.30
171 rdf:rest N6946cc69257c4630bbb2ad026a20b26f
172 Nb6d7acca63674ce28e0d90fc1fa1e7b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Microsatellite Repeats
174 rdf:type schema:DefinedTerm
175 Ncadedb0e7e5145a594593d4538830a69 schema:volumeNumber 49
176 rdf:type schema:PublicationVolume
177 Ncf1082f254ae431ab3e0c8ef2379b6ad rdf:first N24fe0d40f5c94997b96d6365f49d0ae7
178 rdf:rest N9dd28d5033e948fd82e8571456902190
179 Nf94ff8f57af4412abb42ae84fe829af7 rdf:first sg:person.01220643002.08
180 rdf:rest rdf:nil
181 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biological Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
185 schema:name Genetics
186 rdf:type schema:DefinedTerm
187 sg:journal.1294984 schema:issn 1434-5161
188 1435-232X
189 schema:name Journal of Human Genetics
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.01005567302.78 schema:affiliation grid-institutes:grid.410814.8
193 schema:familyName Konishi
194 schema:givenName Noboru
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005567302.78
196 rdf:type schema:Person
197 sg:person.01016413712.17 schema:affiliation grid-institutes:grid.410821.e
198 schema:familyName Yabe
199 schema:givenName Aya
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016413712.17
201 rdf:type schema:Person
202 sg:person.01035725256.12 schema:affiliation grid-institutes:grid.260026.0
203 schema:familyName Baba
204 schema:givenName Masaru
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035725256.12
206 rdf:type schema:Person
207 sg:person.010462130212.30 schema:affiliation grid-institutes:grid.410821.e
208 schema:familyName Nagai
209 schema:givenName Hisaki
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010462130212.30
211 rdf:type schema:Person
212 sg:person.01155067465.94 schema:affiliation grid-institutes:grid.410821.e
213 schema:familyName Ezura
214 schema:givenName Yoichi
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155067465.94
216 rdf:type schema:Person
217 sg:person.01220643002.08 schema:affiliation grid-institutes:grid.410821.e
218 schema:familyName Emi
219 schema:givenName Mitsuru
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220643002.08
221 rdf:type schema:Person
222 sg:person.01357202667.08 schema:affiliation grid-institutes:grid.410821.e
223 schema:familyName Tajiri
224 schema:givenName Takashi
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357202667.08
226 rdf:type schema:Person
227 sg:person.015465413642.39 schema:affiliation grid-institutes:grid.410821.e
228 schema:familyName Onda
229 schema:givenName Masamitsu
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015465413642.39
231 rdf:type schema:Person
232 sg:person.0666416066.97 schema:affiliation grid-institutes:grid.410821.e
233 schema:familyName Nagahata
234 schema:givenName Takemitsu
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666416066.97
236 rdf:type schema:Person
237 sg:person.0750300512.91 schema:affiliation grid-institutes:grid.410821.e
238 schema:familyName Terada
239 schema:givenName Yoshie
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750300512.91
241 rdf:type schema:Person
242 sg:pub.10.1038/2496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016917923
243 https://doi.org/10.1038/2496
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/380152a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046083652
246 https://doi.org/10.1038/380152a0
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/bjc.1997.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034135571
249 https://doi.org/10.1038/bjc.1997.43
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/sj.onc.1201136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043363395
252 https://doi.org/10.1038/sj.onc.1201136
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/sj.onc.1202279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051720680
255 https://doi.org/10.1038/sj.onc.1202279
256 rdf:type schema:CreativeWork
257 grid-institutes:grid.260026.0 schema:alternateName Department of Internal Medicine III, Mie University School of Medicine, Tsu, Japan
258 schema:name Department of Internal Medicine III, Mie University School of Medicine, Tsu, Japan
259 rdf:type schema:Organization
260 grid-institutes:grid.410814.8 schema:alternateName Department of Pathology, Nara Medical University, Kashihara, Japan
261 schema:name Department of Pathology, Nara Medical University, Kashihara, Japan
262 rdf:type schema:Organization
263 grid-institutes:grid.410821.e schema:alternateName Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan
264 Department of Surgery I, Nippon Medical School, Kawasaki, Japan
265 schema:name Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396 Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan
266 Department of Surgery I, Nippon Medical School, Kawasaki, Japan
267 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...