Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-10

AUTHORS

Chiaki Murakami, Yuka Yoshida, Tatsuya Yamazaki, Ayako Yamazaki, Satoshi Nakata, Yohei Hokama, Shogo Ishiuchi, Jiro Akimoto, Yukiko Shishido-Hara, Yuhei Yoshimoto, Nozomi Matsumura, Sumihito Nobusawa, Hayato Ikota, Hideaki Yokoo

ABSTRACT

We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to round polygonal cells including some pleomorphic cells. The tumors had less ability to infiltrate into the adjacent brain parenchyma and presented a circumscribed growth pattern. Mitosis was readily found, accompanied by focal necrosis and/or microvascular proliferation. Tumors were histologically similar in part to pleomorphic xanthoastrocytoma (PXA) or anaplastic PXA, but did not fit criteria for either neoplasm. A BRAF V600E mutation and homozygous deletion of CDKN2A/B were observed, which is similar to the genetic features of PXA or epithelioid glioblastoma, but the additional loss of ATRX nuclear immunoreactivity and absence of TERT promoter mutation were unusual findings, indicating a novel genetic profile. Despite their malignant histological features, all patients had a favorable clinical course and remained alive for 6 months to 28 years under standard medical treatment for malignant glioma. In summary, high grade astrocytomas with BRAF V600E, ATRX, and CDKN2A/B alternations had unique clinicopathological features and may be a novel subset of high grade glioma. More... »

References to SciGraph publications

  • 2018-11. Cerebellar glioblastoma: a clinical series with contemporary molecular analysis in ACTA NEUROCHIRURGICA
  • 2018-10. Pediatric low-grade gliomas can be molecularly stratified for risk in ACTA NEUROPATHOLOGICA
  • 2018-12. The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma in NATURE COMMUNICATIONS
  • 2013-12. Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system in ACTA NEUROPATHOLOGICA
  • 2016-01. BRAF alteration status and the histone H3F3A gene K27M mutation segregate spinal cord astrocytoma histology in ACTA NEUROPATHOLOGICA
  • 2018-12. The genetic landscape of ganglioglioma in ACTA NEUROPATHOLOGICA COMMUNICATIONS
  • 2007-02. Frequent loss of chromosome 9, homozygous CDKN2A/p14ARF/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas in ONCOGENE
  • 2018-08. Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations in ACTA NEUROPATHOLOGICA
  • 2016-12. Glioblastoma multiforme versus pleomorphic xanthoastrocytoma with anaplastic features in the pathological diagnosis: a case report in DIAGNOSTIC PATHOLOGY
  • 2015-05. Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers in ACTA NEUROPATHOLOGICA
  • 2012-10. Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma in BRAIN TUMOR PATHOLOGY
  • 2011-03. Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma in ACTA NEUROPATHOLOGICA
  • 2017-05. Whole-genome landscapes of major melanoma subtypes in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10014-019-00344-z

    DOI

    http://dx.doi.org/10.1007/s10014-019-00344-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113356207

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30972500


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan. m15702002@gunma-u.ac.jp."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Murakami", 
            "givenName": "Chiaki", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshida", 
            "givenName": "Yuka", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamazaki", 
            "givenName": "Tatsuya", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamazaki", 
            "givenName": "Ayako", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakata", 
            "givenName": "Satoshi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of the Ryukyus", 
              "id": "https://www.grid.ac/institutes/grid.267625.2", 
              "name": [
                "Department of Neurosurgery, University of the Ryukyus Graduate School of Medicine, Okinawa, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hokama", 
            "givenName": "Yohei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of the Ryukyus", 
              "id": "https://www.grid.ac/institutes/grid.267625.2", 
              "name": [
                "Department of Neurosurgery, University of the Ryukyus Graduate School of Medicine, Okinawa, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishiuchi", 
            "givenName": "Shogo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410793.8", 
              "name": [
                "Department of Neurosurgery, Tokyo Medical University, Tokyo, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akimoto", 
            "givenName": "Jiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical University", 
              "id": "https://www.grid.ac/institutes/grid.410793.8", 
              "name": [
                "Department of Pathology, Tokyo Medical University, Tokyo, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shishido-Hara", 
            "givenName": "Yukiko", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshimoto", 
            "givenName": "Yuhei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsumura", 
            "givenName": "Nozomi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nobusawa", 
            "givenName": "Sumihito", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ikota", 
            "givenName": "Hayato", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gunma University", 
              "id": "https://www.grid.ac/institutes/grid.256642.1", 
              "name": [
                "Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yokoo", 
            "givenName": "Hideaki", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1200/jco.2014.58.3922", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001241304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/nan.12138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003536768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1492-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003726796", 
              "https://doi.org/10.1007/s00401-015-1492-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1492-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003726796", 
              "https://doi.org/10.1007/s00401-015-1492-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10014-012-0085-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007631511", 
              "https://doi.org/10.1007/s10014-012-0085-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2012.46.0220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011429411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.12.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012801617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013549073", 
              "https://doi.org/10.1038/sj.onc.1209851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013549073", 
              "https://doi.org/10.1038/sj.onc.1209851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1239947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019456048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0802-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021699084", 
              "https://doi.org/10.1007/s00401-011-0802-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/nan.12196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023247140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-013-1195-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025590471", 
              "https://doi.org/10.1007/s00401-013-1195-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-015-1405-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025614916", 
              "https://doi.org/10.1007/s00401-015-1405-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027420732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028617045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.2010.00395.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028639363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034502255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13000-016-0514-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042501779", 
              "https://doi.org/10.1186/s13000-016-0514-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13000-016-0514-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042501779", 
              "https://doi.org/10.1186/s13000-016-0514-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.5456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044412063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1407279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044684277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.1996.tb00848.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048755379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083736368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083736368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/neup.12370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083738972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085123990", 
              "https://doi.org/10.1038/nature22071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature22071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085123990", 
              "https://doi.org/10.1038/nature22071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092131744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092131744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092533887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092533887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1837-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101673014", 
              "https://doi.org/10.1007/s00401-018-1837-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1837-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101673014", 
              "https://doi.org/10.1007/s00401-018-1837-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2018.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103971109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccell.2018.04.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103971109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-04448-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104185743", 
              "https://doi.org/10.1038/s41467-018-04448-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-018-04448-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104185743", 
              "https://doi.org/10.1038/s41467-018-04448-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-018-0551-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104468379", 
              "https://doi.org/10.1186/s40478-018-0551-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40478-018-0551-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104468379", 
              "https://doi.org/10.1186/s40478-018-0551-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-018-1874-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104555462", 
              "https://doi.org/10.1007/s00401-018-1874-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bpa.12639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105874328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00701-018-3673-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1106908194", 
              "https://doi.org/10.1007/s00701-018-3673-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cas.13903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111098915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cas.13903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111098915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cas.13903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1111098915"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-10", 
        "datePublishedReg": "2019-04-10", 
        "description": "We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to round polygonal cells including some pleomorphic cells. The tumors had less ability to infiltrate into the adjacent brain parenchyma and presented a circumscribed growth pattern. Mitosis was readily found, accompanied by focal necrosis and/or microvascular proliferation. Tumors were histologically similar in part to pleomorphic xanthoastrocytoma (PXA) or anaplastic PXA, but did not fit criteria for either neoplasm. A BRAF V600E mutation and homozygous deletion of CDKN2A/B were observed, which is similar to the genetic features of PXA or epithelioid glioblastoma, but the additional loss of ATRX nuclear immunoreactivity and absence of TERT promoter mutation were unusual findings, indicating a novel genetic profile. Despite their malignant histological features, all patients had a favorable clinical course and remained alive for 6\u00a0months to 28\u00a0years under standard medical treatment for malignant glioma. In summary, high grade astrocytomas with BRAF V600E, ATRX, and CDKN2A/B alternations had unique clinicopathological features and may be a novel subset of high grade glioma.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10014-019-00344-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1104595", 
            "issn": [
              "1433-7398", 
              "1861-387X"
            ], 
            "name": "Brain Tumor Pathology", 
            "type": "Periodical"
          }
        ], 
        "name": "Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations.", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10014-019-00344-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113356207"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9716507"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30972500"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10014-019-00344-z", 
          "https://app.dimensions.ai/details/publication/pub.1113356207"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T09:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56196_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s10014-019-00344-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10014-019-00344-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10014-019-00344-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10014-019-00344-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10014-019-00344-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    256 TRIPLES      20 PREDICATES      57 URIs      16 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10014-019-00344-z schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N5fa729a4503e4ecf852673db5dc388b8
    4 schema:citation sg:pub.10.1007/s00401-011-0802-6
    5 sg:pub.10.1007/s00401-013-1195-5
    6 sg:pub.10.1007/s00401-015-1405-4
    7 sg:pub.10.1007/s00401-015-1492-2
    8 sg:pub.10.1007/s00401-018-1837-8
    9 sg:pub.10.1007/s00401-018-1874-3
    10 sg:pub.10.1007/s00701-018-3673-y
    11 sg:pub.10.1007/s10014-012-0085-1
    12 sg:pub.10.1038/nature22071
    13 sg:pub.10.1038/s41467-018-04448-6
    14 sg:pub.10.1038/sj.onc.1209851
    15 sg:pub.10.1186/s13000-016-0514-2
    16 sg:pub.10.1186/s40478-018-0551-z
    17 https://doi.org/10.1016/j.ccell.2018.04.004
    18 https://doi.org/10.1016/j.cell.2015.12.028
    19 https://doi.org/10.1056/nejmoa1407279
    20 https://doi.org/10.1111/bpa.12210
    21 https://doi.org/10.1111/bpa.12367
    22 https://doi.org/10.1111/bpa.12495
    23 https://doi.org/10.1111/bpa.12566
    24 https://doi.org/10.1111/bpa.12572
    25 https://doi.org/10.1111/bpa.12639
    26 https://doi.org/10.1111/cas.13903
    27 https://doi.org/10.1111/j.1750-3639.1996.tb00848.x
    28 https://doi.org/10.1111/j.1750-3639.2010.00395.x
    29 https://doi.org/10.1111/nan.12138
    30 https://doi.org/10.1111/nan.12196
    31 https://doi.org/10.1111/neup.12370
    32 https://doi.org/10.1126/science.1239947
    33 https://doi.org/10.1200/jco.2012.46.0220
    34 https://doi.org/10.1200/jco.2014.58.3922
    35 https://doi.org/10.18632/oncotarget.5456
    36 https://doi.org/10.18632/oncotarget.964
    37 schema:datePublished 2019-04-10
    38 schema:datePublishedReg 2019-04-10
    39 schema:description We report four cases of high-grade astrocytoma with a BRAF V600E mutation, ATRX inactivation, and CDKN2A/B homozygous deletion. Children to young adults aged 3-46 presented with a well demarcated contrast-enhancing mass in the supratentorial area. Pathological examination revealed packed growth of short spindle to round polygonal cells including some pleomorphic cells. The tumors had less ability to infiltrate into the adjacent brain parenchyma and presented a circumscribed growth pattern. Mitosis was readily found, accompanied by focal necrosis and/or microvascular proliferation. Tumors were histologically similar in part to pleomorphic xanthoastrocytoma (PXA) or anaplastic PXA, but did not fit criteria for either neoplasm. A BRAF V600E mutation and homozygous deletion of CDKN2A/B were observed, which is similar to the genetic features of PXA or epithelioid glioblastoma, but the additional loss of ATRX nuclear immunoreactivity and absence of TERT promoter mutation were unusual findings, indicating a novel genetic profile. Despite their malignant histological features, all patients had a favorable clinical course and remained alive for 6 months to 28 years under standard medical treatment for malignant glioma. In summary, high grade astrocytomas with BRAF V600E, ATRX, and CDKN2A/B alternations had unique clinicopathological features and may be a novel subset of high grade glioma.
    40 schema:genre research_article
    41 schema:inLanguage en
    42 schema:isAccessibleForFree false
    43 schema:isPartOf sg:journal.1104595
    44 schema:name Clinicopathological characteristics of circumscribed high-grade astrocytomas with an unusual combination of BRAF V600E, ATRX, and CDKN2A/B alternations.
    45 schema:productId N20849e3ed0ac44d6950cc4bd3e9321c6
    46 N788eb6f0129e45b8a8246028dd7d36de
    47 N990564afd6174f4ead1ee79fb3a54abd
    48 Nc2690ed35b13456c8b30d6be397bd916
    49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113356207
    50 https://doi.org/10.1007/s10014-019-00344-z
    51 schema:sdDatePublished 2019-04-15T09:28
    52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    53 schema:sdPublisher Nda313970221649fb97145fde809dbdf7
    54 schema:url http://link.springer.com/10.1007/s10014-019-00344-z
    55 sgo:license sg:explorer/license/
    56 sgo:sdDataset articles
    57 rdf:type schema:ScholarlyArticle
    58 N02dc2ad97b884206b868451dfc24b733 schema:affiliation https://www.grid.ac/institutes/grid.267625.2
    59 schema:familyName Ishiuchi
    60 schema:givenName Shogo
    61 rdf:type schema:Person
    62 N0da6ef32d02a4eed9f6ac8a962211c0e rdf:first N7303b9638078402581689f04a43cee39
    63 rdf:rest N7c3331d3ad1a40b58c84641b7d766b5f
    64 N18e84e5011174f0e9e65fe7e77e8f4b6 rdf:first Ne75a64b2c413465495841856999f5e72
    65 rdf:rest Ncdaf01fb462d49cd9f50ff6ceae8d319
    66 N20849e3ed0ac44d6950cc4bd3e9321c6 schema:name doi
    67 schema:value 10.1007/s10014-019-00344-z
    68 rdf:type schema:PropertyValue
    69 N2f7271113bcb48968dd04a7d9c592329 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    70 schema:familyName Murakami
    71 schema:givenName Chiaki
    72 rdf:type schema:Person
    73 N322c0445bd8d42d4b11a3f1ad8970eff schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    74 schema:familyName Ikota
    75 schema:givenName Hayato
    76 rdf:type schema:Person
    77 N3949444fcf5642d8925d701c002bd6cf rdf:first Ndb90719b7224451b9dc6a02bc3cbf09c
    78 rdf:rest N0da6ef32d02a4eed9f6ac8a962211c0e
    79 N46dae7151e9a4fa3b66088787cb4a24b rdf:first N322c0445bd8d42d4b11a3f1ad8970eff
    80 rdf:rest Nfeba63b1ebd2449fa0cc3162206fe907
    81 N489b6c719c7c44debdcdb5e8fd88dd14 schema:affiliation https://www.grid.ac/institutes/grid.267625.2
    82 schema:familyName Hokama
    83 schema:givenName Yohei
    84 rdf:type schema:Person
    85 N4e2516238bb6489e8cbb9050c49f813d schema:affiliation https://www.grid.ac/institutes/grid.410793.8
    86 schema:familyName Akimoto
    87 schema:givenName Jiro
    88 rdf:type schema:Person
    89 N55ae267bfae34fc4b3c7e19e52b52716 rdf:first Na040bc729f0f44a38f5e2a4aea98e6a7
    90 rdf:rest N3949444fcf5642d8925d701c002bd6cf
    91 N5fa729a4503e4ecf852673db5dc388b8 rdf:first N2f7271113bcb48968dd04a7d9c592329
    92 rdf:rest N55ae267bfae34fc4b3c7e19e52b52716
    93 N66416ff4f09a4b2c84d661d9a4a9b036 rdf:first N489b6c719c7c44debdcdb5e8fd88dd14
    94 rdf:rest Nbf97a7fac31644d1aff26bd58fa9b5a8
    95 N7205e873da2045558a5bd2a119a2f1c0 schema:affiliation https://www.grid.ac/institutes/grid.410793.8
    96 schema:familyName Shishido-Hara
    97 schema:givenName Yukiko
    98 rdf:type schema:Person
    99 N7303b9638078402581689f04a43cee39 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    100 schema:familyName Yamazaki
    101 schema:givenName Ayako
    102 rdf:type schema:Person
    103 N788eb6f0129e45b8a8246028dd7d36de schema:name dimensions_id
    104 schema:value pub.1113356207
    105 rdf:type schema:PropertyValue
    106 N7c3331d3ad1a40b58c84641b7d766b5f rdf:first Na01ac7ee12fb460d8644fb58632c94f5
    107 rdf:rest N66416ff4f09a4b2c84d661d9a4a9b036
    108 N8a51951413d74f6c920afa5847206bd5 rdf:first N4e2516238bb6489e8cbb9050c49f813d
    109 rdf:rest Nccb4db1a06ff47a0aa03c6525679b795
    110 N8b92120284cd4e7e91bca996a83e0260 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    111 schema:familyName Matsumura
    112 schema:givenName Nozomi
    113 rdf:type schema:Person
    114 N925e7ad0f35549769274db0c2089e5ad schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    115 schema:familyName Yokoo
    116 schema:givenName Hideaki
    117 rdf:type schema:Person
    118 N990564afd6174f4ead1ee79fb3a54abd schema:name nlm_unique_id
    119 schema:value 9716507
    120 rdf:type schema:PropertyValue
    121 Na01ac7ee12fb460d8644fb58632c94f5 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    122 schema:familyName Nakata
    123 schema:givenName Satoshi
    124 rdf:type schema:Person
    125 Na040bc729f0f44a38f5e2a4aea98e6a7 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    126 schema:familyName Yoshida
    127 schema:givenName Yuka
    128 rdf:type schema:Person
    129 Nbf97a7fac31644d1aff26bd58fa9b5a8 rdf:first N02dc2ad97b884206b868451dfc24b733
    130 rdf:rest N8a51951413d74f6c920afa5847206bd5
    131 Nc2690ed35b13456c8b30d6be397bd916 schema:name pubmed_id
    132 schema:value 30972500
    133 rdf:type schema:PropertyValue
    134 Nc5a81c39d18142cbb818b6efd0b6e39d schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    135 schema:familyName Nobusawa
    136 schema:givenName Sumihito
    137 rdf:type schema:Person
    138 Nccb4db1a06ff47a0aa03c6525679b795 rdf:first N7205e873da2045558a5bd2a119a2f1c0
    139 rdf:rest N18e84e5011174f0e9e65fe7e77e8f4b6
    140 Ncdaf01fb462d49cd9f50ff6ceae8d319 rdf:first N8b92120284cd4e7e91bca996a83e0260
    141 rdf:rest Nfb784ef96d6e4350a3b9916664e0bdbc
    142 Nda313970221649fb97145fde809dbdf7 schema:name Springer Nature - SN SciGraph project
    143 rdf:type schema:Organization
    144 Ndb90719b7224451b9dc6a02bc3cbf09c schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    145 schema:familyName Yamazaki
    146 schema:givenName Tatsuya
    147 rdf:type schema:Person
    148 Ne75a64b2c413465495841856999f5e72 schema:affiliation https://www.grid.ac/institutes/grid.256642.1
    149 schema:familyName Yoshimoto
    150 schema:givenName Yuhei
    151 rdf:type schema:Person
    152 Nfb784ef96d6e4350a3b9916664e0bdbc rdf:first Nc5a81c39d18142cbb818b6efd0b6e39d
    153 rdf:rest N46dae7151e9a4fa3b66088787cb4a24b
    154 Nfeba63b1ebd2449fa0cc3162206fe907 rdf:first N925e7ad0f35549769274db0c2089e5ad
    155 rdf:rest rdf:nil
    156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    157 schema:name Medical and Health Sciences
    158 rdf:type schema:DefinedTerm
    159 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Oncology and Carcinogenesis
    161 rdf:type schema:DefinedTerm
    162 sg:journal.1104595 schema:issn 1433-7398
    163 1861-387X
    164 schema:name Brain Tumor Pathology
    165 rdf:type schema:Periodical
    166 sg:pub.10.1007/s00401-011-0802-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021699084
    167 https://doi.org/10.1007/s00401-011-0802-6
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1007/s00401-013-1195-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025590471
    170 https://doi.org/10.1007/s00401-013-1195-5
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1007/s00401-015-1405-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025614916
    173 https://doi.org/10.1007/s00401-015-1405-4
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1007/s00401-015-1492-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003726796
    176 https://doi.org/10.1007/s00401-015-1492-2
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/s00401-018-1837-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101673014
    179 https://doi.org/10.1007/s00401-018-1837-8
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/s00401-018-1874-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104555462
    182 https://doi.org/10.1007/s00401-018-1874-3
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s00701-018-3673-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1106908194
    185 https://doi.org/10.1007/s00701-018-3673-y
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s10014-012-0085-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007631511
    188 https://doi.org/10.1007/s10014-012-0085-1
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nature22071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085123990
    191 https://doi.org/10.1038/nature22071
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/s41467-018-04448-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104185743
    194 https://doi.org/10.1038/s41467-018-04448-6
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/sj.onc.1209851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013549073
    197 https://doi.org/10.1038/sj.onc.1209851
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1186/s13000-016-0514-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042501779
    200 https://doi.org/10.1186/s13000-016-0514-2
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1186/s40478-018-0551-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1104468379
    203 https://doi.org/10.1186/s40478-018-0551-z
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1016/j.ccell.2018.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103971109
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/j.cell.2015.12.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012801617
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1056/nejmoa1407279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044684277
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1111/bpa.12210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027420732
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1111/bpa.12367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028617045
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1111/bpa.12495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083736368
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1111/bpa.12566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092131744
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1111/bpa.12572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092533887
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1111/bpa.12639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105874328
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1111/cas.13903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111098915
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1111/j.1750-3639.1996.tb00848.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048755379
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1111/j.1750-3639.2010.00395.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028639363
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1111/nan.12138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003536768
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1111/nan.12196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023247140
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1111/neup.12370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083738972
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1126/science.1239947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019456048
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1200/jco.2012.46.0220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011429411
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1200/jco.2014.58.3922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001241304
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.18632/oncotarget.5456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044412063
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.18632/oncotarget.964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034502255
    244 rdf:type schema:CreativeWork
    245 https://www.grid.ac/institutes/grid.256642.1 schema:alternateName Gunma University
    246 schema:name Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan.
    247 Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa, Maebashi, 371-8511, Gunma, Japan. m15702002@gunma-u.ac.jp.
    248 Department of Neurosurgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
    249 rdf:type schema:Organization
    250 https://www.grid.ac/institutes/grid.267625.2 schema:alternateName University of the Ryukyus
    251 schema:name Department of Neurosurgery, University of the Ryukyus Graduate School of Medicine, Okinawa, Japan.
    252 rdf:type schema:Organization
    253 https://www.grid.ac/institutes/grid.410793.8 schema:alternateName Tokyo Medical University
    254 schema:name Department of Neurosurgery, Tokyo Medical University, Tokyo, Japan.
    255 Department of Pathology, Tokyo Medical University, Tokyo, Japan.
    256 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...