Solvent free production of porous PDLLA/calcium carbonate composite scaffolds improves the release of bone growth factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-09-03

AUTHORS

H. Schliephake, M. Vucak, J. Boven, S. Backhaus, T. Annen, M. Epple

ABSTRACT

PurposeIncorporation of alkaline nano-/microparticles for neutralization of acidic degradation products into degradable polymer foams requires the use of organic solvents, which may compromise biocompatibility and may be associated with biological hazards. The aim of the present study was to develop and validate a solvent-free method to produce porous poly (DL-lactic acid)/calcium carbonate composite scaffolds (PDLLA/CaCO3) for controlled release of incorporated osteogenic growth factors.MethodsComposite PDLLA/CaCO3 granules were produced using a milling process and compared to composite material fabricated through a solution precipitation process using organic solvents. Particle size and mineral content were comparable in both groups. Supercritical carbon dioxide pressure was used to incorporate rhBMP2 into both composites.ResultsGas foaming resulted in comparable pore structures in both groups exhibiting a homogenous distribution of CaCO3 microparticles in the polymer scaffolds. The elasticity modulus of both types of scaffolds was not significantly different whereas the bending strength of the solvent-free produced scaffolds was significantly lower. The pH values remained constant between 6.90 and 7.25 during degradation of both composites. Release of BMP2 was significantly higher and the induction of alkaline phosphatase was more reliable in the group of scaffolds produced without organic solvents.ConclusionSolvent-free fabrication of composite PDLLA/CaCO3 scaffolds for controlled release of bone growth factors through gas foaming significantly enhances the release of growth factors and improves the biological efficacy of the incorporated growth factors. More... »

PAGES

133-141

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4

DOI

http://dx.doi.org/10.1007/s10006-014-0463-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007563721

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25178431


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biomedical Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0912", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Materials Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alkaline Phosphatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biocompatible Materials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Protein 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium Carbonate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Delayed-Action Preparations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyesters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Solvents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Scaffolds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schliephake", 
        "givenName": "H.", 
        "id": "sg:person.01222177644.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222177644.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Schaefer Kalk GmbH & Co. KG, Diez, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Schaefer Kalk GmbH & Co. KG, Diez, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vucak", 
        "givenName": "M.", 
        "id": "sg:person.015671204547.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015671204547.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boven", 
        "givenName": "J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Backhaus", 
        "givenName": "S.", 
        "id": "sg:person.01314067675.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314067675.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Annen", 
        "givenName": "T.", 
        "id": "sg:person.01217137174.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217137174.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Epple", 
        "givenName": "M.", 
        "id": "sg:person.011342402346.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011342402346.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1015948829632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051247890", 
          "https://doi.org/10.1023/a:1015948829632"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09-03", 
    "datePublishedReg": "2014-09-03", 
    "description": "PurposeIncorporation of alkaline nano-/microparticles for neutralization of acidic degradation products into degradable polymer foams requires the use of organic solvents, which may compromise biocompatibility and may be associated with biological hazards. The aim of the present study was to develop and validate a solvent-free method to produce porous poly (DL-lactic acid)/calcium carbonate composite scaffolds (PDLLA/CaCO3) for controlled release of incorporated osteogenic growth factors.MethodsComposite PDLLA/CaCO3 granules were produced using a milling process and compared to composite material fabricated through a solution precipitation process using organic solvents. Particle size and mineral content were comparable in both groups. Supercritical carbon dioxide pressure was used to incorporate rhBMP2 into both composites.ResultsGas foaming resulted in comparable pore structures in both groups\u00a0exhibiting a homogenous distribution of CaCO3 microparticles in the polymer scaffolds. The elasticity modulus of both types of scaffolds was not significantly different whereas the bending strength of the solvent-free produced scaffolds was significantly lower. The pH values remained constant between 6.90 and 7.25 during degradation of both composites. Release of BMP2 was significantly higher and the induction of alkaline phosphatase was more reliable in the group of scaffolds produced without organic solvents.ConclusionSolvent-free fabrication of composite PDLLA/CaCO3 scaffolds for controlled release of bone growth factors through gas foaming significantly enhances the release of growth factors and improves the biological efficacy of the incorporated growth factors.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10006-014-0463-4", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1412125", 
        "issn": [
          "1865-1550", 
          "1434-3940"
        ], 
        "name": "Oral and Maxillofacial Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "composite scaffolds", 
      "solution-precipitation process", 
      "release of BMP2", 
      "groups of scaffolds", 
      "gas foaming", 
      "composite materials", 
      "polymer foams", 
      "acidic degradation products", 
      "types of scaffolds", 
      "elasticity modulus", 
      "milling process", 
      "porous poly", 
      "pore structure", 
      "organic solvents", 
      "CaCO3 microparticles", 
      "particle size", 
      "bone growth factors", 
      "homogenous distribution", 
      "precipitation process", 
      "solvent-free method", 
      "composites", 
      "foaming", 
      "osteogenic growth factors", 
      "scaffolds", 
      "free production", 
      "fabrication", 
      "foam", 
      "modulus", 
      "nano", 
      "solvent", 
      "biocompatibility", 
      "polymers", 
      "microparticles", 
      "degradation products", 
      "strength", 
      "materials", 
      "process", 
      "poly", 
      "CaCO3", 
      "biological hazards", 
      "degradation", 
      "pressure", 
      "rhBMP2", 
      "structure", 
      "method", 
      "size", 
      "carbon dioxide pressure", 
      "release", 
      "distribution", 
      "hazards", 
      "content", 
      "biological efficacy", 
      "products", 
      "values", 
      "production", 
      "mineral content", 
      "factors", 
      "use", 
      "granules", 
      "types", 
      "present study", 
      "neutralization", 
      "study", 
      "aim", 
      "group", 
      "alkaline phosphatase", 
      "BMP2", 
      "growth factor", 
      "phosphatase", 
      "efficacy", 
      "induction"
    ], 
    "name": "Solvent free production of porous PDLLA/calcium carbonate composite scaffolds improves the release of bone growth factors", 
    "pagination": "133-141", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007563721"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10006-014-0463-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25178431"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10006-014-0463-4", 
      "https://app.dimensions.ai/details/publication/pub.1007563721"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_637.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10006-014-0463-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4'


 

This table displays all metadata directly associated to this object as RDF triples.

228 TRIPLES      21 PREDICATES      110 URIs      100 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10006-014-0463-4 schema:about N0815340fc5dc487e88b89837fa34c54d
2 N11f1ffb0c4b14e369e7d3ac05643cfc2
3 N3e69df2c5d43447a872d2b298945a247
4 N46fbe86a12da49489053571df6f75477
5 N5cdad75bde9c4940a90e022c1e570103
6 N8384fed8135747fd94a51a477e4cd36c
7 N84654bbd50e74ef5bad1ae9a07ef517c
8 Nae7362ca77a74433b20045aafbe9b7f4
9 Ncc51472f37c34662ad1effc3a3f07cba
10 Ndf38f3befca24ba5bb961b1b90404257
11 Ne5f1806397774f6e87ab5148486e4154
12 Nedd1c9f2cbbd441981685b80dd3125ab
13 anzsrc-for:09
14 anzsrc-for:0903
15 anzsrc-for:0912
16 schema:author N66862a61456a4c19bc4a1f3387cfec05
17 schema:citation sg:pub.10.1023/a:1015948829632
18 schema:datePublished 2014-09-03
19 schema:datePublishedReg 2014-09-03
20 schema:description PurposeIncorporation of alkaline nano-/microparticles for neutralization of acidic degradation products into degradable polymer foams requires the use of organic solvents, which may compromise biocompatibility and may be associated with biological hazards. The aim of the present study was to develop and validate a solvent-free method to produce porous poly (DL-lactic acid)/calcium carbonate composite scaffolds (PDLLA/CaCO3) for controlled release of incorporated osteogenic growth factors.MethodsComposite PDLLA/CaCO3 granules were produced using a milling process and compared to composite material fabricated through a solution precipitation process using organic solvents. Particle size and mineral content were comparable in both groups. Supercritical carbon dioxide pressure was used to incorporate rhBMP2 into both composites.ResultsGas foaming resulted in comparable pore structures in both groups exhibiting a homogenous distribution of CaCO3 microparticles in the polymer scaffolds. The elasticity modulus of both types of scaffolds was not significantly different whereas the bending strength of the solvent-free produced scaffolds was significantly lower. The pH values remained constant between 6.90 and 7.25 during degradation of both composites. Release of BMP2 was significantly higher and the induction of alkaline phosphatase was more reliable in the group of scaffolds produced without organic solvents.ConclusionSolvent-free fabrication of composite PDLLA/CaCO3 scaffolds for controlled release of bone growth factors through gas foaming significantly enhances the release of growth factors and improves the biological efficacy of the incorporated growth factors.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf N8ae2ab412fe046c4bc82c48b62d88a99
24 Nf2cf40d7ecb84681a778365b7e86b00a
25 sg:journal.1412125
26 schema:keywords BMP2
27 CaCO3
28 CaCO3 microparticles
29 acidic degradation products
30 aim
31 alkaline phosphatase
32 biocompatibility
33 biological efficacy
34 biological hazards
35 bone growth factors
36 carbon dioxide pressure
37 composite materials
38 composite scaffolds
39 composites
40 content
41 degradation
42 degradation products
43 distribution
44 efficacy
45 elasticity modulus
46 fabrication
47 factors
48 foam
49 foaming
50 free production
51 gas foaming
52 granules
53 group
54 groups of scaffolds
55 growth factor
56 hazards
57 homogenous distribution
58 induction
59 materials
60 method
61 microparticles
62 milling process
63 mineral content
64 modulus
65 nano
66 neutralization
67 organic solvents
68 osteogenic growth factors
69 particle size
70 phosphatase
71 poly
72 polymer foams
73 polymers
74 pore structure
75 porous poly
76 precipitation process
77 present study
78 pressure
79 process
80 production
81 products
82 release
83 release of BMP2
84 rhBMP2
85 scaffolds
86 size
87 solution-precipitation process
88 solvent
89 solvent-free method
90 strength
91 structure
92 study
93 types
94 types of scaffolds
95 use
96 values
97 schema:name Solvent free production of porous PDLLA/calcium carbonate composite scaffolds improves the release of bone growth factors
98 schema:pagination 133-141
99 schema:productId N2fe9498951b445a58898c6e0c61ad87a
100 N30b7891429034c54bee6c6f4f861722d
101 N6710746154814b12addf4c933207a226
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007563721
103 https://doi.org/10.1007/s10006-014-0463-4
104 schema:sdDatePublished 2022-10-01T06:39
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N6b98aa9dd9c540c5ac7e6922ad29bdd8
107 schema:url https://doi.org/10.1007/s10006-014-0463-4
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N05d7ce7cd46b4dc3852d2e1e812cff50 rdf:first sg:person.015671204547.55
112 rdf:rest Na799ba5450ad494e925a2788b79dee44
113 N0815340fc5dc487e88b89837fa34c54d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Solvents
115 rdf:type schema:DefinedTerm
116 N11f1ffb0c4b14e369e7d3ac05643cfc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Calcium Carbonate
118 rdf:type schema:DefinedTerm
119 N2fe9498951b445a58898c6e0c61ad87a schema:name pubmed_id
120 schema:value 25178431
121 rdf:type schema:PropertyValue
122 N30b7891429034c54bee6c6f4f861722d schema:name doi
123 schema:value 10.1007/s10006-014-0463-4
124 rdf:type schema:PropertyValue
125 N34883e3f31f549698f4c96fb2d651cdc schema:affiliation grid-institutes:grid.7450.6
126 schema:familyName Boven
127 schema:givenName J.
128 rdf:type schema:Person
129 N3e69df2c5d43447a872d2b298945a247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Line
131 rdf:type schema:DefinedTerm
132 N46fbe86a12da49489053571df6f75477 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Tissue Scaffolds
134 rdf:type schema:DefinedTerm
135 N56ce0cea4c10479e993f412a5c0a8a4e rdf:first sg:person.011342402346.80
136 rdf:rest rdf:nil
137 N5cdad75bde9c4940a90e022c1e570103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Transforming Growth Factor beta
139 rdf:type schema:DefinedTerm
140 N66862a61456a4c19bc4a1f3387cfec05 rdf:first sg:person.01222177644.57
141 rdf:rest N05d7ce7cd46b4dc3852d2e1e812cff50
142 N6710746154814b12addf4c933207a226 schema:name dimensions_id
143 schema:value pub.1007563721
144 rdf:type schema:PropertyValue
145 N6b98aa9dd9c540c5ac7e6922ad29bdd8 schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N8384fed8135747fd94a51a477e4cd36c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Bone Morphogenetic Protein 2
149 rdf:type schema:DefinedTerm
150 N84654bbd50e74ef5bad1ae9a07ef517c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Recombinant Proteins
152 rdf:type schema:DefinedTerm
153 N8ae2ab412fe046c4bc82c48b62d88a99 schema:volumeNumber 19
154 rdf:type schema:PublicationVolume
155 N9446dd4434c64ec8af54d399235287d2 rdf:first sg:person.01314067675.04
156 rdf:rest Ndb70326aa33d4a73b29e3a8597dbb738
157 Na799ba5450ad494e925a2788b79dee44 rdf:first N34883e3f31f549698f4c96fb2d651cdc
158 rdf:rest N9446dd4434c64ec8af54d399235287d2
159 Nae7362ca77a74433b20045aafbe9b7f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Polyesters
161 rdf:type schema:DefinedTerm
162 Ncc51472f37c34662ad1effc3a3f07cba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Delayed-Action Preparations
164 rdf:type schema:DefinedTerm
165 Ndb70326aa33d4a73b29e3a8597dbb738 rdf:first sg:person.01217137174.99
166 rdf:rest N56ce0cea4c10479e993f412a5c0a8a4e
167 Ndf38f3befca24ba5bb961b1b90404257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Alkaline Phosphatase
169 rdf:type schema:DefinedTerm
170 Ne5f1806397774f6e87ab5148486e4154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Humans
172 rdf:type schema:DefinedTerm
173 Nedd1c9f2cbbd441981685b80dd3125ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Biocompatible Materials
175 rdf:type schema:DefinedTerm
176 Nf2cf40d7ecb84681a778365b7e86b00a schema:issueNumber 2
177 rdf:type schema:PublicationIssue
178 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
179 schema:name Engineering
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biomedical Engineering
183 rdf:type schema:DefinedTerm
184 anzsrc-for:0912 schema:inDefinedTermSet anzsrc-for:
185 schema:name Materials Engineering
186 rdf:type schema:DefinedTerm
187 sg:journal.1412125 schema:issn 1434-3940
188 1865-1550
189 schema:name Oral and Maxillofacial Surgery
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.011342402346.80 schema:affiliation grid-institutes:grid.5718.b
193 schema:familyName Epple
194 schema:givenName M.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011342402346.80
196 rdf:type schema:Person
197 sg:person.01217137174.99 schema:affiliation grid-institutes:grid.5718.b
198 schema:familyName Annen
199 schema:givenName T.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217137174.99
201 rdf:type schema:Person
202 sg:person.01222177644.57 schema:affiliation grid-institutes:grid.7450.6
203 schema:familyName Schliephake
204 schema:givenName H.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222177644.57
206 rdf:type schema:Person
207 sg:person.01314067675.04 schema:affiliation grid-institutes:grid.5718.b
208 schema:familyName Backhaus
209 schema:givenName S.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314067675.04
211 rdf:type schema:Person
212 sg:person.015671204547.55 schema:affiliation grid-institutes:None
213 schema:familyName Vucak
214 schema:givenName M.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015671204547.55
216 rdf:type schema:Person
217 sg:pub.10.1023/a:1015948829632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051247890
218 https://doi.org/10.1023/a:1015948829632
219 rdf:type schema:CreativeWork
220 grid-institutes:None schema:alternateName Schaefer Kalk GmbH & Co. KG, Diez, Germany
221 schema:name Schaefer Kalk GmbH & Co. KG, Diez, Germany
222 rdf:type schema:Organization
223 grid-institutes:grid.5718.b schema:alternateName Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany
224 schema:name Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany
225 rdf:type schema:Organization
226 grid-institutes:grid.7450.6 schema:alternateName Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, Göttingen, Germany
227 schema:name Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, Göttingen, Germany
228 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...