Solvent free production of porous PDLLA/calcium carbonate composite scaffolds improves the release of bone growth factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-09-03

AUTHORS

H. Schliephake, M. Vucak, J. Boven, S. Backhaus, T. Annen, M. Epple

ABSTRACT

PurposeIncorporation of alkaline nano-/microparticles for neutralization of acidic degradation products into degradable polymer foams requires the use of organic solvents, which may compromise biocompatibility and may be associated with biological hazards. The aim of the present study was to develop and validate a solvent-free method to produce porous poly (DL-lactic acid)/calcium carbonate composite scaffolds (PDLLA/CaCO3) for controlled release of incorporated osteogenic growth factors.MethodsComposite PDLLA/CaCO3 granules were produced using a milling process and compared to composite material fabricated through a solution precipitation process using organic solvents. Particle size and mineral content were comparable in both groups. Supercritical carbon dioxide pressure was used to incorporate rhBMP2 into both composites.ResultsGas foaming resulted in comparable pore structures in both groups exhibiting a homogenous distribution of CaCO3 microparticles in the polymer scaffolds. The elasticity modulus of both types of scaffolds was not significantly different whereas the bending strength of the solvent-free produced scaffolds was significantly lower. The pH values remained constant between 6.90 and 7.25 during degradation of both composites. Release of BMP2 was significantly higher and the induction of alkaline phosphatase was more reliable in the group of scaffolds produced without organic solvents.ConclusionSolvent-free fabrication of composite PDLLA/CaCO3 scaffolds for controlled release of bone growth factors through gas foaming significantly enhances the release of growth factors and improves the biological efficacy of the incorporated growth factors. More... »

PAGES

133-141

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4

DOI

http://dx.doi.org/10.1007/s10006-014-0463-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007563721

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25178431


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biomedical Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0912", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Materials Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alkaline Phosphatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biocompatible Materials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Protein 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium Carbonate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Delayed-Action Preparations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyesters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Solvents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Scaffolds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schliephake", 
        "givenName": "H.", 
        "id": "sg:person.01222177644.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222177644.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Schaefer Kalk GmbH & Co. KG, Diez, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Schaefer Kalk GmbH & Co. KG, Diez, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vucak", 
        "givenName": "M.", 
        "id": "sg:person.015671204547.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015671204547.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, G\u00f6ttingen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boven", 
        "givenName": "J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Backhaus", 
        "givenName": "S.", 
        "id": "sg:person.01314067675.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314067675.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Annen", 
        "givenName": "T.", 
        "id": "sg:person.01217137174.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217137174.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany", 
          "id": "http://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Epple", 
        "givenName": "M.", 
        "id": "sg:person.011342402346.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011342402346.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1015948829632", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051247890", 
          "https://doi.org/10.1023/a:1015948829632"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09-03", 
    "datePublishedReg": "2014-09-03", 
    "description": "PurposeIncorporation of alkaline nano-/microparticles for neutralization of acidic degradation products into degradable polymer foams requires the use of organic solvents, which may compromise biocompatibility and may be associated with biological hazards. The aim of the present study was to develop and validate a solvent-free method to produce porous poly (DL-lactic acid)/calcium carbonate composite scaffolds (PDLLA/CaCO3) for controlled release of incorporated osteogenic growth factors.MethodsComposite PDLLA/CaCO3 granules were produced using a milling process and compared to composite material fabricated through a solution precipitation process using organic solvents. Particle size and mineral content were comparable in both groups. Supercritical carbon dioxide pressure was used to incorporate rhBMP2 into both composites.ResultsGas foaming resulted in comparable pore structures in both groups\u00a0exhibiting a homogenous distribution of CaCO3 microparticles in the polymer scaffolds. The elasticity modulus of both types of scaffolds was not significantly different whereas the bending strength of the solvent-free produced scaffolds was significantly lower. The pH values remained constant between 6.90 and 7.25 during degradation of both composites. Release of BMP2 was significantly higher and the induction of alkaline phosphatase was more reliable in the group of scaffolds produced without organic solvents.ConclusionSolvent-free fabrication of composite PDLLA/CaCO3 scaffolds for controlled release of bone growth factors through gas foaming significantly enhances the release of growth factors and improves the biological efficacy of the incorporated growth factors.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10006-014-0463-4", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1412125", 
        "issn": [
          "1865-1550", 
          "1434-3940"
        ], 
        "name": "Oral and Maxillofacial Surgery", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "composite scaffolds", 
      "solution-precipitation process", 
      "release of BMP2", 
      "groups of scaffolds", 
      "gas foaming", 
      "composite materials", 
      "polymer foams", 
      "acidic degradation products", 
      "types of scaffolds", 
      "elasticity modulus", 
      "milling process", 
      "porous poly", 
      "pore structure", 
      "organic solvents", 
      "CaCO3 microparticles", 
      "particle size", 
      "bone growth factors", 
      "homogenous distribution", 
      "precipitation process", 
      "solvent-free method", 
      "composites", 
      "foaming", 
      "osteogenic growth factors", 
      "scaffolds", 
      "free production", 
      "fabrication", 
      "foam", 
      "modulus", 
      "nano", 
      "solvent", 
      "biocompatibility", 
      "polymers", 
      "microparticles", 
      "degradation products", 
      "strength", 
      "materials", 
      "process", 
      "poly", 
      "CaCO3", 
      "biological hazards", 
      "degradation", 
      "pressure", 
      "rhBMP2", 
      "structure", 
      "method", 
      "size", 
      "carbon dioxide pressure", 
      "release", 
      "distribution", 
      "hazards", 
      "content", 
      "biological efficacy", 
      "products", 
      "values", 
      "production", 
      "mineral content", 
      "factors", 
      "use", 
      "granules", 
      "types", 
      "present study", 
      "neutralization", 
      "study", 
      "aim", 
      "group", 
      "alkaline phosphatase", 
      "BMP2", 
      "growth factor", 
      "phosphatase", 
      "efficacy", 
      "induction"
    ], 
    "name": "Solvent free production of porous PDLLA/calcium carbonate composite scaffolds improves the release of bone growth factors", 
    "pagination": "133-141", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007563721"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10006-014-0463-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25178431"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10006-014-0463-4", 
      "https://app.dimensions.ai/details/publication/pub.1007563721"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_623.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10006-014-0463-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10006-014-0463-4'


 

This table displays all metadata directly associated to this object as RDF triples.

228 TRIPLES      21 PREDICATES      110 URIs      100 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10006-014-0463-4 schema:about N232f76644e9541ea9b226f694459933d
2 N30a4933c4c4b4a56a88bc7ad548b85c0
3 N30dfb2e94af0436592dfbce25443431e
4 N34576d25e83d401fb7087e49be5ce574
5 N3d7560db73884a5e96a0fce3b07bb682
6 N4328e0da785c481282860220bbb3fc0a
7 N772af94626d94b248e7e43fefd29e202
8 N999fe7fc27e4480cad6677c08b2e13b5
9 N9f66b8b6584248a9b362fb9984d41065
10 Nc81b21094e59484c8629c3428c563e70
11 Ndb60afd4849f46ccbaee4ecc9eb33786
12 Ned499b6851ec44c2af0c70d488449674
13 anzsrc-for:09
14 anzsrc-for:0903
15 anzsrc-for:0912
16 schema:author N35233d36bd5f4a128f93efeae7c32dee
17 schema:citation sg:pub.10.1023/a:1015948829632
18 schema:datePublished 2014-09-03
19 schema:datePublishedReg 2014-09-03
20 schema:description PurposeIncorporation of alkaline nano-/microparticles for neutralization of acidic degradation products into degradable polymer foams requires the use of organic solvents, which may compromise biocompatibility and may be associated with biological hazards. The aim of the present study was to develop and validate a solvent-free method to produce porous poly (DL-lactic acid)/calcium carbonate composite scaffolds (PDLLA/CaCO3) for controlled release of incorporated osteogenic growth factors.MethodsComposite PDLLA/CaCO3 granules were produced using a milling process and compared to composite material fabricated through a solution precipitation process using organic solvents. Particle size and mineral content were comparable in both groups. Supercritical carbon dioxide pressure was used to incorporate rhBMP2 into both composites.ResultsGas foaming resulted in comparable pore structures in both groups exhibiting a homogenous distribution of CaCO3 microparticles in the polymer scaffolds. The elasticity modulus of both types of scaffolds was not significantly different whereas the bending strength of the solvent-free produced scaffolds was significantly lower. The pH values remained constant between 6.90 and 7.25 during degradation of both composites. Release of BMP2 was significantly higher and the induction of alkaline phosphatase was more reliable in the group of scaffolds produced without organic solvents.ConclusionSolvent-free fabrication of composite PDLLA/CaCO3 scaffolds for controlled release of bone growth factors through gas foaming significantly enhances the release of growth factors and improves the biological efficacy of the incorporated growth factors.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf Nbc5b752617844c4ead21c0644e06f3dc
24 Nf9c8c9853f154d1fb61799c3789830af
25 sg:journal.1412125
26 schema:keywords BMP2
27 CaCO3
28 CaCO3 microparticles
29 acidic degradation products
30 aim
31 alkaline phosphatase
32 biocompatibility
33 biological efficacy
34 biological hazards
35 bone growth factors
36 carbon dioxide pressure
37 composite materials
38 composite scaffolds
39 composites
40 content
41 degradation
42 degradation products
43 distribution
44 efficacy
45 elasticity modulus
46 fabrication
47 factors
48 foam
49 foaming
50 free production
51 gas foaming
52 granules
53 group
54 groups of scaffolds
55 growth factor
56 hazards
57 homogenous distribution
58 induction
59 materials
60 method
61 microparticles
62 milling process
63 mineral content
64 modulus
65 nano
66 neutralization
67 organic solvents
68 osteogenic growth factors
69 particle size
70 phosphatase
71 poly
72 polymer foams
73 polymers
74 pore structure
75 porous poly
76 precipitation process
77 present study
78 pressure
79 process
80 production
81 products
82 release
83 release of BMP2
84 rhBMP2
85 scaffolds
86 size
87 solution-precipitation process
88 solvent
89 solvent-free method
90 strength
91 structure
92 study
93 types
94 types of scaffolds
95 use
96 values
97 schema:name Solvent free production of porous PDLLA/calcium carbonate composite scaffolds improves the release of bone growth factors
98 schema:pagination 133-141
99 schema:productId N0e13739e0a52495d91dc432f6f092232
100 N0e8bf53ec84e4f8facbdb03d497b3b2c
101 N178ba398ac964807ba32983cd0cf28d6
102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007563721
103 https://doi.org/10.1007/s10006-014-0463-4
104 schema:sdDatePublished 2022-12-01T06:31
105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
106 schema:sdPublisher N213263c74e35428589d064bf400d8f0a
107 schema:url https://doi.org/10.1007/s10006-014-0463-4
108 sgo:license sg:explorer/license/
109 sgo:sdDataset articles
110 rdf:type schema:ScholarlyArticle
111 N0e13739e0a52495d91dc432f6f092232 schema:name pubmed_id
112 schema:value 25178431
113 rdf:type schema:PropertyValue
114 N0e8bf53ec84e4f8facbdb03d497b3b2c schema:name dimensions_id
115 schema:value pub.1007563721
116 rdf:type schema:PropertyValue
117 N178ba398ac964807ba32983cd0cf28d6 schema:name doi
118 schema:value 10.1007/s10006-014-0463-4
119 rdf:type schema:PropertyValue
120 N213263c74e35428589d064bf400d8f0a schema:name Springer Nature - SN SciGraph project
121 rdf:type schema:Organization
122 N232f76644e9541ea9b226f694459933d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Recombinant Proteins
124 rdf:type schema:DefinedTerm
125 N30a4933c4c4b4a56a88bc7ad548b85c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Tissue Scaffolds
127 rdf:type schema:DefinedTerm
128 N30dfb2e94af0436592dfbce25443431e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Humans
130 rdf:type schema:DefinedTerm
131 N34576d25e83d401fb7087e49be5ce574 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Line
133 rdf:type schema:DefinedTerm
134 N35233d36bd5f4a128f93efeae7c32dee rdf:first sg:person.01222177644.57
135 rdf:rest N8708478c8ed7495db9acdd2de0d5f944
136 N3d7560db73884a5e96a0fce3b07bb682 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Calcium Carbonate
138 rdf:type schema:DefinedTerm
139 N41e0b27dcb6e43e8a3234685feaafa8d rdf:first N533a914692cd4eef80600f24832399fe
140 rdf:rest N8506b004c9c24d6eba0f06e7c0196849
141 N4328e0da785c481282860220bbb3fc0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Polyesters
143 rdf:type schema:DefinedTerm
144 N533a914692cd4eef80600f24832399fe schema:affiliation grid-institutes:grid.7450.6
145 schema:familyName Boven
146 schema:givenName J.
147 rdf:type schema:Person
148 N772af94626d94b248e7e43fefd29e202 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Bone Morphogenetic Protein 2
150 rdf:type schema:DefinedTerm
151 N8262e929b6264c12b13cec8de5a3f1c6 rdf:first sg:person.011342402346.80
152 rdf:rest rdf:nil
153 N8506b004c9c24d6eba0f06e7c0196849 rdf:first sg:person.01314067675.04
154 rdf:rest Nf9904b3132ad41deb860720a12ad78b5
155 N8708478c8ed7495db9acdd2de0d5f944 rdf:first sg:person.015671204547.55
156 rdf:rest N41e0b27dcb6e43e8a3234685feaafa8d
157 N999fe7fc27e4480cad6677c08b2e13b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Biocompatible Materials
159 rdf:type schema:DefinedTerm
160 N9f66b8b6584248a9b362fb9984d41065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Solvents
162 rdf:type schema:DefinedTerm
163 Nbc5b752617844c4ead21c0644e06f3dc schema:volumeNumber 19
164 rdf:type schema:PublicationVolume
165 Nc81b21094e59484c8629c3428c563e70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Alkaline Phosphatase
167 rdf:type schema:DefinedTerm
168 Ndb60afd4849f46ccbaee4ecc9eb33786 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Delayed-Action Preparations
170 rdf:type schema:DefinedTerm
171 Ned499b6851ec44c2af0c70d488449674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Transforming Growth Factor beta
173 rdf:type schema:DefinedTerm
174 Nf9904b3132ad41deb860720a12ad78b5 rdf:first sg:person.01217137174.99
175 rdf:rest N8262e929b6264c12b13cec8de5a3f1c6
176 Nf9c8c9853f154d1fb61799c3789830af schema:issueNumber 2
177 rdf:type schema:PublicationIssue
178 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
179 schema:name Engineering
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biomedical Engineering
183 rdf:type schema:DefinedTerm
184 anzsrc-for:0912 schema:inDefinedTermSet anzsrc-for:
185 schema:name Materials Engineering
186 rdf:type schema:DefinedTerm
187 sg:journal.1412125 schema:issn 1434-3940
188 1865-1550
189 schema:name Oral and Maxillofacial Surgery
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.011342402346.80 schema:affiliation grid-institutes:grid.5718.b
193 schema:familyName Epple
194 schema:givenName M.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011342402346.80
196 rdf:type schema:Person
197 sg:person.01217137174.99 schema:affiliation grid-institutes:grid.5718.b
198 schema:familyName Annen
199 schema:givenName T.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217137174.99
201 rdf:type schema:Person
202 sg:person.01222177644.57 schema:affiliation grid-institutes:grid.7450.6
203 schema:familyName Schliephake
204 schema:givenName H.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222177644.57
206 rdf:type schema:Person
207 sg:person.01314067675.04 schema:affiliation grid-institutes:grid.5718.b
208 schema:familyName Backhaus
209 schema:givenName S.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314067675.04
211 rdf:type schema:Person
212 sg:person.015671204547.55 schema:affiliation grid-institutes:None
213 schema:familyName Vucak
214 schema:givenName M.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015671204547.55
216 rdf:type schema:Person
217 sg:pub.10.1023/a:1015948829632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051247890
218 https://doi.org/10.1023/a:1015948829632
219 rdf:type schema:CreativeWork
220 grid-institutes:None schema:alternateName Schaefer Kalk GmbH & Co. KG, Diez, Germany
221 schema:name Schaefer Kalk GmbH & Co. KG, Diez, Germany
222 rdf:type schema:Organization
223 grid-institutes:grid.5718.b schema:alternateName Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany
224 schema:name Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117, Essen, Germany
225 rdf:type schema:Organization
226 grid-institutes:grid.7450.6 schema:alternateName Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, Göttingen, Germany
227 schema:name Department of Oral and Maxillofacial Surgery, George-Augusta-University, Robert-Koch-Str, 40 37075, Göttingen, Germany
228 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...