Phosphoribosyltransferase superfamily: A comparative structural analysis View Full Text


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Article Info

DATE

2001-05

AUTHORS

Nuria Campillo, Hampapathalu A. Nagarajaram, Indira Ghosh

ABSTRACT

Purine phosphoribosyltransferases are members of a group of enzymes that are responsible for the formation of purine, pyrimidine and pyridine nucleotides. One feature of this family is a flexible loop, which is involved in the catalytic mechanism. This loop is variable both in sequence and structure in the phosphoribosyltransferase family. This paper describes the modelling and validation of a model of Plasmodium falciparum hypoxanthine-guanidine- phosphoribosyltransferase in an open conformation. A comparison of this model with 3D-structures of other members of the phosphorybosyltransferase family has allowed an assessment of the role of the open and closed conformations of the loop in the catalytic mechanism. More... »

PAGES

80-89

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s008940000001

DOI

http://dx.doi.org/10.1007/s008940000001

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028547708


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