Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-10-07

AUTHORS

Hiro Inoue, Kenta Torigoe, Miki Torigoe, Kumiko Muta, Yoko Obata, Takehiro Suzuki, Chitose Suzuki, Takaaki Abe, Takehiko Koji, Hiroshi Mukae, Tomoya Nishino

ABSTRACT

Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis, attributable to inflammation and mitochondrial dysfunction. Mitochonic acid-5 (MA-5), an indole-3-acetic acid derivative, improves mitochondrial dysfunction and has therapeutic potential against various diseases including kidney diseases. However, whether MA-5 is effective against peritoneal fibrosis remains unclear. Therefore, we investigated the effect of MA-5 using a peritoneal fibrosis mouse model. Peritoneal fibrosis was induced in C57BL/6 mice via intraperitoneal injection of chlorhexidine gluconate (CG) every other day for 3 weeks. MA-5 was administered daily by oral gavage. The mice were divided into control, MA-5, CG, and CG + MA-5 groups. Following treatment, immunohistochemical analyses were performed. Fibrotic thickening of the parietal peritoneum induced by CG was substantially attenuated by MA-5. The number of α-smooth muscle actin-positive myofibroblasts, transforming growth factor β-positive cells, F4/80-positive macrophages, monocyte chemotactic protein 1-positive cells, and 4-hydroxy-2-nonenal-positive cells was considerably decreased. In addition, reduced ATP5a1-positive and uncoupling protein 2-positive cells in the CG group were notably increased by MA-5. MA-5 may ameliorate peritoneal fibrosis by suppressing macrophage infiltration and oxidative stress, thus restoring mitochondrial function. Overall, MA-5 has therapeutic potential against peritoneal fibrosis. More... »

PAGES

27-40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00795-021-00305-6

DOI

http://dx.doi.org/10.1007/s00795-021-00305-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1141721804

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34622315


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1199", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chlorhexidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Indoleacetic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritoneal Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peritoneum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenylbutyrates", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Hiro", 
        "id": "sg:person.016033051373.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016033051373.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Torigoe", 
        "givenName": "Kenta", 
        "id": "sg:person.015102701221.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015102701221.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Torigoe", 
        "givenName": "Miki", 
        "id": "sg:person.013664412507.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013664412507.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muta", 
        "givenName": "Kumiko", 
        "id": "sg:person.01021063322.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021063322.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obata", 
        "givenName": "Yoko", 
        "id": "sg:person.01137214327.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137214327.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Takehiro", 
        "id": "sg:person.015221367244.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015221367244.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Chitose", 
        "id": "sg:person.01372667670.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372667670.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan", 
          "id": "http://www.grid.ac/institutes/grid.69566.3a", 
          "name": [
            "Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abe", 
        "givenName": "Takaaki", 
        "id": "sg:person.011433525272.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011433525272.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koji", 
        "givenName": "Takehiko", 
        "id": "sg:person.010304720544.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010304720544.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mukae", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01143125277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishino", 
        "givenName": "Tomoya", 
        "id": "sg:person.0746567117.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746567117.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/s41420-020-00316-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1130614616", 
          "https://doi.org/10.1038/s41420-020-00316-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.2012.132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018820330", 
          "https://doi.org/10.1038/labinvest.2012.132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11684-017-0571-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091100927", 
          "https://doi.org/10.1007/s11684-017-0571-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2010.113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009038718", 
          "https://doi.org/10.1038/hr.2010.113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-05836-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090696216", 
          "https://doi.org/10.1038/s41598-017-05836-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-10-07", 
    "datePublishedReg": "2021-10-07", 
    "description": "Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis, attributable to inflammation and mitochondrial dysfunction. Mitochonic acid-5 (MA-5), an indole-3-acetic acid derivative, improves mitochondrial dysfunction and has therapeutic potential against various diseases including kidney diseases. However, whether MA-5 is effective against peritoneal fibrosis remains unclear. Therefore, we investigated the effect of MA-5 using a peritoneal fibrosis mouse model. Peritoneal fibrosis was induced in C57BL/6 mice via intraperitoneal injection of chlorhexidine gluconate (CG) every other day for 3\u00a0weeks. MA-5 was administered daily by oral gavage. The mice were divided into control, MA-5, CG, and CG\u2009+\u2009MA-5 groups. Following treatment, immunohistochemical analyses were performed. Fibrotic thickening of the parietal peritoneum induced by CG was substantially attenuated by MA-5. The number of \u03b1-smooth muscle actin-positive myofibroblasts, transforming growth factor \u03b2-positive cells, F4/80-positive macrophages, monocyte chemotactic protein 1-positive cells, and 4-hydroxy-2-nonenal-positive cells was considerably decreased. In addition, reduced ATP5a1-positive and uncoupling protein 2-positive cells in the CG group were notably increased by MA-5. MA-5 may ameliorate peritoneal fibrosis by suppressing macrophage infiltration and oxidative stress, thus restoring mitochondrial function. Overall, MA-5 has therapeutic potential against peritoneal fibrosis.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00795-021-00305-6", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7522371", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295024", 
        "issn": [
          "1860-1480", 
          "1437-773X"
        ], 
        "name": "Medical Molecular Morphology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "keywords": [
      "peritoneal fibrosis", 
      "mitochonic acid 5", 
      "chlorhexidine gluconate", 
      "positive cells", 
      "peritoneal fibrosis mouse model", 
      "therapeutic potential", 
      "long-term peritoneal dialysis", 
      "smooth muscle actin-positive myofibroblasts", 
      "mitochondrial dysfunction", 
      "fibrosis mouse model", 
      "F4/80-positive macrophages", 
      "actin-positive myofibroblasts", 
      "growth factor \u03b2", 
      "serious complications", 
      "fibrotic thickening", 
      "peritoneal dialysis", 
      "oral gavage", 
      "kidney disease", 
      "C57BL/6 mice", 
      "macrophage infiltration", 
      "intraperitoneal injection", 
      "mouse model", 
      "immunohistochemical analysis", 
      "chemotactic protein", 
      "CG group", 
      "parietal peritoneum", 
      "fibrosis", 
      "oxidative stress", 
      "mice", 
      "factor \u03b2", 
      "mitochondrial function", 
      "dysfunction", 
      "disease", 
      "acid 5", 
      "gluconate", 
      "cells", 
      "gavage", 
      "complications", 
      "inflammation", 
      "group", 
      "peritoneum", 
      "myofibroblasts", 
      "dialysis", 
      "macrophages", 
      "weeks", 
      "infiltration", 
      "injection", 
      "treatment", 
      "thickening", 
      "protein", 
      "indole-3-acetic acid derivatives", 
      "days", 
      "acid derivatives", 
      "control", 
      "potential", 
      "effect", 
      "function", 
      "stress", 
      "addition", 
      "number", 
      "analysis", 
      "derivatives", 
      "model"
    ], 
    "name": "Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice", 
    "pagination": "27-40", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1141721804"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00795-021-00305-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "34622315"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00795-021-00305-6", 
      "https://app.dimensions.ai/details/publication/pub.1141721804"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_901.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00795-021-00305-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00795-021-00305-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00795-021-00305-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00795-021-00305-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00795-021-00305-6'


 

This table displays all metadata directly associated to this object as RDF triples.

259 TRIPLES      21 PREDICATES      102 URIs      89 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00795-021-00305-6 schema:about N10f8e4c3c0fc4ad0a9402bc5a8d587d4
2 N1c236d6436c841d1b1b1157b5f8208af
3 N1d6968437dd14b88a8f05bf7cefb9dc2
4 N3c3bac2a519d458f9de952e1e3272562
5 N3c8d0c9d37584274826da5d15100fc45
6 N5d9dcfd2e3bb4882820100fddc2cca1d
7 Nc974937f4afd43998df2d618d83e6376
8 Nd921331093bf40d1ac1e0774c12aff95
9 Nf67b6345547f45f8964910ad8bab0a91
10 anzsrc-for:11
11 anzsrc-for:1199
12 schema:author N5df989d6ea0b45d89a13f8eee4490fe0
13 schema:citation sg:pub.10.1007/s11684-017-0571-2
14 sg:pub.10.1038/hr.2010.113
15 sg:pub.10.1038/labinvest.2012.132
16 sg:pub.10.1038/s41420-020-00316-9
17 sg:pub.10.1038/s41598-017-05836-6
18 schema:datePublished 2021-10-07
19 schema:datePublishedReg 2021-10-07
20 schema:description Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis, attributable to inflammation and mitochondrial dysfunction. Mitochonic acid-5 (MA-5), an indole-3-acetic acid derivative, improves mitochondrial dysfunction and has therapeutic potential against various diseases including kidney diseases. However, whether MA-5 is effective against peritoneal fibrosis remains unclear. Therefore, we investigated the effect of MA-5 using a peritoneal fibrosis mouse model. Peritoneal fibrosis was induced in C57BL/6 mice via intraperitoneal injection of chlorhexidine gluconate (CG) every other day for 3 weeks. MA-5 was administered daily by oral gavage. The mice were divided into control, MA-5, CG, and CG + MA-5 groups. Following treatment, immunohistochemical analyses were performed. Fibrotic thickening of the parietal peritoneum induced by CG was substantially attenuated by MA-5. The number of α-smooth muscle actin-positive myofibroblasts, transforming growth factor β-positive cells, F4/80-positive macrophages, monocyte chemotactic protein 1-positive cells, and 4-hydroxy-2-nonenal-positive cells was considerably decreased. In addition, reduced ATP5a1-positive and uncoupling protein 2-positive cells in the CG group were notably increased by MA-5. MA-5 may ameliorate peritoneal fibrosis by suppressing macrophage infiltration and oxidative stress, thus restoring mitochondrial function. Overall, MA-5 has therapeutic potential against peritoneal fibrosis.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf N7c2fcadaedd14a22b9e6e03bded93b51
24 Nf3170bb2205041e9a501ff253aa2cfc1
25 sg:journal.1295024
26 schema:keywords C57BL/6 mice
27 CG group
28 F4/80-positive macrophages
29 acid 5
30 acid derivatives
31 actin-positive myofibroblasts
32 addition
33 analysis
34 cells
35 chemotactic protein
36 chlorhexidine gluconate
37 complications
38 control
39 days
40 derivatives
41 dialysis
42 disease
43 dysfunction
44 effect
45 factor β
46 fibrosis
47 fibrosis mouse model
48 fibrotic thickening
49 function
50 gavage
51 gluconate
52 group
53 growth factor β
54 immunohistochemical analysis
55 indole-3-acetic acid derivatives
56 infiltration
57 inflammation
58 injection
59 intraperitoneal injection
60 kidney disease
61 long-term peritoneal dialysis
62 macrophage infiltration
63 macrophages
64 mice
65 mitochondrial dysfunction
66 mitochondrial function
67 mitochonic acid 5
68 model
69 mouse model
70 myofibroblasts
71 number
72 oral gavage
73 oxidative stress
74 parietal peritoneum
75 peritoneal dialysis
76 peritoneal fibrosis
77 peritoneal fibrosis mouse model
78 peritoneum
79 positive cells
80 potential
81 protein
82 serious complications
83 smooth muscle actin-positive myofibroblasts
84 stress
85 therapeutic potential
86 thickening
87 treatment
88 weeks
89 schema:name Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice
90 schema:pagination 27-40
91 schema:productId N614235bbb6484081b276dc3de88b242c
92 N6500057f886d4df994e242b64411e7d6
93 N88e7a0c040314e239b129c4f2d646ed1
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1141721804
95 https://doi.org/10.1007/s00795-021-00305-6
96 schema:sdDatePublished 2022-09-02T16:06
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N165ab8273df34a9384a3c9421f1b7f31
99 schema:url https://doi.org/10.1007/s00795-021-00305-6
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N10f8e4c3c0fc4ad0a9402bc5a8d587d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mice, Inbred C57BL
105 rdf:type schema:DefinedTerm
106 N165ab8273df34a9384a3c9421f1b7f31 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N1c236d6436c841d1b1b1157b5f8208af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mice
110 rdf:type schema:DefinedTerm
111 N1d6968437dd14b88a8f05bf7cefb9dc2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Disease Models, Animal
113 rdf:type schema:DefinedTerm
114 N23699afa3cf9456a992262ff215b0e61 rdf:first sg:person.01137214327.54
115 rdf:rest Nbf503ed1fb8442e09ce4edccb13a92b0
116 N351d4bec64e546fcacead50ec1674d40 rdf:first sg:person.013664412507.39
117 rdf:rest N9c64468f19f3494497e5f9a019ce65b0
118 N3c3bac2a519d458f9de952e1e3272562 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Indoleacetic Acids
120 rdf:type schema:DefinedTerm
121 N3c8d0c9d37584274826da5d15100fc45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Chlorhexidine
123 rdf:type schema:DefinedTerm
124 N5d9dcfd2e3bb4882820100fddc2cca1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Phenylbutyrates
126 rdf:type schema:DefinedTerm
127 N5df989d6ea0b45d89a13f8eee4490fe0 rdf:first sg:person.016033051373.68
128 rdf:rest Nff62fb23a3b947b19a30a52acbce44d3
129 N614235bbb6484081b276dc3de88b242c schema:name pubmed_id
130 schema:value 34622315
131 rdf:type schema:PropertyValue
132 N61f0569d365b417e9aed312f9cf5f422 rdf:first sg:person.010304720544.52
133 rdf:rest N73f8119a251a441596224474e5e0c159
134 N6500057f886d4df994e242b64411e7d6 schema:name doi
135 schema:value 10.1007/s00795-021-00305-6
136 rdf:type schema:PropertyValue
137 N6e36ae04f64046c7ba4eee330a3ec0d8 rdf:first sg:person.01372667670.43
138 rdf:rest Nf83155c28d9b442c8ca4feb7ae862078
139 N73f8119a251a441596224474e5e0c159 rdf:first sg:person.01143125277.28
140 rdf:rest Ne412df98dc52454cada1c123ad3d643c
141 N7c2fcadaedd14a22b9e6e03bded93b51 schema:issueNumber 1
142 rdf:type schema:PublicationIssue
143 N88e7a0c040314e239b129c4f2d646ed1 schema:name dimensions_id
144 schema:value pub.1141721804
145 rdf:type schema:PropertyValue
146 N9c64468f19f3494497e5f9a019ce65b0 rdf:first sg:person.01021063322.10
147 rdf:rest N23699afa3cf9456a992262ff215b0e61
148 Nbf503ed1fb8442e09ce4edccb13a92b0 rdf:first sg:person.015221367244.35
149 rdf:rest N6e36ae04f64046c7ba4eee330a3ec0d8
150 Nc974937f4afd43998df2d618d83e6376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Animals
152 rdf:type schema:DefinedTerm
153 Nd921331093bf40d1ac1e0774c12aff95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Peritoneum
155 rdf:type schema:DefinedTerm
156 Ne412df98dc52454cada1c123ad3d643c rdf:first sg:person.0746567117.73
157 rdf:rest rdf:nil
158 Nf3170bb2205041e9a501ff253aa2cfc1 schema:volumeNumber 55
159 rdf:type schema:PublicationVolume
160 Nf67b6345547f45f8964910ad8bab0a91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Peritoneal Fibrosis
162 rdf:type schema:DefinedTerm
163 Nf83155c28d9b442c8ca4feb7ae862078 rdf:first sg:person.011433525272.27
164 rdf:rest N61f0569d365b417e9aed312f9cf5f422
165 Nff62fb23a3b947b19a30a52acbce44d3 rdf:first sg:person.015102701221.50
166 rdf:rest N351d4bec64e546fcacead50ec1674d40
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1199 schema:inDefinedTermSet anzsrc-for:
171 schema:name Other Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 sg:grant.7522371 http://pending.schema.org/fundedItem sg:pub.10.1007/s00795-021-00305-6
174 rdf:type schema:MonetaryGrant
175 sg:journal.1295024 schema:issn 1437-773X
176 1860-1480
177 schema:name Medical Molecular Morphology
178 schema:publisher Springer Nature
179 rdf:type schema:Periodical
180 sg:person.01021063322.10 schema:affiliation grid-institutes:grid.174567.6
181 schema:familyName Muta
182 schema:givenName Kumiko
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021063322.10
184 rdf:type schema:Person
185 sg:person.010304720544.52 schema:affiliation grid-institutes:grid.174567.6
186 schema:familyName Koji
187 schema:givenName Takehiko
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010304720544.52
189 rdf:type schema:Person
190 sg:person.01137214327.54 schema:affiliation grid-institutes:grid.174567.6
191 schema:familyName Obata
192 schema:givenName Yoko
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137214327.54
194 rdf:type schema:Person
195 sg:person.01143125277.28 schema:affiliation grid-institutes:grid.174567.6
196 schema:familyName Mukae
197 schema:givenName Hiroshi
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143125277.28
199 rdf:type schema:Person
200 sg:person.011433525272.27 schema:affiliation grid-institutes:grid.69566.3a
201 schema:familyName Abe
202 schema:givenName Takaaki
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011433525272.27
204 rdf:type schema:Person
205 sg:person.013664412507.39 schema:affiliation grid-institutes:grid.174567.6
206 schema:familyName Torigoe
207 schema:givenName Miki
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013664412507.39
209 rdf:type schema:Person
210 sg:person.01372667670.43 schema:affiliation grid-institutes:grid.69566.3a
211 schema:familyName Suzuki
212 schema:givenName Chitose
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372667670.43
214 rdf:type schema:Person
215 sg:person.015102701221.50 schema:affiliation grid-institutes:grid.174567.6
216 schema:familyName Torigoe
217 schema:givenName Kenta
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015102701221.50
219 rdf:type schema:Person
220 sg:person.015221367244.35 schema:affiliation grid-institutes:grid.69566.3a
221 schema:familyName Suzuki
222 schema:givenName Takehiro
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015221367244.35
224 rdf:type schema:Person
225 sg:person.016033051373.68 schema:affiliation grid-institutes:grid.174567.6
226 schema:familyName Inoue
227 schema:givenName Hiro
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016033051373.68
229 rdf:type schema:Person
230 sg:person.0746567117.73 schema:affiliation grid-institutes:grid.174567.6
231 schema:familyName Nishino
232 schema:givenName Tomoya
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746567117.73
234 rdf:type schema:Person
235 sg:pub.10.1007/s11684-017-0571-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091100927
236 https://doi.org/10.1007/s11684-017-0571-2
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/hr.2010.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009038718
239 https://doi.org/10.1038/hr.2010.113
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/labinvest.2012.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018820330
242 https://doi.org/10.1038/labinvest.2012.132
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/s41420-020-00316-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1130614616
245 https://doi.org/10.1038/s41420-020-00316-9
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/s41598-017-05836-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090696216
248 https://doi.org/10.1038/s41598-017-05836-6
249 rdf:type schema:CreativeWork
250 grid-institutes:grid.174567.6 schema:alternateName Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
251 Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan
252 Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
253 schema:name Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
254 Department of Nephrology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, 852-8501, Nagasaki, Japan
255 Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
256 rdf:type schema:Organization
257 grid-institutes:grid.69566.3a schema:alternateName Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
258 schema:name Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
259 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...