Decreased number and increased volume with mitochondrial enlargement of cerebellar synaptic terminals in a mouse model of chronic demyelination View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Huy Bang Nguyen, Yang Sui, Truc Quynh Thai, Kazuhiro Ikenaka, Toshiyuki Oda, Nobuhiko Ohno

ABSTRACT

Impaired nerve conduction, axonal degeneration, and synaptic alterations contribute to neurological disabilities in inflammatory demyelinating diseases. Cerebellar dysfunction is associated with demyelinating disorders, but the alterations of axon terminals in cerebellar gray matter during chronic demyelination are still unclear. We analyzed the morphological and ultrastructural changes of climbing fiber terminals in a mouse model of hereditary chronic demyelination. Three-dimensional ultrastructural analyses using serial block-face scanning electron microscopy and immunostaining for synaptic markers were performed in a demyelination mouse model caused by extra copies of myelin gene (PLP4e). At 1 month old, many myelinated axons were observed in PLP4e and wild-type mice, but demyelinated axons and axons with abnormally thin myelin were prominent in PLP4e mice at 5 months old. The density of climbing fiber terminals was significantly reduced in PLP4e mice at 5 months old. Reconstruction of climbing fiber terminals revealed that PLP4e climbing fibers had increased varicosity volume and enlarged mitochondria in the varicosities at 5-month-old mice. These results suggest that chronic demyelination is associated with alterations and loss of climbing fiber terminals in the cerebellar cortex, and that synaptic changes may contribute to cerebellar phenotypes observed in hereditary demyelinating disorders. More... »

PAGES

208-216

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00795-018-0193-z

DOI

http://dx.doi.org/10.1007/s00795-018-0193-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104156044

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29796936


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan", 
            "Department of Anatomy and Structural Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nguyen", 
        "givenName": "Huy Bang", 
        "id": "sg:person.0734524721.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734524721.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan", 
            "Department of Anatomy and Structural Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sui", 
        "givenName": "Yang", 
        "id": "sg:person.012747074433.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012747074433.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan", 
            "Department of Anatomy and Structural Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thai", 
        "givenName": "Truc Quynh", 
        "id": "sg:person.01002640121.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002640121.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Physiological Sciences", 
          "id": "https://www.grid.ac/institutes/grid.467811.d", 
          "name": [
            "Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikenaka", 
        "givenName": "Kazuhiro", 
        "id": "sg:person.01022463266.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022463266.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Yamanashi", 
          "id": "https://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Anatomy and Structural Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oda", 
        "givenName": "Toshiyuki", 
        "id": "sg:person.01057571452.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057571452.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan", 
            "Department of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke-shi, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohno", 
        "givenName": "Nobuhiko", 
        "id": "sg:person.01070207732.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070207732.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0896-6273(94)90358-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003454192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006322494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.20275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006322494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-006-6182-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008559427", 
          "https://doi.org/10.1007/s00018-006-6182-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.22567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008844818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awh409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010132009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2009.01.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012069793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2008.09.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015864527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dmcn.13025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016735435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00235210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017602849", 
          "https://doi.org/10.1007/bf00235210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00235210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017602849", 
          "https://doi.org/10.1007/bf00235210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9568.2003.02698.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017968065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(94)90214-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018711018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.10.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019924563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1750-3639.1995.tb00603.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020821490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.22337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021810968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fneur.2013.00199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022014586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10048-004-0207-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027289000", 
          "https://doi.org/10.1007/s10048-004-0207-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029734019", 
          "https://doi.org/10.1038/nature12776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/nen.0b013e31812571b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029974209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpneuro0735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030523567", 
          "https://doi.org/10.1038/ncpneuro0735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2009.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031735693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0394-257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032042993", 
          "https://doi.org/10.1038/ng0394-257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2012.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032502634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5369-12.2013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034616407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1034633628", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-65581-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034633628", 
          "https://doi.org/10.1007/978-3-642-65581-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-65581-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034633628", 
          "https://doi.org/10.1007/978-3-642-65581-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00795-016-0134-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036025332", 
          "https://doi.org/10.1007/s00795-016-0134-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2016.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040248459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2014.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044427473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awv353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045672119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0038011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046232493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2007.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046535066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2013.06.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046925321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2013.06.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046925321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cge.12811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046973771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2011.07894.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047097487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep23721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048122181", 
          "https://doi.org/10.1038/srep23721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1202529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049524688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.202483399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050810500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0125185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051384089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/61.9.747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053630193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/118.5.1225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059439531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3840606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.21-17-06666.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074868499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.22-14-05840.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075087369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2017.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084056673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-017-00260-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090954112", 
          "https://doi.org/10.1038/s41467-017-00260-w"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Impaired nerve conduction, axonal degeneration, and synaptic alterations contribute to neurological disabilities in inflammatory demyelinating diseases. Cerebellar dysfunction is associated with demyelinating disorders, but the alterations of axon terminals in cerebellar gray matter during chronic demyelination are still unclear. We analyzed the morphological and ultrastructural changes of climbing fiber terminals in a mouse model of hereditary chronic demyelination. Three-dimensional ultrastructural analyses using serial block-face scanning electron microscopy and immunostaining for synaptic markers were performed in a demyelination mouse model caused by extra copies of myelin gene (PLP4e). At 1\u00a0month old, many myelinated axons were observed in PLP4e and wild-type mice, but demyelinated axons and axons with abnormally thin myelin were prominent in PLP4e mice at 5\u00a0months old. The density of climbing fiber terminals was significantly reduced in PLP4e mice at 5\u00a0months old. Reconstruction of climbing fiber terminals revealed that PLP4e climbing fibers had increased varicosity volume and enlarged mitochondria in the varicosities at 5-month-old mice. These results suggest that chronic demyelination is associated with alterations and loss of climbing fiber terminals in the cerebellar cortex, and that synaptic changes may contribute to cerebellar phenotypes observed in hereditary demyelinating disorders.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00795-018-0193-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5916605", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6110148", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295024", 
        "issn": [
          "1860-1480", 
          "1437-773X"
        ], 
        "name": "Medical Molecular Morphology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "51"
      }
    ], 
    "name": "Decreased number and increased volume with mitochondrial enlargement of cerebellar synaptic terminals in a mouse model of chronic demyelination", 
    "pagination": "208-216", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "628caab853474c8315d7678ac595722c551632c5c6ce76e8ddf613b3cead9e9c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29796936"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101239023"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00795-018-0193-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104156044"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00795-018-0193-z", 
      "https://app.dimensions.ai/details/publication/pub.1104156044"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000609.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00795-018-0193-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00795-018-0193-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00795-018-0193-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00795-018-0193-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00795-018-0193-z'


 

This table displays all metadata directly associated to this object as RDF triples.

260 TRIPLES      21 PREDICATES      74 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00795-018-0193-z schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N7768abe81e564a99b0507240a36d5c6e
4 schema:citation sg:pub.10.1007/978-3-642-65581-4
5 sg:pub.10.1007/bf00235210
6 sg:pub.10.1007/s00018-006-6182-8
7 sg:pub.10.1007/s00795-016-0134-7
8 sg:pub.10.1007/s10048-004-0207-y
9 sg:pub.10.1038/nature12776
10 sg:pub.10.1038/ncpneuro0735
11 sg:pub.10.1038/ng0394-257
12 sg:pub.10.1038/s41467-017-00260-w
13 sg:pub.10.1038/srep23721
14 https://app.dimensions.ai/details/publication/pub.1034633628
15 https://doi.org/10.1002/ana.22337
16 https://doi.org/10.1002/glia.20275
17 https://doi.org/10.1002/jnr.22567
18 https://doi.org/10.1016/0896-6273(94)90214-3
19 https://doi.org/10.1016/0896-6273(94)90358-1
20 https://doi.org/10.1016/j.ajhg.2017.03.005
21 https://doi.org/10.1016/j.cell.2007.10.036
22 https://doi.org/10.1016/j.celrep.2013.06.040
23 https://doi.org/10.1016/j.nbd.2012.02.005
24 https://doi.org/10.1016/j.neulet.2016.05.028
25 https://doi.org/10.1016/j.neuron.2007.09.010
26 https://doi.org/10.1016/j.neuron.2008.09.018
27 https://doi.org/10.1016/j.neuron.2009.01.030
28 https://doi.org/10.1016/j.neuron.2009.06.008
29 https://doi.org/10.1016/j.neuron.2014.12.020
30 https://doi.org/10.1046/j.1460-9568.2003.02698.x
31 https://doi.org/10.1073/pnas.202483399
32 https://doi.org/10.1093/brain/118.5.1225
33 https://doi.org/10.1093/brain/awh409
34 https://doi.org/10.1093/brain/awv353
35 https://doi.org/10.1093/jnen/61.9.747
36 https://doi.org/10.1097/nen.0b013e31812571b0
37 https://doi.org/10.1111/cge.12811
38 https://doi.org/10.1111/dmcn.13025
39 https://doi.org/10.1111/j.1460-9568.2011.07894.x
40 https://doi.org/10.1111/j.1750-3639.1995.tb00603.x
41 https://doi.org/10.1126/science.1202529
42 https://doi.org/10.1126/science.3840606
43 https://doi.org/10.1371/journal.pone.0038011
44 https://doi.org/10.1371/journal.pone.0125185
45 https://doi.org/10.1523/jneurosci.21-17-06666.2001
46 https://doi.org/10.1523/jneurosci.22-14-05840.2002
47 https://doi.org/10.1523/jneurosci.5369-12.2013
48 https://doi.org/10.3389/fneur.2013.00199
49 schema:datePublished 2018-12
50 schema:datePublishedReg 2018-12-01
51 schema:description Impaired nerve conduction, axonal degeneration, and synaptic alterations contribute to neurological disabilities in inflammatory demyelinating diseases. Cerebellar dysfunction is associated with demyelinating disorders, but the alterations of axon terminals in cerebellar gray matter during chronic demyelination are still unclear. We analyzed the morphological and ultrastructural changes of climbing fiber terminals in a mouse model of hereditary chronic demyelination. Three-dimensional ultrastructural analyses using serial block-face scanning electron microscopy and immunostaining for synaptic markers were performed in a demyelination mouse model caused by extra copies of myelin gene (PLP4e). At 1 month old, many myelinated axons were observed in PLP4e and wild-type mice, but demyelinated axons and axons with abnormally thin myelin were prominent in PLP4e mice at 5 months old. The density of climbing fiber terminals was significantly reduced in PLP4e mice at 5 months old. Reconstruction of climbing fiber terminals revealed that PLP4e climbing fibers had increased varicosity volume and enlarged mitochondria in the varicosities at 5-month-old mice. These results suggest that chronic demyelination is associated with alterations and loss of climbing fiber terminals in the cerebellar cortex, and that synaptic changes may contribute to cerebellar phenotypes observed in hereditary demyelinating disorders.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N2b1209151d334c998404ee42ed597e34
56 N9695c8ac3c434ab69bcf3b3c985be89f
57 sg:journal.1295024
58 schema:name Decreased number and increased volume with mitochondrial enlargement of cerebellar synaptic terminals in a mouse model of chronic demyelination
59 schema:pagination 208-216
60 schema:productId N79eaa58d3a644291842f98f284b2d1ab
61 N803767b9d70d4f94b5224432e2445976
62 N8f2907f5fada4c9ca2898551968060cf
63 N92ce15e13a4e40639d7ab53b61f12f80
64 Ne79e9d59fe774e559f8766ea9e3f9f4c
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104156044
66 https://doi.org/10.1007/s00795-018-0193-z
67 schema:sdDatePublished 2019-04-10T22:49
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher N79e8d1754c624c3cb2273b4a2f3a6c7b
70 schema:url https://link.springer.com/10.1007%2Fs00795-018-0193-z
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N2b1209151d334c998404ee42ed597e34 schema:issueNumber 4
75 rdf:type schema:PublicationIssue
76 N5f0ede1b89f34f848c9d20591f50513c rdf:first sg:person.01022463266.08
77 rdf:rest Nb4d9a11d1fca4c378de4be0bb9842b39
78 N60f299bca68a4f7f98992ac561479811 rdf:first sg:person.01070207732.43
79 rdf:rest rdf:nil
80 N7768abe81e564a99b0507240a36d5c6e rdf:first sg:person.0734524721.22
81 rdf:rest N9209e2a2d75f4e7285a81672f5abe531
82 N79e8d1754c624c3cb2273b4a2f3a6c7b schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N79eaa58d3a644291842f98f284b2d1ab schema:name dimensions_id
85 schema:value pub.1104156044
86 rdf:type schema:PropertyValue
87 N803767b9d70d4f94b5224432e2445976 schema:name readcube_id
88 schema:value 628caab853474c8315d7678ac595722c551632c5c6ce76e8ddf613b3cead9e9c
89 rdf:type schema:PropertyValue
90 N8f2907f5fada4c9ca2898551968060cf schema:name doi
91 schema:value 10.1007/s00795-018-0193-z
92 rdf:type schema:PropertyValue
93 N9209e2a2d75f4e7285a81672f5abe531 rdf:first sg:person.012747074433.35
94 rdf:rest Na37d385a6edf48629c70c1943dcee9d8
95 N92ce15e13a4e40639d7ab53b61f12f80 schema:name nlm_unique_id
96 schema:value 101239023
97 rdf:type schema:PropertyValue
98 N9695c8ac3c434ab69bcf3b3c985be89f schema:volumeNumber 51
99 rdf:type schema:PublicationVolume
100 Na37d385a6edf48629c70c1943dcee9d8 rdf:first sg:person.01002640121.76
101 rdf:rest N5f0ede1b89f34f848c9d20591f50513c
102 Nb4d9a11d1fca4c378de4be0bb9842b39 rdf:first sg:person.01057571452.27
103 rdf:rest N60f299bca68a4f7f98992ac561479811
104 Ne79e9d59fe774e559f8766ea9e3f9f4c schema:name pubmed_id
105 schema:value 29796936
106 rdf:type schema:PropertyValue
107 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
108 schema:name Medical and Health Sciences
109 rdf:type schema:DefinedTerm
110 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
111 schema:name Neurosciences
112 rdf:type schema:DefinedTerm
113 sg:grant.5916605 http://pending.schema.org/fundedItem sg:pub.10.1007/s00795-018-0193-z
114 rdf:type schema:MonetaryGrant
115 sg:grant.6110148 http://pending.schema.org/fundedItem sg:pub.10.1007/s00795-018-0193-z
116 rdf:type schema:MonetaryGrant
117 sg:journal.1295024 schema:issn 1437-773X
118 1860-1480
119 schema:name Medical Molecular Morphology
120 rdf:type schema:Periodical
121 sg:person.01002640121.76 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
122 schema:familyName Thai
123 schema:givenName Truc Quynh
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002640121.76
125 rdf:type schema:Person
126 sg:person.01022463266.08 schema:affiliation https://www.grid.ac/institutes/grid.467811.d
127 schema:familyName Ikenaka
128 schema:givenName Kazuhiro
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022463266.08
130 rdf:type schema:Person
131 sg:person.01057571452.27 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
132 schema:familyName Oda
133 schema:givenName Toshiyuki
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057571452.27
135 rdf:type schema:Person
136 sg:person.01070207732.43 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
137 schema:familyName Ohno
138 schema:givenName Nobuhiko
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070207732.43
140 rdf:type schema:Person
141 sg:person.012747074433.35 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
142 schema:familyName Sui
143 schema:givenName Yang
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012747074433.35
145 rdf:type schema:Person
146 sg:person.0734524721.22 schema:affiliation https://www.grid.ac/institutes/grid.267500.6
147 schema:familyName Nguyen
148 schema:givenName Huy Bang
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734524721.22
150 rdf:type schema:Person
151 sg:pub.10.1007/978-3-642-65581-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034633628
152 https://doi.org/10.1007/978-3-642-65581-4
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/bf00235210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017602849
155 https://doi.org/10.1007/bf00235210
156 rdf:type schema:CreativeWork
157 sg:pub.10.1007/s00018-006-6182-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008559427
158 https://doi.org/10.1007/s00018-006-6182-8
159 rdf:type schema:CreativeWork
160 sg:pub.10.1007/s00795-016-0134-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036025332
161 https://doi.org/10.1007/s00795-016-0134-7
162 rdf:type schema:CreativeWork
163 sg:pub.10.1007/s10048-004-0207-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1027289000
164 https://doi.org/10.1007/s10048-004-0207-y
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/nature12776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029734019
167 https://doi.org/10.1038/nature12776
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/ncpneuro0735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030523567
170 https://doi.org/10.1038/ncpneuro0735
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/ng0394-257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032042993
173 https://doi.org/10.1038/ng0394-257
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/s41467-017-00260-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1090954112
176 https://doi.org/10.1038/s41467-017-00260-w
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/srep23721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048122181
179 https://doi.org/10.1038/srep23721
180 rdf:type schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1034633628 schema:CreativeWork
182 https://doi.org/10.1002/ana.22337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021810968
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1002/glia.20275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006322494
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1002/jnr.22567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008844818
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0896-6273(94)90214-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018711018
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0896-6273(94)90358-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003454192
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.ajhg.2017.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084056673
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.cell.2007.10.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019924563
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.celrep.2013.06.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046925321
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.nbd.2012.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032502634
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.neulet.2016.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040248459
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.neuron.2007.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046535066
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.neuron.2008.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015864527
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.neuron.2009.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012069793
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.neuron.2009.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031735693
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.neuron.2014.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044427473
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1046/j.1460-9568.2003.02698.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017968065
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1073/pnas.202483399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050810500
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/brain/118.5.1225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059439531
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1093/brain/awh409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010132009
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/brain/awv353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045672119
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1093/jnen/61.9.747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053630193
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1097/nen.0b013e31812571b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029974209
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1111/cge.12811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046973771
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1111/dmcn.13025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016735435
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1111/j.1460-9568.2011.07894.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047097487
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/j.1750-3639.1995.tb00603.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020821490
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1126/science.1202529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049524688
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1126/science.3840606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621986
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1371/journal.pone.0038011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046232493
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1371/journal.pone.0125185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051384089
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1523/jneurosci.21-17-06666.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074868499
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1523/jneurosci.22-14-05840.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075087369
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1523/jneurosci.5369-12.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034616407
247 rdf:type schema:CreativeWork
248 https://doi.org/10.3389/fneur.2013.00199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022014586
249 rdf:type schema:CreativeWork
250 https://www.grid.ac/institutes/grid.267500.6 schema:alternateName University of Yamanashi
251 schema:name Department of Anatomy and Structural Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan
252 Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan
253 rdf:type schema:Organization
254 https://www.grid.ac/institutes/grid.410804.9 schema:alternateName Jichi Medical University
255 schema:name Department of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke-shi, Tochigi, Japan
256 Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.467811.d schema:alternateName National Institute for Physiological Sciences
259 schema:name Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan
260 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...