BRI2 as an anti-Alzheimer gene View Full Text


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Article Info

DATE

2019-03

AUTHORS

Shuji Matsuda, Takao Senda

ABSTRACT

There are several theories regarding the etiologies of Alzheimer disease (AD). Considering that all genes responsible for familial AD are amyloid protein precursor (APP) or APP metabolizing enzymes, surely aberrant APP metabolism is crucial to pathogenesis of AD. BRI2, a type II transmembrane protein, binds APP and inhibits all α, β, and γ pathways of APP proteolysis. Crossing AD model mice with BRI2 transgenic or BRI2 knockout mice confirmed that BRI2 is an anti-Alzheimer gene. Mutations of BRI2 are known to cause rare familial dementias in human. Analysis of knock-in mice harboring the disease mutation revealed the memory defect in the mice, attributable to loss of protective function of BRI2. Further studies are needed to decipher this anti-Alzheimer mechanism of BRI2 to develop a novel therapeutic application for AD. In this review, after describing basic assumptions in AD study, we focus on BRI2 as an anti-Alzheimer gene. More... »

PAGES

1-7

References to SciGraph publications

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  • Journal

    TITLE

    Medical Molecular Morphology

    ISSUE

    1

    VOLUME

    52

    Author Affiliations

    From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00795-018-0191-1

    DOI

    http://dx.doi.org/10.1007/s00795-018-0191-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103603594

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29687167


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00795-018-0191-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00795-018-0191-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00795-018-0191-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00795-018-0191-1'


     

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